Information on EC 2.3.1.180 - beta-ketoacyl-[acyl-carrier-protein] synthase III and Organism(s) Escherichia coli and UniProt Accession P0A6R0

-

-

?

acetoacetyl-ACP + acetyl-CoA

acetyl-ACP + acetoacetyl-CoA

-

-

?

acetyl-CoA + a malonyl-[acyl-carrier protein]

an acetoacetyl-[acyl-carrier protein] + CoA + CO2

acetyl-CoA + malonyl-[acyl-carrier protein]

3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2

acetyl-CoA + malonyl-[acyl-carrier protein]

acetoacetyl-[acyl-carrier protein] + CoA + CO2

6 entries

butyryl-CoA + malonyl-[acyl-carrier protein]

3-oxo-hexanoyl-[acyl-carrier protein] + CoA + CO2

-

-

?

malonyl-ACP + acetyl-CoA

CO2 + CoA + acetoacetyl-ACP

-

719068, 719085, 719086, 719087, 719093, 720076

-

?

propionyl-CoA + malonyl-[acyl-carrier protein]

3-oxo-valeryl-[acyl-carrier protein] + CoA + CO2

-

acetyl-CoA and propionyl-CoA are the preferred primers

-

?

additional information

?

-

12 entries

acetyl-CoA + a malonyl-[acyl-carrier protein]

an acetoacetyl-[acyl-carrier protein] + CoA + CO2

-

735963, 736053, 736658, 756435, 757353, 757562, 758264

-

?

acetyl-CoA + malonyl-[acyl-carrier protein]

3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2

acetyl-CoA + malonyl-[acyl-carrier protein]

acetoacetyl-[acyl-carrier protein] + CoA + CO2

4 entries

additional information

?

-

7 entries

acetyl-CoA

-

735963, 736053, 736658

Mg2+

required

(E) -N'-((E)-3-(2-methoxyphenyl)al lyl idene)-2,3-dihydrobenzo[b][1,4]dioxine-2-carbohydrazide

-

(E) -N'-((E)-3-(2-Ni trophenyl)allylidene)-2,3-dihydrobenzo[b][1,4]dioxine-2-carbohydrazide

-

(E) -N'-((E)-3-(4-bromophenyl)al lyl idene)-2,3-dihydrobenzo[b][1,4]dioxine-2-carbohydrazide

-

(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(2,4-dichlorophenyl)acrylate

-

(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(2-bromophenyl)acrylate

-

(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(3-bromophenyl)acrylate

-

(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(3-fluorophenyl)acrylate

-

(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(4-(benzyloxy)phenyl)acrylate

-

(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(4-(dimethylamino)phenyl)acrylate

-

(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(4-bromophenyl)acrylate

-

(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(4-chlorophenyl)acrylate

-

(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(biphenyl-4-yl)acrylate

-

(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(naphthalen-1-yl)acrylate

-

(E)-1-(6-chloropyridin-3-yl)-N-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)methylene)methanamine

-

(E)-1-(6-chloropyridin-3-yl)-N-((3,4-dihydro-2Hbenzo[b][1,4]dioxepin-7-yl)methylene)methanamine

-

(E)-4-chloro-N-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)methylene)pyridin-2-amine

-

(E)-5-chloro-N-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)methylene)pyridin-2-amine

-

(E)-6-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)-methyleneamino)nicotinonitrile

-

(E)-ethyl 2-(4-(benzyloxy)phenyl)-3-(4-bromophenylamino)acrylate

-

(E)-ethyl 2-(4-(benzyloxy)phenyl)-3-(4-isopropylphenylamino)acrylate

-

(E)-N'-((E)-3-phenylallylidene)-2,3-dihydrobenzo[b][1,4]-dioxine-2-carbohydrazide

-

(E)-N-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)-methylene)-3-methylpyridin-2-amine

-

(E)-N-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)-methylene)-4-methylpyridin-2-amine

-

(E)-N-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)-methylene)-5-(trifluoromethyl)pyridin-2-amine

-

(E)-N-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)-methylene)pyridin-3-amine

-

(E)-tert-butyl 4-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)methyleneamino)piperidine-1-carboxylate

-

(Z)-ethyl 2-(4-(benzyloxy)phenyl)-3-(2,4-dibromophenylamino)acrylate

-

(Z)-ethyl 2-(4-(benzyloxy)phenyl)-3-(2-chlorophenylamino)acrylate

-

(Z)-ethyl 2-(4-(benzyloxy)phenyl)-3-(4-bromophenylamino)acrylate

-

(Z)-ethyl 2-(4-(benzyloxy)phenyl)-3-(4-fluorophenylamino)acrylate

-

(Z)-ethyl 3-(p-toluidino)-2-(4-(benzyloxy)phenyl)acrylate

-

1-(2-chlorophenyl)-1-(3,5-dibromo-2-hydroxybenzyl)-3-phenylurea

-

1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl (2E)-3-(biphenyl-4-yl)prop-2-enoate

-

1-(3,5-dibromo-2-hydroxybenzyl)-1-(4-fluorophenyl)-3-phenylurea

-

1-(4-carboxybutyl)-5-[(2,6-dichlorobenzyl)oxy]-1H-indole-2-carboxylic acid

-

1-(4-chlorophenyl)-1-(3,5-dibromo-2-hydroxybenzyl)-3-phenylurea

-

1-(4-[(E)-[3-(benzyloxy)benzylidene]amino]phenyl)-3-phenylthiourea

molecular docking indicates that the compound has one hydrogen bonding interaction with Thr 81 of Escherichia coli FabH

1-(5-bromo-2-hydroxybenzyl)-1-(2-bromophenyl)-3-phenylurea

-

1-(5-bromo-2-hydroxybenzyl)-1-(2-chlorophenyl)-3-phenylurea

-

1-(5-bromo-2-hydroxybenzyl)-1-(2-fluorophenyl)-3-phenylurea

-

1-(5-bromo-2-hydroxybenzyl)-1-(4-bromophenyl)-3-phenylurea

-

1-(5-bromo-2-hydroxybenzyl)-1-(4-chlorophenyl)-3-phenylurea

1-(5-bromo-2-hydroxybenzyl)-1-(4-fluorophenyl)-3-phenylurea

-

1-(5-carboxypentyl)-5-[(2,6-dichlorobenzyl)oxy]-1H-indole-2-carboxylic acid

-

1-cyclohexyl-N-(2'-hydroxy-1,1':3',1''-terphenyl-5'-yl)-5-oxopyrrolidine-3-carboxamide

-

1-[(6-chloro-1,3-benzodioxol-5-yl)methyl]-5-[(2,6-dichlorobenzyl)oxy]-1H-indole-2-carboxylic acid

-

1-[3,5-bis(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone

-

1-[3-(4-methoxyphenyl)-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone

-

1-[3-(4-methoxyphenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl]ethanone

-

1-[5-(2-chlorophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone

-

1-[5-(4-bromophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone

-

1-[5-(4-chlorophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone

-

1-[5-(4-fluorophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone

2,4-dibromo-6-[(E)-(2-[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazinylidene)methyl]phenol

-

2,4-dibromo-6-[(E)-[(4-phenyl-1,3-thiazol-2-yl)hydrazono]methyl]phenol

-

2,4-dibromo-6-[(E)-[2-[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazinylidene]methyl]phenol

the binding model demonstrated that the phenolic hydroxy group of 40 interacts with the amino hydrogen of Asn247 of Escherichia coli FabH by hydrogen bonds

2,4-dibromo-6-[(E)-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol

-

2,4-dibromo-6-[(E)-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol

-

2,4-dichloro-6-[(E)-[(4-phenyl-1,3-thiazol-2-yl)hydrazono]methyl]phenol

-

2,4-dichloro-6-[(E)-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol

-

2,4-dichloro-6-[(E)-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol

-

2,5-anhydro-3,4-dideoxy-3-[[(3-phenoxyphenyl)carbonyl]amino]-2-thiopentonic acid

-

2-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-5-(2-methylbenzyl)-1,3,4-oxadiazole

-

2-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-5-(4-nitrophenyl)-1,3,4-oxadiazol

-

2-(2-methoxyphenyl)-5-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-1,3,4-oxadiazole

-

2-(2-methoxyphenyl)-5-[(2-methyl-5-nitro-1H-imidazol-1-yl)methyl]-1,3,4-oxadiazole

-

2-(2-methyl-5-nitro-1H-imidazol-1-yl)-N'-[(E)-(3,4,5-trimethylphenyl)methylidene]acetohydrazide

-

2-(3,4-diethoxyphenyl)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide

-

2-(3-bromophenyl)-5-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-1,3,4-oxadiazole

-

2-(3-bromophenyl)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide

-

2-(3-bromophenyl)-N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]acetamide

-

2-(3-chlorophenyl)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide

-

2-(3-methoxyphenyl)-5-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-1,3,4-oxadiazole

-

2-(3-methoxyphenyl)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide

-

2-(4-bromophenyl)-5-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-1,3,4-oxadiazole

-

2-(4-bromophenyl)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide

-

2-(4-bromophenyl)-N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]acetamide

-

2-(4-chlorobenzene-1-sulfonyl)naphthalene-1,4-diol

-

2-(4-chlorophenyl)-5-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-1,3,4-oxadiazole

-

2-(4-chlorophenyl)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide

-

2-(4-fluorophenyl)-5-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-1,3,4-oxadiazole

-

2-(4-fluorophenyl)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide

-

2-(4-methylbenzene-1-sulfonyl)anthracene-1,4-diol

-

2-(4-methylbenzene-1-sulfonyl)naphthalene-1,4-diol

-

2-(4-methylbenzene-1-sulfonyl)naphthalene-1,4-dione

-

2-(4-propylbenzene-1-sulfonyl)naphthalene-1,4-diol

-

2-(benzenesulfonyl)naphthalene-1,4-diol

-

2-(decane-1-sulfonyl)acetamide

FAS20013

2-(methanesulfonyl)naphthalene-1,4-diol

-

2-(naphthalene-2-sulfonyl)naphthalene-1,4-diol

-

2-([[2-(diethylsulfamoyl)biphenyl-4-yl]carbonyl]amino)cyclohexanecarboxylic acid

-

2-([[2-phenoxy-3'-(trifluoromethoxy)biphenyl-4-yl]carbonyl]amino)cyclohexanecarboxylic acid

-

2-([[2-phenoxy-4'-(trifluoromethyl)biphenyl-4-yl]carbonyl]amino)cyclohexanecarboxylic acid

