Any feedback?
No. of entries
Information on EC 2.1.1.80 - protein-glutamate O-methyltransferase
for references in articles please use BRENDA:EC2.1.1.80
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree 2 Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.80 protein-glutamate O-methyltransferase
IUBMB Comments
Forms ester groups with L-glutamate residues in a number of membrane proteins.
The enzyme appears in viruses and cellular organisms
- 2.1.1.80
- methyltransferases
-
2.1.1.24
-
chemoreceptor
- cheb
-
methylesterase
- s-adenosyl-l-homocysteine
-
l-isoaspartyl
-
d-aspartyl
- sinefungin
- l-isoaspartate
-
methyl-acceptor
Reaction Schemes
showSynonyms
protein methyltransferase, protein methylase ii, cher1, methyltransferase cher, cher2, protein carboxymethylase, protein carboxymethyltransferase, protein carboxyl-methylase, protein o-methyltransferase, omtf3, more
topPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
CheR
CheR1
CheR2
CheR3
EC 2.1.1.24
-
-
formerly
-
MCP methyltransferase I
-
-
-
-
MCP methyltransferase II
-
-
-
-
methyl-accepting chemotaxis protein methyltransferase II
-
-
-
-
methyl-accepting chemotaxis protein O-methyltransferase
-
-
-
-
methyltransferase, protein O-
-
-
-
-
protein carboxyl-methylase
-
-
-
-
protein carboxyl-O-methyltransferase
-
-
-
-
protein carboxylmethyltransferase II
-
-
-
-
protein carboxymethylase
-
-
-
-
protein carboxymethyltransferase
-
-
-
-
protein methylase II
-
-
-
-
protein methyltransferase II
-
-
-
-
protein O-methyltransferase
-
-
-
-
protein(aspartate)methyltransferase
-
-
-
-
protein(carboxyl)methyltransferase
-
-
-
-
R0248
S-adenosylmethionine-glutamyl methyltransferase
-
-
-
-
S-adenosylmethionine:protein-carboxyl O-methyltransferase
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate methyl ester
S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate methyl ester
random mechanism with no abortive complexes being formed, sequential random bi bi mechanism
-
S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate methyl ester
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
methyl group transfer
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:protein-L-glutamate O-methyltransferase
Forms ester groups with L-glutamate residues in a number of membrane proteins.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CAS REGISTRY NUMBER
COMMENTARY
9055-09-8
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + chemoreceptor carboxyl-terminal pentapeptide NWETF
?
-
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + chemoreceptor Tar L-glutamate
S-adenosyl-L-homocysteine + chemoreceptor Tar L-glutamate methyl ester
-
Substrates: chemoreceptor Tar bearing the carboxylterminal pentapeptide NWETF
Products: -
Products: -
?
S-adenosyl-L-methionine + chemotaxis receptors McpS L-glutamate
S-adenosyl-L-homocysteine + chemotaxis receptors McpS L-glutamate methyl ester
S-adenosyl-L-methionine + chemotaxis receptors McpT L-glutamate
S-adenosyl-L-homocysteine + chemotaxis receptors McpT L-glutamate methyl ester
S-adenosyl-L-methionine + methyl-accepting chemotaxis protein B L-glutamate
S-adenosyl-L-homocysteine + methyl-accepting chemotaxis protein B L-glutamate methyl ester
Substrates: exklusive substrate of CheR2
Products: -
Products: -
?
S-adenosyl-L-methionine + methyl-accepting chemotaxis protein FrzCD-L-glutamate
S-adenosyl-L-homocysteine + methyl-accepting chemotaxis protein FrzCD-L-glutamate methyl ester
-
Substrates: full-length FrzF methylates FrzCD on a single residue, E182, while FrzF lacking tetra trico-peptide repeats methylates FrzCD on three residues, E168, E175, and E182
Products: -
Products: -
?
S-adenosyl-L-methionine + PIP2;1 peptide
?
-
Substrates: the enzyme acts on the N-terminal tail of aquaporin PIP2;1 at Glu6 and is able to methylate both the un- and dimethylated peptide forms
Products: -
Products: -
?
S-adenosyl-L-methionine + protein L-glutamate
S-adenosyl-L-homocysteine + protein L-glutamate methyl ester
S-adenosyl-L-methionine + [chemotaxis receptor Tar]-L-glutamate
S-adenosyl-L-homocysteine + [chemotaxis receptor Tar]-L-glutamate methyl ester
S-adenosyl-L-methionine + [follicle-stimulating hormone]-L-glutamate
S-adenosyl-L-homocysteine + [follicle-stimulating hormone]-L-glutamate methyl ester
-
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + [gamma-globulin]-L-glutamate
S-adenosyl-L-homocysteine + [gamma-globulin]-L-glutamate methyl ester
-
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + [histone]-L-glutamate
S-adenosyl-L-homocysteine + [histone]-L-glutamate methyl ester
-
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + [pancreatic ribonuclease]-L-glutamate
S-adenosyl-L-homocysteine + [pancreatic ribonuclease]-L-glutamate methyl ester
-
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + [protein]-L-glutamate
S-adenosyl-L-homocysteine + [protein]-L-glutamate methyl ester
-
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + chemotaxis receptors McpS L-glutamate
S-adenosyl-L-homocysteine + chemotaxis receptors McpS L-glutamate methyl ester
Substrates: substrate for isoform CheR2 only
Products: -
Products: -
?
