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an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine = an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
RhlI contains no active site cysteine, residues R24, F28, W34, E46, D48, D51, G68, C67, R71, E101, S103, and R104 are critical for catalytic activity
an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine = an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine = an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
substrate binding structure
-
an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine = an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
RhlI shows a sequential, ordered ping-pong reaction mechanism with S-adenosyl-L-methionine binding first
-
an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine = an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
structures of substrate, product, and transition state, overview
-
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S-adenosyl-L-methionine + butyryl-[acyl-carrier protein]
5'-methylthioadenosine + N-butyryl-L-homoserine-1,4-lactone + [acyl-carrier protein]
-
-
-
?
3-oxo-dodecanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxododecanoyl-L-homoserine lactone
-
-
-
-
?
3-oxododecanoyl-[acyl carrier protein] + S-adenosyl-L-methionine
N-(3-oxododecanoyl)-homoserine lactone + [acyl carrier protein] + 5'-methyl-thioadenosine
-
-
-
ir
3-oxododecanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
N-(3-oxododecanoyl)-L-homoserine lactone + [acyl-carrier protein] + S-methyl-5'-thioadenosine
-
-
-
-
?
3-oxododecanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxododecanoyl-L-homoserine lactone
-
LasI
-
-
?
an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine
an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
-
-
-
-
?
butanoyl [acyl carrier protein] + S-adenosyl-L-methionine
N-butanoyl homoserine lactone + [acyl carrier protein] + 5'-methyl-thioadenosine
butanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
N-butanoyl-L-homoserine lactone + [acyl-carrier protein] + S-methyl-5'-thioadenosine
-
-
-
-
?
butanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + butanoyl-L-homoserine lactone
-
RhlI
-
-
?
hexanoyl [acyl carrier protein] + S-adenosyl-L-methionine
N-hexanoyl homoserine lactone + [acyl carrier protein] + 5'-methyl-thioadenosine
-
production is only 1/15 of N-butanoyl homoserine lactone
-
-
ir
S-adenosyl-L-methionine + 3-oxododecanoyl-[acyl-carrier protein]
5'-methylthioadenosine + N-3-oxododecanoyl-L-homoserine-1,4-lactone + [acyl-carrier protein]
-
substrate of LasI
-
-
?
S-adenosyl-L-methionine + butyryl-CoA
5'-methylthioadenosine + N-butyryl-L-homoserine-1,4-lactone + CoA
S-adenosyl-L-methionine + butyryl-S-adenosyl-L-methionine
5'-methylthioadenosine + N-butyryl-L-homoserine-1,4-lactone + S-adenosyl-L-methionine
-
-
-
-
?
S-adenosyl-L-methionine + butyryl-[acyl-carrier protein 1]
5'-methylthioadenosine + N-butyryl-L-homoserine-1,4-lactone + [acyl-carrier protein 1]
-
substrate of RhlI, three different [acyl-carrier-protein] isozymes from Pseudomonas aeruginosa serve as substrates
-
-
?
S-adenosyl-L-methionine + butyryl-[acyl-carrier protein 2]
5'-methylthioadenosine + N-butyryl-L-homoserine-1,4-lactone + [acyl-carrier protein 2]
-
substrate of RhlI, three different [acyl-carrier-protein] isozymes from Pseudomonas aeruginosa serve as substrates
-
-
?
S-adenosyl-L-methionine + butyryl-[acyl-carrier protein 3]
5'-methylthioadenosine + N-butyryl-L-homoserine-1,4-lactone + [acyl-carrier protein 3]
-
substrate of RhlI, three different [acyl-carrier-protein] isozymes from Pseudomonas aeruginosa serve as substrates, very low activity with ACP3
-
-
?
S-adenosyl-L-methionine + butyryl-[acyl-carrier protein]
5'-methylthioadenosine + N-butyryl-L-homoserine-1,4-lactone + [acyl-carrier protein]
S-adenosyl-L-methionine + hexanoyl-[acyl-carrier protein]
5'-methylthioadenosine + N-hexanoyl-L-homoserine-1,4-lactone + [acyl-carrier protein]
-
-
-
-
?
