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Information on EC 2.1.4.2 - scyllo-inosamine-4-phosphate amidinotransferase and Organism(s) Streptomyces griseus and UniProt Accession P08078

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IUBMB Comments
1D-1-Guanidino-3-amino-1,3-dideoxy-scyllo-inositol 6-phosphate, streptamine phosphate and 2-deoxystreptamine phosphate can also act as acceptors; canavanine can act as donor.
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This record set is specific for:
Streptomyces griseus
UNIPROT: P08078
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Word Map
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  • 2.1.4.2
  • histone
  • heat-stable
  • enteroaggregative
  • diarrheic
  • sta
  • stool
  • succinylation
  • piglets
  • enterotoxin
  • farm
  • gnotobiotic
  • succinyltransferase
  • heat-labile
  • adhesins
  • colibacillosis
  • chilean
  • pathotypes
  • lncrnas
  • succinyl-coa
  • enterotoxigenic
The taxonomic range for the selected organisms is: Streptomyces griseus
The enzyme appears in selected viruses and cellular organisms
Synonyms
inosamine-p-amidinotransferase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
aminocyclitolamidinotransferase
-
-
arginine:Xamidinotransferase
-
-
inosamine-P-amidinotransferase
-
-
-
-
inosamine-phosphate amidinotransferase
-
-
-
-
L-arginine:inosamine phosphate amidinotransferase
-
-
-
-
L-arginine:inosamine-P-amidinotransferase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
amidine group transfer
-
-
-
-
SYSTEMATIC NAME
IUBMB Comments
L-arginine:1-amino-1-deoxy-scyllo-inositol-4-phosphate amidinotransferase
1D-1-Guanidino-3-amino-1,3-dideoxy-scyllo-inositol 6-phosphate, streptamine phosphate and 2-deoxystreptamine phosphate can also act as acceptors; canavanine can act as donor.
CAS REGISTRY NUMBER
COMMENTARY hide
52227-63-1
-
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-deoxystreptidine 6-phosphate + scyllo-inosaminephosphate
?
show the reaction diagram
-
-
-
?
arginine + 2-amino-2-deoxy-neo-inositol 5-phosphate
?
show the reaction diagram
-
-
-
?
arginine + 3-amino-3-deoxy-scyllo-inosamine 4-phosphate
?
show the reaction diagram
-
-
-
?
arginine + canaline
?
show the reaction diagram
-
-
-
?
arginine + hydroxylamine
ornithine + hydroxyguanidine
show the reaction diagram
-
-
-
?
arginine + inosamine phosphate
ornithine + ?
show the reaction diagram
-
-
-
-
?
arginine + N-amidinostreptamine 6-phosphate
?
show the reaction diagram
-
-
-
?
arginine + ornithine
?
show the reaction diagram
-
-
-
?
arginine + scyllo-inosamine 4-phosphate
?
show the reaction diagram
-
-
-
?
arginine + scyllo-inosamine 4-phosphate
ornithine + N-amidino-scyllo-inosamine-4-phosphate
show the reaction diagram
-
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
show the reaction diagram
L-arginine + 1-amino-1-deoxy-scyllo-inositol-4-phosphate
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
show the reaction diagram
L-canavanine + L-ornithine
L-canaline + L-arginine
show the reaction diagram
-
-
-
r
N-amidino-scyllo-inosamine 4-phosphate + scyllo-inosaminephosphate
?
show the reaction diagram
weak amidino donor
-
-
?
streptidine 6-phosphate + scyllo-inosaminephosphate
?
show the reaction diagram
-
-
-
?
streptidine phosphate + glycylglycine
?
show the reaction diagram
-
-
-
?
additional information
?
-
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
show the reaction diagram
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
STRB1_STRGR
347
0
38656
Swiss-Prot
-
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
42000
-
SDS-PAGE
68900
-
sedimentation analysis
80300
-
calculated molecular mass
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
tetragonal-bipyramidal shaped crystals, belonging to the tetragonal space group P4(3), a = b = 121.3 A, c = 63.74 A
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
recombinant enzyme
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
strain strB1, cloned as N-terminal hexa-histidine fusion protein
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Walker, J.B.
Amidinotranferases
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
9
497-509
1973
Streptomyces bikiniensis, Streptomyces bluensis, Streptomyces galbus, Streptomyces griseocarneus, Streptomyces griseus, Streptomyces humidus, Streptomyces hygroscopicus
-
Manually annotated by BRENDA team
Guthmiller, P.; Van Pilsum, J.F.; Boen, J.R.; McGuire, D.M.
Cloning and sequencing of rat kidney L-arginine:glycine amidinotransferase. Studies on the mechanism of regulation by growth hormone and creatine
J. Biol. Chem.
269
17556-17560
1994
Streptomyces griseus
Manually annotated by BRENDA team
Humm, A.; Fritsche, E.; Mann, K.; Goehl, M.; Huber, R.
Recombinant expression and isolation of human L-arginine:glycine amidinotransferase and identification of its active-site cysteine residue
Biochem. J.
322
771-776
1997
Streptomyces griseus
-
Manually annotated by BRENDA team
Bedekar, A.; Zink, R.M.; Sherman, D.H.; Line, T.V.; Van Pilsum, J.F.
The comparative amino acid sequences, substrate specificities and gene or cDNA nucleotide sequences of some prokaryote and eukaryote amidinotransferases: implications for evolution
Comp. Biochem. Physiol. B
119B
677-690
1998
Streptomyces bluensis (Q53814), Streptomyces consensus, Streptomyces galbus, Streptomyces galbus (Q54256), Streptomyces glaucescens strB1 (Q54258), Streptomyces glaucescens strB2 (Q54264), Streptomyces griseus, Streptomyces griseus (P08078), Streptomyces griseus ATCC 10137, Streptomyces griseus SPH, Streptomyces griseus strB2 (P29780)
-
Manually annotated by BRENDA team
Fritsche, E.; Humm, A.; Huber, R.
The ligand-induced structural changes of human L-arginine:glycine amidinotransferase. A mutational and crystallographic study
J. Biol. Chem.
274
3026-3032
1999
Streptomyces griseus
Manually annotated by BRENDA team
Walker, M.S.; Walker, J.B.
Enzymic studies on the biosynthesis of streptomycin
J. Biol. Chem.
241
1262-1270
1966
no activity in Streptomyces griseus, no activity in Streptomyces griseus ATCC 10971, Streptomyces bikiniensis, Streptomyces bluensis, Streptomyces griseocarneus, Streptomyces griseus, Streptomyces griseus W4, Streptomyces kanamyceticus
Manually annotated by BRENDA team
Tohyama, H.; Okami, Y.; Umezawa, H.
Nucleotide sequence of the streptomycinphosphotransferase and amidinotransferase from Streptomyces griseus
Nucleic acids Res.
15
1819-1833
1987
Streptomyces bikiniensis, Streptomyces griseus
Manually annotated by BRENDA team
Fritsche, E.; Bergner, A.; Humm, A.; Piepersberg, W.; Huber, R.
Crystal Structure of L-Arginine:Inosamine-Phosphate Amidinotransferase StrB1 from Streptomyces griseus: An Enzyme Involved in Streptomycin Biosynthesis
Biochemistry
37
17664-17672
1998
Streptomyces galbus, Streptomyces galbus strB1, Streptomyces glaucescens strB1 (Q54258), Streptomyces glaucescens strB2 (Q54264), Streptomyces griseus, Streptomyces griseus (P08078), Streptomyces griseus strB1 (P08078)
Manually annotated by BRENDA team