S-adenosyl-L-methionine + chemotaxis receptors McpS L-glutamate
S-adenosyl-L-homocysteine + chemotaxis receptors McpS L-glutamate methyl ester
Substrates: substrate for isoform CheR2 only
Products: -
Products: -
?
S-adenosyl-L-methionine + chemotaxis receptors McpT L-glutamate
S-adenosyl-L-homocysteine + chemotaxis receptors McpT L-glutamate methyl ester
Substrates: substrate for isoform CheR2 only
Products: -
Products: -
?
S-adenosyl-L-methionine + chemotaxis receptors McpT L-glutamate
S-adenosyl-L-homocysteine + chemotaxis receptors McpT L-glutamate methyl ester
Substrates: substrate for isoform CheR2 only
Products: -
Products: -
?
S-adenosyl-L-methionine + protein L-glutamate
S-adenosyl-L-homocysteine + protein L-glutamate methyl ester
-
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + protein L-glutamate
S-adenosyl-L-homocysteine + protein L-glutamate methyl ester
-
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + protein L-glutamate
S-adenosyl-L-homocysteine + protein L-glutamate methyl ester
-
Substrates: methyltransferase I is unable to methylate E. coli membranes
Products: -
Products: -
?
S-adenosyl-L-methionine + protein L-glutamate
S-adenosyl-L-homocysteine + protein L-glutamate methyl ester
-
Substrates: membrane-bound methyl-accepting chemotaxis proteins
Products: -
Products: -
?
S-adenosyl-L-methionine + protein L-glutamate
S-adenosyl-L-homocysteine + protein L-glutamate methyl ester
-
Substrates: S-adenosyl-L-ethionine shows 2.4% donor efficiency compared to S-adenosyl-L-methionine
Products: -
Products: -
?
S-adenosyl-L-methionine + protein L-glutamate
S-adenosyl-L-homocysteine + protein L-glutamate methyl ester
-
Substrates: highly specific for S-adenosylmethionine as methyl donor
Products: -
Products: -
?
S-adenosyl-L-methionine + protein L-glutamate
S-adenosyl-L-homocysteine + protein L-glutamate methyl ester
-
Substrates: membrane protein involved in chemotaxis
Products: -
Products: -
?
S-adenosyl-L-methionine + protein L-glutamate
S-adenosyl-L-homocysteine + protein L-glutamate methyl ester
-
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + protein L-glutamate
S-adenosyl-L-homocysteine + protein L-glutamate methyl ester
-
Substrates: S-adenosyl-L-ethionine shows 2.4% donor efficiency compared to S-adenosyl-L-methionine
Products: -
Products: -
?
S-adenosyl-L-methionine + protein L-glutamate
S-adenosyl-L-homocysteine + protein L-glutamate methyl ester
-
Substrates: highly specific for S-adenosylmethionine as methyl donor
Products: -
Products: -
?
S-adenosyl-L-methionine + protein L-glutamate
S-adenosyl-L-homocysteine + protein L-glutamate methyl ester
-
Substrates: membrane protein involved in chemotaxis
Products: -
Products: -
?
S-adenosyl-L-methionine + protein L-glutamate
S-adenosyl-L-homocysteine + protein L-glutamate methyl ester
-
Substrates: specific for the methyl-accepting chemotaxis proteins
Products: -
Products: -
?
S-adenosyl-L-methionine + protein L-glutamate
S-adenosyl-L-homocysteine + protein L-glutamate methyl ester
-
Substrates: sensory adaptation in bacterial chemotaxis is mediated by covalent modification of chemoreceptors. Specific glutamyl residues are methylated and demethylated in reactions catalyzed by methyltransferase CheR and methylesterase CheB. Efficient modification by either enzyme is dependent on a conserved pentapeptide sequence, NWETF or NWESF, present at the extreme carboxyl terminus of high-abundance chemoreceptors. Maximal enhancement of the reactions of adaptational modification by the pentapeptide NWETF requires that this sequence is the final residues at the carboxyl terminus of a chemoreceptor. Receptors with carboxyl-terminal extensions past the pentapeptide exhibited rates of modification lower than a wild-type receptor but higher than the low rates for receptors deleted of the pentapeptide. The effect is greater for CheB-catalyzed modifications than for CheR-catalyzed methylation
Products: -
Products: -
?
S-adenosyl-L-methionine + protein L-glutamate
S-adenosyl-L-homocysteine + protein L-glutamate methyl ester
-
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + protein L-glutamate
S-adenosyl-L-homocysteine + protein L-glutamate methyl ester
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + protein L-glutamate
S-adenosyl-L-homocysteine + protein L-glutamate methyl ester
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + protein L-glutamate
S-adenosyl-L-homocysteine + protein L-glutamate methyl ester
-
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + protein L-glutamate
S-adenosyl-L-homocysteine + protein L-glutamate methyl ester
-
Substrates: enzyme does not catalyze the methylation of a variety of soluble proteins, including ovalbumin, ribonuclease and lysozyme
Products: -
Products: -
?
