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Enzyme Nomenclature
Information on EC 2.3.1.187 - acetyl-S-ACP:malonate ACP transferase
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The enzyme appears in viruses and cellular organisms
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EC NUMBER 
COMMENTARY 
2.3.1.187
-
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RECOMMENDED NAME
GeneOntology No.
acetyl-S-ACP:malonate ACP transferase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
an acetyl-[acyl-carrier protein] + malonate = a malonyl-[acyl-carrier protein] + acetate
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-
-
-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
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SYSTEMATIC NAME
IUBMB Comments
acetyl-[acyl-carrier-protein]:malonate S-[acyl-carrier-protein]transferase
This is the first step in the catalysis of malonate decarboxylation and involves the exchange of an acetyl thioester residue bound to the activated acyl-carrier protein (ACP) subunit of the malonate decarboxylase complex for a malonyl thioester residue [2]. This enzyme forms the alpha subunit of the multienzyme complexes biotin-independent malonate decarboxylase (EC 4.1.1.88) and biotin-dependent malonate decarboxylase (EC 4.1.1.89). The enzyme can also use acetyl-CoA as a substrate but more slowly [4].
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CAS REGISTRY NUMBER
COMMENTARY
80700-20-5
multienzyme complex malonate decarboxylase
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
metabolism
additional information
metabolism
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to achieve decarboxylation of malonate, the key reaction in the decomposition of this compound, the substrate must be activated by the malonate decarboxylase to a malonyl thio-enzyme ester involving an activation module that comprises the acetylation of a specific thiol group of an acyl carrier protein, ACP, and the transfer of the ACP moiety to malonate, yielding malonyl-S-ACP and acetate. The malonyl-S-ACP is subsequently decarboxylated with regeneration of the acetyl-ACP. Malonate decarboxylation pathway, overview
metabolism
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to achieve decarboxylation of malonate, the key reaction in the decomposition of this compound, the substrate must be activated by the malonate decarboxylase to a malonyl thio-enzyme ester involving an activation module that comprises the acetylation of a specific thiol group of an acyl carrier protein, ACP, and the transfer of the ACP moiety to malonate, yielding malonyl-S-ACP and acetate. The malonyl-S-ACP is subsequently decarboxylated with regeneration of the acetyl-ACP. Malonate decarboxylation pathway, overview
additional information
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the acetyl-S-ACP:malonate ACP transferase is a component of the malonate decarboxylase complex
additional information
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the acetyl-S-acyl carrier protein:malonate acyl carrier protein-SH transferase is a component of the malonate decarboxylase complex
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
malonate + acetyl-[acyl-carrier protein]
acetate + malonyl-[acyl-carrier protein]
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-
-
-
?
malonate + acetyl-[acyl-carrier protein]
acetate + malonyl-[acyl-carrier protein]
-
-
-
-
?
malonyl-CoA + dephospho-CoA
CoA + malonyl-dephospho-CoA
-
-
-
-
?
malonyl-CoA + dephospho-CoA
CoA + malonyl-dephospho-CoA
-
-
-
-
?
methylmalonyl-CoA + dephospho-CoA
CoA + methylmalonyl-dephospho-CoA
-
-
-
-
?
methylmalonyl-CoA + dephospho-CoA
CoA + methylmalonyl-dephospho-CoA
-
-
-
-
?
methylmalonyl-CoA + dephospho-CoA
CoA + methylmalonyl-dephospho-CoA
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transfer proceeds via a covalent methylmalonyl-enzyme intermediate
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-
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
malonate + acetyl-[acyl-carrier protein]
acetate + malonyl-[acyl-carrier protein]
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-
-
-
?
malonate + acetyl-[acyl-carrier protein]
acetate + malonyl-[acyl-carrier protein]
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-
-
-
?
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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
N-ethylmaleimide
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preincubation with malonyl-CoA or methylmalonyl-CoA protects
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
60800
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x * 60800, isolated acetyl-S-ACP:malonate ACP transferase C-terminal alpha subunit of the malonate decarboxylase complex, SDS-PAGE
61200
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x * 61200, isolated acetyl-S-acyl carrier protein:malonate acyl carrier protein-SH transferase moiety of the enzyme complex, SDS-PAGE
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SUBUNITS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
?
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x * 60800, isolated acetyl-S-ACP:malonate ACP transferase C-terminal alpha subunit of the malonate decarboxylase complex, SDS-PAGE
?
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x * 61200, isolated acetyl-S-acyl carrier protein:malonate acyl carrier protein-SH transferase moiety of the enzyme complex, SDS-PAGE
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
isolated soluble native transferase component of the malonate decarboxylase
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
gene mdcA, encoded in the malonate decarboxylase operon mdc, genetic organization
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LINKS TO OTHER DATABASES (specific for EC-Number 2.3.1.187)
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