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canavanine + ornithine
arginine + canaline
L-arginine + glycine
L-ornithine + guanidinoacetate
L-ornithine + guanidinoacetate
L-arginine + glycine
arginine + 3-aminopropionic acid
3-guanidinopropionic acid + ornithine
-
-
-
-
?
arginine + 4-aminobutyric acid
4-guanidinobutyric acid + ornithine
-
-
-
-
?
arginine + 5-aminovaleric acid
5-guanidinovaleric acid + ornithine
-
-
-
-
?
arginine + ethanolamine
2-guanidinoethanol + ornithine
-
-
-
-
?
arginine + hydroxylamine
ornithine + hydroxyguanidine
-
-
-
-
?
arginine + lysine
homoarginine + ornithine
-
-
-
-
?
arginine + ornithine
ornithine + arginine
-
-
-
-
?
arginine + taurine
2-guanidinoethanesulfonic acid + ornithine
-
-
-
-
?
canavanine + canaline
canaline + canavanine
-
-
-
-
?
canavanine + glycine
guanidinoacetate + canaline
-
-
-
-
r
canavanine + hydroxylamine
canaline + hydroxyguanidine
-
-
-
-
?
canavanine + ornithine
arginine + canaline
glycine + guanidinoacetate
guanidinoacetate + glycine
-
-
-
-
r
guanidinoacetate + canaline
glycine + canavanine
-
-
-
-
?
guanidinoacetate + hydroxylamine
hydroxyguanidine + glycine
-
-
-
-
?
guanidinoacetate + ornithine
glycine + arginine
-
-
-
-
?
homoarginine + glycine
homoornithine + guanidinoacetate
-
-
-
-
r
L-arginine + glycine
L-ornithine + guanidinoacetate
additional information
?
-
-
L-glutamic acid, L-aspartic acid and histidine are no substrates
-
-
?
canavanine + ornithine
arginine + canaline
-
-
-
r
canavanine + ornithine
arginine + canaline
-
-
-
r
L-arginine + glycine
L-ornithine + guanidinoacetate
-
-
-
?
L-arginine + glycine
L-ornithine + guanidinoacetate
first reaction in the de novo biosynthesis of creatine
-
-
r
L-arginine + glycine
L-ornithine + guanidinoacetate
first reaction in the de novo biosynthesis of creatine
-
-
r
L-ornithine + guanidinoacetate
L-arginine + glycine
-
-
-
r
L-ornithine + guanidinoacetate
L-arginine + glycine
-
-
-
r
canavanine + ornithine
arginine + canaline
-
-
485961, 485964, 485965, 485966, 485967, 485968, 485969, 485970, 485971, 485972, 485974, 485975 -
-
r
canavanine + ornithine
arginine + canaline
-
-
-
r
canavanine + ornithine
arginine + canaline
-
-
-
-
r
L-arginine + glycine
L-ornithine + guanidinoacetate
-
-
-
-
?
L-arginine + glycine
L-ornithine + guanidinoacetate
-
-
485961, 485964, 485965, 485966, 485967, 485968, 485969, 485970, 485971, 485972, 485974, 485975 -
-
r
L-arginine + glycine
L-ornithine + guanidinoacetate
-
-
-
r
L-arginine + glycine
L-ornithine + guanidinoacetate
-
-
-
-
r
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Walker, J.B.
Studies on the mechanism of action of kidney transamidinase
J. Biol. Chem.
224
57-66
1957
Rattus norvegicus, Sus scrofa
brenda
Walker, J.B.
Amidinotranferases
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
9
497-509
1973
Bos taurus, Canavalia ensiformis, Gallus gallus, Homo sapiens, Lacerta sp., Rana sp., Rattus norvegicus, Sus scrofa
-
brenda
Dubach, U.C.
Transamidinase
Methods Enzym. Anal. , 3rd Ed. (Bergmeyer, H. U. , ed. )
1
740-743
1974
Homo sapiens, Rattus norvegicus, Sus scrofa
-
brenda
McGuire, D.M.; Tormanen, C.D.; Segal, I.S.; Van Pilsum, J.F.
The effect of growth hormone and thyroxine on the amount of L-arginine:glycine amidinotransferase in kidneys of hypophysectomized rats
J. Biol. Chem.
255
1152-1159
1980
Rattus norvegicus, Sus scrofa
brenda
Sipilae, I.