S-adenosyl-L-methionine + octanoyl-[acyl-carrier protein]
5'-methylthioadenosine + N-octanoyl-L-homoserine-1,4-lactone + [acyl-carrier protein]
-
-
-
-
?
additional information
?
-
butanoyl [acyl carrier protein] + S-adenosyl-L-methionine
N-butanoyl homoserine lactone + [acyl carrier protein] + 5'-methyl-thioadenosine
-
-
-
-
ir
butanoyl [acyl carrier protein] + S-adenosyl-L-methionine
N-butanoyl homoserine lactone + [acyl carrier protein] + 5'-methyl-thioadenosine
-
-
-
ir
S-adenosyl-L-methionine + butyryl-CoA
5'-methylthioadenosine + N-butyryl-L-homoserine-1,4-lactone + CoA
-
-
-
-
?
S-adenosyl-L-methionine + butyryl-CoA
5'-methylthioadenosine + N-butyryl-L-homoserine-1,4-lactone + CoA
-
substrate of RhlI, very low activity
-
-
?
S-adenosyl-L-methionine + butyryl-[acyl-carrier protein]
5'-methylthioadenosine + N-butyryl-L-homoserine-1,4-lactone + [acyl-carrier protein]
-
-
-
-
?
S-adenosyl-L-methionine + butyryl-[acyl-carrier protein]
5'-methylthioadenosine + N-butyryl-L-homoserine-1,4-lactone + [acyl-carrier protein]
-
substrate of RhlI, synthesis of a quorum-sensing molecule involved in the regulation of many processes involving the bacterial virulence and infectivity
-
-
?
additional information
?
-
the enzyme is involved in quorum-sensing signaling by synthesizing the signaling molecules, the autoinducers N-acylhomoserine lactones, the enzyme acts as a quorum-sensing signal generator
-
-
?
additional information
?
-
-
the enzyme is involved in quorum-sensing signaling by synthesizing the signaling molecules, the autoinducers N-acylhomoserine lactones, the enzyme acts as a quorum-sensing signal generator
-
-
?
additional information
?
-
-
LasI and LasR form a quorum-sensing system playing a pivotal role in virulence gene regulation of the opportunistic human pathogen Pseudomonas aeruginosa
-
-
?
additional information
?
-
-
the enzyme is involved in quorum-sensing signaling by synthesizing the signaling molecules which regulates the virulence genes, N-acylhomoserine lactones are autoinducers, the enzyme acts as a quorum-sensing signal generator, mechanism, overview
-
-
?
additional information
?
-
-
substrate specificity of RhlI, no activity with butyrate, hexanoyl-CoA, and decanoyl-[acyl-carrier-protein], no activity with S-adenosyl-L-homocysteine, S-adenosyl-L-cysteine, L-homoserine lactone, L-homocystein, L-homoserine, and L-methionine as substrates
-
-
?
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S-adenosyl-L-methionine + butyryl-[acyl-carrier protein]
5'-methylthioadenosine + N-butyryl-L-homoserine-1,4-lactone + [acyl-carrier protein]
-
-
-
?
3-oxo-dodecanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxododecanoyl-L-homoserine lactone
-
-
-
-
?
3-oxododecanoyl-[acyl carrier protein] + S-adenosyl-L-methionine
N-(3-oxododecanoyl)-homoserine lactone + [acyl carrier protein] + 5'-methyl-thioadenosine
-
-
-
ir
3-oxododecanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxododecanoyl-L-homoserine lactone
-
LasI
-
-
?
an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine
an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
-
-
-
-
?
butanoyl [acyl carrier protein] + S-adenosyl-L-methionine
N-butanoyl homoserine lactone + [acyl carrier protein] + 5'-methyl-thioadenosine
butanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + butanoyl-L-homoserine lactone
-
RhlI
-
-
?
hexanoyl [acyl carrier protein] + S-adenosyl-L-methionine
N-hexanoyl homoserine lactone + [acyl carrier protein] + 5'-methyl-thioadenosine
-
production is only 1/15 of N-butanoyl homoserine lactone
-
-
ir
S-adenosyl-L-methionine + 3-oxododecanoyl-[acyl-carrier protein]
5'-methylthioadenosine + N-3-oxododecanoyl-L-homoserine-1,4-lactone + [acyl-carrier protein]
-
substrate of LasI
-
-
?
