Reference on EC 2.3.1.1 - amino-acid N-acetyltransferase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Abadjieva, A.; Pauwels, K.; Hilven, P.; Crabeel, M.
A new yeast metabolon involving at least the two first enzymes of arginine biosynthesis. Acetylglutamate synthase activity requires complex formation with acetylglutamate kinase
J. Biol. Chem.
276
42869-42880
2001
Saccharomyces cerevisiae
Powers-Lee, S.G.
N-Acetylglutamate synthase
Methods Enzymol.
113
27-35
1985
Escherichia coli, Homo sapiens, Pseudomonas aeruginosa, Rattus norvegicus, Salmonella enterica subsp. enterica serovar Typhimurium
Shigesada, K.; Tatibana, M.
N-Acetylglutamate synthetase from rat-liver mitochondria. Partial purification and catalytic properties
Eur. J. Biochem.
84
285-291
1978
Rattus norvegicus
Marvil, D.K.; Leisinger, T.
N-Acetylglutamate synthase of Escherichia coli: purification, characterization, and molecular properties
J. Biol. Chem.
252
3295-3303
1977
Escherichia coli
Driessen, H.P.C.; De Jong, W.W.; Tesser, G.I.; Bloemendal, H.
A rapid and specific assay for N alpha-acetyltransferase activity
Anal. Biochem.
125
352-357
1982
Bos taurus
Kamemoto, E.S.; Atkinson, D.E.
Modulation of the activity of rat liver acetylglutamate synthase by pH and arginine concentration
Arch. Biochem. Biophys.
243
100-107
1985
Rattus norvegicus
Leisinger, T.; Haas, D.
N-Acetylglutamate synthase of Escherichia coli: regulation of synthesis and activity by arginine
J. Biol. Chem.
250
1690-1693
1975
Escherichia coli
Hinde, R.W.; Jacobson, J.A.; Weiss, R.L.; Davis, R.H.
N-Acetyl-L-glutamate synthase of Neurospora crassa. Characteristics, localization, regulation, and genetic control
J. Biol. Chem.
261
5848-5852
1986
Neurospora crassa
Uchiyama, C.; Mori, M.; Tatibana, M.
Subcellular localization and properties of N-acetylglutamate synthase in rat small intestinal mucosa
J. Biochem.
89
1777-1786
1981
Rattus norvegicus
Haas, D.; Leisinger, T.
Multiple control of N-acetylglutamate synthetase from Pseudomonas aeruginosa: synergistic inhibition by acetylglutamate and polyamines
Biochem. Biophys. Res. Commun.
60
42-47
1974
Pseudomonas aeruginosa
Wakabayashi, Y.; Iwashima, A.; Yamada, E.; Yamada, R.
Enzymological evidence for the indispensability of small intestine in the synthesis of arginine from glutamate. II. N-acetylglutamate synthase
Arch. Biochem. Biophys.
291
9-14
1991
Homo sapiens, Rattus norvegicus
Sonoda, T.; Tatibana, M.
Purification of N-acetyl-L-glutamate synthetase from rat liver mitochondria and substrate and activator specificity of the enzyme
J. Biol. Chem.
258
9839-9844
1983
Rattus norvegicus
Yamada, E.; Wakabayashi, Y.
Development of pyrroline-5-carboxylate synthase and N-acetylglutamate synthase and their changes in lactation and aging
Arch. Biochem. Biophys.
291
15-23
1991
Rattus norvegicus
Bachmann, C.; Krahenbuhl, S.; Colombo, J.P.
Purification and properties of acetyl-CoA:L-glutamate N-acetyltransferase from human liver
Biochem. J.
205
123-127
1982
Homo sapiens
Morris, C.J.; Thompson, J.F.
Acetyl coenzyme A-glutamate acetyltransferase and N2-acetylornithine-glutamate acetyltransferase of Chlorella
Plant Physiol.
55
960-967
1975
Chlorella vulgaris
Jain, J.C.; Shargool, P.D.
A modified assay system for enzymes involved in N-acetyl group transfer reactions: its use to study enzymes involved in ornithine biosynthesis in plants
Anal. Biochem.
138
25-29
1984
Pisum sativum
Yu, Y.G.; Turner, G.E.; Weiss, R.L.
Acetylglutamate synthase from Neurospora crassa: structure and regulation of expression
Mol. Microbiol.
22
545-554
1996
Neurospora crassa
Rajagopal, B.S.; Deponte, J.; Tuchman, M.; Malamy, M.H.
Use of inducible feedback-resistant N-acetylglutamate synthetase (argA) genes for enhanced arginine biosynthesis by genetically engineered Escherichia coli K-12 strains
Appl. Environ. Microbiol.
