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Information on EC 2.3.1.137 - carnitine O-octanoyltransferase
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EC Tree
2.3.1.137 carnitine O-octanoyltransferaseIUBMB Comments
Acts on a range of acyl-CoAs, with optimal activity with C6 or C8 acyl groups. cf. EC 2.3.1.7 (carnitine O-acetyltransferase) and EC 2.3.1.21 (carnitine O-palmitoyltransferase).
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Word Map
- 2.3.1.137
- peroxisomal
- acyl-coas
-
beta-oxidation
- malonyl-coa
- acylcarnitine
- palmitoyl-coa
-
ketogenesis
- decanoyl-coa
-
carnitine-dependent
-
crats
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arrhythmogenesis
- 2-bromopalmitate
-
cpt-ii
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malonyl-coa-sensitive
- etomoxir
- palmitoylcarnitine
The enzyme appears in viruses and cellular organisms
Synonyms
carnitine acyltransferase, carnitine octanoyltransferase, carnitine o-octanoyltransferase, medium-chain/long-chain carnitine acyltransferase, medium-chain carnitine acyltransferase, overt mitochondrial carnitine palmitoyltransferase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
carnitine acyltransferase
Carnitine medium-chain acyltransferase
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-
-
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carnitine octanoyltransferase
COT
CRAT
CrOT
easily solubilized mitochondrial carnitine palmitoyltransferase
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-
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medium-chain/long-chain carnitine acyltransferase
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-
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overt mitochondrial carnitine palmitoyltransferase
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additional information
additional information
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enzyme belongs to the family of carnitine acyltransferases
additional information
the enzyme belongs to the carnitine acyltransferase family
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
octanoyl-CoA + L-carnitine = CoA + L-octanoylcarnitine
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-
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octanoyl-CoA + L-carnitine = CoA + L-octanoylcarnitine
acyl-binding hydrophobic pocket structure involving residues G553, C323, and Met335, the acyl-CoA substrate chain length specificity is determined by G553, Met335 is important for catalysis
octanoyl-CoA + L-carnitine = CoA + L-octanoylcarnitine
acyl-CoA substrate specificity is determined by Gly553, active site structure and substrate positioning modeling
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octanoyl-CoA + L-carnitine = CoA + L-octanoylcarnitine
catalytic mechanism, active site structure, substrate recognition mechanism, amino acid residues 343, 564 and 553 determine the acyl-CoA substrate specificity, catalytic residue is His343
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Acyl group transfer
Acyl group transfer
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SYSTEMATIC NAME
IUBMB Comments
octanoyl-CoA:L-carnitine O-octanoyltransferase
Acts on a range of acyl-CoAs, with optimal activity with C6 or C8 acyl groups. cf. EC 2.3.1.7 (carnitine O-acetyltransferase) and EC 2.3.1.21 (carnitine O-palmitoyltransferase).
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CAS REGISTRY NUMBER
COMMENTARY
39369-19-2
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
3-hydroxy-3-methylglutaryl-CoA + L-carnitine
3-hydroxy-3-methylglutaryl-L-carnitine + CoA
-
-
-
-
r
3-methylglutaryl-CoA + L-carnitine
3-methylglutaryl-L-carnitine + CoA
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little capacity to use this substrate
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-
r
3-methylglutaryl-L-carnitine + CoA
3-methylglutaryl-CoA + L-carnitine
-
-
-
-
r
4,8-dimethylnonanoyl-CoA + L-carnitine
4,8-dimethylnonanoyl-L-carnitine + CoA
-
-
-
r
4,8-dimethylnonanoyl-L-carnitine + CoA
4,8-dimethylnonanoyl-CoA + L-carnitine
-
-
-
r
beta-hydroxy-beta-methylglutaryl-L-carnitine + CoA
beta-hydroxy-beta-methylglutaryl-CoA + L-carnitine
-
-
-
-
r
decanoyl-CoA + L-carnitine
CoA + L-decanoylcarnitine
-
best substrate
-
-
?
