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Information on EC 2.3.1.184 - acyl-homoserine-lactone synthase
for references in articles please use BRENDA:EC2.3.1.184
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EC Tree 2 Transferases
2.3 Acyltransferases
2.3.1 Transferring groups other than aminoacyl groups
2.3.1.184 acyl-homoserine-lactone synthase
IUBMB Comments
Acyl-homoserine lactones (AHLs) are produced by a number of bacterial species and are used by them to regulate the expression of virulence genes in a process known as quorum-sensing. Each bacterial cell has a basal level of AHL and, once the population density reaches a critical level, it triggers AHL-signalling which, in turn, initiates the expression of particular virulence genes . N-(3-Oxohexanoyl)-[acyl-carrier protein] and hexanoyl-[acyl-carrier protein] are the best substrates . The fatty-acyl substrate is derived from fatty-acid biosynthesis through acyl-[acyl-carrier protein] rather than from fatty-acid degradation through acyl-CoA . S-Adenosyl-L-methionine cannot be replaced by methionine, S-adenosylhomocysteine, homoserine or homoserine lactone .
The enzyme appears in viruses and cellular organisms
- 2.3.1.184
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quorum
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quorum-sensing
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n-acylhomoserine
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density-dependent
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luxi-type
- chromobacterium
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qs-regulated
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cell-density-dependent
- pyocyanin
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ahl-mediated
- n-3-oxohexanoyl-l-homoserine
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acyl-hsls
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c8-hsl
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ahl-producing
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acyl-acyl
- violacein
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n-acyl-l-homoserine
- chlororaphis
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ahl-based
- medicine
- drug development
- degradation
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ahl-dependent
Reaction Schemes
showSynonyms
ahl synthase, autoinducer synthase, lasi/r, acyl-hsl synthase, rhli/r, luxi protein, acyl homoserine lactone synthase, n-acyl-homoserine lactone synthase, ahsl synthase, acylhomoserine lactone synthase, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
3-oxo-C12-HSL synthase
ACII
acyl homoserine lactone synthase
acyl-homoserine lactone synthase
acyl-homoserinelactone synthase
acyl-HSL synthase
acylhomoserine lactone synthase
AHL synthase
AhyI
AurI
autoinducer synthase
C4-HSL synthase
CsaI
EsaI
ExpI
hdtS
LasI
LasI/R
LuxI
MrlI1
MrlI2
mtqI
open reading frame encoding a protein which has 31% similarity with acyl-homoserine lactone synthase MrtI from Mesorhizobium tianshanense
N-acyl-homoserine lactone synthase
PgaI
PhzI
PppuI
RhlI
RhlI/R
SmaI
SpnI
TofI
YspI
additional information
additional information
-
the enzymes are members of the LuxI family of synthases
additional information
-
the enzyme belongs to the AHL synthase superfamily
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine = an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine = an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
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-
-
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an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine = an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
substrate binding structure
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an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine = an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
functional sites and evolutionary relations, e.g. to the N-acetyltransferase superfamily, ligand docking
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an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine = an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
molecular basis of acyl chain length specificity
an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine = an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
RhlI contains no active site cysteine, residues R24, F28, W34, E46, D48, D51, G68, C67, R71, E101, S103, and R104 are critical for catalytic activity
an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine = an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
RhlI shows a sequential, ordered ping-pong reaction mechanism with S-adenosyl-L-methionine binding first
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an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine = an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
structures of substrate, product, and transition state, overview
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an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine = an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
Thr140 in the acyl-chain binding pocket directs the enzyme towards production of 3-oxohomoserine lactones and is involved in determination of substrate specificity of EsaI
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an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine = an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
RhlI shows a sequential, ordered ping-pong reaction mechanism with S-adenosyl-L-methionine binding first
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PATHWAY SOURCE
PATHWAYS
MetaCyc
autoinducer AI-1 biosynthesis
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SYSTEMATIC NAME
IUBMB Comments
acyl-[acyl-carrier protein]:S-adenosyl-L-methionine acyltranserase (lactone-forming, methylthioadenosine-releasing)
Acyl-homoserine lactones (AHLs) are produced by a number of bacterial species and are used by them to regulate the expression of virulence genes in a process known as quorum-sensing. Each bacterial cell has a basal level of AHL and, once the population density reaches a critical level, it triggers AHL-signalling which, in turn, initiates the expression of particular virulence genes [5]. N-(3-Oxohexanoyl)-[acyl-carrier protein] and hexanoyl-[acyl-carrier protein] are the best substrates [1]. The fatty-acyl substrate is derived from fatty-acid biosynthesis through acyl-[acyl-carrier protein] rather than from fatty-acid degradation through acyl-CoA [1]. S-Adenosyl-L-methionine cannot be replaced by methionine, S-adenosylhomocysteine, homoserine or homoserine lactone [1].
