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Information on EC 2.3.1.224 - acetyl-CoA-benzylalcohol acetyltransferase
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EC Tree
2.3.1.224 acetyl-CoA-benzylalcohol acetyltransferaseIUBMB Comments
The enzyme is found in flowers like Clarkia breweri, where it is important for floral scent production. Unlike EC 2.3.1.84, alcohol O-acetyltransferase, this enzyme is active with alcohols that contain a benzyl ring.
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
Synonyms
beat-1, acetyl-coa:benzylalcohol acetyltransferase, beat-3, benzylalcohol acetyltransferase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
acetyl-CoA:benzylalcohol acetyltransferase
BEAT-1
BEAT-2
benzylalcohol acetyltransferase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
acetyl-CoA + benzyl alcohol = CoA + benzyl acetate
Clarkia breweri
-
-
-
acetyl-CoA + cinnamyl alcohol = CoA + cinnamyl acetate
Clarkia breweri
-
-
-
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PATHWAY SOURCE
PATHWAYS
BRENDA
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SYSTEMATIC NAME
IUBMB Comments
acetyl-CoA:benzylalcohol O-acetyltransferase
The enzyme is found in flowers like Clarkia breweri, where it is important for floral scent production. Unlike EC 2.3.1.84, alcohol O-acetyltransferase, this enzyme is active with alcohols that contain a benzyl ring.
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
acetyl-CoA + 2-(naphthalen-1-yl)ethanol
CoA + 2-(naphthalen-1-yl)ethyl acetate
-
139% activity compared to benzyl alcohol with isoform BEAT-1, 93% activity compared to benzyl alcohol with isoform BEAT-2, 217% activity compared to benzyl alcohol with isoform BEAT-3
-
-
?
acetyl-CoA + 2-(naphthalen-2-yl)ethanol
CoA + 2-(naphthalen-2-yl)ethyl acetate
at 9% of the activity compared to benzyl alcohol, plant purified enzyme, at 28% of the activity compared to benzyl alcohol (Escherichia coli-expressed enzyme)
-
-
?
acetyl-CoA + 2-phenylethanol
CoA + 2-phenylethylacetate
at 33% of the activity compared to benzyl alcohol, plant purified enzyme, at 57% of the activity compared to benzyl alcohol (Escherichia coli-expressed enzyme)
-
-
?
acetyl-CoA + naphthalene ethanol
?
-
57% activity compared to benzyl alcohol with isoform BEAT-1, 50% activity compared to benzyl alcohol with isoform BEAT-2
-
-
?
malonyl-CoA + cyanidin 3-O-(6''-O-4-coumarylglucoside)-5-O-(6'''-O-malonylglucoside)
CoA + ?
-
-
-
?
acetyl-CoA + 2-phenylethanol
CoA + 2-phenylethyl acetate
-
28% activity compared to benzyl alcohol with isoform BEAT-1, 40% activity compared to benzyl alcohol with isoform BEAT-2
-
-
?
acetyl-CoA + 2-phenylethanol
CoA + 2-phenylethyl acetate
-
11% activity compared to benzyl alcohol with isoform BEAT-1, 21% activity compared to benzyl alcohol with isoform BEAT-2, 131% activity compared to benzyl alcohol with isoform BEAT-3
-
-
?
acetyl-CoA + 3-cis-hexene-1-ol
CoA + (3Z)-hex-3-en-1-yl acetate
-
102% activity compared to benzyl alcohol with isoform BEAT-1, 102% activity compared to benzyl alcohol with isoform BEAT-2
-
-
?
acetyl-CoA + 3-cis-hexene-1-ol
CoA + (3Z)-hex-3-en-1-yl acetate
-
70% activity compared to benzyl alcohol with isoform BEAT-1, 128% activity compared to benzyl alcohol with isoform BEAT-2, 66% activity compared to benzyl alcohol with isoform BEAT-3
-
-
?
acetyl-CoA + cinnamyl alcohol
CoA + cinnamyl acetate
at 88% of the activity compared to benzyl alcohol (plant purified enzyme), at 97% of the activity compared to benzyl alcohol (Escherichia coli-expressed enzyme)
-
-
?
acetyl-CoA + cinnamyl alcohol
CoA + cinnamyl acetate
-
97% activity compared to benzyl alcohol with isoform BEAT-1, 122% activity compared to benzyl alcohol with isoform BEAT-2
-
-
?
acetyl-CoA + cinnamyl alcohol
CoA + cinnamyl acetate
-
147% activity compared to benzyl alcohol with isoform BEAT-1, 162% activity compared to benzyl alcohol with isoform BEAT-2, 838% activity compared to benzyl alcohol with isoform BEAT-3
-
-
?
acetyl-CoA + heptanol
CoA + heptyl acetate
-
143% activity compared to benzyl alcohol with isoform BEAT-1, 150% activity compared to benzyl alcohol with isoform BEAT-2
-
-
?
acetyl-CoA + heptanol
CoA + heptyl acetate
-
498% activity compared to benzyl alcohol with isoform BEAT-1, 528% activity compared to benzyl alcohol with isoform BEAT-2, 502% activity compared to benzyl alcohol with isoform BEAT-3
-
-
?
additional information
?
-
no activity with: 2-hydroxybenzylalcohol, 3-hydroxybenzylalcohol, 4-hydroxybenzylalcohol and linalool
-
-
?
additional information
?
