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Information on EC 2.1.2.5 - glutamate formimidoyltransferase
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2.1.2.5 glutamate formimidoyltransferaseIUBMB Comments
The enzyme also catalyses formyl transfer from 5-formyltetrahydrofolate to L-glutamate. In eukaryotes, it occurs as a bifunctional enzyme that also has formimidoyltetrahydrofolate cyclodeaminase (EC 4.3.1.4) activity.
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Word Map
- 2.1.2.5
-
octameric
-
megaloblastic
-
aciduria
-
formylation
-
folinic
- polyglutamate
-
figlu
-
monofunctional
-
polyglutamylated
- methylenetetrahydrofolate
- histidase
- medicine
- molecular biology
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Reaction Schemes
Synonyms
formiminotransferase-cyclodeaminase, glutamate formiminotransferase, glutamate formyltransferase, formiminoglutamic acid formiminotransferase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
EC 2.1.2.6
-
-
formerly
-
formiminoglutamic acid formiminotransferase
-
-
-
-
formiminoglutamic acid transferase
-
-
-
-
formiminoglutamic formiminotransferase
-
-
-
-
formiminotransferase, glutamate
-
-
-
-
FTCD
glutamate formiminotransferase
glutamate formyltransferase
-
-
-
-
glutamate formiminotransferase
-
-
-
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate
5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate
mechanism
-
5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate
mechanism
-
5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate
catalytic mechanism
-
5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate
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-
-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
formimino group transfer
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
BRENDA
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SYSTEMATIC NAME
IUBMB Comments
5-formimidoyltetrahydrofolate:L-glutamate N-formimidoyltransferase
The enzyme also catalyses formyl transfer from 5-formyltetrahydrofolate to L-glutamate. In eukaryotes, it occurs as a bifunctional enzyme that also has formimidoyltetrahydrofolate cyclodeaminase (EC 4.3.1.4) activity.
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CAS REGISTRY NUMBER
COMMENTARY
9032-83-1
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(6R,S)-tetrahydrofolate + N-formimidoyl-L-glutamate
5-formimidoyltetrahydrofolate + L-glutamate
-
-
-
-
r
(6S)-tetrahydropteroylpentaglutamate + N-formimidoyl-L-glutamate
5-formiminotetrahydropteroylpentaglutamate + L-glutamate
-
-
-
-
r
N-formimidoyl-L-Glu-L-Glu-L-Glu + tetrahydrofolate
N-formimidoyl-L-Glu-L-Glu + 5-formimidoyltetrahydrofolate
tetrahydropteroic acid + N-formimino-L-glutamate
5-formiminotetrahydropteroic acid + L-glutamate
-
tetrahydropteroic acid is a good alternate substrate
-
?
tetrahydropteroylpentaglutamate + N-formimino-L-glutamate
5-formiminotetrahydropteroylpentaglutamate + L-glutamate
5-formimidoyltetrahydrofolate + L-glutamate
tetrahydrofolate + N-formimidoyl-L-glutamate
-
-
-
-
?
5-formimidoyltetrahydrofolate + L-glutamate
tetrahydrofolate + N-formimidoyl-L-glutamate
-
-
-
-
?
5-formimidoyltetrahydrofolate + L-glutamate
tetrahydrofolate + N-formimidoyl-L-glutamate
-
-
-
-
?
5-formimidoyltetrahydrofolate + L-glutamate
tetrahydrofolate + N-formimidoyl-L-glutamate
-
-
-
-
?
5-formimidoyltetrahydrofolate + L-glutamate
tetrahydrofolate + N-formimidoyl-L-glutamate
-
-
-
-
?
5-formimidoyltetrahydrofolate + L-glutamate
tetrahydrofolate + N-formimidoyl-L-glutamate
-
-
-
-
?
5-formimidoyltetrahydrofolate + L-glutamate
tetrahydrofolate + N-formimidoyl-L-glutamate
-
-
-
-
?
5-formyltetrahydrofolate + L-glutamate
N-formyl-L-glutamate + tetrahydrofolate
-
formation of N5-formyltetrahydrofolate + L-glutamate
-
?