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CAS REGISTRY NUMBER
COMMENTARY
176023-66-8
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3-hydroxydecanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-hydroxydecanoyl-L-homoserine lactone
3-hydroxydodecanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
N-(3-hydroxydodecanoyl)-L-homoserine lactone + [acyl-carrier protein] + S-methyl-5'-thioadenosine
3-oxo-dodecanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxododecanoyl-L-homoserine lactone
3-oxo-octanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + 3-oxo-octanoyl-L-homoserine lactone
3-oxododecanoyl-[acyl carrier protein] + S-adenosyl-L-methionine
N-(3-oxododecanoyl)-homoserine lactone + [acyl carrier protein] + 5'-methyl-thioadenosine
3-oxododecanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
N-(3-oxododecanoyl)-L-homoserine lactone + [acyl-carrier protein] + S-methyl-5'-thioadenosine
3-oxododecanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxododecanoyl-L-homoserine lactone
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Substrates: LasI
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3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone
3-oxotetradecanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
N-(3-oxotetradecanoyl)-L-homoserine lactone + [acyl-carrier protein] + S-methyl-5'-thioadenosine
Substrates: -
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an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine
an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
butanoyl [acyl carrier protein] + S-adenosyl-L-methionine
N-butanoyl homoserine lactone + [acyl carrier protein] + 5'-methyl-thioadenosine
butanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
N-butanoyl-L-homoserine lactone + [acyl-carrier protein] + S-methyl-5'-thioadenosine
butanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + butanoyl-L-homoserine lactone
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Substrates: RhlI
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butyryl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-butanoyl-L-homoserine lactone
decanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
N-decanoyl-L-homoserine lactone + [acyl-carrier protein] + S-methyl-5'-thioadenosine
Substrates: -
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dodecanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
N-dodecanoyl-L-homoserine lactone + [acyl-carrier protein] + S-methyl-5'-thioadenosine
Substrates: -
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hexanoyl [acyl carrier protein] + S-adenosyl-L-methionine
N-hexanoyl homoserine lactone + [acyl carrier protein] + 5'-methyl-thioadenosine
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Substrates: production is only 1/15 of N-butanoyl homoserine lactone
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hexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-hexanoyl -L-homoserine lactone
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Substrates: -
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N-butanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-butanoyl-L-homoserine lactone
N-decanoyl -[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-decanoyl -L-homoserine lactone
-
Substrates: -
Products: -
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N-hexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-hexanoyl-L-homoserine lactone
octanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
N-octanoyl-L-homoserine lactone + [acyl-carrier protein] + S-methyl-5'-thioadenosine
Substrates: -
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octanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-octanoyl-L-homoserine lactone
S-adenosyl-L-methionine + 3-hydroxybutyryl-[acyl-carrier protein]
5'-methylthioadenosine + N-3-hydroxybutyryl-L-homoserine-1,4-lactone + [acyl-carrier protein]
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Substrates: substrate of LuxM
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S-adenosyl-L-methionine + 3-oxodecanoyl-[acyl-carrier protein]
5'-methylthioadenosine + N-3-oxodecanoyl-L-homoserine-1,4-lactone + [acyl-carrier protein]
S-adenosyl-L-methionine + 3-oxododecanoyl-[acyl-carrier protein]
5'-methylthioadenosine + N-3-oxododecanoyl-L-homoserine-1,4-lactone + [acyl-carrier protein]
S-adenosyl-L-methionine + 3-oxohexanoyl-[acyl-carrier protein]
5'-methylthioadenosine + N-3-oxohexanoyl-L-homoserine-1,4-lactone + [acyl-carrier protein]
S-adenosyl-L-methionine + 3-oxooctanoyl-[acyl-carrier protein]
5'-methylthioadenosine + N-3-oxooctanoyl-L-homoserine-1,4-lactone + [acyl-carrier protein]
S-adenosyl-L-methionine + 3-oxotetradecanoyl-[acyl-carrier protein]
5'-methylthioadenosine + N-3-oxotetradecanoyl-L-homoserine-1,4-lactone + [acyl-carrier protein]
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Substrates: substrate of wild-type and mutant LasI, overview
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S-adenosyl-L-methionine + 3-oxoundecanoyl-[acyl-carrier protein]
5'-methylthioadenosine + N-3-oxoundecanoyl-L-homoserine-1,4-lactone + [acyl-carrier protein]
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Substrates: substrate of wild-type and mutant LasI, overview
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S-adenosyl-L-methionine + butyryl-CoA
