This is the first step in the catalysis of malonate decarboxylation and involves the exchange of an acetyl thioester residue bound to the activated acyl-carrier protein (ACP) subunit of the malonate decarboxylase complex for a malonyl thioester residue . This enzyme forms the alpha subunit of the multienzyme complexes biotin-independent malonate decarboxylase (EC 4.1.1.88) and biotin-dependent malonate decarboxylase (EC 7.2.4.4). The enzyme can also use acetyl-CoA as a substrate but more slowly .
Specify your search results
The enzyme appears in viruses and cellular organisms
This is the first step in the catalysis of malonate decarboxylation and involves the exchange of an acetyl thioester residue bound to the activated acyl-carrier protein (ACP) subunit of the malonate decarboxylase complex for a malonyl thioester residue [2]. This enzyme forms the alpha subunit of the multienzyme complexes biotin-independent malonate decarboxylase (EC 4.1.1.88) and biotin-dependent malonate decarboxylase (EC 7.2.4.4). The enzyme can also use acetyl-CoA as a substrate but more slowly [4].
to achieve decarboxylation of malonate, the key reaction in the decomposition of this compound, the substrate must be activated by the malonate decarboxylase to a malonyl thio-enzyme ester involving an activation module that comprises the acetylation of a specific thiol group of an acyl carrier protein, ACP, and the transfer of the ACP moiety to malonate, yielding malonyl-S-ACP and acetate. The malonyl-S-ACP is subsequently decarboxylated with regeneration of the acetyl-ACP. Malonate decarboxylation pathway, overview
to achieve decarboxylation of malonate, the key reaction in the decomposition of this compound, the substrate must be activated by the malonate decarboxylase to a malonyl thio-enzyme ester involving an activation module that comprises the acetylation of a specific thiol group of an acyl carrier protein, ACP, and the transfer of the ACP moiety to malonate, yielding malonyl-S-ACP and acetate. The malonyl-S-ACP is subsequently decarboxylated with regeneration of the acetyl-ACP. Malonate decarboxylation pathway, overview
Formation of catalytically active acetyl-S-malonate decarboxylase requires malonyl-coenzyme A:acyl carrier protein transacylase as auxiliary enzyme [corrected]
HOME
login
history
all enzymes
BRENDA home
History
2.3.1.187 acetyl-S-ACP:malonate ACP transferase
more
top
Information