S-adenosyl-L-methionine + butyryl-[acyl-carrier protein]
5'-methylthioadenosine + N-butyryl-L-homoserine-1,4-lactone + [acyl-carrier protein]
-
substrate of RhlI, synthesis of a quorum-sensing molecule involved in the regulation of many processes involving the bacterial virulence and infectivity
-
-
?
additional information
?
-
butanoyl [acyl carrier protein] + S-adenosyl-L-methionine
N-butanoyl homoserine lactone + [acyl carrier protein] + 5'-methyl-thioadenosine
-
-
-
-
ir
butanoyl [acyl carrier protein] + S-adenosyl-L-methionine
N-butanoyl homoserine lactone + [acyl carrier protein] + 5'-methyl-thioadenosine
-
-
-
ir
additional information
?
-
the enzyme is involved in quorum-sensing signaling by synthesizing the signaling molecules, the autoinducers N-acylhomoserine lactones, the enzyme acts as a quorum-sensing signal generator
-
-
?
additional information
?
-
-
the enzyme is involved in quorum-sensing signaling by synthesizing the signaling molecules, the autoinducers N-acylhomoserine lactones, the enzyme acts as a quorum-sensing signal generator
-
-
?
additional information
?
-
-
LasI and LasR form a quorum-sensing system playing a pivotal role in virulence gene regulation of the opportunistic human pathogen Pseudomonas aeruginosa
-
-
?
additional information
?
-
-
the enzyme is involved in quorum-sensing signaling by synthesizing the signaling molecules which regulates the virulence genes, N-acylhomoserine lactones are autoinducers, the enzyme acts as a quorum-sensing signal generator, mechanism, overview
-
-
?
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Tannic acid
efficiently inhibits N-acylhomoserine lactone production by isoform RhlI, specifically target short-chain N-acylhomoserine lactone synthase RhlI
trans-cinnamaldehyde
efficiently inhibits N-acylhomoserine lactone production by isoform RhlI, specifically target short-chain N-acylhomoserine lactone synthase RhlI. trans-Cinnamaldehyde reduces the quorum-sensing-regulated pyocyanin production up to 42%
2-(4-cyclopentyl-1H-1,2,3-triazol-1-yl)-N-[(3S)-2-oxotetrahydrofuran-3-yl]acetamide
-
IC50 value for growth of Pseudomonas aeruginosa 0.610 mM
2-(4-hexyl-1H-1,2,3-triazol-1-yl)-N-[(3S)-2-oxotetrahydrofuran-3-yl]acetamide
-
IC50 value for growth of Pseudomonas aeruginosa 0.425 mM
3-[4-(3-formylphenyl)-1H-1,2,3-triazol-1-yl]-N-[(3S)-2-oxotetrahydrofuran-3-yl]propanamide
-
IC50 value for growth of Pseudomonas aeruginosa 0.381 mM
5'-methylthioadenosine
-
67% inhibition at 0.05 mM, 91% inhibition at 0.5 mM
butyryl-S-adenosyl-L-methionine
-
24% inhibition at 0.05 mM, 65% inhibition at 0.5 mM
S-Adenosyl-D-homocysteine
-
43% inhibition at 0.05 mM, 88% inhibition at 0.5 mM
S-adenosyl-L-cysteine
-
77% inhibition at 0.05 mM, 97% inhibition at 0.5 mM
S-adenosyl-L-homocysteine
-
62% inhibition at 0.05 mM, 91% inhibition at 0.5 mM
sinefungin
-
58% inhibition at 0.1 mM
trans-cinnamaldehyde
molecular docking ananlysis, mainly interacts with substrate binding sites. trans-Cinnamaldehyde is locked deeply into the binding site and forms hydrophobic and Pi-Pi interactions with surrounding residues Phe27, Trp33 and Phe105 and one hydrogen bond with Arg30
[Acyl-carrier-protein]
-
holo-[acyl-carrier-protein], 2% inhibition at 0.05 mM, 55% inhibition at 0.5 mM
additional information
-
no inhibition by N-butyryl-L-homoserine-1,4-lactone, CoA, NADH, L-methionine, L-homocysteine, L-homoserine-1,4-lactone, pantothenate, L-homoserine, butyric acid, cerulenin, ATP, ADP, 4-hydroxybutyrate, butyryl-CoA, and apo-ACP