5'-methylthioadenosine + N-butyryl-L-homoserine-1,4-lactone + CoA
S-adenosyl-L-methionine + butyryl-S-adenosyl-L-methionine
5'-methylthioadenosine + N-butyryl-L-homoserine-1,4-lactone + S-adenosyl-L-methionine
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Substrates: -
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S-adenosyl-L-methionine + butyryl-[acyl-carrier protein 1]
5'-methylthioadenosine + N-butyryl-L-homoserine-1,4-lactone + [acyl-carrier protein 1]
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Substrates: substrate of RhlI, three different [acyl-carrier-protein] isozymes from Pseudomonas aeruginosa serve as substrates
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S-adenosyl-L-methionine + butyryl-[acyl-carrier protein 2]
5'-methylthioadenosine + N-butyryl-L-homoserine-1,4-lactone + [acyl-carrier protein 2]
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Substrates: substrate of RhlI, three different [acyl-carrier-protein] isozymes from Pseudomonas aeruginosa serve as substrates
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S-adenosyl-L-methionine + butyryl-[acyl-carrier protein 3]
5'-methylthioadenosine + N-butyryl-L-homoserine-1,4-lactone + [acyl-carrier protein 3]
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Substrates: substrate of RhlI, three different [acyl-carrier-protein] isozymes from Pseudomonas aeruginosa serve as substrates, very low activity with ACP3
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S-adenosyl-L-methionine + butyryl-[acyl-carrier protein]
5'-methylthioadenosine + N-butyryl-L-homoserine-1,4-lactone + [acyl-carrier protein]
S-adenosyl-L-methionine + decanoyl-[acyl-carrier protein]
5'-methylthioadenosine + N-decanoyl-L-homoserine-1,4-lactone + [acyl-carrier protein]
S-adenosyl-L-methionine + hexanoyl-[acyl-carrier protein]
5'-methylthioadenosine + N-hexanoyl-L-homoserine-1,4-lactone + [acyl-carrier protein]
S-adenosyl-L-methionine + octanoyl-CoA
5'-methylthioadenosine + N-octanoyl-L-homoserine-1,4-lactone + CoA
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Substrates: substrate of recombinant MBP-AinS, lower activity
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S-adenosyl-L-methionine + octanoyl-[acyl-carrier protein]
5'-methylthioadenosine + N-octanoyl-L-homoserine-1,4-lactone + [acyl-carrier protein]
tetradecanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
N-tetradecanoyl-L-homoserine lactone + [acyl-carrier protein] + S-methyl-5'-thioadenosine
Substrates: -
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3-hydroxydecanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-hydroxydecanoyl-L-homoserine lactone
-
Substrates: -
Products: -
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3-hydroxydecanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-hydroxydecanoyl-L-homoserine lactone
-
Substrates: -
Products: -
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3-hydroxydodecanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
N-(3-hydroxydodecanoyl)-L-homoserine lactone + [acyl-carrier protein] + S-methyl-5'-thioadenosine
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Substrates: -
Products: N-(3-hydroxydodecanoyl)-L-homoserine lactone is produced more abundantly than N-(3-oxododecanoyl)-L-homoserine lactone
Products: N-(3-hydroxydodecanoyl)-L-homoserine lactone is produced more abundantly than N-(3-oxododecanoyl)-L-homoserine lactone
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3-hydroxydodecanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
N-(3-hydroxydodecanoyl)-L-homoserine lactone + [acyl-carrier protein] + S-methyl-5'-thioadenosine
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Substrates: -
Products: N-(3-hydroxydodecanoyl)-L-homoserine lactone is produced more abundantly than N-(3-oxododecanoyl)-L-homoserine lactone
Products: N-(3-hydroxydodecanoyl)-L-homoserine lactone is produced more abundantly than N-(3-oxododecanoyl)-L-homoserine lactone
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3-oxo-dodecanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxododecanoyl-L-homoserine lactone
-
Substrates: -
Products: -
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3-oxo-dodecanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxododecanoyl-L-homoserine lactone
-
Substrates: -
Products: -
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3-oxo-dodecanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxododecanoyl-L-homoserine lactone
-
Substrates: -
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3-oxo-octanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + 3-oxo-octanoyl-L-homoserine lactone
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Substrates: -
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3-oxo-octanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + 3-oxo-octanoyl-L-homoserine lactone
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Substrates: TraI synthesizes primarily 3-oxo-octanoyl homoserine lactone
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3-oxododecanoyl-[acyl carrier protein] + S-adenosyl-L-methionine
N-(3-oxododecanoyl)-homoserine lactone + [acyl carrier protein] + 5'-methyl-thioadenosine
Substrates: -
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3-oxododecanoyl-[acyl carrier protein] + S-adenosyl-L-methionine
N-(3-oxododecanoyl)-homoserine lactone + [acyl carrier protein] + 5'-methyl-thioadenosine
