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Information on EC 2.3.1.177 - 3,5-dihydroxybiphenyl synthase

for references in articles please use BRENDA:EC2.3.1.177

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IUBMB Comments

A polyketide synthase that is involved in the production of the phytoalexin aucuparin. 2-Hydroxybenzoyl-CoA can also act as substrate but it leads to the derailment product 4-hydroxycoumarin (cf. EC 2.3.1.208, 4-hydroxycoumarin synthase) . This enzyme uses the same starter substrate as EC 2.3.1.151, benzophenone synthase.

The enzyme appears in viruses and cellular organisms

Synonyms
biphenyl synthase, pcbis2, mdbis1, pcbis1, mdbis3, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
3 malonyl-CoA + benzoyl-CoA = 4 CoA + 3,5-dihydroxybiphenyl + 4 CO2
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
MetaCyc
aucuparin biosynthesis