-
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0.038
butyryl-S-adenosyl-L-methionine
-
pH 7.8, 37°C, recombinant RhlI
0.0074
butyryl-[acyl-carrier protein 1]
-
pH 8.8, 25°C, recombinant enzyme
0.0059
butyryl-[acyl-carrier protein 2]
-
pH 8.8, 25°C, recombinant enzyme
0.283
butyryl-[acyl-carrier protein 3]
-
pH 8.8, 25°C, recombinant enzyme
0.006
butyryl-[acyl-carrier protein]
-
pH 7.8, 37°C, recombinant RhlI
0.008
hexanoyl-[acyl-carrier protein]
-
pH 7.8, 37°C, recombinant RhlI
0.043
octanoyl-[acyl-carrier protein]
-
pH 7.8, 37°C, recombinant RhlI
0.014
S-adenosyl-L-methionine
-
pH 7.8, 37°C, recombinant RhlI
additional information
additional information
-
reaction kinetics of recombinant RhlI
-
0.2
butyryl-CoA
-
pH 8.8, 25°C, recombinant enzyme
0.23
butyryl-CoA
-
pH 7.8, 37°C, recombinant RhlI
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additional information
-
the LasR protein of Pseudomonas aeruginosa is a central component of a regulatory web that controls the expression of hundreds of genes, some of which play direct roles in disease, molecular mechanism of action of LasR as transcription factor, it detects 3-oxododecanoyl-L-homoserine lactone, overview. The so-called orphan receptor QscR, which also detects 3-oxododecanoyl-L-homoserine lactone. The second quorum sensing receptor, RhlR, detects butanoyl-L-homoserine lactone and interacts with its cognate AHL synthase, RhlI. Unlike LuxR, LasR does not detectably release its N-acyl-homoserine lactone. It binds to six LasR-dependent promoters
physiological function
quorum sensing regulates motility and lipase, and antifungal activities
physiological function
quorum sensing regulates motility and lipase, protease, and antifungal activities
physiological function
-
chemical communication within populations of bacteria enable them to estimate their population density, a process sometimes referred to as quorum sensing. Signalling among Proteobacteria often involves N-acyl-homoserine lactones, which have identical polar head groups and a variety of hydrophobic acyl groups that differ in length, oxidation, and desaturation. AHL signal molecules are often referred to as autoinducers. They are synthesized by LuxI-type AHL synthases. Most LuxR-type receptors, i.e. LuxR, LasR, and TraR, require N-acyl-homoserine lactones for function and in at least some cases, N-acyl-homoserine lactones are required for protein folding and protease resistance. The LasR/LasI system stimulates production of the RhlI/RhlR system, causing the two Pseudomonas aeruginosa quorum-sensing circuits to initiate sequentially
physiological function
-
quorum sensing systems rely on a signal receptor and a synthase producing N-acyl-homoserine lactone(s) as the signal molecule(s). The rsaL gene, located between the signal receptor and synthase genes, encodes a repressor limiting signal synthase expression and hence signal molecule production, molecular mechannism, overview
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C126S
site-directed mutagenesis, the mutant shows 81.5% activity compared to the wild-type enzyme
C67S
site-directed mutagenesis, the mutant shows 1.9% activity compared to the wild-type enzyme
C67S/C69S
site-directed mutagenesis, the mutant shows 0.8% activity compared to the wild-type enzyme
C69S
site-directed mutagenesis, the mutant shows 30.4% activity compared to the wild-type enzyme