Substrates: -
Products: -
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3-oxododecanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
N-(3-oxododecanoyl)-L-homoserine lactone + [acyl-carrier protein] + S-methyl-5'-thioadenosine
-
Substrates: -
Products: -
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3-oxododecanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
N-(3-oxododecanoyl)-L-homoserine lactone + [acyl-carrier protein] + S-methyl-5'-thioadenosine
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Substrates: -
Products: -
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3-oxododecanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
N-(3-oxododecanoyl)-L-homoserine lactone + [acyl-carrier protein] + S-methyl-5'-thioadenosine
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Substrates: -
Products: -
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3-oxododecanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
N-(3-oxododecanoyl)-L-homoserine lactone + [acyl-carrier protein] + S-methyl-5'-thioadenosine
-
Substrates: -
Products: -
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3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone
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Substrates: -
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3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone
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Substrates: -
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3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone
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Substrates: -
Products: -
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3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone
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Substrates: -
Products: -
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3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone
-
Substrates: -
Products: -
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3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone
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Substrates: PsyI synthesize predominantly N-3-oxohexanoyl-L-homoserine lactone
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3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone
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Substrates: -
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3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone
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Substrates: SpnI (like EsaI) synthesizes primarily N-3-oxohexanoyl-L-homoserine lactone
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3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone
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Substrates: -
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3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone
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Substrates: SpnI (like EsaI) synthesizes primarily N-3-oxohexanoyl-L-homoserine lactone
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3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone
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Substrates: -
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3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone
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Substrates: -
Products: -
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3-oxohexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-3-oxohexanoyl-L-homoserine lactone
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Substrates: -
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an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine
an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
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Substrates: -
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an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine
an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
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Substrates: -
Products: -
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an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine
an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
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Substrates: -
Products: -
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an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine
an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
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Substrates: -
Products: -
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an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine
an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
-
Substrates: -
Products: -
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an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine
an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
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Substrates: -
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an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine
an [acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
-
Substrates: -
Products: -
Products: -
?
an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
Substrates: -
Products: -
Products: -
?