5-formyltetrahydrofolate + L-glutamate
N-formyl-L-glutamate + tetrahydrofolate
-
N5-formyl group of Citrovorum factor, specific with respect to substrates, formation of N5-formiminotetrahydrofolate and anhydro-Citrovorum factor precedes the formation of the N10-formyl folate derivatives
-
r
5-formyltetrahydrofolate + L-glutamate
N-formyl-L-glutamate + tetrahydrofolate
-
folinic acid binding site, preference for (6R)-enantiomer of folinic acid
-
-
?
N-formimidoyl-L-Glu-L-Glu-L-Glu + tetrahydrofolate
N-formimidoyl-L-Glu-L-Glu + 5-formimidoyltetrahydrofolate
-
-
-
-
?
N-formimidoyl-L-Glu-L-Glu-L-Glu + tetrahydrofolate
N-formimidoyl-L-Glu-L-Glu + 5-formimidoyltetrahydrofolate
-
-
-
-
?
N-formimidoyl-L-Glu-L-Glu-L-Glu + tetrahydrofolate
N-formimidoyl-L-Glu-L-Glu + 5-formimidoyltetrahydrofolate
-
-
-
-
?
N-formimidoyl-L-Glu-L-Glu-L-Glu + tetrahydrofolate
N-formimidoyl-L-Glu-L-Glu + 5-formimidoyltetrahydrofolate
-
-
-
-
?
N-formimidoyl-L-Glu-L-Glu-L-Glu + tetrahydrofolate
N-formimidoyl-L-Glu-L-Glu + 5-formimidoyltetrahydrofolate
-
-
-
-
?
N-formimidoyl-L-Glu-L-Glu-L-Glu + tetrahydrofolate
N-formimidoyl-L-Glu-L-Glu + 5-formimidoyltetrahydrofolate
-
-
-
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
histidine degradation
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
histidine degradation
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
histidine degradation
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
in addition to its enzymatic activity enzyme may have a second physiological function in mediating interaction of Golgi-derived membranes with microtubules
-
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
histidine degradation
-
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
histidine degradation
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
histidine degradation
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
histidine degradation
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
bifunctional formiminotransferase cyclodeaminase, 58K, is associated with the cytoplasmatic surface of the Golgi apparatus in vivo
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
bifunctional formiminotransferase cyclodeaminase, 58K, is associated with the cytoplasmatic surface of the Golgi apparatus in vivo
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
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metabolic enzyme involved in the conversion of histidine to glutamic acid
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
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histidine metabolism pathway, reaction occurs in vivo within the soluble phase of cytoplasm
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
physiological substrate is (6S)-tetrahydrofolate
natural biosynthetic product is N5-formiminotetrahydrofolate
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
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enzyme serves as additional entry point for the folate pool in liver
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
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histidine degradation
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
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histidine degradation
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
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histidine degradation
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
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histidine degradation
natural biosynthetic product is N5-formiminotetrahydrofolate
?
tetrahydrofolate + N-formimidoyl-L-glutamate
5-formimidoyltetrahydrofolate + L-glutamate
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-
-
?
tetrahydrofolate + N-formimidoyl-L-glutamate
5-formimidoyltetrahydrofolate + L-glutamate
FTCD in the centrosome may be associated with polyglutamylated residues of centriole microtubules and may play a role in providing centrioles with glutamate produced by cyclodeaminase domains of FTCD
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-
?
tetrahydrofolate + N-formimino-L-glutamate
5-formiminotetrahydrofolate + L-glutamate
-
-
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r
tetrahydrofolate + N-formimino-L-glutamate
5-formiminotetrahydrofolate + L-glutamate
-
alpha-L-formamidinoglutaric acid, absolute specificity with regard to the isomers of tetrahydrofolate at position 6, reduced pteroylaspartic acid and reduced pteroyltriglutamic acid can replace tetrahydrofolate
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r
tetrahydrofolate + N-formimino-L-glutamate
5-formiminotetrahydrofolate + L-glutamate
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specificity, equilibrium lies far on formation of formiminotetrahydrofolate and glutamate
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r
tetrahydrofolate + N-formimino-L-glutamate
5-formiminotetrahydrofolate + L-glutamate
-
-
-
r
tetrahydrofolate + N-formimino-L-glutamate
5-formiminotetrahydrofolate + L-glutamate
-
-
-
r
tetrahydrofolate + N-formimino-L-glutamate
5-formiminotetrahydrofolate + L-glutamate
-
-
?
