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Information on EC 2.2.1.11 - 6-deoxy-5-ketofructose 1-phosphate synthase
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The expected taxonomic range for this enzyme is: Methanocaldococcus jannaschii
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EC NUMBER 
COMMENTARY 
2.2.1.11
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RECOMMENDED NAME
GeneOntology No.
6-deoxy-5-ketofructose 1-phosphate synthase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
2-oxopropanal + D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate
(1)
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2-oxopropanal + D-fructose 1-phosphate = D-glyceraldehyde + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate
(2)
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-
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
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SYSTEMATIC NAME
IUBMB Comments
2-oxopropanal:D-fructose 1,6-bisphosphate glycerone-phosphotransferase
The enzyme plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids. The enzyme can also catalyse the reaction of EC 4.1.2.13, fructose-bisphosphate aldolase.
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ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
metabolism
the enzyme is required in the biosynthetic pathway for creating 6-deoxy-5-ketofructose 1-phosphate, DKFP, a precursor sugar for aromatic amino acid biosynthesis in Methanocaldococcus jannaschii. This pathway is not leading via the nucleoside diphosphate mannose pathway nor a pathway involving nucleoside diphosphate derivatives of fructose 1-phosphate, fructose 2-phosphate, or fructose 1,6-bisphosphate, but methylglyoxal and a fructose 1-phosphate- or fructose 1,6-bisphosphate-derived dihydroxyacetone phosphate fragment are key intermediates in DKFP production, detailed overview. The stereochemistry of the aldolase reaction is consistent with MJ1585 also functioning as the fructose 1,6-bisphosphate aldolase, EC 4.1.2.13, used in glycolysis. The MJ1585 aldolase does not catalyze the reaction of DL-lactaldehyde with fructose 1-phosphate, fructose 1,6-phosphate, or DHAP to form 6-deoxyallulose 1-phosphate or fuculose 1-phosphate
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
methylglyoxal + D-fructose 1,6-bisphosphate
D-glyceraldehyde 3-phosphate + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate
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-
-
?
methylglyoxal + D-fructose 1-phosphate
D-glyceraldehyde + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate
-
-
-
?
additional information
?
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the enzyme catalyzes the condensation of methylglyoxal with a dihydroxyacetone-phosphate fragment, which is derived from fructose 1-phosphate and/or fructose 1,6-bisphosphate, generating 6-deoxy-5-ketofructose 1-phosphate
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
methylglyoxal + D-fructose 1,6-bisphosphate
D-glyceraldehyde 3-phosphate + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate
Q58980
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-
-
?
methylglyoxal + D-fructose 1-phosphate
D-glyceraldehyde + 1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate
Q58980
-
-
-
?
additional information
?
-
Q58980
the enzyme catalyzes the condensation of methylglyoxal with a dihydroxyacetone-phosphate fragment, which is derived from fructose 1-phosphate and/or fructose 1,6-bisphosphate, generating 6-deoxy-5-ketofructose 1-phosphate
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pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
gene MJ1585, expression in Escherichia coli using primersforward 5'-GGTCATATGGGGATTTTTATG-3' and reverse 5'-GCTGGATCCTTATTTCCTATCTC-3'
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LINKS TO OTHER DATABASES (specific for EC-Number 2.2.1.11)
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