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Synonyms
cpt1a, carnitine palmitoyltransferase, cpt i, carnitine palmitoyltransferase i, cpt-1, cpt ii, cpt1b, carnitine palmitoyltransferase 1, carnitine palmitoyltransferase-1, cpt1c,
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acylcarnitine transferase
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carnitine O-palmitoyltransferase
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carnitine O-palmitoyltransferase I
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carnitine palmitoyl transferase 1
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carnitine palmitoyl transferase 1A
carnitine palmitoyl transferase-1A
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carnitine palmitoyl transferase-I
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carnitine palmitoyl-transferase-1c
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carnitine palmitoyltransferae 1A
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carnitine palmitoyltransferase
carnitine palmitoyltransferase 1
carnitine palmitoyltransferase 1A
carnitine palmitoyltransferase 1B
carnitine palmitoyltransferase 2
carnitine palmitoyltransferase I
carnitine palmitoyltransferase IA
carnitine palmitoyltransferase II
carnitine palmitoyltransferase-1
carnitine palmitoyltransferase-1c
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carnitine palmitoyltransferase-A
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carnitine palmitoyltransferase-I
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carnitine palmitoyltransferases 2
ubiquitous protein
CPT-Ialpha
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liver isoform
CPT1-B
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muscle isoenzyme
L-carnitine palmitoyltransferase
muscle carnitine palmitoyltransferase I
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palmitoylcarnitine transferase
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palmitoyltransferase, carnitine
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carnitine palmitoyl transferase 1A
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carnitine palmitoyl transferase 1A
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carnitine palmitoyl transferase 1A
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carnitine palmitoyltransferase
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carnitine palmitoyltransferase
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carnitine palmitoyltransferase
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carnitine palmitoyltransferase 1
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splice variant exon 6A
carnitine palmitoyltransferase 1
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splice variant exon 6B
carnitine palmitoyltransferase 1
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carnitine palmitoyltransferase 1
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carnitine palmitoyltransferase 1
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carnitine palmitoyltransferase 1A
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carnitine palmitoyltransferase 1A
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carnitine palmitoyltransferase 1B
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carnitine palmitoyltransferase 1B
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carnitine palmitoyltransferase 2
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carnitine palmitoyltransferase 2
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carnitine palmitoyltransferase 2
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carnitine palmitoyltransferase 2
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carnitine palmitoyltransferase I
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carnitine palmitoyltransferase I
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carnitine palmitoyltransferase I
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carnitine palmitoyltransferase I
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heart/muscle-type isoenzyme
carnitine palmitoyltransferase I
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liver-type isoenzyme
carnitine palmitoyltransferase I
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carnitine palmitoyltransferase I
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carnitine palmitoyltransferase I
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carnitine palmitoyltransferase I
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carnitine palmitoyltransferase I
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carnitine palmitoyltransferase I
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carnitine palmitoyltransferase I
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carnitine palmitoyltransferase I
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carnitine palmitoyltransferase I
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carnitine palmitoyltransferase I
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carnitine palmitoyltransferase IA
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carnitine palmitoyltransferase IA
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carnitine palmitoyltransferase IA
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carnitine palmitoyltransferase II
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carnitine palmitoyltransferase II
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carnitine palmitoyltransferase II
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carnitine palmitoyltransferase II
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carnitine palmitoyltransferase-1
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carnitine palmitoyltransferase-1
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carnitine palmitoyltransferase-1
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carnitine palmitoyltransferase-1
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CPT
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CPT I
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CPT I
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outer membrane carnitine palmitoyl transferase
CPT-1
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CPT1
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CPT1A
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CPT1B
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CPT1c
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CPT2
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CPTi
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CPTi
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inner form, tightly membrane bound
CPTi
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inner, initially latent carnitine transferase
L-carnitine palmitoyltransferase
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L-carnitine palmitoyltransferase
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M-CPTI
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palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine
palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine
random sequential mechanism
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palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine
2 independent inhibitory sites
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palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine
broad sepcificity to acyl group, over the range C8 to C18
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palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine
sigmoidal kinetics with both substrates
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palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine
rapid-equilibrium random-order mechanism
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palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine
flexible active site
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palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine
active site three-dimensional structure model
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palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine
optimal activity with palmitoyl-CoA
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palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine
CPT I acts at 2 distinct sites, a regulatory and an active site
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palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine
the catalytic triad is composed of Cys305, His473, and Asp454, with Cys305 serving as a probable nucleophile, thus acting as a site for covalent attachment of the acyl molecule and formation of a stable acyl-enzyme intermediate, mechanism
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Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
4,8-dimethylnonanoyl-CoA + L-carnitine
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4,8-dimethylnonanoyl-CoA + L-carnitine
CoA + 4,8-dimethylnonanoyl-L-carnitine
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?