tetrahydrofolate + N-formimino-L-glutamate
5-formiminotetrahydrofolate + L-glutamate
-
-
-
r
tetrahydrofolate + N-formimino-L-glutamate
5-formiminotetrahydrofolate + L-glutamate
-
-
-
?
tetrahydrofolate + N-formimino-L-glutamate
5-formiminotetrahydrofolate + L-glutamate
-
-
-
r
tetrahydrofolate + N-formimino-L-glutamate
5-formiminotetrahydrofolate + L-glutamate
-
-
-
r
tetrahydrofolate + N-formimino-L-glutamate
5-formiminotetrahydrofolate + L-glutamate
-
-
-
?
tetrahydrofolate + N-formimino-L-glutamate
5-formiminotetrahydrofolate + L-glutamate
-
-
-
?
tetrahydrofolate + N-formimino-L-glutamate
5-formiminotetrahydrofolate + L-glutamate
-
transfer of a single carbon from formiminoglutamate to tetrahydrofolate, product is 5-formiminotetrahydrofolate
-
?
tetrahydrofolate + N-formimino-L-glutamate
5-formiminotetrahydrofolate + L-glutamate
-
-
-
?
tetrahydrofolate + N-formimino-L-glutamate
5-formiminotetrahydrofolate + L-glutamate
-
-
?
tetrahydrofolate + N-formimino-L-glutamate
5-formiminotetrahydrofolate + L-glutamate
-
relatively specific for formiminoglutamic acid
-
r
tetrahydrofolate + N-formimino-L-glutamate
5-formiminotetrahydrofolate + L-glutamate
-
mode of substrate binding and channeling, 3 glutamate-binding sites, mechanism for product release, His-82 may act as catalytic base required for the formiminotransferase mechanism, an electrostatic tunnel through the width of the domain facilitates recognition of the substrates
labile 5-formiminotetrahydrofolate product
?
tetrahydrofolate + N-formimino-L-glutamate
5-formiminotetrahydrofolate + L-glutamate
-
tetrahydropteroic acid can replace tetrahydrofolate
-
?
tetrahydrofolate + N-formimino-L-glutamate
5-formiminotetrahydrofolate + L-glutamate
-
transfer of a single carbon from formiminoglutamate to tetrahydrofolate, product is 5-formiminotetrahydrofolate
-
?
tetrahydropteroylpentaglutamate + N-formimino-L-glutamate
5-formiminotetrahydropteroylpentaglutamate + L-glutamate
-
bifunctional formiminotetrahydrofolate cyclodeaminase: preference for polyglutamylated substrates, polyglutamylation improves binding of both the folate substrates and formiminoglutamate
-
?
tetrahydropteroylpentaglutamate + N-formimino-L-glutamate
5-formiminotetrahydropteroylpentaglutamate + L-glutamate
-
optimum number of glutamates for channeling of the product to the cyclodeaminase domain is five
-
?
additional information
?
-
-
primary reaction of the over-all reaction formimino-L-glutamate + tetrahydrofolate = N10-formyltetrahydrofolate + glutamate + NH3
-
-
?
additional information
?
-
-
primary reaction of the over-all reaction formimino-L-glutamate + tetrahydrofolate = N10-formyltetrahydrofolate + glutamate + NH3
-
-
?
additional information
?
-
-
not: formamidinoacetic acid, formylisoglutamine, formylglutamine, acetylglutamic acid
-
-
?
additional information
?
-
-
formation of glutamic acid is reversible while formation of ammonia is not
-
-
?
additional information
?
-
p60: bifunctional formiminotransferase cyclodeaminase, can mediate interaction between trans-Golgi network derived vesicles and microtubule in vitro, p60 may bind to the polyglutamate on microtubules, globular hydrophilic protein
-
-
?
additional information
?
-
-
p60: bifunctional formiminotransferase cyclodeaminase, can mediate interaction between trans-Golgi network derived vesicles and microtubule in vitro, p60 may bind to the polyglutamate on microtubules, globular hydrophilic protein
-
-
?
additional information
?
