Disease on EC 2.3.1.136 - polysialic-acid O-acetyltransferase
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DISEASE 
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Blindness
Loss of cone photoreceptors caused by chromophore depletion is partially prevented by the artificial chromophore pro-drug, 9-cis-retinyl acetate.
Breast Neoplasms
Reduced lecithin:retinol acyltransferase expression in human breast cancer.
Carcinogenesis
Diethylnitrosamine-induced hepatocarcinogenesis is suppressed in lecithin:retinol acyltransferase-deficient mice primarily through retinoid actions immediately after carcinogen administration.
Carcinogenesis
Non-alcoholic steatohepatitis-related liver tumorigenesis is suppressed in mice lacking hepatic retinoid storage.
Carcinogenesis
Oral carcinogenesis induced by 4-nitroquinoline 1-oxide in lecithin:retinol acyltransferase gene knockout mice.
Carcinogenesis
Overexpression of lecithin:retinol acyltransferase in the epithelial basal layer makes mice more sensitive to oral cavity carcinogenesis induced by a carcinogen.
Carcinoma
Esterification of all-trans-retinol in normal human epithelial cell strains and carcinoma lines from oral cavity, skin and breast: reduced expression of lecithin:retinol acyltransferase in carcinoma lines.
Carcinoma
Retinol metabolism and lecithin:retinol acyltransferase levels are reduced in cultured human prostate cancer cells and tissue specimens.
Cholestasis
Altered Expression of Retinol Metabolism-Related Genes in an ANIT-Induced Cholestasis Rat Model.
Fatty Liver
Non-alcoholic steatohepatitis-related liver tumorigenesis is suppressed in mice lacking hepatic retinoid storage.
Infections
Mycobacterium tuberculosis infection is exacerbated in mice lacking lecithin:retinol acyltransferase.
Kidney Neoplasms
Differential expression of the enzyme that esterifies retinol, lecithin:retinol acyltransferase, in subtypes of human renal cancer and normal kidney.
Leber Congenital Amaurosis
Loss of cone photoreceptors caused by chromophore depletion is partially prevented by the artificial chromophore pro-drug, 9-cis-retinyl acetate.
Neoplasms
LRAT-specific domain facilitates vitamin A metabolism by domain swapping in HRASLS3.
Prostatic Neoplasms
Retinol metabolism and lecithin:retinol acyltransferase levels are reduced in cultured human prostate cancer cells and tissue specimens.
Retinitis Pigmentosa
Safety and Proof-of-Concept Study of Oral QLT091001 in Retinitis Pigmentosa Due to Inherited Deficiencies of Retinal Pigment Epithelial 65 Protein (RPE65) or Lecithin:Retinol Acyltransferase (LRAT).
Tuberculosis
Mycobacterium tuberculosis infection is exacerbated in mice lacking lecithin:retinol acyltransferase.
Vision Disorders
Loss of cone photoreceptors caused by chromophore depletion is partially prevented by the artificial chromophore pro-drug, 9-cis-retinyl acetate.
Vitamin A Deficiency
Disruption of the lecithin:retinol acyltransferase gene makes mice more susceptible to vitamin A deficiency.
Vitamin A Deficiency
Retinoid X receptor beta (RXRB) expression in Sertoli cells controls cholesterol homeostasis and spermiation.
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