Information on EC 2.1.4.2 - scyllo-inosamine-4-phosphate amidinotransferase

for references in articles please use BRENDA:EC2.1.4.2
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Specify your search results
Select one or more organisms in this record:


The expected taxonomic range for this enzyme is: Streptomyces

EC NUMBER
COMMENTARY hide
2.1.4.2
-
RECOMMENDED NAME
GeneOntology No.
scyllo-inosamine-4-phosphate amidinotransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate = L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
show the reaction diagram
1D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol 6-phosphate, streptamine phosphate and 2-deoxystreptamine phosphate can also act as acceptors; canavanine can act as donor
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
amidine group transfer
-
-
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
streptomycin biosynthesis
-
-
Streptomycin biosynthesis
-
-
Biosynthesis of antibiotics
-
-
SYSTEMATIC NAME
IUBMB Comments
L-arginine:1-amino-1-deoxy-scyllo-inositol-4-phosphate amidinotransferase
1D-1-Guanidino-3-amino-1,3-dideoxy-scyllo-inositol 6-phosphate, streptamine phosphate and 2-deoxystreptamine phosphate can also act as acceptors; canavanine can act as donor.
CAS REGISTRY NUMBER
COMMENTARY hide
52227-63-1
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
no activity in Streptomyces griseus
-
-
-
Manually annotated by BRENDA team
no activity in Streptomyces griseus ATCC 10971
-
-
-
Manually annotated by BRENDA team
Streptomyces consensus
-
-
-
Manually annotated by BRENDA team
strB1, genebank acc. No.
SwissProt
Manually annotated by BRENDA team
strB2, genebank acc. No.
SwissProt
Manually annotated by BRENDA team
EMBL accession number
SwissProt
Manually annotated by BRENDA team
ATCC 12760
-
-
Manually annotated by BRENDA team
forma glebosus, ATCC 14607
-
-
Manually annotated by BRENDA team
ATCC 12853
-
-
Manually annotated by BRENDA team
ATCC 23265
-
-
Manually annotated by BRENDA team
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2-deoxystreptidine 6-phosphate + scyllo-inosaminephosphate
?
show the reaction diagram
-
-
-
?
arginine + 1,4-diaminobutylphosphonic acid
ornithine + ?
show the reaction diagram
-
-
-
-
?
arginine + 1-D-1,3-diamino-1,2,3-trideoxy-scyllo-inositol 6-phosphate
ornithine + ?
show the reaction diagram
-
-
-
-
?
arginine + 1-D-1,3-diamino-1,3-dideoxy-scyllo-inositol 6-phosphate
ornithine + ?
show the reaction diagram
-
-
-
-
?
arginine + 1-D-1-guanidino-3-amino-1,3-dideoxy-scyllo-inositol 6-phosphate
ornithine + ?
show the reaction diagram
-
-
-
-
?
arginine + 1-D-1-O-carbamoyl-3-amino-3-deoxy-scyllo-inositol 6-phosphate
ornithine + ?
show the reaction diagram
-
-
-
-
?
arginine + 2-amino-2-deoxy-neo-inositol 5-phosphate
?
show the reaction diagram
-
-
-
?
arginine + 2-amino-2-deoxy-neoinositol 5-phosphate
ornithine + ?
show the reaction diagram
arginine + 2-deoxystreptamine 6-phosphate
N-amidino-2-deoxystreptamine 6-phosphate + ornithine
show the reaction diagram
arginine + 2-deoxystreptidine
ornithine + ?
show the reaction diagram
arginine + 3-amino-3-deoxy-scyllo-inosamine 4-phosphate
?
show the reaction diagram
-
-
-
?
arginine + canaline
?
show the reaction diagram
-
-
-
?
arginine + hydroxylamine
ornithine + hydroxyguanidine
show the reaction diagram
arginine + inosamine phosphate
ornithine + ?
show the reaction diagram
-
-
-
-
?
arginine + N-amidinostreptamine 6-phosphate
?
show the reaction diagram
-
-
-
?
arginine + NH2OH
ornithine + ?
show the reaction diagram
-
-
-
-
?
arginine + ornithine
?
show the reaction diagram
-
-
-
?
arginine + scyllo-inosamine 4-phosphate
?
show the reaction diagram
-
-
-
?
arginine + scyllo-inosamine 4-phosphate
ornithine + N-amidino-scyllo-inosamine-4-phosphate
show the reaction diagram
arginine + streptamine 6-phosphate
ornithine + N-amidinostreptamine 6-phosphate
show the reaction diagram
-
-
-
-
?
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
show the reaction diagram
L-arginine + 1-amino-1-deoxy-scyllo-inositol-4-phosphate
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
show the reaction diagram
L-canavanine + L-ornithine
L-canaline + L-arginine
show the reaction diagram
N-amidino-scyllo-inosamine 4-phosphate + scyllo-inosaminephosphate
?
show the reaction diagram
weak amidino donor
-
-
?
streptidine 6-phosphate + scyllo-inosaminephosphate
?
show the reaction diagram
-
-
-
?
streptidine phosphate + glycylglycine
?
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate
show the reaction diagram
INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
cystamine
cystine
formamidine disulfidedihydrochloride
ornithine
p-chloromercuribenzoate
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
42000
-
SDS-PAGE
68900
-
sedimentation analysis
80300
-
calculated molecular mass
Crystallization/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
tetragonal-bipyramidal shaped crystals, belonging to the tetragonal space group P4(3), a = b = 121.3 A, c = 63.74 A
Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
strain strB1, cloned as N-terminal hexa-histidine fusion protein