The enzyme plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. The enzyme can also catalyse the reaction of EC 4.1.2.13, fructose-bisphosphate aldolase.
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The enzyme appears in viruses and cellular organisms
The enzyme plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. The enzyme can also catalyse the reaction of EC 4.1.2.13, fructose-bisphosphate aldolase.
the enzyme catalyzes the condensation of methylglyoxal with a dihydroxyacetone-phosphate fragment, which is derived from fructose 1-phosphate and/or fructose 1,6-bisphosphate, generating 6-deoxy-5-ketofructose 1-phosphate
the enzyme catalyzes the condensation of methylglyoxal with a dihydroxyacetone-phosphate fragment, which is derived from fructose 1-phosphate and/or fructose 1,6-bisphosphate, generating 6-deoxy-5-ketofructose 1-phosphate
the enzyme is required in the biosynthetic pathway for creating 6-deoxy-5-ketofructose 1-phosphate, DKFP, a precursor sugar for aromatic amino acid biosynthesis in Methanocaldococcus jannaschii. This pathway is not leading via the nucleoside diphosphate mannose pathway nor a pathway involving nucleoside diphosphate derivatives of fructose 1-phosphate, fructose 2-phosphate, or fructose 1,6-bisphosphate, but methylglyoxal and a fructose 1-phosphate- or fructose 1,6-bisphosphate-derived dihydroxyacetone phosphate fragment are key intermediates in DKFP production, detailed overview. The stereochemistry of the aldolase reaction is consistent with MJ1585 also functioning as the fructose 1,6-bisphosphate aldolase, EC 4.1.2.13, used in glycolysis. The MJ1585 aldolase does not catalyze the reaction of DL-lactaldehyde with fructose 1-phosphate, fructose 1,6-phosphate, or DHAP to form 6-deoxyallulose 1-phosphate or fuculose 1-phosphate
Methylglyoxal is an intermediate in the biosynthesis of 6-deoxy-5-ketofructose-1-phosphate: a precursor for aromatic amino acid biosynthesis in Methanocaldococcus jannaschii
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Enzyme Nomenclature
2.2.1.11 6-deoxy-5-ketofructose 1-phosphate synthase
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