an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
-
Substrates: -
Products: -
Products: -
?
an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
-
Substrates: -
Products: -
Products: -
?
an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
-
Substrates: -
Products: -
Products: -
?
an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
-
Substrates: -
Products: -
Products: -
?
an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
-
Substrates: -
Products: -
Products: -
?
an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
-
Substrates: -
Products: -
Products: -
?
an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
-
Substrates: -
Products: -
Products: -
?
an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
-
Substrates: -
Products: -
Products: -
?
an acyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + an N-acyl-L-homoserine lactone
-
Substrates: -
Products: -
Products: -
?
butanoyl [acyl carrier protein] + S-adenosyl-L-methionine
N-butanoyl homoserine lactone + [acyl carrier protein] + 5'-methyl-thioadenosine
-
Substrates: -
Products: -
Products: -
ir
butanoyl [acyl carrier protein] + S-adenosyl-L-methionine
N-butanoyl homoserine lactone + [acyl carrier protein] + 5'-methyl-thioadenosine
Substrates: -
Products: -
Products: -
ir
butanoyl [acyl carrier protein] + S-adenosyl-L-methionine
N-butanoyl homoserine lactone + [acyl carrier protein] + 5'-methyl-thioadenosine
Substrates: -
Products: -
Products: -
ir
butanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
N-butanoyl-L-homoserine lactone + [acyl-carrier protein] + S-methyl-5'-thioadenosine
-
Substrates: -
Products: -
Products: -
?
butanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
N-butanoyl-L-homoserine lactone + [acyl-carrier protein] + S-methyl-5'-thioadenosine
-
Substrates: -
Products: -
Products: -
?
butyryl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-butanoyl-L-homoserine lactone
Substrates: -
Products: -
Products: -
-
butyryl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-butanoyl-L-homoserine lactone
Aeromonas hydrophila HX-3
Substrates: -
Products: -
Products: -
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N-butanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-butanoyl-L-homoserine lactone
-
Substrates: -
Products: -
Products: -
?
N-butanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-butanoyl-L-homoserine lactone
-
Substrates: -
Products: -
Products: -
?
N-hexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-hexanoyl-L-homoserine lactone
-
Substrates: -
Products: -
Products: -
?
N-hexanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-hexanoyl-L-homoserine lactone
-
Substrates: -
Products: -
Products: -
?
octanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-octanoyl-L-homoserine lactone
-
Substrates: -
Products: -
Products: -
?
octanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-octanoyl-L-homoserine lactone
-
Substrates: -
Products: -
Products: -
?
octanoyl-[acyl-carrier protein] + S-adenosyl-L-methionine
[acyl-carrier protein] + S-methyl-5'-thioadenosine + N-octanoyl-L-homoserine lactone
-
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + 3-oxodecanoyl-[acyl-carrier protein]
5'-methylthioadenosine + N-3-oxodecanoyl-L-homoserine-1,4-lactone + [acyl-carrier protein]
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Substrates: substrate of wild-type and mutant LasI, overview
Products: -
Products: -
?
S-adenosyl-L-methionine + 3-oxodecanoyl-[acyl-carrier protein]
5'-methylthioadenosine + N-3-oxodecanoyl-L-homoserine-1,4-lactone + [acyl-carrier protein]
-
Substrates: substrate of YspI
Products: mass spectrometry product determination
Products: mass spectrometry product determination
?
S-adenosyl-L-methionine + 3-oxodecanoyl-[acyl-carrier protein]
5'-methylthioadenosine + N-3-oxodecanoyl-L-homoserine-1,4-lactone + [acyl-carrier protein]
-
Substrates: substrate of YspI
Products: mass spectrometry product determination
Products: mass spectrometry product determination
?
S-adenosyl-L-methionine + 3-oxododecanoyl-[acyl-carrier protein]
5'-methylthioadenosine + N-3-oxododecanoyl-L-homoserine-1,4-lactone + [acyl-carrier protein]
-
Substrates: substrate of wild-type and mutant LasI, overview
Products: -
Products: -
?