C89S
site-directed mutagenesis, the mutant shows 63% activity compared to the wild-type enzyme
D48N
site-directed mutagenesis, inactive mutant
D51N
site-directed mutagenesis, nearly inactive mutant
E101K
site-directed mutagenesis, inactive mutant
E144K
site-directed mutagenesis, the mutant shows 43.5% activity compared to the wild-type enzyme
E46K
site-directed mutagenesis, inactive mutant
F28L
site-directed mutagenesis, the mutant shows 0.18% activity compared to the wild-type enzyme
G159E
site-directed mutagenesis, the mutant shows 44.6% activity compared to the wild-type enzyme
G68D
site-directed mutagenesis, the mutant shows 0.075% activity compared to the wild-type enzyme
G68E
site-directed mutagenesis, inactive mutant
R104C
site-directed mutagenesis, nearly inactive mutant
R104H
site-directed mutagenesis, nearly inactive mutant
R24W
site-directed mutagenesis, inactive mutant
R71C
site-directed mutagenesis, the mutant shows 0.05% activity compared to the wild-type enzyme
R71H
site-directed mutagenesis, inactive mutant
S103E
site-directed mutagenesis, the mutant shows 5.4% activity compared to the wild-type enzyme
W34G
site-directed mutagenesis, the mutant shows 0.10% activity compared to the wild-type enzyme
W34Y
site-directed mutagenesis, the mutant shows 60% activity compared to the wild-type enzyme
E7K/F147L/P159E/E182G
-
strain R2: cells produce twicefold amount of butanoyl homoserine lactone compared to wild type and yield a hexanoyl homoserine lactone level comparable to the butanoyl homoserine lactone concentration
E7K/F147L/V201M
-
strain R1: cells produce twicefold amount of butanoyl homoserine lactone compared to wild type
K150E/R154QE
-
site-directed mutagenesis, the mutant shows highly reduced activity compared to the fully active mutant LasIDELTAG
K150Q
-
site-directed mutagenesis, the mutant shows similar activity as the fully active mutant LasIDELTAG
K150Q/R154Q
-
site-directed mutagenesis, the mutant shows reduced activity compared to the fully active mutant LasIDELTAG
R154E
-
site-directed mutagenesis, the mutant shows reduced activity compared to the fully active mutant LasIDELTAG
R154Q
-
site-directed mutagenesis, the mutant shows similar activity as the fully active mutant LasIDELTAG
R172A
-
site-directed mutagenesis, the mutant shows increased activity compared to the fully active mutant LasIDELTAG
additional information
screening of diverse mutants constructrd by random mutagenesis, overview
additional information
-
screening of diverse mutants constructrd by random mutagenesis, overview
additional information
strains lacking RhlI/R or LasI/R are created
additional information
strains lacking RhlI/R or LasI/R are created
additional information
-
strains lacking RhlI/R or LasI/R are created
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Raychaudhuri, A.; Jerga, A.; Tipton, P.A.
Chemical mechanism and substrate specificity of RhlI, an acylhomoserine lactone synthase from Pseudomonas aeruginosa
Biochemistry
44
2974-2981
2005
Pseudomonas aeruginosa
brenda
Parsek, M.R.; Schaefer, A.L.; Greenberg, E.P.
Analysis of random and site-directed mutations in rhlI, a Pseudomonas aeruginosa gene encoding an acylhomoserine lactone synthase
Mol. Microbiol.
26
301-310
1997
Pseudomonas aeruginosa (P54291), Pseudomonas aeruginosa
brenda
Gould, T.A.; Schweizer, H.P.; Churchill, M.E.
Structure of the Pseudomonas aeruginosa acyl-homoserinelactone synthase LasI
Mol. Microbiol.
