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Information on EC 2.3.1.182 - (R)-citramalate synthase and Organism(s) Geobacter sulfurreducens and UniProt Accession Q74C76

for references in articles please use BRENDA:EC2.3.1.182
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EC Tree
     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.182 (R)-citramalate synthase
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Select one or more organisms in this record:
This record set is specific for:
Geobacter sulfurreducens
UNIPROT: Q74C76 not found.
Word Map
The expected taxonomic range for this enzyme is: Bacteria, Archaea
The taxonomic range for the selected organisms is: Geobacter sulfurreducens
Synonyms
CimA, cimA protein, CimA3.7, citramalate lyase, citramalate synthase, CMS, DET0825, LA2350, LiCMS, LiCMSC, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
citramalate lyase
285758
-
citramalate synthase
276898
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
acetyl-CoA + pyruvate + H2O
CoA + (2S)-2-hydroxy-2-methylbutanedioate
show the reaction diagram
-
-
-
r
acetyl-CoA + pyruvate
CoA + citramalate
show the reaction diagram
-
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
acetyl-CoA + pyruvate + H2O
CoA + (2S)-2-hydroxy-2-methylbutanedioate
show the reaction diagram
Q74C76
-
-
-
r
acetyl-CoA + pyruvate
CoA + citramalate
show the reaction diagram
-
-
-
-
?
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.0004
strain DLCR6, cimA::Gmr; strain DLCR7, tdcB::Knr cimA::Gmr
0.0051
strain DLCR5, tdcB::Knr
0.0074
strain DL1, wild type
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
2-isopropylmalate synthase
UniProt
Manually annotated by BRENDA team
CLONED/commentary
ORGANISM
UNIPROT
LITERATURE
expressed in Saccharomyces cerevisiae
-
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Risso, C.; Van Dien, S.J.; Orloff, A.; Lovley, D.R.; Coppi, M.V.
Elucidation of an alternate isoleucine biosynthesis pathway in Geobacter sulfurreducens
J. Bacteriol.
190
2266-2274
2008
Geobacter sulfurreducens (Q74C76)
Manually annotated by BRENDA team
Shi, S.; Si, T.; Liu, Z.; Zhang, H.; Ang, E.L.; Zhao, H.
Metabolic engineering of a synergistic pathway for n-butanol production in Saccharomyces cerevisiae
Sci. Rep.
6
25675
2016
Geobacter sulfurreducens, Leptospira interrogans, Methanocaldococcus jannaschii
Manually annotated by BRENDA team
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