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IUBMB Comments Other acyl-CoAs can also act, but more slowly. α-Saturated dolichols are acylated more rapidly than the α-unsaturated analogues.
Synonyms
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acyl-CoA:dolichol acyltransferase
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acyltransferase, dolichol
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palmitoyl-CoA + dolichol = CoA + dolichyl palmitate
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Acyl group transfer
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palmitoyl-CoA:dolichol O-palmitoyltransferase
Other acyl-CoAs can also act, but more slowly. alpha-Saturated dolichols are acylated more rapidly than the alpha-unsaturated analogues.
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acetyl-CoA + dolichol
CoA + dolichyl acetate
arachidonoyl-CoA + dolichol
CoA + dolichyl arachidonate
myristoyl-CoA + dolichol
CoA + dolichyl myristate
oleoyl-CoA + dolichol
CoA + dolichyl oleate
palmitoyl-CoA + dolichol
CoA + dolichyl palmitate
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Substrates: -
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stearoyl-CoA + dolichol
CoA + dolichyl stearate
additional information
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acetyl-CoA + dolichol
CoA + dolichyl acetate
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Substrates: 30% of activity compared to palmitoyl-CoA
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acetyl-CoA + dolichol
CoA + dolichyl acetate
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Substrates: -
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arachidonoyl-CoA + dolichol
CoA + dolichyl arachidonate
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Substrates: 30% of activity compared to palmitoyl-CoA
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arachidonoyl-CoA + dolichol
CoA + dolichyl arachidonate
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Substrates: -
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myristoyl-CoA + dolichol
CoA + dolichyl myristate
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Substrates: 40% of activity compared to palmitoyl-CoA
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myristoyl-CoA + dolichol
CoA + dolichyl myristate
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Substrates: -
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oleoyl-CoA + dolichol
CoA + dolichyl oleate
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Substrates: 40% of activity compared to palmitoyl-CoA
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oleoyl-CoA + dolichol
CoA + dolichyl oleate
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Substrates: -
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stearoyl-CoA + dolichol
CoA + dolichyl stearate
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Substrates: 40% of activity compared to palmitoyl-CoA
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stearoyl-CoA + dolichol
CoA + dolichyl stearate
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Substrates: -
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additional information
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Substrates: alpha-saturated dolichols are acylated more rapidly than alpha-unsaturated analogues
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additional information
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Substrates: esterfication may play a role in targeting the lipid from the endoplasmic reticulum to lysosomes
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acetyl-CoA + dolichol
CoA + dolichyl acetate
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Substrates: -
?
arachidonoyl-CoA + dolichol
CoA + dolichyl arachidonate
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Substrates: -
?
myristoyl-CoA + dolichol
CoA + dolichyl myristate
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Substrates: -
?
oleoyl-CoA + dolichol
CoA + dolichyl oleate
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Substrates: -
?
palmitoyl-CoA + dolichol
CoA + dolichyl palmitate
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Substrates: -
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stearoyl-CoA + dolichol
CoA + dolichyl stearate
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Substrates: -
?
additional information
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Substrates: esterfication may play a role in targeting the lipid from the endoplasmic reticulum to lysosomes
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additional information
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KCl and MgCl2 have no influence
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beta-octylglycopyranoside
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strong, almost complete inactivation at 0.04%
Ca2+
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20 mM, 50-60% inhibition
deoxycholate
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strong, almost complete inactivation at 0.04%
Mn2+
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20 mM, 50-60% inhibition
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Triton X-100
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activates at low concentrations by 50%
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5 - 7
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20% of maximal activity at pH 5.0, 40% of maximal activity at pH 7.0
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male
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brenda
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slight activity
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slight activity
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slight activity
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slight activity
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slight activity
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slight activity
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slight activity
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slight activity
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liver, esterification takes place on cytoplasmic side of membranes of the endoplasmic reticulum and is subsequently distributed to different organelles
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Triton X-100 stabilizes
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-20°C, microsomes are stable for several months
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4°C, microsomes in 0.25 M sucrose, after 5 days 50% remaining activity
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Tollbom, .; Valtersson, C.; Chojnacki, T.; Dallner, G.
Esterification of dolichol in rat liver
J. Biol. Chem.
263
1347-1352
1988
Rattus norvegicus
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