acetyl-CoA + L-carnitine
CoA + L-acetylcarnitine
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acyl-CoA + L-carnitine
CoA + L-acylcarnitine
arachidoyl-CoA + L-carnitine
CoA + L-arachidoylcarnitine
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?
butyryl-CoA + L-carnitine
CoA + L-butyrylcarnitine
decanoyl-CoA + L-carnitine
CoA + L-decanoylcarnitine
docosanhexaenoyl-CoA + L-carnitine
CoA + L-docosanhexaenoylcarnitine
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?
dodecanoyl-CoA + L-carnitine
CoA + L-dodecanoylcarnitine
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?
erucoyl-CoA + L-carnitine
CoA + L-erucoylcarnitine
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?
hexanoyl-CoA + L-carnitine
CoA + L-hexanoylcarnitine
L-carnitine + palmitoyl-CoA
L-palmitoylcarnitine + CoA
lauroyl-CoA + L-carnitine
CoA + L-lauroylcarnitine
linoleoyl-CoA + L-carnitine
CoA + L-linoleoylcarnitine
myristoyl-CoA + L-carnitine
CoA + L-myristoylcarnitine
octanoyl-CoA + L-carnitine
CoA + L-octanoylcarnitine
oleoyl-CoA + L-carnitine
CoA + L-oleoylcarnitine
palmitoleoyl-CoA + L-carnitine
CoA + L-palmitoleoylcarnitine
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activity is 47% higher than with palmitoyl-CoA
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?
palmitoyl-CoA + DL-carnitine
CoA + DL-palmitoylcarnitine
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r
palmitoyl-CoA + L-carnitine
CoA + L-palmitoylcarnitine
palmitoyl-CoA + L-carnitine
L-palmitoylcarnitine + CoA
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forward reaction by CPT I and reverse reaction by CPT II
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r
stearoyl-CoA + L-carnitine
CoA + L-stearoylcarnitine
trans-2-hexadecenoyl-CoA + L-carnitine
CoA + trans-2-hexadecenoyl-L-carnitine
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additional information
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acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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r
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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r
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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r
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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reverse reaction with palmitoylcarnitine, reverse reaction: myristoylcarnitine
r
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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substrate specificity
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?, r
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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effect of octylglucoside and Triton X-100 on specificity
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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substrate specificity
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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substrate specificity
reverse reaction: acyl-CoA substrates are C4 to C18 acylcarnitines
r
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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C4 to C18 acyl-CoAs
reverse reaction: acyl-CoA substrates are C4 to C18 acylcarnitines
r
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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r
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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r
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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r
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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substrate specificity
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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CPT I activity is involved in cardiac mitochondrial beta-oxidation flux control
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r
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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enzyme has a key function in regulation of fatty acid beta-oxidation
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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enzyme has a key function in regulation of fatty acid beta-oxidation
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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CPT I, involved in regulation of fatty acid oxidation
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acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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substrate specificity
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r
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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preference for desaturated long-chain acyl CoAs
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r
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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C4 to C18 acyl-CoAs
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r
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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enzyme has a key function in regulation of fatty acid beta-oxidation
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r
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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-
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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-
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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-
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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-
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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-
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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-
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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-
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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-
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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-
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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-
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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-
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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-
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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-
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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-
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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-
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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-
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
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?
acyl-CoA + L-carnitine
CoA + L-acylcarnitine
2.3.1.21 carnitine O-palmitoyltransferase
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