The enzyme, found in both eukaryotes and in prokaryotes, is involved in degradation pathways such as fatty acid beta-oxidation. The enzyme acts on 3-oxoacyl-CoAs to produce acetyl-CoA and an acyl-CoA shortened by two carbon atoms. The reaction starts with the acylation of a nucleophilic cysteine at the active site by a 3-oxoacyl-CoA, with the concomitant release of acetyl-CoA. In the second step the acyl group is transferred to CoA. Most enzymes have a broad substrate range for the 3-oxoacyl-CoA. cf. EC 2.3.1.9, acetyl-CoA C-acetyltransferase.
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SYSTEMATIC NAME
IUBMB Comments
acyl-CoA:acetyl-CoA C-acyltransferase
The enzyme, found in both eukaryotes and in prokaryotes, is involved in degradation pathways such as fatty acid beta-oxidation. The enzyme acts on 3-oxoacyl-CoAs to produce acetyl-CoA and an acyl-CoA shortened by two carbon atoms. The reaction starts with the acylation of a nucleophilic cysteine at the active site by a 3-oxoacyl-CoA, with the concomitant release of acetyl-CoA. In the second step the acyl group is transferred to CoA. Most enzymes have a broad substrate range for the 3-oxoacyl-CoA. cf. EC 2.3.1.9, acetyl-CoA C-acetyltransferase.
multifunctional enzyme is composed of 2 subunits: alpha and beta, alpha subunit exhibits 3-hydroxyacyl-CoA dehydrogenase and 2-enoyl-CoA hydratase activity, beta-subunit exhibits 3-oxoacyl-CoA thiolase activity, primary structure of genes for alpha and beta subunit
multifunctional enzyme is composed of 2 subunits: alpha and beta, alpha subunit exhibits 3-hydroxyacyl-CoA dehydrogenase and 2-enoyl-CoA hydratase activity, beta-subunit exhibits 3-oxoacyl-CoA thiolase activity, primary structure of genes for alpha and beta subunit
Sato, S.; Hayashi, M.; Imamura, S.; Ozeki, Y.; Kawaguchi, A.
Primary structures of the genes, faoA and faoB, from Pseudomonas fragi B-0771 which encode the two subunits of the HDT multienzyme complex involved in fatty acid beta-oxidation