HOME
login
history
all enzymes
BRENDA home
History
Enzyme Nomenclature
Information on EC 2.3.1.109 - arginine N-succinyltransferase
for references in articles please use BRENDA:EC2.3.1.109
Word Map on EC 2.3.1.109
- 2.3.1.109
- ornithine
- aeruginosa
-
dihydrolase
- putida
-
anabolic
-
carbamoyltransferase
- dnase
-
ammonia-producing
- pao
-
5-aminotransferase
- carbamoylphosphate
- citrulline
-
transaminase
-
amidinotransferase
-
footprint
- aminooxyacetate
-
regulon
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
The enzyme appears in viruses and cellular organisms
topPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
EC NUMBER 
COMMENTARY 
2.3.1.109
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
RECOMMENDED NAME
GeneOntology No.
arginine N-succinyltransferase
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
succinyl-CoA + L-arginine = CoA + N2-succinyl-L-arginine
also acts on L-ornithine
-
-
-
succinyl-CoA + L-arginine = CoA + N2-succinyl-L-arginine
catalytic mechanism involving Glu121, His229, and Leu125, catalytic domain structure
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Acyl group transfer
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYSTEMATIC NAME
IUBMB Comments
succinyl-CoA:L-arginine N2-succinyltransferase
Also acts on L-ornithine. This is the first enzyme in the arginine succinyltransferase (AST) pathway for the catabolism of arginine [1]. This pathway converts the carbon skeleton of arginine into glutamate, with the concomitant production of ammonia and conversion of succinyl-CoA into succinate and CoA. The five enzymes involved in this pathway are EC 2.3.1.109 (arginine N-succinyltransferase), EC 3.5.3.23 (N-succinylarginine dihydrolase), EC 2.6.1.81 (succinylornithine transaminase), EC 1.2.1.71 (succinylglutamate-semialdehyde dehydrogenase) and EC 3.5.1.96 (succinylglutamate desuccinylase) [2,6].
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CAS REGISTRY NUMBER
COMMENTARY
99676-48-9
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
succinyl-CoA + L-homoarginine
CoA + N2-succinyl-L-homoarginine
-
-
-
-
?
succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
-
arginine succinyltransferase pathway
-
-
?
succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
-
arginine succinyltransferase pathway
-
-
?
succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
-
-
-
-
?
succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
-
arginine succinyltransferase pathway
-
-
?
succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
-
first step in arginine succinyltransferase pathway of arginine catabolism, pathway evolution, overview
-
-
?
succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
-
arginine succinyltransferase pathway
-
-
?
succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
-
-
-
-
?
succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
-
catabolism of arginine
-
-
?
succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
arginine succinyltransferase pathway
-
-
?
succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
-
arginine succinyltransferase pathway
-
-
?
succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
-
arginine succinyltransferase pathway
-
-
?
succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
-
-
-
-
?
succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
-
arginine succinyltransferase pathway
-
-
?
succinyl-CoA + L-ornithine
CoA + N2-succinyl-L-ornithine
-
-
-
-
?
succinyl-CoA + L-ornithine
CoA + N2-succinyl-L-ornithine
-
ornithine catabolic pathway
-
-
?
additional information
?
-
-
inactivation of the gene for arginine succinyltransferase (astA) resulted in a 7-fold increase in cyanophycin content
-
-
-
additional information
?
-
-
D-arginine, D-ornithine, L-lysine, L-citrulline, 2,4-aminobutyrate, 5-aminovalerate, 2-aminovalerate, agmatine or the polyamines propanediamine, putrescine, cadaverine and spermidine are not substrates
-
-
-
additional information
?
-
-
devoid of ornithine succinyltransferase activity
-
-
-
additional information
?
-
-
devoid of ornithine succinyltransferase activity
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
succinyl-CoA + L-ornithine
CoA + N2-succinyl-L-ornithine
-
ornithine catabolic pathway
-
-
?
additional information
?
-
-
inactivation of the gene for arginine succinyltransferase (astA) resulted in a 7-fold increase in cyanophycin content
-
-
-
succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
-
arginine succinyltransferase pathway
-
-
?
succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
-
arginine succinyltransferase pathway
-
-
?
succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
-
arginine succinyltransferase pathway
-
-
?
succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
-
first step in arginine succinyltransferase pathway of arginine catabolism, pathway evolution, overview
-
-
?
succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
-
arginine succinyltransferase pathway
-
-
?
succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
-
catabolism of arginine
-
-
?
succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
P80358
arginine succinyltransferase pathway
-
-
?
succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
-
arginine succinyltransferase pathway
-
-
?
succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
-
arginine succinyltransferase pathway
-
-
?
succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
-
arginine succinyltransferase pathway
-
-
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ACTIVATING COMPOUND
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
L-arginine
-
allosteric activator of the ornithine succinyltransferase activity
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PDB
SCOP
CATH
ORGANISM
UNIPROT
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SUBUNITS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
-20°C, retains full activity with both substrates for several weeks, loses 10-40% of its activity following repeated freezing and thawing
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Purification/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
partial
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
LINKS TO OTHER DATABASES (specific for EC-Number 2.3.1.109)
html completed
Use of this online version of BRENDA is free but requires a license. See terms of use.
Information