-

2-([[3'-(1-methylethyl)-2-phenoxybiphenyl-4-yl]carbonyl]amino)cyclohexanecarboxylic acid

-

2-([[3-(4-fluorophenoxy)phenyl]carbonyl]amino)cyclohexanecarboxylic acid

-

2-([[3-(diethylsulfamoyl)-4-fluorophenyl]carbonyl]amino)cyclohexanecarboxylic acid

-

2-([[3-(diethylsulfamoyl)-4-methoxyphenyl]carbonyl]amino)cyclohexanecarboxylic acid

-

2-([[3-(diethylsulfamoyl)-4-phenoxyphenyl]carbonyl]amino)cyclohexanecarboxylic acid

-

2-([[3-(diethylsulfamoyl)-4-piperidin-1-ylphenyl]carbonyl]amino)cyclohexanecarboxylic acid

-

2-([[3-(pyridin-2-yloxy)phenyl]carbonyl]amino)cyclohexanecarboxylic acid

-

2-([[3-phenoxy-4-(1H-pyrazol-4-yl)phenyl]carbonyl]amino)cyclohexanecarboxylic acid

-

2-([[4'-(methylsulfonyl)-2-phenoxybiphenyl-4-yl]carbonyl]amino)cyclohexanecarboxylic acid

-

2-([[4-(3,5-dimethylpiperidin-1-yl)-3-phenoxyphenyl]carbonyl]amino)benzoic acid

-

2-([[4-(3,5-dimethylpiperidin-1-yl)-3-phenoxyphenyl]carbonyl]amino)cyclohexanecarboxylic acid

-

2-([[4-(cyclopentylmethoxy)-3-(diethylsulfamoyl)phenyl]carbonyl]amino)cyclohexanecarboxylic acid

-

2-([[4-bromo-3-(diethylsulfamoyl)-5-methylphenyl]carbonyl]amino)cyclohexanecarboxylic acid

-

2-([[4-bromo-3-(diethylsulfamoyl)phenyl]carbonyl]amino)cyclohexanecarboxylic acid

-

2-hydroxy-6-[[(2-phenoxybiphenyl-4-yl)carbonyl]amino]benzoic acid

-

2-phenyl-N-(4-phenyl-1,3-thiazol-2-yl)acetamide

-

2-[(2E)-2-[(4-bromophenyl)methylidene]hydrazino]-4-(3,4-dichlorophenyl)-1,3-thiazole

-

2-[(2E)-2-[(4-bromophenyl)methylidene]hydrazino]-4-(4-chlorophenyl)-1,3-thiazole

-

2-[(2E)-2-[(4-bromophenyl)methylidene]hydrazino]-4-phenyl-1,3-thiazole

-

2-[(2E)-2-[(4-chlorophenyl)methylidene]hydrazino]-4-(3,4-dichlorophenyl)-1,3-thiazole

-

2-[(2E)-2-[(4-chlorophenyl)methylidene]hydrazino]-4-phenyl-1,3-thiazole

-

2-[(2E)-2-[(4-fluorophenyl)methylidene]hydrazino]-4-phenyl-1,3-thiazole

-

2-[(2E)-2-[(4-methoxyphenyl)methylidene]hydrazino]-4-phenyl-1,3-thiazole

-

2-[(2E)-2-[(4-methylphenyl)methylidene]hydrazino]-4-phenyl-1,3-thiazole

-

2-[([4-[(3,5-dimethylpiperazin-1-yl)methyl]-3-phenoxyphenyl]carbonyl)amino]cyclohexanecarboxylic acid

-

2-[([4-[(4-methylpiperazin-1-yl)methyl]-3-phenoxyphenyl]carbonyl)amino]cyclohexanecarboxylic acid

-

2-[3-(3,4-dichlorophenyl)-5-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole

-

2-[3-(4-bromophenyl)-5-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-(4-methoxyphenyl)-1,3-thiazole

-

2-[3-(4-bromophenyl)-5-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole

-

2-[3-(4-bromophenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one

-

2-[3-(4-bromophenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole

-

2-[3-(4-fluorophenyl)-5-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one

-

2-[3-(4-fluorophenyl)-5-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole

-

2-[3-(4-methoxyphenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one

-

2-[3-(4-methoxyphenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole

-

2-[3-(4-methylphenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one

-

2-[3-(4-methylphenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole

-

2-[4-(2,4-dinitrophenyl)-1H-pyrazol-1-yl]-4-(trifluoromethyl)pyrimidine

-

2-[5-(furan-2-yl)-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one

-

2-[5-(furan-2-yl)-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-4-(4-methoxyphenyl)-1,3-thiazole

-

2-[5-(furan-2-yl)-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole

-

2-[5-(furan-2-yl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one

-

2-[[(2',4'-difluoro-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid

-

2-[[(2-hydroxy-6-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid

-

2-[[(2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid

-

2-[[(3',4'-difluoro-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid

-

2-[[(3'-chloro-4'-fluoro-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid

-

2-[[(3-phenoxy-4-piperazin-1-ylphenyl)carbonyl]amino]cyclohexanecarboxylic acid

-

2-[[(3-phenoxy-4-piperidin-1-ylphenyl)carbonyl]amino]benzoic acid

-

2-[[(3-phenoxy-4-piperidin-1-ylphenyl)carbonyl]amino]cyclohexanecarboxylic acid

-

2-[[(3-phenoxy-4-pyridin-3-ylphenyl)carbonyl]amino]cyclohexanecarboxylic acid

-

2-[[(3-phenoxy-4-thiomorpholin-4-ylphenyl)carbonyl]amino]benzoic acid

-

2-[[(3-phenoxy-4-thiomorpholin-4-ylphenyl)carbonyl]amino]cyclohexanecarboxylic acid

-

2-[[(3-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid

-

2-[[(3-phenoxyphenyl)carbonyl]amino]piperidine-3-carboxylic acid

-

2-[[(3-phenoxyphenyl)carbonyl]amino]tetrahydrothiophene-3-carboxylic acid

-

2-[[(4'-chloro-3'-methyl-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid

-

2-[[(4'-ethoxy-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid

-

2-[[(4'-fluoro-3'-methyl-2-phenoxybiphenyl-4-yl)carbonyl]amino]-6-hydroxybenzoic acid

-

2-[[(4'-fluoro-3'-methyl-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid

-

2-[[(4'-hydroxy-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid

-

2-[[(4'-methyl-2-phenoxybiphenyl-4-yl)carbonyl]amino]cyclohexanecarboxylic acid

-

2-[[(4-bromo-3-hydroxy-5-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid

-

2-[[(4-bromo-3-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid

-

2-[[(4-fluoro-3-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid

-

2-[[(4-hydroxy-3-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid

-

2-[[(4-morpholin-4-yl-3-phenoxyphenyl)carbonyl]amino]cyclohexanecarboxylic acid

-

3-(1,4-dihydroxynaphthalene-2-sulfonyl)propanoic acid

-

3-(2-phenylethyl)-1,3-thiazolidin-2-one 1,1-dioxide

3-(2-phenylethyl)-1,3-thiazolidine-2-thione

IC50: 0.1 mM, above

3-(2-phenylethyl)-1lambda6,3-thiazolidine-1,1,2-trione

-

3-(4-phenoxybenzyl)-1,3-thiazolidin-2-one

-

3-(4-phenoxybenzyl)-1,3-thiazolidin-2-one 1,1-dioxide

-

3-(biphenyl-4-ylmethyl)-1,3-thiazolidin-2-one

IC50: 0.0109 mM

3-(biphenyl-4-ylmethyl)-1,3-thiazolidin-2-one 1,1-dioxide

IC50: 0.0009 mM

3-(biphenyl-4-ylmethyl)-1,3-thiazolidine-2-thione

3-(pyridin-3-ylmethyl)-1,3-thiazolidin-2-one

3-(pyridin-3-ylmethyl)-1,3-thiazolidine-2-thione

IC50: 0.1 mM, above

3-benzyl-1,3-thiazolidin-2-one

3-benzyl-1,3-thiazolidin-2-one 1,1-dioxide

3-benzyl-1,3-thiazolidine-2-thione

IC50: 0.1 mM, above

3-benzyl-1lambda6,3-thiazolidine-1,1,2-trione

-

3-bromo-N-(4-phenyl-1,3-thiazol-2-yl)benzamide

-

3-bromo-N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]benzamide

fitting 3-bromo-N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]benzamide into the active site of Escherichia coli FabH,PDB ID 3IL9

3-chloro-N-(4-phenyl-1,3-thiazol-2-yl)benzamide

-

3-ethoxy-N-(4-phenyl-1,3-thiazol-2-yl)benzamide

-

3-methoxy-N-(4-phenyl-1,3-thiazol-2-yl)benzamide

-

3-methyl-1,3-thiazolidin-2-one 1,1-dioxide

IC50: 0.1 mM, above

3-methyl-1,3-thiazolidine-2-thione

IC50: 0.1 mM, above

3-propyl-1,3-thiazolidin-2-one 1,1-dioxide

IC50: 0.1 mM, above

3-propyl-1,3-thiazolidine-2-thione

IC50: 0.1 mM, above

3-[(4'-cyclopentylbiphenyl-4-yl)methyl]-1,3-thiazolidin-2-one 1,1-dioxide

IC50: 0.0024 mM

3-[(4-phenoxyphenyl)methyl]-1,3-thiazolidin-2-one

-

3-[(4-phenoxyphenyl)methyl]-1lambda6,3-thiazolidine-1,1,2-trione

-

3-[3-[(2-carboxycyclohexyl)carbamoyl]phenoxy]benzoic acid

-

3-[4-(4-cyclopentylphenoxy)benzyl]-1,3-thiazolidin-2-one

-

3-[4-(4-cyclopentylphenoxy)benzyl]-1,3-thiazolidin-2-one 1,1-dioxide

-

3-[4-(4-cyclopentylphenoxy)benzyl]-1,3-thiazolidine-2-thione

-

3-[[(3-phenoxyphenyl)carbonyl]amino]piperidine-2-carboxylic acid

-

3-[[4-(4-cyclopentylphenoxy)phenyl]methyl]-1,3-thiazolidin-2-one

-

3-[[4-(4-cyclopentylphenoxy)phenyl]methyl]-1,3-thiazolidine-2-thione

-

3-[[4-(4-cyclopentylphenoxy)phenyl]methyl]-1lambda6,3-thiazolidine-1,1,2-trione

-

4'-[(2-carboxycyclohexyl)carbamoyl]-2'-phenoxybiphenyl-4-carboxylic acid

-

4,5-dichloro-1,2-dithiole-3-one

IC50 is 0.002 mM

4,5-dichloro-3H-1,2-dithiol-3-one

4-(3,4-dichlorophenyl)-2-[(2E)-2-[(4-fluorophenyl)methylidene]hydrazino]-1,3-thiazole