S-adenosyl-L-methionine + 3-oxododecanoyl-[acyl-carrier protein]
5'-methylthioadenosine + N-3-oxododecanoyl-L-homoserine-1,4-lactone + [acyl-carrier protein]
-
Substrates: substrate of LasI
Products: -
Products: -
?
S-adenosyl-L-methionine + 3-oxohexanoyl-[acyl-carrier protein]
5'-methylthioadenosine + N-3-oxohexanoyl-L-homoserine-1,4-lactone + [acyl-carrier protein]
-
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + 3-oxohexanoyl-[acyl-carrier protein]
5'-methylthioadenosine + N-3-oxohexanoyl-L-homoserine-1,4-lactone + [acyl-carrier protein]
-
Substrates: substrate of LuxI
Products: -
Products: -
?
S-adenosyl-L-methionine + 3-oxohexanoyl-[acyl-carrier protein]
5'-methylthioadenosine + N-3-oxohexanoyl-L-homoserine-1,4-lactone + [acyl-carrier protein]
-
Substrates: substrate of wild-type EsaI and EsaI mutant T140A
Products: -
Products: -
?
S-adenosyl-L-methionine + 3-oxohexanoyl-[acyl-carrier protein]
5'-methylthioadenosine + N-3-oxohexanoyl-L-homoserine-1,4-lactone + [acyl-carrier protein]
Substrates: substrate of wild-type ExpISCC1, specific for
Products: -
Products: -
?
S-adenosyl-L-methionine + 3-oxohexanoyl-[acyl-carrier protein]
5'-methylthioadenosine + N-3-oxohexanoyl-L-homoserine-1,4-lactone + [acyl-carrier protein]
-
Substrates: substrate of YspI
Products: mass spectrometry product determination
Products: mass spectrometry product determination
?
S-adenosyl-L-methionine + 3-oxohexanoyl-[acyl-carrier protein]
5'-methylthioadenosine + N-3-oxohexanoyl-L-homoserine-1,4-lactone + [acyl-carrier protein]
-
Substrates: substrate of YspI
Products: mass spectrometry product determination
Products: mass spectrometry product determination
?
S-adenosyl-L-methionine + 3-oxooctanoyl-[acyl-carrier protein]
5'-methylthioadenosine + N-3-oxooctanoyl-L-homoserine-1,4-lactone + [acyl-carrier protein]
Substrates: substrate of wild-type ExpISCC3065, specific for
Products: -
Products: -
?
S-adenosyl-L-methionine + 3-oxooctanoyl-[acyl-carrier protein]
5'-methylthioadenosine + N-3-oxooctanoyl-L-homoserine-1,4-lactone + [acyl-carrier protein]
-
Substrates: substrate of YspI
Products: mass spectrometry product determination
Products: mass spectrometry product determination
?
S-adenosyl-L-methionine + 3-oxooctanoyl-[acyl-carrier protein]
5'-methylthioadenosine + N-3-oxooctanoyl-L-homoserine-1,4-lactone + [acyl-carrier protein]
-
Substrates: substrate of YspI
Products: mass spectrometry product determination
Products: mass spectrometry product determination
?
S-adenosyl-L-methionine + butyryl-CoA
5'-methylthioadenosine + N-butyryl-L-homoserine-1,4-lactone + CoA
-
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + butyryl-CoA
5'-methylthioadenosine + N-butyryl-L-homoserine-1,4-lactone + CoA
-
Substrates: substrate of RhlI, very low activity
Products: -
Products: -
?
S-adenosyl-L-methionine + butyryl-[acyl-carrier protein]
5'-methylthioadenosine + N-butyryl-L-homoserine-1,4-lactone + [acyl-carrier protein]
-
Substrates: substrate of AhyI
Products: -
Products: -
?
S-adenosyl-L-methionine + butyryl-[acyl-carrier protein]
5'-methylthioadenosine + N-butyryl-L-homoserine-1,4-lactone + [acyl-carrier protein]
-
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + butyryl-[acyl-carrier protein]
5'-methylthioadenosine + N-butyryl-L-homoserine-1,4-lactone + [acyl-carrier protein]
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + butyryl-[acyl-carrier protein]
5'-methylthioadenosine + N-butyryl-L-homoserine-1,4-lactone + [acyl-carrier protein]
-
Substrates: substrate of RhlI, synthesis of a quorum-sensing molecule involved in the regulation of many processes involving the bacterial virulence and infectivity
Products: -
Products: -
?
