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Information on EC 2.1.1.96 - thioether S-methyltransferase and Organism(s) Mus musculus and UniProt Accession P40936

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     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.96 thioether S-methyltransferase
IUBMB Comments
Also acts on dimethyl selenide, dimethyl telluride, diethyl sulfide, 1,4-dithiane and many other thioethers.
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This record set is specific for:
Mus musculus
UNIPROT: P40936
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The taxonomic range for the selected organisms is: Mus musculus
The enzyme appears in selected viruses and cellular organisms
Synonyms
thioether s-methyltransferase, thioether methyltransferase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
S-adenosyl-L-methionine:thioether S-methyltransferase
-
-
-
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Temt
-
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thioether methyltransferase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
methyl group transfer
-
-
-
-
PATHWAY SOURCE
PATHWAYS
SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:dimethyl-sulfide S-methyltransferase
Also acts on dimethyl selenide, dimethyl telluride, diethyl sulfide, 1,4-dithiane and many other thioethers.
CAS REGISTRY NUMBER
COMMENTARY hide
114797-02-3
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + 1,4-dithiane
S-adenosyl-L-homocysteine + methyl-1,4-dithiane
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + 2-methylthioethanol
S-adenosyl-L-homocysteine + 2,2-dimethylthioethanol
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + 2-methylthioethylamine
S-adenosyl-L-homocysteine + 2,2-dimethylthioethylamine
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + 3-methylthiopropionaldehyde
S-adenosyl-L-homocysteine + 3,3-dimethylthiopropionaldehyde
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + benzyl methyl sulfide
S-adenosyl-L-homocysteine + benzyl dimethyl sulfonium
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + diethyl sulfide
S-adenosyl-L-homocysteine + diethylmethylsulfonium
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + dimethyl selenide
S-adenosyl-L-homocysteine + trimethylselenonium
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + dimethyl sulfide
S-adenosyl-L-homocysteine + trimethylsulfonium
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + dimethyl telluride
S-adenosyl-L-homocysteine + trimethyltelluronium
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + ethyl vinyl sulfide
S-adenosyl-L-homocysteine + methyl ethyl vinyl sulfonium
show the reaction diagram
S-adenosyl-L-methionine + methyl n-propyl sulfide
S-adenosyl-L-homocysteine + dimethyl n-propyl sulfonium
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + pentamethylene sulfide
S-adenosyl-L-homocysteine + pentamethylenemethylsulfonium
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + selenium
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + sulfur
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + tellurium
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + tetrahydrothiophene
S-adenosyl-L-homocysteine + methyltetrahydrothiophene
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + thiomorpholine
S-adenosyl-L-homocysteine + methylthiomorpholine
show the reaction diagram
-
-
-
?
additional information
?
-
-
strain- and infection-related alterations in sleep may be influenced by Temt expression and perhaps by subsequent effects on prostaglandin metabolism, mice treated with the Temt-inhibitor sinefungin develop enhanced sleep
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + selenium
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + sulfur
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
S-adenosyl-L-methionine + tellurium
S-adenosyl-L-homocysteine + ?
show the reaction diagram
-
-
-
-
?
additional information
?
-
-
strain- and infection-related alterations in sleep may be influenced by Temt expression and perhaps by subsequent effects on prostaglandin metabolism, mice treated with the Temt-inhibitor sinefungin develop enhanced sleep
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
ethyl vinyl sulfide
-
suicide substrate, inactivation rate constant: 0.05/min, dimethyl sulfide protects
methyl ethyl vinyl sulfonium
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product of ethyl vinyl sulfide methylation inactivates
S-adenosyl-L-homocysteine
-
0.04 mM, 50% inhibition
sinefungin
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0004
dimethyl selenide
-
-
0.001
Dimethyl sulfide
-
-
0.001
S-adenosylmethionine
-
-
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.275
ethyl vinyl sulfide
-
suicide substrate
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6.3
-
sharp drop in activity below
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
SwissProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
-
-
Manually annotated by BRENDA team
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
INMT_MOUSE
264
0
29460
Swiss-Prot
other Location (Reliability: 1)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
29460
1 * 29460, deduced from nucleotide sequence
28000
-
gel filtration
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
monomer
1 * 29460, deduced from nucleotide sequence
monomer
-
1 * 28000, SDS-PAGE
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
DEAE, gel filtration, chromatofocusing
-
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
cloning of cDNA
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
upon exposure of pregnant mice to sodium arsenate in drinking water and subsequent injection of offspring on postpartum days 1-5 with diethylstilbestrol, transcripts for homocysteine cycling genes betaine-homocysteine methyltransferase and thioether S-methyltransferase and developmental marker genes alpha-fetoprotein, insulin-like growth factor 2 and IGF binding protein-1 are higher than with either treatment alone
-
APPLICATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
medicine
-
exposure of the mouse to arsenic during a critical period of fetal development may potentially alter adrenal genetic programming, leading to endocrine disruption and potentially enhancing tumor formation together with diethylstilbestrol at other sites much later in life
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Mozier, N.M.; McConnel, K.P.; Hoffman, J.L.
S-Adenosyl-L-methionine:thioether S-methyltransferase, a new enzyme in sulfur and selenium metabolism
J. Biol. Chem.
263
4527-4531
1988
Mus musculus
Manually annotated by BRENDA team
Warner, D.R.; Mozier, N.M.; Pearson, J.D.; Hoffman, J.L.
Cloning and base sequence analysis of a cDNA encoding mouse lung thioether S-methyltransferase
Biochim. Biophys. Acta
1246
160-166
1995
Mus musculus (P40936), Mus musculus
Manually annotated by BRENDA team
Warner, D.R.; Hoffman, J.L.
Suicide inactivation of thioether S-methyltransferase by ethyl vinyl sulfide
Biochemistry
35
4480-4484
1996
Mus musculus
Manually annotated by BRENDA team
Ding, M.; Toth, L.A.
mRNA expression in mouse hypothalamus and basal forebrain during influenza infection: a novel model for sleep regulation
Physiol. Genomics
24
225-234
2006
Mus musculus
Manually annotated by BRENDA team
Liu, J.; Yu, L.; Coppin, J.F.; Tokar, E.J.; Diwan, B.A.; Waalkes, M.P.
Fetal arsenic exposure appears to facilitate endocrine disruption by postnatal diethylstilbestrol in neonatal mouse adrenal
Chem. Biol. Interact.
182
253-258
2009
Mus musculus
Manually annotated by BRENDA team