-

4-(3,4-dichlorophenyl)-2-[(2E)-2-[(4-methoxyphenyl)methylidene]hydrazino]-1,3-thiazole

-

4-(3,4-dichlorophenyl)-2-[(2E)-2-[(4-methylphenyl)methylidene]hydrazino]-1,3-thiazole

-

4-(4-biphenyl-4-ylcyclohexyl)-1,3-thiazolidin-2-one

IC50: 0.0144 mM

4-(4-biphenyl-4-ylcyclohexyl)-1,3-thiazolidine-2-thione

IC50: 0.0177 mM

4-(4-chlorophenyl)-2-[(2E)-2-[(4-chlorophenyl)methylidene]hydrazino]-1,3-thiazole

-

4-(4-chlorophenyl)-2-[(2E)-2-[(4-fluorophenyl)methylidene]hydrazino]-1,3-thiazole

-

4-(4-chlorophenyl)-2-[(2E)-2-[(4-methoxyphenyl)methylidene]hydrazino]-1,3-thiazole

-

4-(4-chlorophenyl)-2-[(2E)-2-[(4-methylphenyl)methylidene]hydrazino]-1,3-thiazole

-

4-bromo-2-[(E)-[(4-phenyl-1,3-thiazol-2-yl)hydrazono]methyl]phenol

-

4-bromo-2-[(E)-[2-[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazinylidene]methyl]phenol

-

4-bromo-2-[(E)-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol

-

4-bromo-2-[(E)-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol

-

4-bromo-N-(4-phenyl-1,3-thiazol-2-yl)benzamide

-

4-bromo-N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]benzamide

-

4-chloro-2-[(E)-[(4-phenyl-1,3-thiazol-2-yl)hydrazono]methyl]phenol

-

4-chloro-2-[(E)-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol

-

4-chloro-2-[(E)-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol

-

4-chloro-N-(4-phenyl-1,3-thiazol-2-yl)benzamide

-

4-fluoro-2-[(E)-[[2-(4-hydroxyphenyl)ethyl]imino]methyl]phenol

-

735943, 735963

4-fluoro-N-(4-phenyl-1,3-thiazol-2-yl)benzamide

-

4-[(1Z)-N,2-bis(4-chlorophenyl)ethanimidoyl]benzene-1,3-diol

-

735943, 735963

4-[(E)-(cyclohexylimino)methyl]benzene-1,3-diol

-

4-[(E)-[2-[5-(trifluoromethyl)pyridin-2-yl]hydrazinylidene]methyl]benzene-1,3-diol

-

4-[(Z)-(cyclohexylimino)methyl]benzene-1,3-diol

YKAs3003

4-[3-[(2-carboxycyclohexyl)carbamoyl]phenoxy]benzoic acid

-

5-chloro-1,2-dithiole-3-ones

binding mode, structural features for optimal complex formation, inhibition potencies of derivatives, the derivatives differ in case of reversibility of the inhibition dependent on the substituting groups, overview

5-chloro-1,2-dithiole-3-thiones

binding mode, structural features for optimal complex formation, inhibition potencies of derivatives, the derivatives differ in case of reversibility of the inhibition dependent on the substituting groups, overview

5-ethyl-4-fluoro-2-[(2-fluoropyridin-3-yl)oxy]phenol

-

5-hydroxy-2-phenyl-7-(2-(piperazin-1-yl)ethoxy)-4H-chromen-4-one

5-hydroxy-2-phenyl-7-(2-(piperidin-1-yl)ethoxy)-4H-chromen-4-one

-

5-hydroxy-2-phenyl-7-(2-(pyrrolidin-1-yl)ethoxy)-4H-chromen-4-one

-

5-hydroxy-2-phenyl-7-(3-(2-hydroxyethylamino)propoxy)-4H-chromen-4-one

-

5-hydroxy-2-phenyl-7-(3-(piperazin-1-yl)propoxy)-4H-chromen-4-one

-

5-hydroxy-2-phenyl-7-(3-(propylamino)propoxy)-4H-chromen-4-one

-

5-hydroxy-2-phenyl-7-[3-(pyrrolidin-1-yl)propoxy]-2,3-dihydro-4H-chromen-4-one

a strong inhibitor, interacts with Escherichia coli FabH via a hydrogen bond between its 5-hydroxy group and the amino hydrogen of Asn247 and a hydrophobic interaction between the pyrrolidine moiety at the C7 position and Asn274, Ile 156, Phe157, and Met2

5-hydroxy-7-(2-(4-methylpiperazin-1-yl)ethoxy)-2-phenyl-4H-chromen-4-one

-

5-hydroxy-7-(3-(4-methylpiperazin-1-yl)propoxy)-2-phenyl-4H-chromen-4-one

-

5-[(2,6-dichlorobenzyl)oxy]-1-[(6-methyl-1,3-benzodioxol-5-yl)methyl]-1H-indole-2-carboxylic acid

-

6-[(2,6-dichlorophenyl)methoxy]-3-(phenylsulfanyl)-1H-indole-2-carboxylic acid

SB418011

7-(2-(dibutylamino)ethoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one

-

7-(2-(diethylamino)ethoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one

-

7-(2-(dipropylamino)ethoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one

-

7-(2-(propylamino)ethoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one

-

7-(3-(dibutylamino)propoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one

-

7-(3-(diethylamino)propoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one

-

7-(3-(dipropylamino)propoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one

-

7-[(1E)-nonadec-1-en-1-yl]-3,4-dihydro-2H-1,5-benzodioxepine

-

acetoxyanthecotulide

-

acyl-[acyl-carrier protein]

-

mixed inhibition type, the enzyme is a target for fatty acid synthesis regulation by acyl-[acyl-carrier-protein], inhibitory potency increases with increasing chain length between C12 and C20

anthecotulide

-

cerulenin

-

chrysine

i.e 1,5,7-dihydroxyflavone

Cinnamic acid

-

CoA methyldisulfide

CoA methyldisulfide shows rapid inhibition of one monomer of FabH through formation of a methyl disulfide conjugate. Reaction of the second subunit with either MeSSCoA or acetyl-CoA is much slower. In the presence of malonyl-ACP, the acylation rate of the second subunit is restored to that of the native FabH

ethyl (2Z)-2-[4-(benzyloxy)phenyl]-3-[(4-methylphenyl)amino]prop-2-enoate

displays effective FabH inhibitory activity and excellent antibacterial activity against Gram-negative Escherichia coli. Binds to FabH through two interactions: a hydrogen bond between the N-H group and the side chain carbonyl group of Gly 209 and a hydro

FAS20013

-

HR45

-

hydroxyanthecotulide

-

kanamycin

-

kanamycin B

-

methyl-CoA disulfide

-

N'-[(1E,2E)-3-(2-fluorophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine 2-carbohydrazide

-

N'-[(1E,2E)-3-(2-fluorophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-2-carbohydrazide

-

N'-[(1E,2E)-3-(2-fluorophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide

-

N'-[(1E,2E)-3-(2-fluorophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide

-

N'-[(1E,2E)-3-(2-methoxyphenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-2-carbohydrazide

-

N'-[(1E,2E)-3-(2-methoxyphenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide

-

N'-[(1E,2E)-3-(2-methoxyphenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide

-

N'-[(1E,2E)-3-(2-nitrophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-2-carbohydrazide

-

N'-[(1E,2E)-3-(2-nitrophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide

-

N'-[(1E,2E)-3-(2-nitrophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide

-

N'-[(1E,2E)-3-(4-bromophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-2-carbohydrazide

-

N'-[(1E,2E)-3-(4-bromophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide

-

N'-[(1E,2E)-3-(4-bromophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide

-

N'-[(1E,2E)-3-(4-methoxyphenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-2-carbohydrazide

-

N'-[(1E,2E)-3-(4-methoxyphenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide

-

N'-[(1E,2E)-3-(4-methoxyphenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide

-

N'-[(1E,2E)-3-(4-nitrophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-2-carbohydrazide

-

N'-[(1E,2E)-3-(4-nitrophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide

-

N'-[(1E,2E)-3-(4-nitrophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide

-

N'-[(1E,2E)-3-phenylprop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-2-carbohydrazide

-

-

N'-[(1E,2E)-3-phenylprop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide

-

N'-[(1E,2E)-3-phenylprop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide

-

N'-[(E)-(3,5-dibromo-2,4-dihydroxyphenyl)methylidene]naphthalene-2-carbohydrazide

-

N'-[(E)-(3,5-dichloro-2-hydroxyphenyl)methylidene]-4-hydroxy-3-methoxybenzohydrazide

-

N-(3-(5-bromo-2-hydroxybenzylideneamino)propyl)-2-hydroxybenzamide

-

N-(4-(4-bromophenyl)thiazol-2-yl)-2-(3-chlorophenyl)acetamid

the malonyl carboxylate forms hydrogen bonds to the backbone nitrogen of Phe304, inhibitor binding mode, overview

N-(4-phenyl-1,3-thiazol-2-yl)-5,8-dihydronaphthalene-2-carboxamide

-

N-(4-phenyl-1,3-thiazol-2-yl)benzamide

-

N-(4-phenyl-1,3-thiazol-2-yl)morpholine-4-carboxamide

-

N-(4-phenyl-1,3-thiazol-2-yl)naphthalene-1-carboxamide

-

N-(4-phenyl-1,3-thiazol-2-yl)naphthalene-2-carboxamide

-

N-[3-[(E)-(5-bromo-2-hydroxybenzylidene)amino]propyl]-2-hydroxybenzamide

-

N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-2-(3,4-diethoxyphenyl)acetamide

-

N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-2-(3-methoxyphenyl)acetamide

-

N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-2-(4-chlorophenyl)acetamide

-

N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-2-(4-fluorophenyl)acetamide

-

N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-2-phenylacetamide

-

N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-3-chlorobenzamide

-

N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-3-ethoxybenzamide

-

N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-3-methoxybenzamide

-

N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-4-chlorobenzamide

-

N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-4-fluorobenzamide

-

N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-5,8-dihydronaphthalene-2-carboxamide

-

N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]benzamide

-

N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]morpholine-4-carboxamide

-

N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]naphthalene-1-carboxamide

-

N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]naphthalene-2-carboxamide

-

penicillin G

platencin

a dual inhibitor of FabH and FabF/FabB

SB-418011

-

SB418011

-

secnidazole

-

thiolactomycin

YKAs3003

-

[4-(1,4-dihydroxynaphthalene-2-sulfonyl)phenyl]carbamic acid

-

additional information

18 entries

-

0.04 - 0.045

acetyl-CoA

0.005

malonyl-[acyl-carrier protein]