64
1805-1811
1998
Escherichia coli (P0A6C5), Escherichia coli
Kawamoto, S.; Sonoda, T.; Ohtake, A.; Suzuki, Y.; Okuda, K.; Tatibana, M.
Alteration in arginine activation of N-acetylglutamate synthetase in vitro by disulfide or thiol compounds
J. Mol. Catal. B
10
191-197
2000
Mus musculus
-
Caldovic, L.; Morizono, H.; Yu, X.; Thompson, M.; Shi, D.; Gallegos, R.; Allewell, N.M.; Malamy, M.H.; Tuchman, M.
Identification, cloning and expression of the mouse N-acetylglutamate synthase gene
Biochem. J.
364
825-831
2002
Mus musculus (Q8R4H7), Mus musculus
Pauwels, K.; Abadjieva, A.; Hilven, P.; Stankiewicz, A.; Crabeel, M.
The N-acetylglutamate synthase/N-acetylglutamate kinase metabolon of Saccharomyces cerevisiae allows co-ordinated feedback regulation of the first two steps in arginine biosynthesis
Eur. J. Biochem.
270
1014-1024
2003
Saccharomyces cerevisiae
Schmidt, E.; Nuoffer, J.M.; Haberle, J.; Pauli, S.; Guffon, N.; Vianey-Saban, C.; Wermuth, B.; Koch, H.G.
Identification of novel mutations of the human N-acetylglutamate synthase gene and their functional investigation by expression studies
Biochim. Biophys. Acta
1740
54-59
2005
Homo sapiens
Haas, D.; Kurer, V.; Leisinger, T.
N-acetylglutamate synthetase of Pseudomonas aeruginosa. An assay in vitro and feedback inhibition by arginine
Eur. J. Biochem.
31
290-295
1972
Pseudomonas aeruginosa
Errey, J.C.; Blanchard, J.S.
Functional characterization of a novel ArgA from Mycobacterium tuberculosis
J. Bacteriol.
187
3039-3044
2005
Mycobacterium tuberculosis
Morizono, H.; Caldovic, L.; Shi, D.; Tuchman, M.
Mammalian N-acetylglutamate synthase
Mol. Genet. Metab.
81 Suppl 1
S4-11
2004
Homo sapiens, Mus musculus
Shi, D.; Caldovic, L.; Jin, Z.; Yu, X.; Qu, Q.; Roth, L.; Morizono, H.; Hathout, Y.; Allewell, N.M.; Tuchman, M.
Expression, crystallization and preliminary crystallographic studies of a novel bifunctional N-acetylglutamate synthase/kinase from Xanthomonas campestris homologous to vertebrate N-acetylglutamate synthase
Acta Crystallogr. Sect. F
F62
1218-1222
2006
Xanthomonas campestris
Qu, Q.; Morizono, H.; Shi, D.; Tuchman, M.; Caldovic, L.
A novel bifunctional N-acetylglutamate synthase-kinase from Xanthomonas campestris that is closely related to mammalian N-acetylglutamate synthase
BMC Biochem.
8
4
2007
Xanthomonas campestris
Xu, Y.; Glansdorff, N.; Labedan, B.
Bioinformatic analysis of an unusual gene-enzyme relationship in the arginine biosynthetic pathway among marine gamma proteobacteria: implications concerning the formation of N-acetylated intermediates in prokaryotes
BMC Genomics
7
4
2006
Aliivibrio fischeri, Moritella profunda, Moritella abyssi, Pseudoalteromonas haloplanktis, Vibrio parahaemolyticus, Vibrio vulnificus, Colwellia psychrerythraea, Idiomarina loihiensis
Kim, J.; Myong, K.; Shim, W.; Yun, S.; Lee, Y.
Functional characterization of acetylglutamate synthase and phosphoribosylamine-glycine ligase genes in Gibberella zeae
Curr. Genet.
51
99-108
2007
Fusarium graminearum
Caldovic, L.; Morizono, H.; Tuchman, M.
Mutations and polymorphisms in the human N-acetylglutamate synthase (NAGS) Gene
Hum. Mutat.
28
754-759
2007
Homo sapiens (Q8N159), Homo sapiens
Tujioka, K.; Fukaya, Y.; Sano, A.; Hayase, K.; Yokogoshi, H.
Role of N-acetylglutamate turnover in urea synthesis of rats given proteins of different quality
J. Nutr. Sci. Vitaminol.
51
93-98
2005
Rattus norvegicus
Caldovic, L.; Lopez, G.Y.; Haskins, N.; Panglao, M.; Shi, D.; Morizono, H.; Tuchman, M.
Biochemical properties of recombinant human and mouse N-acetylglutamate synthase
Mol. Genet. Metab.
