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Information on EC 2.3.1.189 - mycothiol synthase

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EC Tree
     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.189 mycothiol synthase
IUBMB Comments
This enzyme catalyses the last step in the biosynthesis of mycothiol, the major thiol in most actinomycetes, including Mycobacterium . The enzyme is a member of a large family of GCN5-related N-acetyltransferases (GNATs) . The enzyme has been purified from Mycobacterium tuberculosis H37Rv. Acetyl-CoA is the preferred CoA thioester but propionyl-CoA is also a substrate .
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The enzyme appears in viruses and cellular organisms
Synonyms
msh synthase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
desacetylmycothiol + acetyl-CoA = CoA + mycothiol
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PATHWAY SOURCE
PATHWAYS
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