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Information on EC 2.1.2.9 - methionyl-tRNA formyltransferase and Organism(s) Saccharomyces cerevisiae and UniProt Accession P32785

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Saccharomyces cerevisiae
UNIPROT: P32785 not found.
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The taxonomic range for the selected organisms is: Saccharomyces cerevisiae
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
mtfmt, methionyl-trna formyltransferase, methionyl-trna transformylase, mitochondrial methionyl-trna formyltransferase, methionyl-trna-formyltransferase, fmt1p, formyl-methionyl transferase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
FMT
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formylmethionyl-transfer ribonucleic synthetase
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methionyl ribonucleic formyltransferase
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methionyl-transfer ribonucleic transformylase
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methionyl-transfer RNA transformylase
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methionyl-tRNA formyltransferase
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methionyl-tRNA Met formyltransferase
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methionyl-tRNA transformylase
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methionyl-tRNA-Formyltransferase
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methyltransferase, methionyl-transfer ribonucleate
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MTF
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N10-formyltetrahydrofolic-methionyl-transfer ribonucleic transformylase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
formyl group transfer
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SYSTEMATIC NAME
IUBMB Comments
10-formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase
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CAS REGISTRY NUMBER
COMMENTARY hide
9015-76-3
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
10-formyltetrahydrofolate + L-methionyl-tRNAfMet + H2O
tetrahydrofolate + N-formylmethionyl-tRNAfMet
show the reaction diagram
10-formyltetrahydrofolate + E. coli L-isoleucyl-tRNAfMet
tetrahydrofolate + E. coli N-formylisoleucyl-tRNAfMet
show the reaction diagram
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-
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r
10-formyltetrahydrofolate + E. coli L-methionyl-tRNAfMet
tetrahydrofolate + E. coli N-formylmethionyl-tRNAfMet
show the reaction diagram
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-
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r
10-formyltetrahydrofolate + E. coli L-methionyl-tRNAfMet
tetrahydrofolate + N-formylmethionyl-tRNAfMet
show the reaction diagram
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r
10-formyltetrahydrofolate + E. coli L-valyl-tRNAfMet
tetrahydrofolate + E. coli N-formylvalyl-tRNAfMet
show the reaction diagram
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-
-
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r
10-formyltetrahydrofolate + E. coli L-valyl-tRNAfMet
tetrahydrofolate + N-formylvalyl-tRNAfMet
show the reaction diagram
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-
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r
10-formyltetrahydrofolate + isoleucyl-tRNAfMet + H2O
tetrahydrofolate + N-formylisoleucyl-tRNAfMet
show the reaction diagram
10-formyltetrahydrofolate + L-isoleucyl-tRNAfMet
tetrahydrofolate + N-formylisoleucyl-tRNAfMet
show the reaction diagram
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r
10-formyltetrahydrofolate + L-methionyl-tRNAfMet
tetrahydrofolate + N-formylmethionyl-tRNAfMet
show the reaction diagram
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?
10-formyltetrahydrofolate + L-methionyl-tRNAfMet + H2O
tetrahydrofolate + N-formylmethionyl-tRNAfMet
show the reaction diagram
10-formyltetrahydrofolate + valyl-tRNAfMet + H2O
tetrahydrofolate + N-formylvalyl-tRNAfMet
show the reaction diagram
additional information
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
10-formyltetrahydrofolate + L-methionyl-tRNAfMet + H2O
tetrahydrofolate + N-formylmethionyl-tRNAfMet
show the reaction diagram
the dispensable mitochondrial methionyl-tRNAformyltransferase, Fmt1p, is essential for respiratory growth in the absence of Rsm28p
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?
10-formyltetrahydrofolate + L-methionyl-tRNAfMet
tetrahydrofolate + N-formylmethionyl-tRNAfMet
show the reaction diagram
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?
10-formyltetrahydrofolate + L-methionyl-tRNAfMet + H2O
tetrahydrofolate + N-formylmethionyl-tRNAfMet
show the reaction diagram
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initiation of protein synthesis in mitochondria
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?
additional information
?
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mitochondrial protein synthesis
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?
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0003
E. coli L-isoleucyl-tRNAfMet, E. coli L-methionyl-tRNAfMet
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0.0005
E. coli L-valyl-tRNAfMet
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additional information
additional information
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kinetic parameters of the formylation of various mutant methionyl-tRNAs
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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.13
E. coli L-methionyl-tRNAfMet
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0.0005
L-isoleucyl-tRNAfMet
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0.009
L-valyl-tRNAfMet
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additional information
additional information
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kinetic parameters of the formylation of various mutant methionyl-tRNAs
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TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
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despite deletion of gene for methionyl-tRNA still initiation of mitochondrial protein syntesis by nonformylatet Met-tRNA
physiological function
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influence on protein synthesis in mitochondria and chloroplasts by producing a formylated initiator methionyl-tRNA
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
deltafmt1
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in combination with mutation of AEP3, a gene encodes for a peripheral mitochondrial inner membrane protein, respiratory defect
additional information
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
purification of recombinant enzyme, expressed in Escherichia coli
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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
cloning and expression of the gene encoding mitochondrial enzyme in Escherichia coli Pal13Tr-pMAF and in yeast, several strains lacking gene exhibit in minimal medium a thermosensitive respiratory growth and a slower growth rate
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Halbreich, A.; Rabinowitz, M.
Isolation of Saccharomyces cerevisiae mitochondrial formyltetrahydrofolic acid:methionyl-tRNA transformylase and the hybridization of mitochondrial fMet-tRNA with mitochondrial DNA
Proc. Natl. Acad. Sci. USA
68
294-298
1971
Saccharomyces cerevisiae, Saccharomyces cerevisiae D243-2B-R1
Manually annotated by BRENDA team
Vial, L.; Gomez, P.; Panvert, M.; Schmitt, E.; Blanquet, S.; Mechulam, Y.
Mitochondrial methionyl-tRNAfMet formyltransferase from Saccharomyces cerevisiae: Gene disruption and tRNA substrate specificity
Biochemistry
42
932-939
2003
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Williams, E.H.; Butler, C.A.; Bonnefoy, N.; Fox, T.D.
Translation initiation in Saccharomyces cerevisiae mitochondria: functionalinteractions among mitochondrial ribosomal protein Rsm28p, initiation factor 2, methionyl-tRNA-formyltransferase and novel protein Rmd9p
Genetics
175
1117-1126
2007
Saccharomyces cerevisiae, Saccharomyces cerevisiae (P32785)
Manually annotated by BRENDA team
Lee, C.; Tibbetts, A.S.; Kramer, G.; Appling, D.R.
Yeast AEP3p is an accessory factor in initiation of mitochondrial translation
J. Biol. Chem.
284
34116-34125
2009
Saccharomyces cerevisiae
Manually annotated by BRENDA team
Franco, L.V.R.; Moda, B.S.; Soares, M.A.K.M.; Barros, M.H.
Msc6p is required for mitochondrial translation initiation in the absence of formylated Met-tRNAfMet
FEBS J.
286
1407-1419
2019
Saccharomyces cerevisiae
Manually annotated by BRENDA team