87
226-232
2006
Homo sapiens (Q8N159), Homo sapiens, Mus musculus (Q8R4H7), Mus musculus
Haskins, N.; Panglao, M.; Qu, Q.; Majumdar, H.; Cabrera-Luque, J.; Morizono, H.; Tuchman, M.; Caldovic, L.
Inversion of allosteric effect of arginine on N-acetylglutamate synthase, a molecular marker for evolution of tetrapods
BMC Biochem.
9
24
2008
Arabidopsis thaliana, Danio rerio, Escherichia coli, Mus musculus, Takifugu rubripes, Xanthomonas campestris, Xenopus laevis, Xenopus tropicalis, Maricaulis maris, Pseudomonas aeruginosa (P22567), Pseudomonas aeruginosa
Altarescu, G.; Brooks, B.; Eldar-Geva, T.; Margalioth, E.J.; Singer, A.; Levy-Lahad, E.; Renbaum, P.
Polar Body-Based Preimplantation Genetic Diagnosis for N-Acetylglutamate Synthase Deficiency
Fetal. Diagn. Ther.
24
170-176
2008
Homo sapiens
Davies, A.M.; Tata, R.; Chauviac, F.X.; Sutton, B.J.; Brown, P.R.
Structure of a putative acetyltransferase (PA1377) from Pseudomonas aeruginosa
Acta Crystallogr. Sect. F
64
338-342
2008
Pseudomonas aeruginosa (Q9I3W7), Pseudomonas aeruginosa
Sancho-Vaello, E.; Fernandez-Murga, M.L.; Rubio, V.
Site-directed mutagenesis studies of acetylglutamate synthase delineate the site for the arginine inhibitor
FEBS Lett.
582
1081-1086
2008
Pseudomonas aeruginosa (P22567), Pseudomonas aeruginosa
Sancho-Vaello, E.; Fernandez-Murga, M.L.; Rubio, V.
Mechanism of arginine regulation of acetylglutamate synthase, the first enzyme of arginine synthesis
FEBS Lett.
583
202-206
2009
Pseudomonas aeruginosa
Shi, D.; Sagar, V.; Jin, Z.; Yu, X.; Caldovic, L.; Morizono, H.; Allewell, N.M.; Tuchman, M.
The crystal structure of N-acetyl-L-glutamate synthase from Neisseria gonorrhoeae provides insights into mechanisms of catalysis and regulation
J. Biol. Chem.
283
7176-7184
2008
Neisseria gonorrhoeae
Min, L.; Jin, Z.; Caldovic, L.; Morizono, H.; Allewell, N.M.; Tuchman, M.; Shi, D.
Mechanism of allosteric inhibition of N-acetyl-L-glutamate synthase by L-arginine
J. Biol. Chem.
284
4873-4880
2009
Neisseria gonorrhoeae (Q5FAK7), Neisseria gonorrhoeae
Kalamaki, M.S.; Alexandrou, D.; Lazari, D.; Merkouropoulos, G.; Fotopoulos, V.; Pateraki, I.; Aggelis, A.; Carrillo-Lopez, A.; Rubio-Cabetas, M.J.; Kanellis, A.K.
Over-expression of a tomato N-acetyl-L-glutamate synthase gene (SlNAGS1) in Arabidopsis thaliana results in high ornithine levels and increased tolerance in salt and drought stresses
J. Exp. Bot.
60
1859-1871
2009
Solanum lycopersicum (C4NFG1), Solanum lycopersicum
Geng, M.; Li, T.; Kong, X.; Song, X.; Chu, W.; Huang, R.; Yin, Y.; Wu, G.
Reduced expression of intestinal N-acetylglutamate synthase in suckling piglets: a novel molecular mechanism for arginine as a nutritionally essential amino acid for neonates
Amino Acids
40
1513-1522
2011
Sus scrofa (A4GTP3), Sus scrofa
Nissim, I.; Horyn, O.; Nissim, I.; Daikhin, Y.; Caldovic, L.; Barcelona, B.; Cervera, J.; Tuchman, M.; Yudkoff, M.
Down-regulation of hepatic urea synthesis by oxypurines: xanthine and uric acid inhibit N-acetylglutamate synthase
J. Biol. Chem.
286
22055-22068
2011
Rattus norvegicus
Shi, D.; Li, Y.; Cabrera-Luque, J.; Jin, Z.; Yu, X.; Zhao, G.; Haskins, N.; Allewell, N.M.; Tuchman, M.
A novel N-acetylglutamate synthase architecture revealed by the crystal structure of the bifunctional enzyme from Maricaulis maris
PLoS ONE
6
e28825
2011
Homo sapiens, Maricaulis maris (Q0ASS9), Maricaulis maris
Van de Casteele, M.; Demarez, M.; Legrain, C.; Glansdorff, N.; Pierard, A.
