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2-(3-fluorophenyl)-4-oxoquinazolin-3(4H)-yl 3-(trifluoromethyl)benzoate
-
30% inhibition at 0.1 mM
2-(3-fluorophenyl)-4-oxoquinazolin-3(4H)-yl 3-chlorobenzoate
-
42.5% inhibition at 0.1 mM
2-(3-fluorophenyl)-4-oxoquinazolin-3(4H)-yl 3-fluorobenzoate
-
72% inhibition at 0.1 mM
2-(3-fluorophenyl)-4-oxoquinazolin-3(4H)-yl 3-methoxybenzoate
-
28% inhibition at 0.1 mM
2-(3-fluorophenyl)-4-oxoquinazolin-3(4H)-yl benzoate
-
26% inhibition at 0.1 mM
2-(3-methoxyphenyl)-4-oxoquinazolin-3(4H)-yl 3-(trifluoromethyl)benzoate
-
73.2% inhibition at 0.1 mM
2-(3-methoxyphenyl)-4-oxoquinazolin-3(4H)-yl 3-chlorobenzoate
-
23.5% inhibition at 0.1 mM
2-(3-methoxyphenyl)-4-oxoquinazolin-3(4H)-yl 3-nitrobenzoate
-
94% inhibition at 0.1 mM
2-chloro-3-oxocyclohex-1-en-1-yl 3-(trifluoromethyl)benzoate
-
2-chloro-5,5-dimethyl-3-oxocyclohex-1-en-1-yl 4-chlorobenzoate
-
2-chloro-5,5-dimethyl-3-oxocyclohex-1-en-1-yl 4-chlorobenzoic acid
no inhibition by bensulfuron methyl. Feedback inhibition takes place in the holoenzyme containing the regulatory and the catalytic subunits. The branched-chain amino acids are believed to bind only to the regulatory subunit and inhibit the enzyme. Molecular docking of benzoyl ester compounds. AHAS-inhibitors and the probable binding pattern
2-chloro-6-(methoxycarbonyl)-5,5-dimethyl-3-oxocyclohex-1-en-1-yl 4-chlorobenzoate
-
2-chloro-N-(4-chloro-3-[[(4-methoxypyrimidin-2-yl)carbamoyl]sulfamoyl]phenyl)acetamide
-
2-chloro-N-(4-chloro-3-[[(4-methylpyrimidin-2-yl)carbamoyl]sulfamoyl]phenyl)acetamide
-
2-nitro-5-(phenylsulfonyl)phenyl 4-chlorobenzoate
-
2-phenyl-3-[[3-(trifluoromethyl)benzoyl]oxy]quinazolin-4(3H)-one
-
3-[(3-bromobenzoyl)oxy]-2-phenylquinazolin-4(3H)-one
-
3-[(4-nitrobenzoyl)oxy]quinazolin-4(3H)-one
-
4-(cyclopropylcarbonyl)-N-[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]-1-methyl-1H-pyrazole-5-sulfonamide
-
i.e. K13030
4-acetyl-N-[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]-1-methyl-1H-pyrazole-5-sulfonamide
-
i.e. K13010
4-oxo-2-m-tolylquinazolin-3(4H)-yl 3-fluorobenzoate
-
9.5% inhibition at 0.1 mM
4-oxo-2-m-tolylquinazolin-3(4H)-yl 3-methylbenzoate
-
10.5% inhibition at 0.1 mM
4-oxo-2-m-tolylquinazolin-3(4H)-yl 4-chlorobenzoate
-
no inhibition at 0.1 mM
4-oxo-2-m-tolylquinazolin-3(4H)-yl 4-methylbenzoate
-
33% inhibition at 0.1 mM
4-oxo-2-m-tolylquinazolin-3(4H)-yl benzoate
-
40.5% inhibition at 0.1 mM
4-oxo-2-m-tolylquinazolin-3(4H)-yl-3-(trifluoromethyl)benzoate
-
9.5% inhibition at 0.1 mM
4-oxo-2-o-tolylquinazolin-3(4H)-yl 3-fluorobenzoate
-
30% inhibition at 0.1 mM
4-oxo-2-phenylquinazolin-3(4H)-yl 2-methylbenzoate
-
16.5% inhibition at 0.1 mM
4-oxo-2-phenylquinazolin-3(4H)-yl 3-chlorobenzoate
-
80.5% inhibition at 0.1 mM
4-oxo-2-phenylquinazolin-3(4H)-yl 3-fluorobenzoate
-
26% inhibition at 0.1 mM
4-oxo-2-phenylquinazolin-3(4H)-yl 3-methoxybenzoate
-
27% inhibition at 0.1 mM
4-oxo-2-phenylquinazolin-3(4H)-yl 3-methylbenzoate
-
4% inhibition at 0.1 mM