-
-
58K: formiminotransferase cyclodeaminase, bifunctional enzyme catalyzing two consecutive steps in the modification of tetrahydrofolate to 5,10-methenyl tetrahydrofolate
-
-
?
additional information
?
-
-
58K: formiminotransferase cyclodeaminase, bifunctional enzyme catalyzing two consecutive steps in the modification of tetrahydrofolate to 5,10-methenyl tetrahydrofolate
-
-
?
additional information
?
-
FTCD: bifunctional enzyme with 5-formiminotetrahydrofolate:L-glutamate N-formiminotransferase activity, EC 2.1.2.5, and formiminotetrahydrofolate cyclodeaminase activity, EC 4.3.1.4
-
-
?
additional information
?
-
-
primary reaction of the over-all reaction formimino-L-glutamate + tetrahydrofolate = N10-formyltetrahydrofolate + glutamate + NH3
-
-
?
additional information
?
-
-
not: formiminoglycine, very poor substrates: formimino-L-aspartic acid, formyl-L-glutamic acid
-
-
?
additional information
?
-
-
twin enzyme EC 2.1.2.5 and formiminotetrahydrofolate cyclodeaminase EC 4.3.1.4: enzyme system forming N5,10-methenyltetrahydrofolate from formiminoglutamate and tetrahydrofolate
-
-
?
additional information
?
-
-
FTCD: bifunctional enzyme formiminotransferase cyclodeaminase efficiently channels polyglutamated folate between catalytic sites, only the octamer is able to directly transfer pentaglutamated intermediate between active sites, subunit structure
-
-
?
additional information
?
-
-
FTCD: bifunctional enzyme formiminotransferase cyclodeaminase, EC 2.1.2.5 and EC 4.3.1.4, formiminotransferase domain: N-terminal 326 residues, detailed structure
-
-
?
additional information
?
-
-
molecular enzyme complex with formiminotransferase and cyclodeaminase activity, EC 2.1.2.5 and EC 4.3.1.4, both activities are contained in a single polypeptide chain, no substrate: formiminoaspartate
-
-
?
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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
tetrahydrofolate + N-formimidoyl-L-glutamate
5-formimidoyltetrahydrofolate + L-glutamate
FTCD in the centrosome may be associated with polyglutamylated residues of centriole microtubules and may play a role in providing centrioles with glutamate produced by cyclodeaminase domains of FTCD
-
-
?
5-formimidoyltetrahydrofolate + L-glutamate
tetrahydrofolate + N-formimidoyl-L-glutamate
-
-
-
-
?
5-formimidoyltetrahydrofolate + L-glutamate
tetrahydrofolate + N-formimidoyl-L-glutamate
-
-
-
-
?
5-formimidoyltetrahydrofolate + L-glutamate
tetrahydrofolate + N-formimidoyl-L-glutamate
-
-
-
-
?
5-formimidoyltetrahydrofolate + L-glutamate
tetrahydrofolate + N-formimidoyl-L-glutamate
-
-
-
-
?
5-formimidoyltetrahydrofolate + L-glutamate
tetrahydrofolate + N-formimidoyl-L-glutamate
-
-
-
-
?
5-formimidoyltetrahydrofolate + L-glutamate
tetrahydrofolate + N-formimidoyl-L-glutamate
-
-
-
-
?
5-formimidoyltetrahydrofolate + L-glutamate
tetrahydrofolate + N-formimidoyl-L-glutamate
-
-
-
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
histidine degradation
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
histidine degradation
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
histidine degradation
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
in addition to its enzymatic activity enzyme may have a second physiological function in mediating interaction of Golgi-derived membranes with microtubules
-
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
histidine degradation
-
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
histidine degradation
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
histidine degradation
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
histidine degradation
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
bifunctional formiminotransferase cyclodeaminase, 58K, is associated with the cytoplasmatic surface of the Golgi apparatus in vivo
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
bifunctional formiminotransferase cyclodeaminase, 58K, is associated with the cytoplasmatic surface of the Golgi apparatus in vivo
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
metabolic enzyme involved in the conversion of histidine to glutamic acid
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
histidine metabolism pathway, reaction occurs in vivo within the soluble phase of cytoplasm
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
physiological substrate is (6S)-tetrahydrofolate
natural biosynthetic product is N5-formiminotetrahydrofolate
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
enzyme serves as additional entry point for the folate pool in liver
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
histidine degradation
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
histidine degradation
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
histidine degradation
-
?