-

pH 7.0, 37°C, recombinant enzyme

additional information

-

kinetics

486932

-

additional information

-

inhibition kinetics

-

0.0094

(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(2,4-dichlorophenyl)acrylate

Escherichia coli

-

pH 7.0, temperature not specified in the publication

0.0401

(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(2-bromophenyl)acrylate

Escherichia coli

-

pH 7.0, temperature not specified in the publication

0.0275

(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(3-bromophenyl)acrylate

Escherichia coli

-

pH 7.0, temperature not specified in the publication

0.0082

(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(3-fluorophenyl)acrylate

Escherichia coli

-

pH 7.0, temperature not specified in the publication

0.0067

(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(4-(benzyloxy)phenyl)acrylate

Escherichia coli

-

pH 7.0, temperature not specified in the publication

0.0198

(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(4-(dimethylamino)phenyl)acrylate

Escherichia coli

-

pH 7.0, temperature not specified in the publication

0.0156

(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(4-bromophenyl)acrylate

Escherichia coli

-

pH 7.0, temperature not specified in the publication

0.0343

(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(4-chlorophenyl)acrylate

Escherichia coli

-

pH 7.0, temperature not specified in the publication

0.0025

(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(biphenyl-4-yl)acrylate

Escherichia coli

-

pH 7.0, temperature not specified in the publication

0.0489

(E)-1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl 3-(naphthalen-1-yl)acrylate

Escherichia coli

-

pH 7.0, temperature not specified in the publication

0.0067

(E)-1-(6-chloropyridin-3-yl)-N-((3,4-dihydro-2Hbenzo[b][1,4]dioxepin-7-yl)methylene)methanamine

Escherichia coli

at pH 7.0 and 37°C

0.0123

(E)-4-chloro-N-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)methylene)pyridin-2-amine

Escherichia coli

at pH 7.0 and 37°C

0.0128

(E)-5-chloro-N-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)methylene)pyridin-2-amine

Escherichia coli

at pH 7.0 and 37°C

0.0099

(E)-6-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)-methyleneamino)nicotinonitrile

Escherichia coli

at pH 7.0 and 37°C

0.043

(E)-ethyl 2-(4-(benzyloxy)phenyl)-3-(4-bromophenylamino)acrylate

Escherichia coli

-

pH 7.0, temperature not specified in the publication

0.0085

(E)-ethyl 2-(4-(benzyloxy)phenyl)-3-(4-isopropylphenylamino)acrylate

Escherichia coli

-

pH 7.0, temperature not specified in the publication

0.0857

(E)-N'-((E)-3-phenylallylidene)-2,3-dihydrobenzo[b][1,4]-dioxine-2-carbohydrazide

Escherichia coli

pH 7.4, 37°C

0.0074

(E)-N-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)-methylene)-3-methylpyridin-2-amine

Escherichia coli

at pH 7.0 and 37°C

0.0151

(E)-N-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)-methylene)-4-methylpyridin-2-amine

Escherichia coli

at pH 7.0 and 37°C

0.0038

(E)-N-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)-methylene)-5-(trifluoromethyl)pyridin-2-amine

Escherichia coli

at pH 7.0 and 37°C

0.0145

(E)-N-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)-methylene)pyridin-3-amine

Escherichia coli

at pH 7.0 and 37°C

0.0021

(E)-tert-butyl 4-((3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)methyleneamino)piperidine-1-carboxylate

Escherichia coli

at pH 7.0 and 37°C

0.024

(Z)-ethyl 2-(4-(benzyloxy)phenyl)-3-(2,4-dibromophenylamino)acrylate

Escherichia coli

-

pH 7.0, temperature not specified in the publication

0.028

(Z)-ethyl 2-(4-(benzyloxy)phenyl)-3-(2-chlorophenylamino)acrylate

Escherichia coli

-

pH 7.0, temperature not specified in the publication

0.0033

(Z)-ethyl 2-(4-(benzyloxy)phenyl)-3-(4-bromophenylamino)acrylate

Escherichia coli

-

pH 7.0, temperature not specified in the publication

0.0082

(Z)-ethyl 2-(4-(benzyloxy)phenyl)-3-(4-fluorophenylamino)acrylate

Escherichia coli

-

pH 7.0, temperature not specified in the publication

0.0026

(Z)-ethyl 3-(p-toluidino)-2-(4-(benzyloxy)phenyl)acrylate

Escherichia coli

-

pH 7.0, temperature not specified in the publication

0.0515

1-(2-chlorophenyl)-1-(3,5-dibromo-2-hydroxybenzyl)-3-phenylurea

Escherichia coli

-

pH 7.0, temperature not specified in the publication

0.0025

1-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-yl (2E)-3-(biphenyl-4-yl)prop-2-enoate

Escherichia coli

pH and temperature not specified in the publication

0.0717

1-(3,5-dibromo-2-hydroxybenzyl)-1-(4-fluorophenyl)-3-phenylurea

Escherichia coli

-

pH 7.0, temperature not specified in the publication

0.00014

1-(4-carboxybutyl)-5-[(2,6-dichlorobenzyl)oxy]-1H-indole-2-carboxylic acid

Escherichia coli

-

0.0101

1-(4-chlorophenyl)-1-(3,5-dibromo-2-hydroxybenzyl)-3-phenylurea

Escherichia coli

-

pH 7.0, temperature not specified in the publication

0.0043

1-(4-[(E)-[3-(benzyloxy)benzylidene]amino]phenyl)-3-phenylthiourea

Escherichia coli

pH and temperature not specified in the publication

0.0564

1-(5-bromo-2-hydroxybenzyl)-1-(2-bromophenyl)-3-phenylurea

Escherichia coli

-

pH 7.0, temperature not specified in the publication

0.0218

1-(5-bromo-2-hydroxybenzyl)-1-(2-chlorophenyl)-3-phenylurea

Escherichia coli

-

pH 7.0, temperature not specified in the publication

0.0374

1-(5-bromo-2-hydroxybenzyl)-1-(2-fluorophenyl)-3-phenylurea

Escherichia coli

-

pH 7.0, temperature not specified in the publication

0.041

1-(5-bromo-2-hydroxybenzyl)-1-(4-bromophenyl)-3-phenylurea

Escherichia coli

-

pH 7.0, temperature not specified in the publication

0.0047

1-(5-bromo-2-hydroxybenzyl)-1-(4-chlorophenyl)-3-phenylurea

0.0066

1-(5-bromo-2-hydroxybenzyl)-1-(4-fluorophenyl)-3-phenylurea

Escherichia coli

-

pH 7.0, temperature not specified in the publication

0.00088

1-[(6-chloro-1,3-benzodioxol-5-yl)methyl]-5-[(2,6-dichlorobenzyl)oxy]-1H-indole-2-carboxylic acid

Escherichia coli

-

0.0196

1-[3,5-bis(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone

Escherichia coli

-

pH not specified in the publication, temperature not specified in the publication

0.0173

1-[3-(4-methoxyphenyl)-5-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone

Escherichia coli

-

pH not specified in the publication, temperature not specified in the publication

0.0467

1-[3-(4-methoxyphenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-1-yl]ethanone

Escherichia coli

-

pH not specified in the publication, temperature not specified in the publication

0.0314

1-[5-(2-chlorophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone

Escherichia coli

-

pH not specified in the publication, temperature not specified in the publication

0.0104

1-[5-(4-bromophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone

Escherichia coli

-

pH not specified in the publication, temperature not specified in the publication

0.0076

1-[5-(4-chlorophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone

Escherichia coli

-

pH not specified in the publication, temperature not specified in the publication

0.0042

1-[5-(4-fluorophenyl)-3-(4-methoxyphenyl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone

0.0036

2,4-dibromo-6-[(E)-[2-[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazinylidene]methyl]phenol

Escherichia coli

pH and temperature not specified in the publication

0.0036

2,4-dibromo-6-[(E)-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol

Escherichia coli

-

0.0784

2,4-dibromo-6-[(E)-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol

Escherichia coli

-

0.0165

2,4-dichloro-6-[(E)-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol

Escherichia coli

-

0.0576

2,4-dichloro-6-[(E)-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol

Escherichia coli

-

0.0051

2-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-5-(2-methylbenzyl)-1,3,4-oxadiazole

Escherichia coli

-

pH 7.0, temperature not specified in the publication

0.0405

2-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-5-(4-nitrophenyl)-1,3,4-oxadiazol

Escherichia coli

-

pH 7.0, temperature not specified in the publication

0.0043

2-(2-methoxyphenyl)-5-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-1,3,4-oxadiazole

Escherichia coli

-

pH 7.0, temperature not specified in the publication

0.0043

2-(2-methoxyphenyl)-5-[(2-methyl-5-nitro-1H-imidazol-1-yl)methyl]-1,3,4-oxadiazole

Escherichia coli

pH and temperature not specified in the publication

0.0169

2-(3-bromophenyl)-5-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-1,3,4-oxadiazole

Escherichia coli

-

pH 7.0, temperature not specified in the publication

0.0269

2-(3-bromophenyl)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide

Escherichia coli

pH and temperature not specified in the publication

0.0098

2-(3-bromophenyl)-N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]acetamide

Escherichia coli

pH and temperature not specified in the publication

0.0123

2-(3-chlorophenyl)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide

Escherichia coli

pH and temperature not specified in the publication

0.0094

2-(3-methoxyphenyl)-5-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-1,3,4-oxadiazole

Escherichia coli

-

pH 7.0, temperature not specified in the publication

0.0438

2-(4-bromophenyl)-5-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-1,3,4-oxadiazole

Escherichia coli

-

pH 7.0, temperature not specified in the publication

0.0481

2-(4-bromophenyl)-N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]acetamide

Escherichia coli

pH and temperature not specified in the publication

0.0000088

2-(4-chlorobenzene-1-sulfonyl)naphthalene-1,4-diol

Escherichia coli

pH 7.4, 23°C

0.0283

2-(4-chlorophenyl)-5-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-1,3,4-oxadiazole

Escherichia coli

-

pH 7.0, temperature not specified in the publication

0.0418

2-(4-chlorophenyl)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide

Escherichia coli

pH and temperature not specified in the publication

0.0186

2-(4-fluorophenyl)-5-((2-methyl-5-nitro-1H-imidazol-1-yl)methyl)-1,3,4-oxadiazole