53
1135-1146
2004
Pseudomonas aeruginosa
brenda
Parsek, M.R.; Val, D.L.; Hanzelka, B.L.; Cronan, J.E.; Greenberg, E.P.
Acyl homoserine-lactone quorum-sensing signal generation
Proc. Natl. Acad. Sci. USA
96
4360-4365
1999
Pseudomonas aeruginosa, Pseudomonas aeruginosa PAO-JP1
brenda
Steindler, L.; Bertani, I.; De Sordi, L.; Schwager, S.; Eberl, L.; Venturi, V.
LasI/R and RhlI/R quorum sensing in a strain of Pseudomonas aeruginosa beneficial to plants
Appl. Environ. Microbiol.
75
5131-5140
2009
Pseudomonas aeruginosa (A9JPX3), Pseudomonas aeruginosa (A9JPX5), Pseudomonas aeruginosa, Pseudomonas aeruginosa PUPa3 (A9JPX3), Pseudomonas aeruginosa PUPa3 (A9JPX5)
brenda
Kambam, P.K.; Eriksen, D.T.; Lajoie, J.; Sayut, D.J.; Sun, L.
Altering the substrate specificity of RhlI by directed evolution
ChemBioChem
10
553-558
2009
Pseudomonas aeruginosa
brenda
Rampioni, G.; Bertani, I.; Pillai, C.R.; Venturi, V.; Zennaro, E.; Leoni, L.
Functional characterization of the quorum sensing regulator RsaL in the plant-beneficial strain Pseudomonas putida WCS358
Appl. Environ. Microbiol.
78
726-734
2012
Pseudomonas aeruginosa, Pseudomonas putida, Pseudomonas putida WCS358
brenda
Tsai, C.S.; Winans, S.C.
LuxR-type quorum-sensing regulators that are detached from common scents
Mol. Microbiol.
77
1072-1082
2010
Agrobacterium tumefaciens, Aliivibrio fischeri, Dickeya chrysanthemi, Escherichia coli, Pantoea stewartii, Pectobacterium carotovorum, Pseudomonas aeruginosa, Pseudomonas syringae, Serratia marcescens, Serratia marcescens SS-1, Serratia sp., Serratia sp. 39006, Yersinia enterocolitica, Yersinia pestis, Yersinia pseudotuberculosis
brenda
Mangwani, N.; Kumari, S.; Das, S.
Involvement of quorum sensing genes in biofilm development and degradation of polycyclic aromatic hydrocarbons by a marine bacterium Pseudomonas aeruginosa N6P6
Appl. Microbiol. Biotechnol.
99
10283-10297
2015
Pseudomonas aeruginosa, Pseudomonas aeruginosa N6P6
brenda
Hansen, M.R.; Jakobsen, T.H.; Bang, C.G.; Cohrt, A.E.; Hansen, C.L.; Clausen, J.W.; Le Quement, S.T.; Tolker-Nielsen, T.; Givskov, M.; Nielsen, T.E.
Triazole-containing N-acyl homoserine lactones targeting the quorum sensing system in Pseudomonas aeruginosa
Bioorg. Med. Chem.
23
1638-1650
2015
Escherichia coli, Pseudomonas aeruginosa
brenda
Chang, C.; Krishnan, T.; Wang, H.; Chen, Y.; Yin, W.; Chong, Y.; Tan, L.; Chong, T.; Chan, K.
Non-antibiotic quorum sensing inhibitors acting against N-acyl homoserine lactone synthase as druggable target
Sci. Rep.
4
7245
2014
Pseudomonas aeruginosa (P33883), Pseudomonas aeruginosa (P54291), Pseudomonas aeruginosa
brenda
Yang, Y.; Zhou, M.; Hardwidge, P.; Cui, H.; Zhu, G.
Isolation and characterization of N-acyl homoserine lactone-producing bacteria from cattle rumen and swine intestines
Front. Cell. Infect. Microbiol.
8
155
2018
Aeromonas hydrophila, Pseudomonas aeruginosa, Pseudomonas aeruginosa YZ1, Aeromonas hydrophila YZ2
brenda