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Information on EC 2.3.1.133 - shikimate O-hydroxycinnamoyltransferase and Organism(s) Nicotiana tabacum and UniProt Accession Q8GSM7

for references in articles please use BRENDA:EC2.3.1.133
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EC Tree
IUBMB Comments
Caffeoyl-CoA, feruloyl-CoA and sinapoyl-CoA can also act as donors, but more slowly.
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Select one or more organisms in this record:
This record set is specific for:
Nicotiana tabacum
UNIPROT: Q8GSM7
Word Map
The taxonomic range for the selected organisms is: Nicotiana tabacum
The enzyme appears in selected viruses and cellular organisms
Synonyms
CST, HCS/QT, HCT, HCT1, HCT1806, HCT2, HCT2a, HCT4918, HQT, HST, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
CST
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HCT
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-
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HST
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hydroxycinnamoyl-CoA:shikimate hydroxycinnamoyl transferase
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hydroxycinnamoyl-CoA:shikimate O-hydroxycinnamoyl transferase
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hydroxycinnamoyl-CoA:shikimate/quinate hydroxycinnamoyltransferase
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hydroxycinnamoyltransferase, shikimate
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p-coumaroyl-CoA:shikimic acid p-coumaroyl transferase
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p-hydroxycinnamoyl-CoA:shikimate-p-hydroxycinnamoyl transferase
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shikimate hydroxycinnamoyltransferase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
Acyl group transfer
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SYSTEMATIC NAME
IUBMB Comments
4-coumaroyl-CoA:shikimate O-(hydroxycinnamoyl)transferase
Caffeoyl-CoA, feruloyl-CoA and sinapoyl-CoA can also act as donors, but more slowly.
CAS REGISTRY NUMBER
COMMENTARY hide
73904-44-6
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
4-coumaroyl-CoA + quinate
CoA + 4-coumaroylquinate
show the reaction diagram
-
-
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r
4-coumaroyl-CoA + shikimate
CoA + 5-O-(4-coumaroyl)shikimate
show the reaction diagram
caffeoyl-CoA + shikimate
CoA + 5-O-caffeoylshikimate
show the reaction diagram
-
-
-
r
feruloyl-CoA + shikimate
CoA + 5-O-feruloylshikimate
show the reaction diagram
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-
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r
additional information
?
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no substrate: anthranilate, glucose, malate, tyramine, spermidine, spermine, putrescine, agmatine, benzyl alcohol
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
4-coumaroyl-CoA + shikimate
CoA + 5-O-(4-coumaroyl)shikimate
show the reaction diagram
Q8GSM7
enzyme appears to play a critical role in the phenylpropanoid pathway, both upstream and downstream of the 3-hydroxylation step
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.6
4-Coumaroyl-CoA
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0.05
caffeoyl-CoA
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0.35
feruloyl-CoA
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0.75
shikimate
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
Sequence
HST_TOBAC
435
0
48265
Swiss-Prot
PURIFICATION/commentary
ORGANISM
UNIPROT
LITERATURE
recombinant enzyme
CLONED/commentary
ORGANISM
UNIPROT
LITERATURE
expression in Escherichia coli
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hoffmann, L.; Maury, S.; Martz, F.; Geoffroy, P.; Legrand, M.
Purification, cloning, and properties of an acyltransferase controlling shikimate and quinate ester intermediates in phenylpropanoid metabolism
J. Biol. Chem.
278
95-103
2003
Nicotiana tabacum, Nicotiana tabacum (Q8GSM7)
Manually annotated by BRENDA team
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