Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

BRENDA Home
show all | hide all No of entries

Information on EC 2.3.1.23 - 1-acylglycerophosphocholine O-acyltransferase and Organism(s) Arabidopsis thaliana and UniProt Accession Q9CAN8

for references in articles please use BRENDA:EC2.3.1.23
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree
IUBMB Comments
Acts preferentially with unsaturated acyl-CoA derivatives. 1-Acyl-sn-glycero-3-phosphoinositol can also act as acceptor.
Specify your search results
Select one or more organisms in this record: ?
This record set is specific for:
Arabidopsis thaliana
UNIPROT: Q9CAN8
Show additional data
Do not include text mining results
Include (text mining) results
Include results (AMENDA + additional results, but less precise)
Word Map
The taxonomic range for the selected organisms is: Arabidopsis thaliana
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
pcat1, lpcat3, lpcat, lysophosphatidylcholine acyltransferase, alcat1, lpcat2, lysolecithin acyltransferase, lycat, lyso-paf acetyltransferase, lysophosphatidylcholine acyltransferase 1, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
lysophospholipid acyltransferase
-
lysophospholipid:acyl-CoA acyltransferase
-
1-acyl-sn-glycero-3-phosphocholine acyltransferase
-
-
-
-
acyl coenzyme A-monoacylphosphatidylcholine acyltransferase
-
-
-
-
acyl-CoA:1-acyl-glycero-3-phosphocholine transacylase
-
-
-
-
acyltransferase, lysolecithin
-
-
-
-
lysolecithin acyltransferase
-
-
-
-
lysophosphatide acyltransferase
-
-
-
-
lysophosphatidylcholine acyltransferase
-
-
-
-
lysophospholipid acyltransferase
-
N-acylphosphatidylethanolamine synthase
UniProt
NAPE synthase
UniProt
additional information
see also EC 2.3.1.121 and EC 2.3.1.51
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acyl group transfer
-
-
-
-
PATHWAY SOURCE
PATHWAYS
-
-, -, -, -, -, -, -, -, -, -, -
SYSTEMATIC NAME
IUBMB Comments
acyl-CoA:1-acyl-sn-glycero-3-phosphocholine O-acyltransferase
Acts preferentially with unsaturated acyl-CoA derivatives. 1-Acyl-sn-glycero-3-phosphoinositol can also act as acceptor.
CAS REGISTRY NUMBER
COMMENTARY hide
9027-64-9
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
oleoyl-CoA + 1-oleoyl-lysophosphatidic acid
CoA + 1,2-dioleoyl-sn-lysophosphatidic acid
show the reaction diagram
oleoyl-CoA + 1-oleoyl-sn-lysophosphatidylcholine
CoA + 1,2-dioleoyl-sn-lysophosphatidylcholine
show the reaction diagram
oleoyl-CoA + 1-oleoyl-sn-lysophosphatidylethanolamine
CoA + 1,2-dioleoyl-sn-lysophosphatidylethanolamine
show the reaction diagram
acyl-CoA + 1-acyl-lysophosphatidylethanolamine
CoA + 1,2-diacyl-lysophosphatidylethanolamine
show the reaction diagram
-
-
-
?
acyl-CoA + 1-acyl-lysophosphatidylglycerol
CoA + 1,2-diacyl-lysophosphatidylglycerol
show the reaction diagram
-
-
-
?
acyl-CoA + 1-acyl-lysophosphatidylinositol
CoA + 1,2-diacyl-lysophosphatidylinositol
show the reaction diagram
-
-
-
?
acyl-CoA + 1-acyl-lysophosphatidylserine
CoA + 1,2-diacyl-lysophosphatidylserine
show the reaction diagram
-
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
oleoyl-CoA + 1-oleoyl-lysophosphatidic acid
CoA + 1,2-dioleoyl-sn-lysophosphatidic acid
show the reaction diagram
-
-
-
r
oleoyl-CoA + 1-oleoyl-sn-lysophosphatidylcholine
CoA + 1,2-dioleoyl-sn-lysophosphatidylcholine
show the reaction diagram
-
-
-
r
oleoyl-CoA + 1-oleoyl-sn-lysophosphatidylethanolamine
CoA + 1,2-dioleoyl-sn-lysophosphatidylethanolamine
show the reaction diagram
-
-
-
r
acyl-CoA + 1-acyl-lysophosphatidylethanolamine
CoA + 1,2-diacyl-lysophosphatidylethanolamine
show the reaction diagram
-
-
-
?
acyl-CoA + 1-acyl-lysophosphatidylglycerol
CoA + 1,2-diacyl-lysophosphatidylglycerol
show the reaction diagram
-
-
-
?
acyl-CoA + 1-acyl-lysophosphatidylinositol
CoA + 1,2-diacyl-lysophosphatidylinositol
show the reaction diagram
-
-
-
?
acyl-CoA + 1-acyl-lysophosphatidylserine
CoA + 1,2-diacyl-lysophosphatidylserine
show the reaction diagram
-
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
DTNB
complete inhibition of LPCAT in wild-type and in recombinant heterologous yeast microsomes
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
enzyme At1g78690 shares high homology (about 40%) with the cardiolipin remodeling enzyme tafazzin, but the cardiolipin remodeling enzyme tafazzin and the lysophospholipid acyltransferase catalyze unique reactions
malfunction
despite di-acylate phosphatidylglycerol being a substrate, overexpression of At1g78690 in Escherichia coli leads to the accumulation of acyl-PG. Cardiolipin also accumulates in cells overexpressing At1g78690, cardiolipin is found in the inner mitochondrial membrane in eukaryotes and is critical for mitochondrial function. It serves as a necessary proton trap for oxidative phosphorylation and is a trigger for apoptosis
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
MBOA2_ARATH
465
8
52769
Swiss-Prot
Secretory Pathway (Reliability: 2)
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene AtLPCAT2, recombinant overexpression in Saccharomyces cerevisiae haploid ALE1-knockout strain (BY4742, Matalpa, his3DELTA1, leu2DELTA0, lys2DELTA0, ura3DELTA0, YOR175c::kanMX4)
gene At1g78690, recombinant expression of His-tagged enzyme in Escherichia coli strain BLR(DE3)pLysS
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Moncada, R.M.; Blackshear, K.J.; Garrett, T.A.
The Arabidopsis thaliana lysophospholipid acyltransferase At1g78690p acylates lysocardiolipins
Biochem. Biophys. Res. Commun.
493
340-345
2017
Arabidopsis thaliana (Q9ZV87), Arabidopsis thaliana
Manually annotated by BRENDA team
Jasieniecka-Gazarkiewicz, K.; Demski, K.; Lager, I.; Stymne, S.; Banas, A.
Possible role of different yeast and plant lysophospholipid acyl-CoA acyltransferases (LPLATs) in acyl remodelling of phospholipids
Lipids
51
15-23
2016
Arabidopsis thaliana (Q9CAN8), Saccharomyces cerevisiae (Q08548)
Manually annotated by BRENDA team