N-formiminoglutamate + tetrahydrofolate
5-formiminotetrahydrofolate + L-glutamate
-
histidine degradation
natural biosynthetic product is N5-formiminotetrahydrofolate
?
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COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
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METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
NH4+
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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Ca2+
-
0.1 M, strong inhibition in decreasing order: La3+, Ca2+, Mg2+, Li+, Na+, K+
La3+
-
0.1 M, strong inhibition in decreasing order: La3+, Ca2+, Mg2+, Li+, Na+, K+
Li+
-
0.1 M, strong inhibition in decreasing order: La3+, Ca2+, Mg2+, Li+, Na+, K+
Mg2+
-
0.1 M, strong inhibition in decreasing order: La3+, Ca2+, Mg2+, Li+, Na+, K+
Na+
-
0.1 M, strong inhibition in decreasing order: La3+, Ca2+, Mg2+, Li+, Na+, K+
proteinase K
-
degradation of bifunctional formiminotransferase cyclodeaminase
-
additional information
-
not inhibited by formamidinoacetic acid, gamma-benzyl-formamidinoglutaric acid, formic acid, formamide, formylglutamine, formylisoglutamine
-
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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
glutamate formimidoyltransferase deficiency
Characteristics and outcomes of patients with formiminoglutamic aciduria detected through newborn screening.
glutamate formimidoyltransferase deficiency
Cloning and characterization of human FTCD on 21q22.3, a candidate gene for glutamate formiminotransferase deficiency.
glutamate formimidoyltransferase deficiency
Falsely elevated C4-carnitine as expression of glutamate formiminotransferase deficiency in tandem mass spectrometry newborn screening.
glutamate formimidoyltransferase deficiency
Formiminoglutamic aciduria in a slightly retarded boy with chronic obstructive lung disease.
glutamate formimidoyltransferase deficiency
Structure of the bifunctional and Golgi-associated formiminotransferase cyclodeaminase octamer.
glutamate formimidoyltransferase deficiency
The molecular basis of glutamate formiminotransferase deficiency.
glutamate formimidoyltransferase deficiency
Update and new concepts in vitamin responsive disorders of folate transport and metabolism.
Hepatitis, Autoimmune
Characterization of the antigenicity of the formiminotransferase-cyclodeaminase in type 2 autoimmune hepatitis.
Hepatitis, Autoimmune
Structure of the bifunctional and Golgi-associated formiminotransferase cyclodeaminase octamer.
Malnutrition
Resistance of liver formiminoglutamic acid transferase to experimental protein malnutrition in weanling rats.
methionine synthase deficiency
Update and new concepts in vitamin responsive disorders of folate transport and metabolism.
methylenetetrahydrofolate dehydrogenase (nad+) deficiency
Update and new concepts in vitamin responsive disorders of folate transport and metabolism.
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.111
(6R,S)-tetrahydrofolate
-
recombinant His-tagged formiminotransferase domain
0.141
(6R,S)-tetrahydrofolate
-
wild-type bifunctional formiminotransferase cyclodeaminase
0.148
(6R,S)-tetrahydrofolate
-
recombinant His-tagged bifunctional formiminotransferase cyclodeaminase
0.0017
(6S)-tetrahydropteroylpentaglutamate
-
recombinant His-tagged bifunctional formiminotransferase cyclodeaminase
0.075
(6S)-tetrahydropteroylpentaglutamate
-
recombinant His-tagged formiminotransferase domain
5.8
N-formimino-L-glutamate
-
wild-type bifunctional formiminotransferase cyclodeaminase
6.7
N-formimino-L-glutamate
-
recombinant His-tagged bifunctional formiminotransferase cyclodeaminase
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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
additional information
-
26000 per min per mol or 3250 per min per chain
-
additional information
additional information
-
3480-4620 per min: bifunctional formiminotransferase cyclodeaminase, 1920 per min: recombinant His-tagged formiminotransferase domain
-
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Ki VALUE [mM]
INHIBITOR
ORGANISM