4-oxo-2-phenylquinazolin-3(4H)-yl 3-nitrobenzoate
-
91.5% inhibition at 0.1 mM
4-oxo-2-phenylquinazolin-3(4H)-yl 4-chlorobenzoate
-
7.5% inhibition at 0.1 mM
4-oxo-2-phenylquinazolin-3(4H)-yl 4-methylbenzoate
-
18% inhibition at 0.1 mM
4-oxo-2-phenylquinazolin-3(4H)-yl benzoate
-
20.5% inhibition at 0.1 mM
ethyl 4-chloro-2-[[(4-methylpyrimidin-2-yl)carbamoyl]sulfamoyl]benzoate
-
isoleucine
feedback inhibition
leucine
feedback inhibition
methyl-2-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)carbamoylsulfamoyl]benzoate
-
N-phenyl-3-(phenyldisulfanyl)-1H-1,2,4-triazole-1-carboxamide
strong inhibition
N-[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]-2-(ethylsulfanyl)-6-(2-fluoro-1-hydroxyethyl)benzenesulfonamide
-
i.e. K12147
primisulfuron methyl
-
IC50: 0.0042 mM, over 80% inhibition at 0.04 mM
propan-2-yl 4-bromo-3-[[(4-methylpyrimidin-2-yl)carbamoyl]sulfamoyl]benzoate
-
chlorimuron ethyl
-
chlorimuron ethyl
-
IC50: 0.009 mM, over 80% inhibition at 0.04 mM
chlorimuron ethyl
a sulfonylurea derivative herbicide
KHG20612
-
KHG20612
strong inhibition
KHG20612
-
inhibition kinetics and antimycobacterial activity, overview
metsulfuron methyl
-
-
metsulfuron methyl
-
IC50: 0.006 mM, over 80% inhibition at 0.04 mM
pyrazosulfuron ethyl
-
-
pyrazosulfuron ethyl
-
IC50: 870 nM
pyrazosulfuron ethyl
-
IC50: 87 nM, over 80% inhibition at 0.04 mM
sulfometuron methyl
-
sulfometuron methyl
-
IC50: 0.0048 mM, over 80% inhibition at 0.04 mM
sulfometuron methyl
-
active against Mycobacterium tuberculosis both in vitro and in vivo
valine
-
-
valine
feedback inhibition
additional information
-
mechanism and potency of enzyme inhibition by sulfonylurea herbicides, overview
-
additional information
-
screening of chemical libraries for effective inhibitors of the enzyme, overview
-
additional information
-
screening of 100 sulfonylurea analogues for antimycobacterial activity, minimal inhibitory concentrations, overview
-
additional information
-
not inhibited by bensulfuron methyl
-
additional information
not inhibited by bensulfuron methyl
-
additional information
-
single stranded DNA aptamers Apt1 (CGAGTGAGGGCGAGGCGCGCTCCTGCCGGT) and Apt6 (CGGCCAGGGGACGAGCGCGCCCTGATCGTG) demonstrate the greatest inhibitory potential against the enzyme activity with IC50 values in the low nanomolar range (28.94 and 22.35 nM respectively). Aptamers Apt2, Apt3 and Apt4 show moderate to lower inhibition specificities
-
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0.1
2-(3-fluorophenyl)-4-oxoquinazolin-3(4H)-yl 3-(trifluoromethyl)benzoate
Mycobacterium tuberculosis
-
IC50 above 0.1 mM, at pH 7.5 and 37°C
0.1
2-(3-fluorophenyl)-4-oxoquinazolin-3(4H)-yl 3-chlorobenzoate
Mycobacterium tuberculosis
-
IC50 above 0.1 mM, at pH 7.5 and 37°C
0.0065
2-(3-fluorophenyl)-4-oxoquinazolin-3(4H)-yl 3-fluorobenzoate
Mycobacterium tuberculosis
-
at pH 7.5 and 37°C
0.1
2-(3-fluorophenyl)-4-oxoquinazolin-3(4H)-yl 3-methoxybenzoate
Mycobacterium tuberculosis
-
IC50 above 0.1 mM, at pH 7.5 and 37°C
0.1