Inhibition of arginine-glycine amidinotransferase by ornithine. A possible mechanism for the muscular and chorioretinal atrophies in gyrate atrophy of the choroid and retina with hyperornithinemia
Biochim. Biophys. Acta
613
79-84
1980
Gallus gallus, Homo sapiens, Rattus norvegicus, Rattus norvegicus Sprague-Dawley, Sus scrofa
brenda
Gross, M.D.; Eggen, M.A.; Simon, A.M.; Van Pilsum, J.F.
The purification and charcterization of human kidney L-arginine:glycine amidinotransferase
Arch. Biochem. Biophys.
251
747-755
1986
Homo sapiens, Rattus norvegicus, Sus scrofa
brenda
Gross, M.D.; Simon, A.M.; Jenny, R.J.; Gray, E.D.; McGuire, D.M.; Van Pilsum, J.F.
Multiple forms of rat kidney L-arginine:glycine amidinotransferase
J. Nutr.
118
1403-1409
1988
Rattus norvegicus
brenda
Raman Rao, S.V.R.; Indira, K.
Effects of guanidine hydrochloride on catalytic efficiency of glycine amidinotransferase of rat
Biochem. Mol. Biol. Int.
29
63-67
1993
Rattus norvegicus, Rattus norvegicus Wistar
brenda
Guthmiller, P.; Van Pilsum, J.F.; Boen, J.R.; McGuire, D.M.
Cloning and sequencing of rat kidney L-arginine:glycine amidinotransferase. Studies on the mechanism of regulation by growth hormone and creatine
J. Biol. Chem.
269
17556-17560
1994
Homo sapiens, Rattus norvegicus, Sus scrofa
brenda
Watanabe, Y.; Van Pilsum, J.F.; Yokoi, I.; Mori, A.
Synthesis of neuroactive guanidino compounds by rat kidney L-arginine:glycine amidinotransferase
Life Sci.
55
351-358
1994
Felis domestica, Homo sapiens, Mus musculus, Oryctolagus cuniculus, Rattus norvegicus, Rattus norvegicus Sprague-Dawley
brenda
Humm, A.; Fritsche, E.; Mann, K.; Goehl, M.; Huber, R.
Recombinant expression and isolation of human L-arginine:glycine amidinotransferase and identification of its active-site cysteine residue
Biochem. J.
322
771-776
1997
Homo sapiens, Homo sapiens (P50440), Sus scrofa, Rattus norvegicus (P50442)
-
brenda
Humm, A.; Fritsche, E.; Steinbacher, S.
Structure and reaction mechanism of L-arginine:glycine amidinotransferase
Biol. Chem.
378
193-197
1997
Homo sapiens, Rattus norvegicus, Sus scrofa
brenda
Humm, A.; Fritsche, E.; Steinbacher, S.; Huber, R.
Crystal structure and mechanism of human L-arginine:glycine amidinotransferase: a mitochondrial enzyme involved in creatine biosynthesis
EMBO J.
16
3373-3385
1997
Homo sapiens, Homo sapiens (P50440), Rattus norvegicus, Rattus norvegicus (P50442), Sus scrofa
brenda
Bedekar, A.; Zink, R.M.; Sherman, D.H.; Line, T.V.; Van Pilsum, J.F.
The comparative amino acid sequences, substrate specificities and gene or cDNA nucleotide sequences of some prokaryote and eukaryote amidinotransferases: implications for evolution
Comp. Biochem. Physiol. B
119B
677-690
1998
Homo sapiens, Lampetra planeri, no activity in Streptomyces sp., Rattus norvegicus, Sus scrofa
-
brenda
Zhu, Y.; Evans, M.I.
Estrogen modulates the expression of L-arginine:glycine amidinotransferase in chick liver
Mol. Cell. Biochem.
221
139-145
2001
Gallus gallus, Gallus gallus (Q9I9K9), Homo sapiens, Rana sp., Rattus norvegicus, Sus scrofa
brenda
Braissant, O.; Cagnon, L.; Monnet-Tschudi, F.; Speer, O.; Wallimann, T.; Honegger, P.; Henry, H.
Ammonium alters creatine transport and synthesis in a 3D culture of developing brain cells, resulting in secondary cerebral creatine deficiency
Eur. J. Neurosci.
27
1673-1685
2008
Rattus norvegicus (P50442)
brenda
Braissant, O.; Bachmann, C.; Henry, H.
Expression and function of AGAT, GAMT and CT1 in the mammalian brain
Subcell. Biochem.
46
67-81
2007
Rattus norvegicus
brenda