hexadecanoyl-CoA + L-carnitine
CoA + L-hexadecanoylcarnitine
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low activity
-
-
?
pivaloyl-CoA + L-carnitine
L-pivaloyl-L-carnitine + CoA
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little capacity to use this substrate
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-
r
valproyl-CoA + L-carnitine
L-valproyl-L-carnitine + CoA
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little capacity to use this substrate
-
-
r
acyl-CoA + L-carnitine
acyl-L-carnitine + CoA
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-
-
-
r
acyl-CoA + L-carnitine
acyl-L-carnitine + CoA
central role in fatty acid metabolism
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-
r
acyl-CoA + L-carnitine
acyl-L-carnitine + CoA
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metabolic pathway of peroxisomal beta-oxidation in yeasts
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r
acyl-CoA + L-carnitine
acyl-L-carnitine + CoA
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-
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-
r
acyl-CoA + L-carnitine
acyl-L-carnitine + CoA
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gamma-trimethylamino-beta-hydroxybutyrate
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-
r
acyl-CoA + L-carnitine
acyl-L-carnitine + CoA
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-
486290, 486291, 486292, 486293, 486294, 486295, 486296, 486297, 486298, 486299, 486300, 486301, 486304, 486308, 486309
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r
acyl-CoA + L-carnitine
acyl-L-carnitine + CoA
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-
-
r
acyl-CoA + L-carnitine
acyl-L-carnitine + CoA
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gamma-trimethylamino-beta-hydroxybutyrate
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-
r
acyl-CoA + L-carnitine
acyl-L-carnitine + CoA
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beta-oxidation of fatty acids
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r
acyl-CoA + L-carnitine
acyl-L-carnitine + CoA
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gamma-trimethylamino-beta-hydroxybutyrate
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r
acyl-CoA + L-carnitine
acyl-L-carnitine + CoA
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-
-
-
r
acyl-L-carnitine + CoA
acyl-CoA + L-carnitine
-
-
-
-
r
acyl-L-carnitine + CoA
acyl-CoA + L-carnitine
-
-
-
-
r
decanoyl-CoA + L-carnitine
L-decanoyl-L-carnitine + CoA
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-
-
-
r
decanoyl-CoA + L-carnitine
L-decanoyl-L-carnitine + CoA
-
-
-
-
r
decanoyl-L-carnitine + CoA
decanoyl-CoA + L-carnitine
-
-
-
-
r
decanoyl-L-carnitine + CoA
decanoyl-CoA + L-carnitine
-
-
-
-
r
dodecanoyl-CoA + L-carnitine
L-dodecanoyl-L-carnitine + CoA
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-
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-
r
dodecanoyl-CoA + L-carnitine
L-dodecanoyl-L-carnitine + CoA
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-
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-
r
dodecanoyl-L-carnitine + CoA
dodecanoyl-CoA + L-carnitine
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-
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-
r
dodecanoyl-L-carnitine + CoA
dodecanoyl-CoA + L-carnitine
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-
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r
heptanoyl-CoA + L-carnitine
L-heptanoyl-L-carnitine + CoA
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-
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-
r
heptanoyl-L-carnitine + CoA
heptanoyl-CoA + L-carnitine
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-
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r
hexadecanoyl-CoA + L-carnitine
L-hexadecanoyl-L-carnitine + CoA
-
-
-
-
r
hexadecanoyl-CoA + L-carnitine
L-hexadecanoyl-L-carnitine + CoA
-
-
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-
r
hexadecanoyl-L-carnitine + CoA
hexadecanoyl-CoA + L-carnitine
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-
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-
r
hexadecanoyl-L-carnitine + CoA
hexadecanoyl-CoA + L-carnitine
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r
hexanoyl-CoA + L-carnitine
CoA + L-hexanoylcarnitine
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-
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-
r
hexanoyl-CoA + L-carnitine
CoA + L-hexanoylcarnitine
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-
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r
hexanoyl-CoA + L-carnitine
CoA + L-hexanoylcarnitine
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best substrate
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-
?