2-(3-fluorophenyl)-4-oxoquinazolin-3(4H)-yl benzoate
Mycobacterium tuberculosis
-
IC50 above 0.1 mM, at pH 7.5 and 37°C
0.00957
2-(3-methoxyphenyl)-4-oxoquinazolin-3(4H)-yl 3-(trifluoromethyl)benzoate
Mycobacterium tuberculosis
-
at pH 7.5 and 37°C
0.1
2-(3-methoxyphenyl)-4-oxoquinazolin-3(4H)-yl 3-chlorobenzoate
Mycobacterium tuberculosis
-
IC50 above 0.1 mM, at pH 7.5 and 37°C
0.00874
2-(3-methoxyphenyl)-4-oxoquinazolin-3(4H)-yl 3-nitrobenzoate
Mycobacterium tuberculosis
-
at pH 7.5 and 37°C
0.00267
2-chloro-3-oxocyclohex-1-en-1-yl 3-(trifluoromethyl)benzoate
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.0141
2-chloro-5,5-dimethyl-3-oxocyclohex-1-en-1-yl 4-chlorobenzoate
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.00178
2-chloro-6-(methoxycarbonyl)-5,5-dimethyl-3-oxocyclohex-1-en-1-yl 4-chlorobenzoate
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.00202
2-phenyl-3-[[3-(trifluoromethyl)benzoyl]oxy]quinazolin-4(3H)-one
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.00185
3-[(3-bromobenzoyl)oxy]-2-phenylquinazolin-4(3H)-one
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.01413
3-[(4-nitrobenzoyl)oxy]quinazolin-4(3H)-one
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.1
4-oxo-2-m-tolylquinazolin-3(4H)-yl 3-fluorobenzoate
Mycobacterium tuberculosis
-
IC50 above 0.1 mM, at pH 7.5 and 37°C
0.1
4-oxo-2-m-tolylquinazolin-3(4H)-yl 3-methylbenzoate
Mycobacterium tuberculosis
-
IC50 above 0.1 mM, at pH 7.5 and 37°C
0.1
4-oxo-2-m-tolylquinazolin-3(4H)-yl 4-chlorobenzoate
Mycobacterium tuberculosis
-
IC50 above 0.1 mM, at pH 7.5 and 37°C
0.1
4-oxo-2-m-tolylquinazolin-3(4H)-yl 4-methylbenzoate
Mycobacterium tuberculosis
-
IC50 above 0.1 mM, at pH 7.5 and 37°C
0.1
4-oxo-2-m-tolylquinazolin-3(4H)-yl benzoate
Mycobacterium tuberculosis
-
IC50 above 0.1 mM, at pH 7.5 and 37°C
0.1
4-oxo-2-m-tolylquinazolin-3(4H)-yl-3-(trifluoromethyl)benzoate
Mycobacterium tuberculosis
-
IC50 above 0.1 mM, at pH 7.5 and 37°C
0.1
4-oxo-2-o-tolylquinazolin-3(4H)-yl 3-fluorobenzoate
Mycobacterium tuberculosis
-
IC50 above 0.1 mM, at pH 7.5 and 37°C
0.1
4-oxo-2-phenylquinazolin-3(4H)-yl 2-methylbenzoate
Mycobacterium tuberculosis
-
IC50 above 0.1 mM, at pH 7.5 and 37°C
0.01208
4-oxo-2-phenylquinazolin-3(4H)-yl 3-chlorobenzoate
Mycobacterium tuberculosis
-
at pH 7.5 and 37°C
0.1
4-oxo-2-phenylquinazolin-3(4H)-yl 3-fluorobenzoate
Mycobacterium tuberculosis
-
IC50 above 0.1 mM, at pH 7.5 and 37°C
0.1
4-oxo-2-phenylquinazolin-3(4H)-yl 3-methoxybenzoate
Mycobacterium tuberculosis
-
IC50 above 0.1 mM, at pH 7.5 and 37°C
0.1
4-oxo-2-phenylquinazolin-3(4H)-yl 3-methylbenzoate
Mycobacterium tuberculosis
-
IC50 above 0.1 mM, at pH 7.5 and 37°C
0.00968
4-oxo-2-phenylquinazolin-3(4H)-yl 3-nitrobenzoate
Mycobacterium tuberculosis
-
at pH 7.5 and 37°C
0.1
4-oxo-2-phenylquinazolin-3(4H)-yl 4-chlorobenzoate
Mycobacterium tuberculosis
-
IC50 above 0.1 mM, at pH 7.5 and 37°C
0.1
4-oxo-2-phenylquinazolin-3(4H)-yl 4-methylbenzoate
Mycobacterium tuberculosis
-
IC50 above 0.1 mM, at pH 7.5 and 37°C
