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Enzyme Nomenclature
Information on EC 2.3.1.109 - arginine N-succinyltransferase
for references in articles please use BRENDA:EC2.3.1.109
Word Map on EC 2.3.1.109
- 2.3.1.109
- ornithine
- aeruginosa
-
dihydrolase
-
carbamoyltransferase
-
anabolic
- putida
-
footprint
-
ammonia-producing
-
5-aminotransferase
- citrulline
- pao
- aminooxyacetate
-
regulon
- carbamoylphosphate
-
transaminase
- dnase
-
amidinotransferase
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The enzyme appears in viruses and cellular organisms
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EC NUMBER 
COMMENTARY 
2.3.1.109
-
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RECOMMENDED NAME
GeneOntology No.
arginine N-succinyltransferase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
succinyl-CoA + L-arginine = CoA + N2-succinyl-L-arginine
also acts on L-ornithine
-
-
-
succinyl-CoA + L-arginine = CoA + N2-succinyl-L-arginine
catalytic mechanism involving Glu121, His229, and Leu125, catalytic domain structure
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Acyl group transfer
-
-
-
-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
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SYSTEMATIC NAME
IUBMB Comments
succinyl-CoA:L-arginine N2-succinyltransferase
Also acts on L-ornithine. This is the first enzyme in the arginine succinyltransferase (AST) pathway for the catabolism of arginine [1]. This pathway converts the carbon skeleton of arginine into glutamate, with the concomitant production of ammonia and conversion of succinyl-CoA into succinate and CoA. The five enzymes involved in this pathway are EC 2.3.1.109 (arginine N-succinyltransferase), EC 3.5.3.23 (N-succinylarginine dihydrolase), EC 2.6.1.81 (succinylornithine transaminase), EC 1.2.1.71 (succinylglutamate-semialdehyde dehydrogenase) and EC 3.5.1.96 (succinylglutamate desuccinylase) [2,6].
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CAS REGISTRY NUMBER
COMMENTARY
99676-48-9
-
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
succinyl-CoA + L-homoarginine
CoA + N2-succinyl-L-homoarginine
-
-
-
-
?
succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
-
arginine succinyltransferase pathway
-
-
?
succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
-
arginine succinyltransferase pathway
-
-
?
succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
-
-
-
-
?
succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
-
arginine succinyltransferase pathway
-
-
?
succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
-
first step in arginine succinyltransferase pathway of arginine catabolism, pathway evolution, overview
-
-
?
succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
-
arginine succinyltransferase pathway
-
-
?
succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
-
-
-
-
?
succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
-
-
-
?
succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
-
catabolism of arginine
-
-
?
succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
arginine succinyltransferase pathway
-
-
?
succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
-
arginine succinyltransferase pathway
-
-
?
succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
-
arginine succinyltransferase pathway
-
-
?
succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
-
-
-
-
?
succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
-
arginine succinyltransferase pathway
-
-
?
succinyl-CoA + L-ornithine
CoA + N2-succinyl-L-ornithine
-
-
-
-
?
succinyl-CoA + L-ornithine
CoA + N2-succinyl-L-ornithine
-
ornithine catabolic pathway
-
-
?
additional information
?
-
-
inactivation of the gene for arginine succinyltransferase (astA) resulted in a 7-fold increase in cyanophycin content
-
-
-
additional information
?
-
-
D-arginine, D-ornithine, L-lysine, L-citrulline, 2,4-aminobutyrate, 5-aminovalerate, 2-aminovalerate, agmatine or the polyamines propanediamine, putrescine, cadaverine and spermidine are not substrates
-
-
-
additional information
?
-
-
devoid of ornithine succinyltransferase activity
-
-
-
additional information
?
-
-
devoid of ornithine succinyltransferase activity
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-
-
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
succinyl-CoA + L-ornithine
CoA + N2-succinyl-L-ornithine
-
ornithine catabolic pathway
-
-
?
additional information
?
-
-
inactivation of the gene for arginine succinyltransferase (astA) resulted in a 7-fold increase in cyanophycin content
-
-
-
succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
-
arginine succinyltransferase pathway
-
-
?
succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
-
arginine succinyltransferase pathway
-
-
?
succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
-
arginine succinyltransferase pathway
-
-
?
succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
-
first step in arginine succinyltransferase pathway of arginine catabolism, pathway evolution, overview
-
-
?
succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
-
arginine succinyltransferase pathway
-
-
?
succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
-
catabolism of arginine
-
-
?
succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
P80358
arginine succinyltransferase pathway
-
-
?
succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
-
arginine succinyltransferase pathway
-
-
?
succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
-
arginine succinyltransferase pathway
-
-
?
succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
-
arginine succinyltransferase pathway
-
-
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
L-arginine
-
allosteric activator of the ornithine succinyltransferase activity
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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PDB
SCOP
CATH
UNIPROT
ORGANISM
P80357
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1);
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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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SUBUNITS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-20°C, retains full activity with both substrates for several weeks, loses 10-40% of its activity following repeated freezing and thawing
-
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Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
partial
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
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LINKS TO OTHER DATABASES (specific for EC-Number 2.3.1.109)
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