Escherichia coli

-

pH 7.0, temperature not specified in the publication

0.0384

2-(4-fluorophenyl)-N-(4-phenyl-1,3-thiazol-2-yl)acetamide

Escherichia coli

pH and temperature not specified in the publication

0.0001124

2-(4-methylbenzene-1-sulfonyl)anthracene-1,4-diol

Escherichia coli

pH 7.4, 23°C

0.0000136

2-(4-methylbenzene-1-sulfonyl)naphthalene-1,4-diol

Escherichia coli

pH 7.4, 23°C

0.0001872

2-(4-methylbenzene-1-sulfonyl)naphthalene-1,4-dione

Escherichia coli

pH 7.4, 23°C

0.0000097

2-(4-propylbenzene-1-sulfonyl)naphthalene-1,4-diol

Escherichia coli

pH 7.4, 23°C

0.00000212

2-(benzenesulfonyl)naphthalene-1,4-diol

Escherichia coli

pH 7.4, 23°C

0.0000873

2-(methanesulfonyl)naphthalene-1,4-diol

Escherichia coli

pH 7.4, 23°C

0.0000154

2-(naphthalene-2-sulfonyl)naphthalene-1,4-diol

Escherichia coli

pH 7.4, 23°C

0.0057

2-([[4-(3,5-dimethylpiperidin-1-yl)-3-phenoxyphenyl]carbonyl]amino)benzoic acid

Escherichia coli

-

0.0014

2-hydroxy-6-[[(2-phenoxybiphenyl-4-yl)carbonyl]amino]benzoic acid

Escherichia coli

-

0.0046

2-[3-(3,4-dichlorophenyl)-5-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole

Escherichia coli

pH and temperature not specified in the publication

0.0197

2-[3-(4-bromophenyl)-5-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-(4-methoxyphenyl)-1,3-thiazole

Escherichia coli

-

pH 7.0, temperature not specified in the publication

0.0097

2-[3-(4-bromophenyl)-5-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole

Escherichia coli

-

pH 7.0, temperature not specified in the publication

0.0271

2-[3-(4-bromophenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one

Escherichia coli

-

pH 7.0, temperature not specified in the publication

0.0233

2-[3-(4-bromophenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole

Escherichia coli

-

pH 7.0, temperature not specified in the publication

0.0084

2-[3-(4-fluorophenyl)-5-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one

Escherichia coli

-

pH 7.0, temperature not specified in the publication

0.0223

2-[3-(4-fluorophenyl)-5-(furan-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole

Escherichia coli

-

pH 7.0, temperature not specified in the publication

0.0899

2-[3-(4-methoxyphenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one

Escherichia coli

-

pH 7.0, temperature not specified in the publication

0.0306

2-[3-(4-methoxyphenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole

Escherichia coli

-

pH 7.0, temperature not specified in the publication

0.0136

2-[3-(4-methylphenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one

Escherichia coli

-

pH 7.0, temperature not specified in the publication

0.0109

2-[3-(4-methylphenyl)-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole

Escherichia coli

-

pH 7.0, temperature not specified in the publication

0.0184

2-[5-(furan-2-yl)-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-1,3-thiazol-4(5H)-one

Escherichia coli

-

pH 7.0, temperature not specified in the publication

0.0157

2-[5-(furan-2-yl)-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-4-(4-methoxyphenyl)-1,3-thiazole

Escherichia coli

-

pH 7.0, temperature not specified in the publication

0.0046

2-[5-(furan-2-yl)-3-(4-methylphenyl)-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole

Escherichia coli

-

pH 7.0, temperature not specified in the publication

0.002

2-[[(3-phenoxy-4-piperidin-1-ylphenyl)carbonyl]amino]benzoic acid

Escherichia coli

-

0.001

2-[[(3-phenoxy-4-thiomorpholin-4-ylphenyl)carbonyl]amino]benzoic acid

Escherichia coli

-

0.0000965

3-(1,4-dihydroxynaphthalene-2-sulfonyl)propanoic acid

Escherichia coli

pH 7.4, 23°C

0.0019

3-(2-phenylethyl)-1,3-thiazolidin-2-one 1,1-dioxide

0.1

3-(2-phenylethyl)-1,3-thiazolidine-2-thione

Escherichia coli

IC50: 0.1 mM, above

0.0019

3-(2-phenylethyl)-1lambda6,3-thiazolidine-1,1,2-trione

Escherichia coli

pH not specified in the publication, temperature not specified in the publication

0.0109

3-(4-phenoxybenzyl)-1,3-thiazolidin-2-one

Escherichia coli

-

0.0009

3-(4-phenoxybenzyl)-1,3-thiazolidin-2-one 1,1-dioxide

Escherichia coli

-

0.0109

3-(biphenyl-4-ylmethyl)-1,3-thiazolidin-2-one

Escherichia coli

IC50: 0.0109 mM

0.0009

3-(biphenyl-4-ylmethyl)-1,3-thiazolidin-2-one 1,1-dioxide

Escherichia coli

IC50: 0.0009 mM

0.0177 - 0.1

3-(biphenyl-4-ylmethyl)-1,3-thiazolidine-2-thione

0.0207

3-(pyridin-3-ylmethyl)-1,3-thiazolidin-2-one

0.1

3-(pyridin-3-ylmethyl)-1,3-thiazolidine-2-thione

Escherichia coli

IC50: 0.1 mM, above

0.0137

3-benzyl-1,3-thiazolidin-2-one

0.0011

3-benzyl-1,3-thiazolidin-2-one 1,1-dioxide

0.1

3-benzyl-1,3-thiazolidine-2-thione

Escherichia coli

IC50: 0.1 mM, above

0.0011

3-benzyl-1lambda6,3-thiazolidine-1,1,2-trione

Escherichia coli

pH not specified in the publication, temperature not specified in the publication

0.0269

3-bromo-N-(4-phenyl-1,3-thiazol-2-yl)benzamide

Escherichia coli

pH 7.0, 37°C, recombinant His-tagged enzyme

0.0058

3-bromo-N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]benzamide

Escherichia coli

pH 7.0, 37°C, recombinant His-tagged enzyme

0.0123

3-chloro-N-(4-phenyl-1,3-thiazol-2-yl)benzamide

Escherichia coli

pH 7.0, 37°C, recombinant His-tagged enzyme

0.1

3-methyl-1,3-thiazolidin-2-one 1,1-dioxide

Escherichia coli

IC50: 0.1 mM, above

0.1

3-methyl-1,3-thiazolidine-2-thione

Escherichia coli

IC50: 0.1 mM, above

0.1

3-propyl-1,3-thiazolidin-2-one 1,1-dioxide

Escherichia coli

IC50: 0.1 mM, above

0.1

3-propyl-1,3-thiazolidine-2-thione

Escherichia coli

IC50: 0.1 mM, above

0.0024

3-[(4'-cyclopentylbiphenyl-4-yl)methyl]-1,3-thiazolidin-2-one 1,1-dioxide

Escherichia coli

IC50: 0.0024 mM

0.0109

3-[(4-phenoxyphenyl)methyl]-1,3-thiazolidin-2-one

Escherichia coli

pH not specified in the publication, temperature not specified in the publication

0.0009

3-[(4-phenoxyphenyl)methyl]-1lambda6,3-thiazolidine-1,1,2-trione

Escherichia coli

pH not specified in the publication, temperature not specified in the publication

0.0144

3-[4-(4-cyclopentylphenoxy)benzyl]-1,3-thiazolidin-2-one

Escherichia coli

-

0.0024

3-[4-(4-cyclopentylphenoxy)benzyl]-1,3-thiazolidin-2-one 1,1-dioxide

Escherichia coli

-

0.0177

3-[4-(4-cyclopentylphenoxy)benzyl]-1,3-thiazolidine-2-thione

Escherichia coli

-

0.0144

3-[[4-(4-cyclopentylphenoxy)phenyl]methyl]-1,3-thiazolidin-2-one

Escherichia coli

pH not specified in the publication, temperature not specified in the publication

0.0177

3-[[4-(4-cyclopentylphenoxy)phenyl]methyl]-1,3-thiazolidine-2-thione

Escherichia coli

pH not specified in the publication, temperature not specified in the publication

0.0024

3-[[4-(4-cyclopentylphenoxy)phenyl]methyl]-1lambda6,3-thiazolidine-1,1,2-trione

Escherichia coli

pH not specified in the publication, temperature not specified in the publication

0.002

4,5-dichloro-1,2-dithiole-3-one

Escherichia coli

IC50 is 0.002 mM

0.0144

4-(4-biphenyl-4-ylcyclohexyl)-1,3-thiazolidin-2-one

Escherichia coli

IC50: 0.0144 mM

0.0177

4-(4-biphenyl-4-ylcyclohexyl)-1,3-thiazolidine-2-thione

Escherichia coli

IC50: 0.0177 mM

0.0434

4-bromo-2-[(E)-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol

Escherichia coli

-

0.0068

4-bromo-2-[(E)-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol

Escherichia coli

-

0.0481

4-bromo-N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]benzamide

Escherichia coli

pH 7.0, 37°C, recombinant His-tagged enzyme

0.0396

4-chloro-2-[(E)-[[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol

Escherichia coli

-

0.0117

4-chloro-2-[(E)-[[4-(4-chlorophenyl)-1,3-thiazol-2-yl]hydrazono]methyl]phenol

Escherichia coli

-

0.0418

4-chloro-N-(4-phenyl-1,3-thiazol-2-yl)benzamide

Escherichia coli

pH 7.0, 37°C, recombinant His-tagged enzyme

0.0027

4-fluoro-2-[(E)-[[2-(4-hydroxyphenyl)ethyl]imino]methyl]phenol

Escherichia coli

pH and temperature not specified in the publication

0.0384

4-fluoro-N-(4-phenyl-1,3-thiazol-2-yl)benzamide

Escherichia coli

pH 7.0, 37°C, recombinant His-tagged enzyme

0.0018

4-[(1Z)-N,2-bis(4-chlorophenyl)ethanimidoyl]benzene-1,3-diol

Escherichia coli

pH and temperature not specified in the publication

0.0434

Cinnamic acid

Escherichia coli

-

pH 7.0, temperature not specified in the publication

0.0571

CoA methyldisulfide

Escherichia coli

pH 7.4, 23°C

0.0026

ethyl (2Z)-2-[4-(benzyloxy)phenyl]-3-[(4-methylphenyl)amino]prop-2-enoate

Escherichia coli

pH and temperature not specified in the publication

0.0571

methyl-CoA disulfide

Escherichia coli

-

686047

0.1

N'-[(1E,2E)-3-(2-fluorophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide

Escherichia coli

above, pH 7.4, 37°C

0.0035

N'-[(1E,2E)-3-(2-nitrophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide

Escherichia coli

pH 7.4, 37°C

0.0147

N'-[(1E,2E)-3-(2-nitrophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide

Escherichia coli

pH 7.4, 37°C

0.0113

N'-[(1E,2E)-3-(4-bromophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide

Escherichia coli

pH 7.4, 37°C

0.0148

N'-[(1E,2E)-3-(4-bromophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide

Escherichia coli

pH 7.4, 37°C

0.0591

N'-[(1E,2E)-3-(4-methoxyphenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide

Escherichia coli

pH 7.4, 37°C

0.0066

N'-[(1E,2E)-3-(4-methoxyphenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-6-carbohydrazide

Escherichia coli

pH 7.4, 37°C

0.009

N'-[(1E,2E)-3-(4-nitrophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-2-carbohydrazide

Escherichia coli

pH 7.4, 37°C

0.0094

N'-[(1E,2E)-3-(4-nitrophenyl)prop-2-en-1-ylidene]-2,3-dihydro-1,4-benzodioxine-5-carbohydrazide

Escherichia coli

pH 7.4, 37°C

0.0021

N'-[(E)-(3,5-dichloro-2-hydroxyphenyl)methylidene]-4-hydroxy-3-methoxybenzohydrazide

Escherichia coli

pH and temperature not specified in the publication

0.00088

N-(3-(5-bromo-2-hydroxybenzylideneamino)propyl)-2-hydroxybenzamide

Escherichia coli

pH and temperature not specified in the publication

0.0053

N-(4-(4-bromophenyl)thiazol-2-yl)-2-(3-chlorophenyl)acetamid

Escherichia coli

pH and temperature not specified in the publication

0.1

N-(4-phenyl-1,3-thiazol-2-yl)benzamide

Escherichia coli

above, pH 7.0, 37°C, recombinant His-tagged enzyme

0.0656

N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-2-(3-methoxyphenyl)acetamide

Escherichia coli

pH and temperature not specified in the publication

0.0347

N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-2-(4-chlorophenyl)acetamide

Escherichia coli

pH and temperature not specified in the publication

0.0293

N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-2-(4-fluorophenyl)acetamide

Escherichia coli

pH and temperature not specified in the publication

0.0093

N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-3-chlorobenzamide

Escherichia coli

pH 7.0, 37°C, recombinant His-tagged enzyme

0.0066

N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-3-methoxybenzamide

Escherichia coli

pH 7.0, 37°C, recombinant His-tagged enzyme

0.0347

N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-4-chlorobenzamide

Escherichia coli

pH 7.0, 37°C, recombinant His-tagged enzyme

0.0293

N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]-4-fluorobenzamide

Escherichia coli

pH 7.0, 37°C, recombinant His-tagged enzyme

0.1

N-[4-(4-bromophenyl)-1,3-thiazol-2-yl]benzamide

Escherichia coli

above, pH 7.0, 37°C, recombinant His-tagged enzyme

0.0049

penicillin G

Escherichia coli

pH 7.0, 37°C

0.0285

secnidazole

Escherichia coli

-

pH 7.0, temperature not specified in the publication

0.11

thiolactomycin

Escherichia coli

-

0.0000118

[4-(1,4-dihydroxynaphthalene-2-sulfonyl)phenyl]carbamic acid

Escherichia coli

pH 7.4, 23°C

0.004

-

purified His-tagged recombinant enzyme

5.9

-

purified recombinant enzyme

additional information

-

recombinant enzyme in Brassica napus seeds

7

7.3

assay at

25

-

assay at

30

assay at

37

5.1

-

isoelectric focusing, recombinant enzyme

evolution

metabolism

physiological function

4 entries

additional information

molecular dynamics simulations to characterize the conformational space accessible to enzyme homologues under native conditions, using the FabH crystal structure PDB ID 1MZS, with a bound indole analogue inhibitor, to start. Analysis of protein-ligand interactions in the ecFabH co-crystal structure

736658

8d1u, download, 3D-view

33516

-

2 * 33516, amino acid sequence calculation, 2 * 33889, selenomethionine-labeled recombinant enzyme, mass spectrometry

33889

-

2 * 33516, amino acid sequence calculation, 2 * 33889, selenomethionine-labeled recombinant enzyme, mass spectrometry

35000

2 * 35000, structural details of the dimer interface region by means of computational modeling, including molecular dynamics simulations, overview

736551

65000

-

selenomethionine-labeled recombinant enzyme, gel filtration

?

x * 34000, SDS-PAGE

dimer

homodimer

2 * 35000, structural details of the dimer interface region by means of computational modeling, including molecular dynamics simulations, overview

736551

additional information

7 entries

cyrstals of ecFabH and the ecFabH/methyl-CoA disulfide complex are obtained by the hanging drop method

-

686047

enzyme in complex with inhibitor CoA methyldisulfide

purified FabH as apoenzyme or ligand-bound complex, X-ray diffraction structure determination and analysis at 1.46 A resolution

666011

purified FabH as apoenzyme or with bound acetyl-CoA, structure and reaction mechanism modeling

-

665472

purified FabH, sitting drop vapour diffusion method, 2 crystal forms

-

663471

purified recombinant His-tagged, selenomethionine-labeled wild-type enzyme, hanging drop vapour diffusion method, 15 mg/ml protein in 20 mM Tris, pH 7.4, 1 mM EDTA, and 1 mM DTT, crystallization solution contains 1.8-2.0 M ammonium acetate, 2% PEG 400, 0.1 M HEPES, pH 7.5, X-ray diffraction structure determination and analysis at 1.8-2.5 A resolution, modeling

-

purified recombinant selenomethionine-labeled enzyme, 0.002 ml of 13 mg/ml protein in 20 mM Tris, pH 7.5, 50 mM NaCl, 10 mM DTT, and 4 mM acetyl-CoA, versus 0.002 ml reservoir solution containing 12-14% PEG 4000, 40 mM Bis-Tris propane, pH 7.0, and 80 mM magnesium acetate, overnight, X-ray diffraction structure determination and analysis at 1.9 A resolution

-

C112S

-

site-directed mutagenesis, the mutant enzyme shows abolished condensation and transacylation activities, but 4fold increased decarboxylation activity compared to the wild-type enzyme

F87A

-

site-directed mutagenesis, coexpression of the mutant enzyme with the phaC gene from Aeromonas caviae in a recombinant strain confers the ability to synthesize polyhydroxyalkanoates, coexpression of the mutant with gene phaC1 from Pseudomonas sp. strain 61-3 in Escherichia coli confers the ability to synthesize polyhydroxyalkanoates, overview

F87C

F87C/H244A

-

H244 plays a key role in stabilizing the oxyanion generated in the condensation reaction through hydrogen bonding

F87D

-

site-directed mutagenesis, coexpression of the mutant enzyme with the phaC gene from Aeromonas caviae in a recombinant strain does not confer the ability to synthesize polyhydroxyalkanoates, coexpression of the mutant with gene phaC1 from Pseudomonas sp. strain 61-3 in Escherichia coli does not confer the ability to synthesize polyhydroxyalkanoates, overview

F87E

-

site-directed mutagenesis, coexpression of the mutant enzyme with the phaC gene from Aeromonas caviae in a recombinant strain does not confer the ability to synthesize polyhydroxyalkanoates, coexpression of the mutant with gene phaC1 from Pseudomonas sp. strain 61-3 in Escherichia coli does not confer the ability to synthesize polyhydroxyalkanoates, overview

F87G

-

site-directed mutagenesis, coexpression of the mutant enzyme with the phaC gene from Aeromonas caviae in a recombinant strain does not confer the ability to synthesize polyhydroxyalkanoates, coexpression of the mutant with gene phaC1 from Pseudomonas sp. strain 61-3 in Escherichia coli does not confer the ability to synthesize polyhydroxyalkanoates, overview

F87H

-

site-directed mutagenesis, coexpression of the mutant enzyme with the phaC gene from Aeromonas caviae in a recombinant strain does not confer the ability to synthesize polyhydroxyalkanoates, coexpression of the mutant with gene phaC1 from Pseudomonas sp. strain 61-3 in Escherichia coli does not confer the ability to synthesize polyhydroxyalkanoates, overview

F87I

-

site-directed mutagenesis, coexpression of the mutant enzyme with the phaC gene from Aeromonas caviae in a recombinant strain confers the ability to synthesize polyhydroxyalkanoates, coexpression of the mutant with gene phaC1 from Pseudomonas sp. strain 61-3 in Escherichia coli confers the ability to synthesize polyhydroxyalkanoates, overview

F87I/H244A

-

H244 plays a key role in stabilizing the oxyanion generated in the condensation reaction through hydrogen bonding

F87K

-

site-directed mutagenesis, coexpression of the mutant enzyme with the phaC gene from Aeromonas caviae in a recombinant strain does not confer the ability to synthesize polyhydroxyalkanoates, coexpression of the mutant with gene phaC1 from Pseudomonas sp. strain 61-3 in Escherichia coli does not confer the ability to synthesize polyhydroxyalkanoates, overview

F87L

-

site-directed mutagenesis, coexpression of the mutant enzyme with the phaC gene from Aeromonas caviae in a recombinant strain confers the ability to synthesize polyhydroxyalkanoates, coexpression of the mutant with gene phaC1 from Pseudomonas sp. strain 61-3 in Escherichia coli confers the ability to synthesize polyhydroxyalkanoates, overview

F87M

-

site-directed mutagenesis, coexpression of the mutant enzyme with the phaC gene from Aeromonas caviae in a recombinant strain confers the ability to synthesize polyhydroxyalkanoates, coexpression of the mutant with gene phaC1 from Pseudomonas sp. strain 61-3 in Escherichia coli confers the ability to synthesize polyhydroxyalkanoates, overview

F87N

-

site-directed mutagenesis, coexpression of the mutant enzyme with the phaC gene from Aeromonas caviae in a recombinant strain does not confer the ability to synthesize polyhydroxyalkanoates, coexpression of the mutant with gene phaC1 from Pseudomonas sp. strain 61-3 in Escherichia coli does not confer the ability to synthesize polyhydroxyalkanoates, overview

F87P

-

site-directed mutagenesis, coexpression of the mutant enzyme with the phaC gene from Aeromonas caviae in a recombinant strain does not confer the ability to synthesize polyhydroxyalkanoates, coexpression of the mutant with gene phaC1 from Pseudomonas sp. strain 61-3 in Escherichia coli does not confer the ability to synthesize polyhydroxyalkanoates, overview