0.1
4-oxo-2-phenylquinazolin-3(4H)-yl benzoate
Mycobacterium tuberculosis
-
IC50 above 0.1 mM, at pH 7.5 and 37°C
0.00897 - 0.009
chlorimuron ethyl
0.00177
KHG20612
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.012 - 0.32
L-isoleucine
0.0014 - 0.0016
L-leucine
0.00596
methyl-2-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)carbamoylsulfamoyl]benzoate
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.00596 - 0.006
metsulfuron methyl
0.00177
N-phenyl-3-(phenyldisulfanyl)-1H-1,2,4-triazole-1-carboxamide
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.0042
primisulfuron methyl
Mycobacterium tuberculosis
-
IC50: 0.0042 mM, over 80% inhibition at 0.04 mM
0.000087 - 0.00087
pyrazosulfuron ethyl
0.00479 - 0.0048
sulfometuron methyl
0.00897
chlorimuron ethyl
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.009
chlorimuron ethyl
Mycobacterium tuberculosis
-
IC50: 0.009 mM, over 80% inhibition at 0.04 mM
0.012
L-isoleucine
Mycobacterium tuberculosis
wild-type, pH 7.5, 37°C
0.04
L-isoleucine
Mycobacterium tuberculosis
R101A, pH 7.5, 37°C
0.062
L-isoleucine
Mycobacterium tuberculosis
mutant S27A, pH 7.5, 37°C
0.32
L-isoleucine
Mycobacterium tuberculosis
L89A, pH 7.5, 37°C
0.0014
L-leucine
Mycobacterium tuberculosis
R101A, pH 7.5, 37°C
0.0016
L-leucine
Mycobacterium tuberculosis
wild-type, pH 7.5, 37°C
0.004
L-valine
Mycobacterium tuberculosis
R101A, pH 7.5, 37°C
0.005
L-valine
Mycobacterium tuberculosis
wild-type, pH 7.5, 37°C
0.0075
L-valine
Mycobacterium tuberculosis
mutant S27A, pH 7.5, 37°C
0.012
L-valine
Mycobacterium tuberculosis
L89A, pH 7.5, 37°C
0.00064
Londax
Mycobacterium tuberculosis
wild-type, pH 7.5, 37°C
0.021
Londax
Mycobacterium tuberculosis
mutant L141A, pH 7.5, 37°C
0.00596
metsulfuron methyl
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.006
metsulfuron methyl
Mycobacterium tuberculosis
-
IC50: 0.006 mM, over 80% inhibition at 0.04 mM
0.011
NC-311
Mycobacterium tuberculosis
mutant L141A, pH 7.5, 37°C
0.048
NC-311
Mycobacterium tuberculosis
wild-type, pH 7.5, 37°C
0.000087
pyrazosulfuron ethyl
Mycobacterium tuberculosis
-
IC50: 87 nM, over 80% inhibition at 0.04 mM
0.00087
pyrazosulfuron ethyl
Mycobacterium tuberculosis
-
IC50: 870 nM
0.00479
sulfometuron methyl
Mycobacterium tuberculosis
-
at pH 7.5 and 37°C
0.00479
sulfometuron methyl
Mycobacterium tuberculosis
pH and temperature not specified in the publication
0.0048
sulfometuron methyl
Mycobacterium tuberculosis
-
IC50: 0.0048 mM, over 80% inhibition at 0.04 mM
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F147A
4fold decrease in vmax value, strong resistance to sulfonylurea inhibitors
F147R
2.5fold decrease in vmax value, strong resistance to sulfonylurea inhibitors
L141A
5fold decrease in vmax value
P126A
site-directed mutagenesis, the mutant exhibits similar kinetics but significantly lower activity compared to the wild-type enzyme
P126A,
the mutant exhibits significantly lower activity than the wild type enzyme
W561R
