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EC Tree
IUBMB Comments Also acts on L-ornithine. This is the first enzyme in the arginine succinyltransferase (AST) pathway for the catabolism of arginine . This pathway converts the carbon skeleton of arginine into glutamate, with the concomitant production of ammonia and conversion of succinyl-CoA into succinate and CoA. The five enzymes involved in this pathway are EC 2.3.1.109 (arginine N-succinyltransferase), EC 3.5.3.23 (N-succinylarginine dihydrolase), EC 2.6.1.81 (succinylornithine transaminase), EC 1.2.1.71 (succinylglutamate-semialdehyde dehydrogenase) and EC 3.5.1.96 (succinylglutamate desuccinylase) [2,6].
The enzyme appears in viruses and cellular organisms
Synonyms
arginine succinyl transferase, arginine succinyltransferase, AST, AstA, More,
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arginine succinyl transferase
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arginine succinyltransferase
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additional information
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enzyme belongs to the acyl-CoA N-acyltransferase superfamily
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succinyl-CoA + L-arginine = CoA + N2-succinyl-L-arginine
succinyl-CoA + L-arginine = CoA + N2-succinyl-L-arginine
also acts on L-ornithine
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succinyl-CoA + L-arginine = CoA + N2-succinyl-L-arginine
catalytic mechanism involving Glu121, His229, and Leu125, catalytic domain structure
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Acyl group transfer
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succinyl-CoA:L-arginine N2-succinyltransferase
Also acts on L-ornithine. This is the first enzyme in the arginine succinyltransferase (AST) pathway for the catabolism of arginine [1]. This pathway converts the carbon skeleton of arginine into glutamate, with the concomitant production of ammonia and conversion of succinyl-CoA into succinate and CoA. The five enzymes involved in this pathway are EC 2.3.1.109 (arginine N-succinyltransferase), EC 3.5.3.23 (N-succinylarginine dihydrolase), EC 2.6.1.81 (succinylornithine transaminase), EC 1.2.1.71 (succinylglutamate-semialdehyde dehydrogenase) and EC 3.5.1.96 (succinylglutamate desuccinylase) [2,6].
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succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
succinyl-CoA + L-homoarginine
CoA + N2-succinyl-L-homoarginine
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succinyl-CoA + L-ornithine
CoA + N2-succinyl-L-ornithine
additional information
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succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
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succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
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arginine succinyltransferase pathway
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succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
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succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
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arginine succinyltransferase pathway
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succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
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succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
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arginine succinyltransferase pathway
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succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
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first step in arginine succinyltransferase pathway of arginine catabolism, pathway evolution, overview
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succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
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succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
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arginine succinyltransferase pathway
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succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
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succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
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succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
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catabolism of arginine
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succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
arginine succinyltransferase pathway
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succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
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succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
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arginine succinyltransferase pathway
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succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
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succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
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arginine succinyltransferase pathway
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succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
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succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
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arginine succinyltransferase pathway
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succinyl-CoA + L-ornithine
CoA + N2-succinyl-L-ornithine
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succinyl-CoA + L-ornithine
CoA + N2-succinyl-L-ornithine
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ornithine catabolic pathway
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additional information
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inactivation of the gene for arginine succinyltransferase (astA) resulted in a 7-fold increase in cyanophycin content
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additional information
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inactivation of the gene for arginine succinyltransferase (astA) resulted in a 7-fold increase in cyanophycin content
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additional information
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D-arginine, D-ornithine, L-lysine, L-citrulline, 2,4-aminobutyrate, 5-aminovalerate, 2-aminovalerate, agmatine or the polyamines propanediamine, putrescine, cadaverine and spermidine are not substrates
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additional information
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devoid of ornithine succinyltransferase activity
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additional information
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devoid of ornithine succinyltransferase activity
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succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
succinyl-CoA + L-ornithine
CoA + N2-succinyl-L-ornithine
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ornithine catabolic pathway
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additional information
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succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
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arginine succinyltransferase pathway
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succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
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arginine succinyltransferase pathway
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succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
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succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
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arginine succinyltransferase pathway
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succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
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first step in arginine succinyltransferase pathway of arginine catabolism, pathway evolution, overview
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succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
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arginine succinyltransferase pathway
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succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
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succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
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catabolism of arginine
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succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
arginine succinyltransferase pathway
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succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
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arginine succinyltransferase pathway
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succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
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arginine succinyltransferase pathway
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succinyl-CoA + L-arginine
CoA + N2-succinyl-L-arginine
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arginine succinyltransferase pathway
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additional information
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inactivation of the gene for arginine succinyltransferase (astA) resulted in a 7-fold increase in cyanophycin content
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additional information
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inactivation of the gene for arginine succinyltransferase (astA) resulted in a 7-fold increase in cyanophycin content
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D-arginine
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competitive inhibition
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L-arginine
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allosteric activator of the ornithine succinyltransferase activity
L-lysine
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activator of the ornithine succinyltransferase activity
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0.5
L-arginine
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0.007 - 0.37
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depending on growth substrate
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8.5
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L-homoarginine as substrate
8.7
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L-arginine as substrate
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L-ornithine as substrate
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brenda
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brenda
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brenda
NCTC 10743
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brenda
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brenda
IRC204
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brenda
IRC204
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brenda
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brenda
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brenda
Kohara clone 327
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brenda
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brenda
GenBank/EMBL/DDJB accession no.