S-adenosyl-L-methionine + butyryl-[acyl-carrier protein]
5'-methylthioadenosine + N-butyryl-L-homoserine-1,4-lactone + [acyl-carrier protein]
-
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + decanoyl-[acyl-carrier protein]
5'-methylthioadenosine + N-decanoyl-L-homoserine-1,4-lactone + [acyl-carrier protein]
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Substrates: substrate of recombinant MBP-AinS
Products: -
Products: -
?
S-adenosyl-L-methionine + decanoyl-[acyl-carrier protein]
5'-methylthioadenosine + N-decanoyl-L-homoserine-1,4-lactone + [acyl-carrier protein]
-
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + hexanoyl-[acyl-carrier protein]
5'-methylthioadenosine + N-hexanoyl-L-homoserine-1,4-lactone + [acyl-carrier protein]
-
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + hexanoyl-[acyl-carrier protein]
5'-methylthioadenosine + N-hexanoyl-L-homoserine-1,4-lactone + [acyl-carrier protein]
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Substrates: substrate of recombinant MBP-AinS
Products: -
Products: -
?
S-adenosyl-L-methionine + hexanoyl-[acyl-carrier protein]
5'-methylthioadenosine + N-hexanoyl-L-homoserine-1,4-lactone + [acyl-carrier protein]
-
Substrates: substrate of BtaI1 and BtaI3
Products: -
Products: -
?
S-adenosyl-L-methionine + hexanoyl-[acyl-carrier protein]
5'-methylthioadenosine + N-hexanoyl-L-homoserine-1,4-lactone + [acyl-carrier protein]
-
Substrates: preferred substrate of EsaI mutant T140A, no substrate of wild-type EsaI
Products: -
Products: -
?
S-adenosyl-L-methionine + hexanoyl-[acyl-carrier protein]
5'-methylthioadenosine + N-hexanoyl-L-homoserine-1,4-lactone + [acyl-carrier protein]
Substrates: substrate of wild-type ExpISCC1, very low activity
Products: -
Products: -
?
S-adenosyl-L-methionine + hexanoyl-[acyl-carrier protein]
5'-methylthioadenosine + N-hexanoyl-L-homoserine-1,4-lactone + [acyl-carrier protein]
-
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + hexanoyl-[acyl-carrier protein]
5'-methylthioadenosine + N-hexanoyl-L-homoserine-1,4-lactone + [acyl-carrier protein]
-
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + hexanoyl-[acyl-carrier protein]
5'-methylthioadenosine + N-hexanoyl-L-homoserine-1,4-lactone + [acyl-carrier protein]
-
Substrates: substrate of YspI
Products: mass spectrometry product determination
Products: mass spectrometry product determination
?
S-adenosyl-L-methionine + octanoyl-[acyl-carrier protein]
5'-methylthioadenosine + N-octanoyl-L-homoserine-1,4-lactone + [acyl-carrier protein]
-
Substrates: substrate of AinS
Products: -
Products: -
?
S-adenosyl-L-methionine + octanoyl-[acyl-carrier protein]
5'-methylthioadenosine + N-octanoyl-L-homoserine-1,4-lactone + [acyl-carrier protein]
-
Substrates: preferred substrate of native AinS and recombinant MBP-AinS
Products: -
Products: -
?
S-adenosyl-L-methionine + octanoyl-[acyl-carrier protein]
5'-methylthioadenosine + N-octanoyl-L-homoserine-1,4-lactone + [acyl-carrier protein]
-
Substrates: substrate of BtaI1 and BtaI3
Products: -
Products: -
?
S-adenosyl-L-methionine + octanoyl-[acyl-carrier protein]
5'-methylthioadenosine + N-octanoyl-L-homoserine-1,4-lactone + [acyl-carrier protein]