30fold decrease in vmax value, strong resistance to sulfonylurea inhibitors
E85A
site-directed mutagenesis, the mutation leads to severe drop in catalyticactivity with reduced affinity toward thiamine diphosphate, , the enzyme shows reduced activity compared to the wild-type enzyme
E85A
the mutation leads to severe drop in catalytic activity (0.08% of wild type activity) with reduced affinity toward thiamine diphosphate
E85A
the mutation leads to severe drop in catalytic activity with reduced affinity toward thiamine diphosphate
E85D
site-directed mutagenesis, the mutation leads to severe drop in catalyticactivity with reduced affinity toward thiamine diphosphate
E85D
the mutation leads to severe drop in catalytic activity (2.23% of wild type activity) with reduced affinity toward thiamine diphosphate
E85Q
site-directed mutagenesis, the mutation leads to severe drop in catalyticactivity with reduced affinity toward thiamine diphosphate
E85Q
the mutation leads to severe drop in catalytic activity (1.2% of wild type activity) with reduced affinity toward thiamine diphosphate
H84A
site-directed mutagenesis, the mutation leads to the loss of many hydrogen bonds among residues His84, Glu85, and Gln86 in wild-type enzyme
H84A
the mutation leads to severe drop in catalytic activity with reduced affinity toward thiamine diphosphate
H84T
site-directed mutagenesis, the enzyme shows reduced activity compared to the wild-type enzyme
H84T
the mutation leads to severe drop in catalytic activity with reduced affinity toward thiamine diphosphate
P126E
inactive
P126E
site-directed mutagenesis, inactive mutant
P126T
site-directed mutagenesis, the mutant exhibits significantly lower activity than wild-type enzyme and a significantly decreased preference toward thiamine diphosphate as cofactor
P126T
the mutant exhibits significantly lower activity than the wild type enzyme
P126V
site-directed mutagenesis, the mutant exhibits significantly lower activity than wild-type enzyme and a significantly decreased preference toward pyruvate as substrate
P126V
the mutant exhibits significantly lower activity than the wild type enzyme
Q86A
site-directed mutagenesis, the enzyme shows reduced activity compared to the wild-type enzyme
Q86A
the mutation leads to severe drop in catalytic activity with reduced affinity toward thiamine diphosphate
Q86W
site-directed mutagenesis, inactive mutant
Q86W
the mutation completely abolishes the enzyme's activity
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Choi, K.; Noh, K.M.; Choi, J.; Park, J.; Won, H.; Kim, J.; Kim, J.; Yoon, M.
Sulfonylurea is a non-competitive inhibitor of acetohydroxyacid synthase from Mycobacterium tuberculosis
Bull. Korean Chem. Soc.
27
1697-1700
2006
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
-
brenda
Choi, K.J.; Yu, Y.G.; Hahn, H.G.; Choi, J.D.; Yoon, M.Y.
Characterization of acetohydroxyacid synthase from Mycobacterium tuberculosis and the identification of its new inhibitor from the screening of a chemical library
FEBS Lett.