SwissProt
brenda
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35000
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2 * 35000 + 2 * 37000, heterotetramer, SDS-PAGE
37000
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2 * 35000 + 2 * 37000, heterotetramer, SDS-PAGE
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tetramer
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2 * 35000 + 2 * 37000, heterotetramer, SDS-PAGE
additional information
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three-dimensional structure analysis
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-20°C, retains full activity with both substrates for several weeks, loses 10-40% of its activity following repeated freezing and thawing
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4°C, 10 mM potassium phosphate, pH 7.5, stable for 48 h
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partial
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Vander Wauven, C.; Stalon, V.
Occurence of succinyl derivatives in the catabolism of arginine in Pseudomonas cepacia
J. Bacteriol.
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882-886
1985
Burkholderia cepacia
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brenda
Vander Wauven, C.; Jann, A.; Haas, D.; Leisinger, T.; Stalon, V.
N2-Succinylornithine in ornithine catabolism of Pseudomonas aeruginosa
Arch. Microbiol.
150
400-404
1988
Pseudomonas aeruginosa
brenda
Tricot, C.; Stalon, V.; Legrain, C.
Isolation and characterization of Pseudomonas putida mutants affected in arginine, ornithine and citrulline catabolism: function of the arginine oxidase and arginine succinyltransferase pathways
J. Gen. Microbiol.
137
2911-2918
1991
Pseudomonas putida, Pseudomonas putida IRC204
brenda
Tricot, C.; Vander Wauven, C.; Wattiez, R.; Falmagne, P.; Stalon, V.
Purification and properties of a succinyltransferase from Pseudomonas aeruginosa specific for both arginine and ornithine
Eur. J. Biochem.
224
853-861
1994
Pseudomonas aeruginosa
brenda
Itoh, Y.
Cloning and characterization of the aru genes encoding enzymes of the catabolic arginine succinyltransferase pathway in Pseudomonas aeruginosa
J. Bacteriol.
179
7280-7290
1997
Klebsiella aerogenes, Aeromonas caviae, Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium, Pseudomonas aeruginosa (P80358), Pseudomonas aeruginosa
brenda
Schneider, B.L.; Kiupakis, A.K.; Reitzer, L.J.
Arginine catabolism and the arginine succinyltransferase pathway in Escherichia coli
J. Bacteriol.
180
4278-4286
1998
Klebsiella aerogenes, Escherichia coli
brenda
Shirai, H.; Mizuguchi, K.
Prediction of the structure and function of AstA and AstB, the first two enzymes of the arginine succinyltransferase pathway of arginine catabolism
FEBS Lett.
555
505-510
2003
Escherichia coli
brenda
Elbahloul, Y.; Steinbuechel, A.
Engineering the genotype of Acinetobacter sp. strain ADP1 to enhance biosynthesis of cyanophycin
Appl. Environ. Microbiol.
72
1410-1419
2006
Acinetobacter sp., Acinetobacter sp. ADP1
brenda
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2.3.1.109 arginine N-succinyltransferase
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