F87Q

-

site-directed mutagenesis, coexpression of the mutant enzyme with the phaC gene from Aeromonas caviae in a recombinant strain confers the ability to synthesize polyhydroxyalkanoates, coexpression of the mutant with gene phaC1 from Pseudomonas sp. strain 61-3 in Escherichia coli does not confer the ability to synthesize polyhydroxyalkanoates, overview

F87R

-

site-directed mutagenesis, coexpression of the mutant enzyme with the phaC gene from Aeromonas caviae in a recombinant strain does not confer the ability to synthesize polyhydroxyalkanoates, coexpression of the mutant with gene phaC1 from Pseudomonas sp. strain 61-3 in Escherichia coli does not confer the ability to synthesize polyhydroxyalkanoates, overview

F87S

F87S/N274A

-

N274 plays a key role in stabilizing the oxyanion generated in the condensation reaction through hydrogen bonding

F87T

3 entries

F87T/H244A

-

H244 plays a key role in stabilizing the oxyanion generated in the condensation reaction through hydrogen bonding

F87V

-

site-directed mutagenesis, coexpression of the mutant enzyme with the phaC gene from Aeromonas caviae in a recombinant strain confers the ability to synthesize polyhydroxyalkanoates, coexpression of the mutant with gene phaC1 from Pseudomonas sp. strain 61-3 in Escherichia coli does not confer the ability to synthesize polyhydroxyalkanoates, overview

F87W

-

site-directed mutagenesis, coexpression of the mutant enzyme with the phaC gene from Aeromonas caviae in a recombinant strain confers the ability to synthesize polyhydroxyalkanoates, coexpression of the mutant with gene phaC1 from Pseudomonas sp. strain 61-3 in Escherichia coli confers the ability to synthesize polyhydroxyalkanoates, overview

F87Y

-

site-directed mutagenesis, coexpression of the mutant enzyme with the phaC gene from Aeromonas caviae in a recombinant strain confers the ability to synthesize polyhydroxyalkanoates, coexpression of the mutant with gene phaC1 from Pseudomonas sp. strain 61-3 in Escherichia coli confers the ability to synthesize polyhydroxyalkanoates, overview

H244A

H244A/N274A

-

N274 and H244 play key roles in stabilizing the oxyanion generated in the condensation reaction through hydrogen bonding

N274A

additional information

50

-

unfolding of the recombinant selenomethionine-labeld enzyme starts above

70

-

about, Tm, recombinant selenomethionine-labeld enzyme

immobilized metal ion affinity chromatography (Ni2+)

-

719087, 719093

Q-Sepharose, MonoQ, and hydroxyapatite column chromatographies (native enzyme) or Ni-NTA agarose column chromatography (selenomethionine-substituted enzyme)

recombinant His-tagged enzyme from Escherichia coli strain BL21(DE3) by nickel affinity chromatography and dialysis

recombinant His-tagged enzyme from strain BL21(DE3)

-

recombinant His-tagged wild-type and mutant enzymes from strain BL21(DE3)

-

recombinant native and selenomethionine-labeled enzyme from Escherichia coli strain DH10B to homogeneity by two different steps of anion exchange and a step of hydroxyapatite chromatography

recombinant selenomethionine-labeled enzyme by ion exchange, hydroxylapatite, and affinity chromatography, and gel filtration

-

to homogeneity in three chromatographic steps (Q-Sepharose, MonoQ, and hydroxyapatite)

-

to homogeneity in three chromatographic steps (Q-Sepharose, MonoQ, and hydroxyapatite), immobilized metal ion affinity chromatography (Ni2+)

-

719068, 719086

expressed in Escherichia coli BL21(DE3) cells

757353

expressed in Escherichia coli K-12 MG1655

-

expressed in Escherichia coli strains DH10B (native enzyme) and BL21(DE3) (selenomethionine-substituted enzyme)

expressed in Ralstonia solanacearum fabH mutant RsmH

758264

expression of mutant F87T in Arabidopsis thaliana plastids

-

702531

expression of selenomethionine-labeled enzyme in strain BL21(DE3)

-

expression of the His-tagged enzyme in strain BL21(DE3)

-

expression of the native and the selenomethionine-labeled enzyme in Escherichia coli strain DH10B

expression of wild-type and mutant enzymes in strain JM109, coexpression with gene phaC from Aeromonas caviae and gene phaC1 from Pseudomonas sp. strain 61-3

-

gene fabH, expression of His-tagged wild-type and mutant enzymes in strain BL21(DE3)

-

gene fabH, recombinant His-tagged enzyme expression in Escherichia coli strain BL21(DE3)

His-tagged protein expressed in Escherichia coli BL21(DE3)

-

719087, 719093

overexpressed in E. coli DH10B cells using the pET30 vector, selenomethionine-substituted protein expressed in Escherichia coli BL21(DE3)

-

overexpressed in Escherichia coli DH10B cells using the pET30 vector, selenomethionine-substituted protein expressed in Escherichia coli BL21(DE3)

-

719068, 719085

overexpression in strain JM101 inhibits bacterial cell growth and alters the membrane fatty acid composition, overexpression of the chimeric enzyme possessing a transit peptide in Brassica napus seeds and cotyledons via Agrobacterium transfection

-

drug development

pharmacology

-

the enzyme is a target for development of antibiotics

663471, 665472

486932

Verwoert, I.I.G.S.; van der Linden, K.H.; Walsh, M.C.; Nijkamp, H.J.J.; Stuitje, A.R.

Modification of Brassica napus seed oil by expression of the Escherichia coli fabH gene, encoding 3-ketoacyl-acyl carrier protein synthase III

Plant Mol. Biol.

27

875-886

1995

Escherichia coli

7766878

659294

Lai, C.Y.; Cronan, J.E.

beta-Ketoacyl-acyl carrier protein synthase III (FabH) is essential for bacterial fatty acid synthesis

J. Biol. Chem.

278

51494-51503

2003

Escherichia coli, Lactococcus lactis ssp. lactis, Lactococcus lactis ssp. lactis IL1403

14523010

663471

Janson, C.A.; Konstantinidis, A.K.; Lonsdale, J.T.; Qiu, X.

Crystallization of Escherichia coli beta-ketoacyl-ACP synthase III and the use of a dry flash-cooling technique for data collection

Acta Crystallogr. Sect. D

56

747-748

2000

Escherichia coli

10818351

He, X.; Reeve, A.M.; Desai, U.R.; Kellogg, G.E.; Reynolds, K.A.

1,2-dithiole-3-ones as potent inhibitors of the bacterial 3-ketoacyl acyl carrier protein synthase III (FabH)

Antimicrob. Agents Chemother.

48

3093-3102

2004

Staphylococcus aureus, Escherichia coli (P0A6R0), Escherichia coli

15273125

Nomura, C.T.; Taguchi, K.; Taguchi, S.; Doi, Y.

Coexpression of genetically engineered 3-ketoacyl-ACP synthase III (fabH) and polyhydroxyalkanoate synthase (phaC) genes leads to short-chain-length-medium-chain-length polyhydroxyalkanoate copolymer production from glucose in Escherichia coli JM109

Appl. Environ. Microbiol.

70

999-1007

2004

Escherichia coli

14766582

Khandekar, S.S.; Konstantinidis, A.K.; Silverman, C.; Janson, C.A.; McNulty, D.E.; Nwagwu, S.; Van Aller, G.S.; Doyle, M.L.; Kane, J.F.; Qiu, X.; Lonsdale, J.

Expression, purification, and crystallization of the Escherichia coli selenomethionyl beta-ketoacyl-acyl carrier protein synthase III

Biochem. Biophys. Res. Commun.

270

100-107

2000

Escherichia coli

10733911

Heath, R.J.; Rock, C.O.

Inhibition of beta-ketoacyl-acyl carrier protein synthase III (FabH) by acyl-acyl carrier protein in Escherichia coli

J. Biol. Chem.

271

10996-11000

1996

Escherichia coli

8631920

665472

Qiu, X.; Janson, C.A.; Konstantinidis, A.K.; Nwagwu, S.; Silverman, C.; Smith, W.W.; Khandekar, S.; Lonsdale, J.; Abdel-Meguid, S.S.

Crystal structure of beta-ketoacyl-acyl carrier protein synthase III. A key condensing enzyme in bacterial fatty acid biosynthesis

J. Biol. Chem.

274

36465-36471

1999

Escherichia coli

10593943

666011

Qiu, X.; Janson, C.A.; Smith, W.W.; Head, M.; Lonsdale, J.; Konstantinidis, A.K.

Refined structures of beta-ketoacyl-acyl carrier protein synthase III

J. Mol. Biol.

307

341-356

2001

Escherichia coli (P0A6R0), Escherichia coli

11243824

Davies, C.; Heath, R.J.; White, S.W.; Rock, C.O.

The 1.8 A crystal structure and active-site architecture of beta-ketoacyl-acyl carrier protein synthase III (FabH) from Escherichia coli

Structure

8

185-195

2000

Escherichia coli

10673437

Alhamadsheh, M.M.; Waters, N.C.; Huddler, D.P.; Kreishman-Deitrick, M.; Florova, G.; Reynolds, K.A.

Synthesis and biological evaluation of thiazolidine-2-one 1,1-dioxide as inhibitors of Escherichia coli beta-ketoacyl-ACP-synthase III (FabH)

Bioorg. Med. Chem. Lett.

17

879-883

2007

Escherichia coli (P0A6R0), Escherichia coli, Mycobacterium tuberculosis (P9WNG3), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WNG3), Plasmodium falciparum, Plasmodium falciparum D6

17189694

686047

Alhamadsheh, M.M.; Musayev, F.; Komissarov, A.A.; Sachdeva, S.; Wright, H.T.; Scarsdale, N.; Florova, G.; Reynolds, K.A.

Alkyl-CoA disulfides as inhibitors and mechanistic probes for FabH enzymes

Chem. Biol.

14

513-524

2007

Escherichia coli, Mycobacterium tuberculosis

17524982

Castillo, Y.P.; Perez, M.A.

Bacterial beta-ketoacyl-acyl carrier protein synthase III (FabH): an attractive target for the design of new broad-spectrum antimicrobial agents

Mini Rev. Med. Chem.

8

36-45

2008

Streptococcus pneumoniae, Escherichia coli, Enterococcus faecium, Haemophilus influenzae, Staphylococcus aureus, Mycobacterium tuberculosis, Neisseria meningitidis, Pseudomonas aeruginosa, Streptococcus pyogenes

18220983

702531

Matsumoto, K.; Murata, T.; Nagao, R.; Nomura, C.T.; Arai, S.; Arai, Y.; Takase, K.; Nakashita, H.; Taguchi, S.; Shimada, H.