579
4903-4910
2005
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
brenda
Sohn, H.; Lee, K.S.; Ko, Y.K.; Ryu, J.W.; Woo, J.C.; Koo, D.W.; Shin, S.J.; Ahn, S.J.; Shin, A.R.; Song, C.H.; Jo, E.K.; Park, J.K.; Kim, H.J.
In vitro and ex vivo activity of new derivatives of acetohydroxyacid synthase inhibitors against Mycobacterium tuberculosis and non-tuberculous mycobacteria
Int. J. Antimicrob. Agents
31
567-571
2008
Mycobacterium tuberculosis, Mycobacterium avium, Mycobacterium kansasii, Mycobacteroides abscessus
brenda
Choi, J.; Gedi, V.; Pham, C.; Ryu, K.; Lee, H.; Kim, G.; Yoon, M.
Site-directed mutagenesis of catalytic and regulatory subunits of Mycobacterium tuberculosis acetohydroxyacid synthase
Enzyme Microb. Technol.
46
304-308
2010
Mycobacterium tuberculosis, Mycobacterium tuberculosis (P9WG41), Mycobacterium tuberculosis H37Rv (P9WG41)
-
brenda
Singh, V.; Chandra, D.; Srivastava, B.S.; Srivastava, R.
Biochemical and transcription analysis of acetohydroxyacid synthase isoforms in Mycobacterium tuberculosis identifies these enzymes as potential targets for drug development
Microbiology
157
29-37
2011
Mycobacterium tuberculosis (O06335), Mycobacterium tuberculosis (O53554), Mycobacterium tuberculosis (P9WG39), Mycobacterium tuberculosis (P9WG41), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WG39), Mycobacterium tuberculosis H37Rv (P9WG41)
brenda
Gokhale, K.; Tilak, B.
Mechanisms of bacterial acetohydroxyacid synthase (AHAS) and specific inhibitors of Mycobacterium tuberculosis AHAS as potential drug candidates against tuberculosis
Curr. Drug Targets
16
689-699
2015
Saccharomyces cerevisiae, Mycobacterium tuberculosis, Mycobacterium tuberculosis (P9WG41 and P9WKJ3), Pseudomonas aeruginosa, Salmonella enterica subsp. enterica serovar Typhimurium, Escherichia coli (P00892 and P0ADG1), Escherichia coli (P00893 and P00894), Escherichia coli (P08142 and P0ADF8), Mycobacterium tuberculosis H37Rv (P9WG41 and P9WKJ3)
brenda
Baig, I.A.; Gedi, V.; Lee, S.C.; Koh, S.H.; Yoon, M.Y.
Role of a highly conserved proline-126 in ThDP binding of Mycobacterium tuberculosis acetohydroxyacid synthase
Enzyme Microb. Technol.
53
243-249
2013
Mycobacterium tuberculosis, Mycobacterium tuberculosis (P9WG39), Mycobacterium tuberculosis H37Rv, Mycobacterium tuberculosis H37Rv (P9WG39)
brenda
Baig, I.A.; Moon, J.Y.; Kim, M.S.; Koo, B.S.; Yoon, M.Y.
Structural and functional significance of the highly-conserved residues in Mycobacterium tuberculosis acetohydroxyacid synthase
Enzyme Microb. Technol.
58-59
52-59
2014
Mycobacterium tuberculosis (P9WG41), Mycobacterium tuberculosis H37Rv (P9WG41)
brenda
Baig, I.A.; Moon, J.Y.; Lee, S.C.; Ryoo, S.W.; Yoon, M.Y.
Development of ssDNA aptamers as potent inhibitors of Mycobacterium tuberculosis acetohydroxyacid synthase
Biochim. Biophys. Acta
1854
1338-1350
2015
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
brenda
Lu, W.; Baig, I.A.; Sun, H.J.; Cui, C.J.; Guo, R.; Jung, I.P.; Wang, D.; Dong, M.; Yoon, M.Y.; Wang, J.G.
Synthesis, crystal structure and biological evaluation of substituted quinazolinone benzoates as novel antituberculosis agents targeting acetohydroxyacid synthase
Eur. J. Med. Chem.
94
298-305
2015
Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv
brenda