-
-
no activity with: 2-hydroxybenzylalcohol, 3-hydroxybenzylalcohol, 4-hydroxybenzylalcohol and linalool
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
malonyl-CoA + cyanidin 3-O-(6''-O-4-coumarylglucoside)-5-O-(6'''-O-malonylglucoside)
CoA + ?
-
-
-
?
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
additional information
not influenced by Ca2+, Co2+, Mg2+, Mn2+, Ni2+, and Sn2+
additional information
-
not influenced by Ca2+, Co2+, Mg2+, Mn2+, Ni2+, and Sn2+
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Coronary Artery Disease
The response of the oxygen pulse during a stress test in patients with coronary artery disease.
Stroke
Altered cardiovascular haemodynamics and baroreceptor-heart rate reflex in adult sheep after prenatal exposure to dexamethasone.
Stroke
Captopril versus placebo in congestive heart failure: effects on oxygen delivery to exercising skeletal muscle.
Stroke
Cardiovascular functions in two macruran decapod crustaceans (Procambarus clarkii and Homarus americanus) during periods of inactivity, tail flexion and cardiorespiratory pauses
Stroke
Comparison of the haemodynamic effects of dobutamine with enoximone after open heart surgery in small children.
Stroke
Dobutamine in the treatment of depressed cardiac function: a study in patients with ischaemic heart disease during the early post-operative period.
Stroke
Effects of clonidine on narcotic requirements and hemodynamic response during induction of fentanyl anesthesia and endotracheal intubation.
Stroke
Global and regional function in the regionally ischaemic left ventricle related to plasma ionised calcium.
Stroke
Haemodynamic effects of the lateral decubitus position and the kidney rest lateral decubitus position during anaesthesia.
Stroke
Haemodynamic findings in experimental right ventricular ischaemia after right coronary arterial ligation.
Stroke
The acute effects of intravenous xamoterol ('Corwin', I.C.I. 118, 587) on resting and exercise haemodynamics in patients with mild to moderate heart failure.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.024
acetyl-CoA
-
in 250 mM Tris-HCl pH 7.5, 25 mM MgCl2, 25 mM KC1, 10 mM 2-mercaptoethanol, at 30°C
0.12
benzyl alcohol
-
isoform BEAT-1, in 250 mM Tris-HCl pH 7.5, 25 mM MgCl2, 25 mM KC1, 10 mM 2-mercaptoethanol, at 30°C
0.12
benzyl alcohol
-
isoform BEAT-2, in 250 mM Tris-HCl pH 7.5, 25 mM MgCl2, 25 mM KC1, 10 mM 2-mercaptoethanol, at 30°C
0.34
benzyl alcohol
-
isoform BEAT-2, in 250 mM Tris-HCl pH 7.5, 25 mM MgCl2, 25 mM KC1, 10 mM 2-mercaptoethanol, at 30°C
0.24
benzyl alcohol
-
isoform BEAT-1, in 250 mM Tris-HCl pH 7.5, 25 mM MgCl2, 25 mM KC1, 10 mM 2-mercaptoethanol, at 30°C
0.0563
monodemalonylsalvianin
recombinant enzyme, at pH 7.0 and 30°C
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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
additional information
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
physiological function
the enzyme is important for floral scent production
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UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). BEATH_CLABR
433
0
48198
Swiss-Prot
other Location (Reliability: 4)
BEATL_CLABR
433
0
48195
Swiss-Prot
other Location (Reliability: 4)
BEBT1_PETHY
460
0
51042
Swiss-Prot
other Location (Reliability: 2)
CFAT_PETHY
454
0
51120
Swiss-Prot
other Location (Reliability: 3)
A0A2G9H8V9_9LAMI
429
0
48890
TrEMBL
other Location (Reliability: 5)
A0A2G9I7D6_9LAMI
429
0
48939
TrEMBL
other Location (Reliability: 5)
A0A513ZRX6_9LAMI
208
0
23478
TrEMBL
Secretory Pathway (Reliability: 4)
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
ammonium sulfate fractionation, DEAE-Sepharose column chromatography, phenyl Sepharose column chromatography, Mono Q column chromatography, and Superdex 200 gel filtration
DEAE column chromatography, hydroxyapatite column chromatography, and Mono Q column chromatography
DEAE column chromatography, hydroxyapatite column chromatography, and Mono Q column chromatography
-
DEAE column chromatography, hydroxyapatite column chromatography, and Mono Q column chromatography
-
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli BL21 cells
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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
the levels of BEAT mRNA in the petals increases as the bud matures, and peaks at anthesis
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Suzuki, H.; Sawada, S.; Watanabe, K.; Nagae, S.; Yamaguchi, M.A.; Nakayama, T.; Nishino, T.
Identification and characterization of a novel anthocyanin malonyltransferase from scarlet sage (Salvia splendens) flowers: an enzyme that is phylogenetically separated from other anthocyanin acyltransferases
Plant J.
38
994-1003
2004
Salvia splendens (Q6TXD2), Salvia splendens
brenda
Dudareva, N.; D'Auria, J.C.; Nam, K.H.; Raguso, R.A.; Pichersky, E.
Acetyl-CoA:benzylalcohol acetyltransferase - an enzyme involved in floral scent production in Clarkia breweri
Plant J.
14
297-304
1998
Clarkia breweri (O64988), Clarkia breweri
brenda
Nam, K.H.; Dudareva, N.; Pichersky, E.
Characterization of benzylalcohol acetyltransferases in scented and non-scented Clarkia species
Plant Cell Physiol.
40
916-923
1999
Clarkia breweri, Clarkia concinna
brenda
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