Production of short-chain-length/medium-chain-length polyhydroxyalkanoate (PHA) copolymer in the plastid of Arabidopsis thaliana using an engineered 3-ketoacyl-acyl carrier protein synthase III

Biomacromolecules

10

686-690

2009

Arabidopsis thaliana, Escherichia coli

19265441

Lv, P.C.; Wang, K.R.; Yang, Y.; Mao, W.J.; Chen, J.; Xiong, J.; Zhu, H.L.

Design, synthesis and biological evaluation of novel thiazole derivatives as potent FabH inhibitors

Bioorg. Med. Chem. Lett.

19

6750-6754

2009

Escherichia coli

19836235

Li, H.Q.; Shi, L.; Li, Q.S.; Liu, P.G.; Luo, Y.; Zhao, J.; Zhu, H.L.

Synthesis of C(7) modified chrysin derivatives designing to inhibit beta-ketoacyl-acyl carrier protein synthase III (FabH) as antibiotics

Bioorg. Med. Chem.

17

6264-6269

2009

Escherichia coli (P0A6R0), Escherichia coli

19664929

Singh, S.; Soni, L.; Gupta, M.; Prabhakar, Y.; Kaskhedikar, S.

QSAR studies on benzoylaminobenzoic acid derivatives as inhibitors of beta-ketoacyl-acyl carrier protein synthase III

Eur. J. Med. Chem.

43

1071-1080

2008

Streptococcus pneumoniae, Escherichia coli, Enterococcus faecalis, Staphylococcus aureus, Neisseria meningitidis, Streptococcus pyogenes

17707951

Lv, P.C.; Sun, J.; Luo, Y.; Yang, Y.; Zhu, H.L.

Design, synthesis, and structure-activity relationships of pyrazole derivatives as potential FabH inhibitors

Bioorg. Med. Chem. Lett.

20

4657-4660

2010

Escherichia coli

20594840

Yang, Y.S.; Zhang, F.; Gao, C.; Zhang, Y.B.; Wang, X.L.; Tang, J.F.; Sun, J.; Gong, H.B.; Zhu, H.L.

Discovery and modification of sulfur-containing heterocyclic pyrazoline derivatives as potential novel class of beta-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors

Bioorg. Med. Chem. Lett.

22

4619-4624

2012

Escherichia coli

22721711

Li, Z.L.; Li, Q.S.; Zhang, H.J.; Hu, Y.; Zhu, D.D.; Zhu, H.L.

Design, synthesis and biological evaluation of urea derivatives from o-hydroxybenzylamines and phenylisocyanate as potential FabH inhibitors

Bioorg. Med. Chem.

19

4413-4420

2011

Escherichia coli

21752655

Li, H.Q.; Luo, Y.; Zhu, H.L.

Discovery of vinylogous carbamates as a novel class of beta-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors

Bioorg. Med. Chem.

19

4454-4459

2011

Escherichia coli

21742506

Zhang, H.J.; Zhu, D.D.; Li, Z.L.; Sun, J.; Zhu, H.L.

Synthesis, molecular modeling and biological evaluation of beta-ketoacyl-acyl carrier protein synthase III (FabH) as novel antibacterial agents

Bioorg. Med. Chem.

19

4513-4519

2011

Escherichia coli

21741250

Li, Y.; Luo, Y.; Hu, Y.; Zhu, D.D.; Zhang, S.; Liu, Z.J.; Gong, H.B.; Zhu, H.L.

Design, synthesis and antimicrobial activities of nitroimidazole derivatives containing 1,3,4-oxadiazole scaffold as FabH inhibitors

Bioorg. Med. Chem.

20

4316-4322

2012

Escherichia coli

22710102

Mueller, A.P.; Nomura, C.T.

Mutations to the active site of 3-ketoacyl-ACP synthase III (FabH) increase polyhydroxyalkanoate biosynthesis in transgenic Escherichia coli

J. Biosci. Bioeng.

113

300-306

2012

Escherichia coli

22143070

Cheng, K.; Xue, J.Y.; Zhu, H.L.

Design, synthesis and antibacterial activity studies of thiazole derivatives as potent ecKAS III inhibitors

Bioorg. Med. Chem. Lett.

23

4235-4238

2013

Escherichia coli (P0A6R0), Escherichia coli

23731945

Song, X.; Yang, Y.; Zhao, J.; Chen, Y.

Synthesis and antibacterial activity of cinnamaldehyde acylhydrazone with a 1,4-benzodioxan fragment as a novel class of potent beta-ketoacyl-acyl carrier protein synthase III (FabH) inhibitor

Chem. Pharm. Bull.

62

1110-1118

2014

Staphylococcus aureus, Bacillus subtilis (O07600), Escherichia coli (P0A6R0), Pseudomonas aeruginosa (Q9HYR2), Bacillus subtilis 168 (O07600), Staphylococcus aureus ATCC 6538

25196128

Wang, Y.; Ma, S.

Recent advances in inhibitors of bacterial fatty acid synthesis type II (FASII) system enzymes as potential antibacterial agents

ChemMedChem

8

1589-1608

2013

Bacillus subtilis (O34746), Escherichia coli (P0A6R0), Haemophilus influenzae (P43711), Mycobacterium tuberculosis (P9WNG3), Mycobacterium tuberculosis H37Rv (P9WNG3), Pseudomonas aeruginosa (A0A072ZQE7), Staphylococcus aureus (P99159), Staphylococcus aureus N315 (P99159), Streptococcus pneumoniae (P0A3C5)

23894064

Li, J.R.; Li, D.D.; Wang, R.R.; Sun, J.; Dong, J.J.; Du, Q.R.; Fang, F.; Zhang, W.M.; Zhu, H.L.

Design and synthesis of thiazole derivatives as potent FabH inhibitors with antibacterial activity

Eur. J. Med. Chem.

75

438-447

2014

Escherichia coli (P0A6R0)

24561667

736551

Ramamoorthy, D.; Turos, E.; Guida, W.C.

Identification of a new binding site in E. coli FabH using molecular dynamics simulations: validation by computational alanine mutagenesis and docking studies

J. Chem. Inf. Model.

53

1138-1156

2013

Escherichia coli (P0A6R0)

23581389

736658

Mittal, A.; Johnson, M.E.

Conformational diversity of bacterial FabH: implications for molecular recognition specificity

J. Mol. Graph. Model.

55

115-122

2015

Escherichia coli (P0A6R0), Enterococcus faecalis (Q820T1), Enterococcus faecalis ATCC 700802 (Q820T1)

25437098

Zhou, Y.; Yang, Y.S.; Song, X.D.; Lu, L.; Zhu, H.L.

Study of Schiff-base-derived with dioxygenated rings and nitrogen heterocycle as potential beta-ketoacyl-acyl carrier protein synthase III (FabH) inhibitors

Chem. Pharm. Bull.

65

178-185

2017

Escherichia coli (P0A6R0)

28154310

757353

Cao, W.; Ma, W.; Zhang, B.; Wang, X.; Chen, K.; Li, Y.; Ouyang, P.

Improved pinocembrin production in Escherichia coli by engineering fatty acid synthesis

J. Ind. Microbiol. Biotechnol.

43

557-566

2016

Escherichia coli (P0A6R0)

26733394

757562

Nofiani, R.; Philmus, B.; Nindita, Y.; Mahmud, T.

3-Ketoacyl-ACP synthase (KAS) III homologues and their roles in natural product biosynthesis

MedChemComm

10

1517-1530

2019

Actinomadura kijaniata, Actinomadura kijaniata SCC1256, Actinoplanes deccanensis, Corallococcus coralloides, Corallococcus coralloides B035, Dactylosporangium aurantiacum subsp. hamdenensis, Dactylosporangium aurantiacum subsp. hamdenensis NRRL 18085, Escherichia coli (P0A6R0), Micromonospora carbonacea, Micromonospora echinospora, Micromonospora echinospora NRRL 15839, Micromonospora maris, Micromonospora maris AB-18-032, Myxococcus fulvus, Myxococcus fulvus Mxf50, Polymorphospora rubra, Polymorphospora rubra K07-0510, Pseudomonas aeruginosa (Q9HYR2), Pseudomonas chlororaphis subsp. aurantiaca, Pseudomonas chlororaphis subsp. aurantiaca BL915, Pseudomonas putida, Pseudomonas putida BW11M1, Streptomyces albus, Streptomyces albus XM211, Streptomyces antibioticus, Streptomyces antibioticus DSM 4072, Streptomyces antibioticus Tue2706, Streptomyces coelicolor, Streptomyces coelicolor M511, Streptomyces galilaeus, Streptomyces galilaeus 3AR-33, Streptomyces griseoruber, Streptomyces griseus, Streptomyces griseus ATCC 49344, Streptomyces nodosus subsp. asukaensis, Streptomyces pactum, Streptomyces pactum ATCC 27456, Streptomyces peucetius, Streptomyces roseofulvus, Streptomyces roseofulvus AM-3867, Streptomyces sp. 88-682, Streptomyces sp. A2991200, Streptomyces sp. CL190, Streptomyces sp. CM020, Streptomyces sp. KCTC 11604BP, Streptomyces sp. MA347, Streptomyces sp. NRRL 11266, Streptomyces sp. NRRL 12068, Streptomyces sp. SF2575, Streptomyces sp. SN-593, Streptomyces tendae, Streptomyces tendae HKI 017, Streptomyces toxytricini, Streptomyces viridochromogenes, Streptomyces viridochromogenes Tue57

31673313

758264

Yu, Y.; Ma, J.; Miao, X.; Wang, H.

Biological function research of 3-ketoacyl ACP synthase III from different bacteria

Prog. Biochem. Biophys.

43

1004-1012

2016

Staphylococcus aureus, Ralstonia solanacearum, Streptomyces coelicolor, Xanthomonas oryzae pv. oryzae, Bacillus subtilis (O34746 AND O07600), Escherichia coli (P0A6R0), Bacillus subtilis 168 (O34746 AND O07600)

-

Alhamadsheh, M.; Waters, N.; Sachdeva, S.; Lee, P.; Reynolds, K.

Synthesis and biological evaluation of novel sulfonyl-naphthalene-1,4-diols as FabH inhibitors

Bioorg. Med. Chem. Lett.

18

6402-6405

2008

Escherichia coli (P0A6R0), Escherichia coli, Plasmodium falciparum

17189694