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Information on EC 2.2.1.5 - 2-hydroxy-3-oxoadipate synthase

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EC Tree
IUBMB Comments
The bacterial enzyme requires thiamine diphosphate. The product decarboxylates to 5-hydroxy-4-oxopentanoate. The enzyme can decarboxylate 2-oxoglutarate. Acetaldehyde can replace glyoxylate.
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Word Map
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
carboligase, rv1248c, 2-hydroxy-3-oxoadipate synthase, alpha-ketoglutarate:glyoxylate carboligase, hoa synthase, 2-oxoglutarate glyoxylate carboligase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2-oxoglutarate + glyoxylate = 2-hydroxy-3-oxoadipate + CO2
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PATHWAY SOURCE
PATHWAYS