Pathways of arginine biosynthesis in extreme thermophilic archaeo- and eubacteria
J. Gen. Microbiol.
136
1177-1183
1990
Saccharolobus solfataricus, Saccharolobus solfataricus P1
-
Zhao, G.; Jin, Z.; Allewell, N.M.; Tuchman, M.; Shi, D.
Structures of the N-acetyltransferase domain of Xylella fastidiosa N-acetyl-L-glutamate synthase/kinase with and without a His tag bound to N-acetyl-L-glutamate
Acta Crystallogr. Sect. F
71
86-95
2015
Xylella fastidiosa, Xylella fastidiosa (Q87EL2), Xylella fastidiosa ATCC 35881D
Zhao, G.; Haskins, N.; Jin, Z.; M Allewell, N.; Tuchman, M.; Shi, D.
Structure of N-acetyl-L-glutamate synthase/kinase from Maricaulis maris with the allosteric inhibitor L-arginine bound
Biochem. Biophys. Res. Commun.
437
585-590
2013
Maricaulis maris (Q0ASS9), Maricaulis maris
Dercksen, M.; IJlst, L.; Duran, M.; Mienie, L.J.; van Cruchten, A.; van der Westhuizen, F.H.; Wanders, R.J.
Inhibition of N-acetylglutamate synthase by various monocarboxylic and dicarboxylic short-chain coenzyme A esters and the production of alternative glutamate esters
Biochim. Biophys. Acta
1842
2510-2516
2014
Homo sapiens
Petri, K.; Walter, F.; Persicke, M.; Rueckert, C.; Kalinowski, J.
A novel type of N-acetylglutamate synthase is involved in the first step of arginine biosynthesis in Corynebacterium glutamicum
BMC Genomics
14
713
2013
Corynebacterium glutamicum (CAF20762), Corynebacterium glutamicum (Q8NM40), Corynebacterium glutamicum, Corynebacterium glutamicum ATCC 13032 (CAF20762), Corynebacterium glutamicum ATCC 13032 (Q8NM40)
Shi, D.; Allewell, N.M.; Tuchman, M.
The N-acetylglutamate synthase family: structures, function and mechanisms
Int. J. Mol. Sci.
16
13004-13022
2015
Escherichia coli, Homo sapiens, Rattus norvegicus
Zhao, G.; Jin, Z.; Allewell, N.M.; Tuchman, M.; Shi, D.
Crystal structure of the N-acetyltransferase domain of human N-acetyl-L-glutamate synthase in complex with N-acetyl-L-glutamate provides insights into its catalytic and regulatory mechanisms
PLoS ONE
8
e70369
2013
Homo sapiens, Homo sapiens (Q8N159)
Caldovic, L.; Haskins, N.; Mumo, A.; Majumdar, H.; Pinter, M.; Tuchman, M.; Krufka, A.
Expression pattern and biochemical properties of zebrafish N-acetylglutamate synthase
PLoS ONE
9
e85597
2014
Danio rerio
Yang, X.; Wu, L.; Ran, Y.; Xu, A.; Zhang, B.; Yang, X.; Zhang, R.; Rao, Z.; Li, J.
Crystal structure of L-glutamate N-acetyltransferase ArgA from Mycobacterium tuberculosis
Biochim. Biophys. Acta
1865
1800-1807
2017
Mycobacterium tuberculosis (O33289), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (O33289)
Das, U.; Singh, E.; Dharavath, S.; Tiruttani Subhramanyam, U.K.; Pal, R.K.; Vijayan, R.; Menon, S.; Kumar, S.; Gourinath, S.; Srinivasan, A.
Structural insights into the substrate binding mechanism of novel ArgA from Mycobacterium tuberculosis
Int. J. Biol. Macromol.
125
970-978
2019
Mycobacterium tuberculosis (O33289), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (O33289)
Dercksen, M.; Duran, M.; IJlst, L.; Kulik, W.; Ruiter, J.P.; van Cruchten, A.; Tuchman, M.; Wanders, R.J.
A novel UPLC-MS/MS based method to determine the activity of N-acetylglutamate synthase in liver tissue
Mol. Genet. Metab.
119
307-310
2016
Homo sapiens (Q8N159), Homo sapiens
Haskins, N.; Mumo, A.; Brown, P.H.; Tuchman, M.; Morizono, H.; Caldovic, L.
Effect of arginine on oligomerization and stability of N-acetylglutamate synthase
Sci. Rep.
6
38711
2016
Maricaulis maris (Q0ASS9), Maricaulis maris, Mus musculus (Q8R4H7), Mus musculus, Xanthomonas campestris
html completed
