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Information on EC 2.3.1.159 - acridone synthase

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EC Tree
     2 Transferases
         2.3 Acyltransferases
             2.3.1 Transferring groups other than aminoacyl groups
                2.3.1.159 acridone synthase
IUBMB Comments
Belongs to a superfamily of plant polyketide synthases. Has many similarities to chalcone and stilbene synthases (see reaction synthesis)
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This record set is specific for:
UNIPROT: A3E7Z7
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
acridone synthase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
synthatase, acridone (9Cl)
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acyl group transfer
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SYSTEMATIC NAME
IUBMB Comments
malonyl-CoA:N-methylanthraniloyl-CoA malonyltransferase (cyclizing)
Belongs to a superfamily of plant polyketide synthases. Has many similarities to chalcone and stilbene synthases (see reaction synthesis)
CAS REGISTRY NUMBER
COMMENTARY hide
99085-53-7
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
4-coumaroyl-CoA + 3 malonyl-CoA
naringenin chalcone + 4 CoA + 3 CO2
show the reaction diagram
-
small amounts of bisnoryangonin and 4-coumaroyltriacetic acid lactone are formed as byproducts
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?
4-methoxycinnamoyl-CoA + malonyl-CoA
? + CoA + CO2
show the reaction diagram
-
-
-
?
acetyl-CoA + malonyl-CoA
? + CoA + CO2
show the reaction diagram
-
-
-
?
benzoyl-CoA + malonyl-CoA
2,3',4,6-tetrahydroxybenzophenone + CoA + CO2
show the reaction diagram
-
-
-
?
hexanoyl-CoA + malonyl-CoA
? + CoA + CO2
show the reaction diagram
-
-
-
?
N-methylanthraniloyl-CoA + 3 malonyl-CoA
1,3-dihydroxy-N-methylacridone + 4 CoA + 3 CO2
show the reaction diagram
-
-
-
?
phenylacetyl-CoA + malonyl-CoA
2,4,6-trihydroxyphenylbenzylketone + CoA + CO2
show the reaction diagram
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?
additional information
?
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
19.7
4-coumaroyl-CoA
pH 7.0, 30°C
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.034
4-coumaroyl-CoA
pH 7.0, 30°C
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
recombinant enzyme expressed in Escherichia coli
SwissProt
Manually annotated by BRENDA team
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
A3E7Z7_HUPSR
399
0
43367
TrEMBL
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
45831
x * 45831, calculated
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 45831, calculated
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in Escherichia coli with an additional hexahistidine tag at the N-terminus
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Wanibuchi, K.; Zhang, P.; Abe, T.; Morita, H.; Kohno, T.; Chen, G.; Noguchi, H.; Abe, I.
An acridone-producing novel multifunctional type III polyketide synthase from Huperzia serrata
FEBS J.
274
1073-1082
2007
Huperzia serrata (A3E7Z7), Huperzia serrata
Manually annotated by BRENDA team