hexanoyl-CoA + L-carnitine
CoA + L-hexanoylcarnitine
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r
hexanoyl-CoA + L-carnitine
CoA + L-hexanoylcarnitine
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-
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r
L-carnitine + octanoyl-CoA
octanoyl-L-carnitine + CoA
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-
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r
L-carnitine + octanoyl-CoA
octanoyl-L-carnitine + CoA
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r
L-carnitine + octanoyl-CoA
octanoyl-L-carnitine + CoA
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-
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r
L-carnitine + octanoyl-CoA
octanoyl-L-carnitine + CoA
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-
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r
L-hexanoylcarnitine + CoA
hexanoyl-CoA + L-carnitine
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-
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r
L-hexanoylcarnitine + CoA
hexanoyl-CoA + L-carnitine
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r
L-hexanoylcarnitine + CoA
hexanoyl-CoA + L-carnitine
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-
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r
L-hexanoylcarnitine + CoA
hexanoyl-CoA + L-carnitine
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r
octanoyl-CoA + L-carnitine
CoA + L-octanoylcarnitine
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step in the transport of fatty acids across the inner mitochondrial membrane, reaction plays a role in balancing cellular CoA:acyl-CoA ratio
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r
octanoyl-CoA + L-carnitine
CoA + L-octanoylcarnitine
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carnitine binding site structure involving the highly conserved R518, Y452 and T465, CoA binding site n the active site tunnel via His343, fatty acid binding site
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r
octanoyl-CoA + L-carnitine
CoA + L-octanoylcarnitine
preferred substrate
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r
octanoyl-L-carnitine + CoA
L-carnitine + octanoyl-CoA
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-
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r
octanoyl-L-carnitine + CoA
L-carnitine + octanoyl-CoA
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-
-
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r
octanoyl-L-carnitine + CoA
L-carnitine + octanoyl-CoA
-
-
-
-
r
palmitoyl-CoA + L-carnitine
L-palmitoyl-L-carnitine + CoA
-
-
-
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r
palmitoyl-CoA + L-carnitine
L-palmitoyl-L-carnitine + CoA
-
-
-
-
r
palmitoyl-CoA + L-carnitine
L-palmitoyl-L-carnitine + CoA
-
-
-
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r
palmitoyl-L-carnitine + CoA
palmitoyl-CoA + L-carnitine
-
-
-
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r
palmitoyl-L-carnitine + CoA
palmitoyl-CoA + L-carnitine
-
-
-
-
r
palmitoyl-L-carnitine + CoA
palmitoyl-CoA + L-carnitine
-
-
-
-
r
tetradecanoyl-CoA + L-carnitine
CoA + L-tetradecanoylcarnitine
low activity
-
-
?
additional information
?
-
2,6-dimethyl-heptanoyl-CoA is not a substrate
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-
?
additional information
?
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2,6-dimethyl-heptanoyl-CoA is not a substrate
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?
additional information
?
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peroxisomal carnitine acyltransferases and acyl-CoA thioesterases are differently expressed to function as complementary enzymes for transport of beta-oxidation metabolites
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?
additional information
?
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peroxisomes contain carnitine acetyltransferase and octanoyltransferase that produce carnitine ester for transport out of the peroxisomes
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?
additional information
?
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peroxisomal carnitine acyltransferases and acyl-CoA thioesterases are differently expressed to function as complementary enzymes for transport of beta-oxidation metabolites
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?
additional information
?
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peroxisomes contain carnitine acetyltransferase and octanoyltransferase that produce carnitine ester for transport out of the peroxisomes
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?
additional information
?
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succinyl-CoA and beta-hydroxy-beta-methylglutaryl-CoA are no substrates
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-
?