S-adenosyl-L-methionine + protein L-glutamate
S-adenosyl-L-homocysteine + protein L-glutamate methyl ester
-
Substrates: membrane chemoreceptor protein
Products: -
Products: -
?
S-adenosyl-L-methionine + protein L-glutamate
S-adenosyl-L-homocysteine + protein L-glutamate methyl ester
-
Substrates: specific for proteins in Salmonella typhimurium and E. coli membranes
Products: -
Products: -
?
S-adenosyl-L-methionine + protein L-glutamate
S-adenosyl-L-homocysteine + protein L-glutamate methyl ester
-
Substrates: S-adenosyl-L-ethionine shows 2.4% donor efficiency compared to S-adenosyl-L-methionine
Products: -
Products: -
?
S-adenosyl-L-methionine + protein L-glutamate
S-adenosyl-L-homocysteine + protein L-glutamate methyl ester
-
Substrates: highly specific for S-adenosylmethionine as methyl donor
Products: -
Products: -
?
S-adenosyl-L-methionine + protein L-glutamate
S-adenosyl-L-homocysteine + protein L-glutamate methyl ester
-
Substrates: membrane protein involved in chemotaxis
Products: -
Products: -
?
S-adenosyl-L-methionine + protein L-glutamate
S-adenosyl-L-homocysteine + protein L-glutamate methyl ester
-
Substrates: specific for the methyl-accepting chemotaxis proteins
Products: -
Products: -
?
S-adenosyl-L-methionine + protein L-glutamate
S-adenosyl-L-homocysteine + protein L-glutamate methyl ester
-
Substrates: membrane chemoreceptor proteins
Products: -
Products: -
?
S-adenosyl-L-methionine + protein L-glutamate
S-adenosyl-L-homocysteine + protein L-glutamate methyl ester
-
Substrates: enzyme is essential for maintaining the appropriate rate constants and levels of the regulator of the chemotactic response
Products: -
Products: -
?
S-adenosyl-L-methionine + protein L-glutamate
S-adenosyl-L-homocysteine + protein L-glutamate methyl ester
-
Substrates: anti-bovine serum albumin antibody can be carboxylmethylated via spleen PCMT to a level similar to gamma-globulinglobulin. This carboxylmethylation increased the hydrophobicity of the anti-bovine serum albumin antibody up to 11.4%, and enhances the antigen-binding activity of this antibody up to 24.6%. Protein carboxylmethylation may reversibly regulate the antibody-mediated immunological events via the Fc region
Products: -
Products: -
?
S-adenosyl-L-methionine + protein L-glutamate
S-adenosyl-L-homocysteine + protein L-glutamate methyl ester
-
Substrates: anti-bovine serum albumin antibody can be carboxylmethylated via spleen PCMT to a level similar to gamma-globulinglobulin. This carboxylmethylation increases the hydrophobicity of the anti-bovine serum albumin antibody up to 11.4%, and enhances the antigen-binding activity of this antibody up to 24.6%
Products: -
Products: -
?
S-adenosyl-L-methionine + protein L-glutamate
S-adenosyl-L-homocysteine + protein L-glutamate methyl ester
-
Substrates: adaptation in bacterial chemotaxis involves reversible methylation of specific glutamate residues within the cytoplasmic domains of methyl-accepting chemotaxis proteins. Fifteen sites of methylation are identified within the cytoplasmic domains of four different chemoreceptors. The results establish a consensus sequence for chemoreceptor methylation sites in Thermotoga maritima that is distinct from the previously identified consensus sequence
Products: -
Products: -
?
S-adenosyl-L-methionine + protein L-glutamate
S-adenosyl-L-homocysteine + protein L-glutamate methyl ester
-
Substrates: methylation of specific glutamate residues within the cytoplasmic domains of methyl-accepting chemotaxis proteins: TM0429fl, TM0429c, TM1143fl, TM1143c, TM1428fl, TM1428c
Products: -
Products: -
?
S-adenosyl-L-methionine + [chemotaxis receptor Tar]-L-glutamate
S-adenosyl-L-homocysteine + [chemotaxis receptor Tar]-L-glutamate methyl ester
-
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + [chemotaxis receptor Tar]-L-glutamate
S-adenosyl-L-homocysteine + [chemotaxis receptor Tar]-L-glutamate methyl ester
-
Substrates: -
Products: -
Products: -
?
additional information
?
-
-
Substrates: the catalytic efficiency of the enzyme increases when Lys3 is present in its di-methylated rather than in its nonmethylated form
Products: -
Products: -
?
additional information
?
-
Substrates: no activity with chemotaxis receptors McpS and chemotaxis receptors McpT
Products: -
Products: -
?
additional information
?
-
Substrates: no activity with chemotaxis receptors McpS and chemotaxis receptors McpT
Products: -
Products: -
?
additional information
?
-
Substrates: no activity with chemotaxis receptors McpS and chemotaxis receptors McpT
Products: -
Products: -
?
additional information
?
-
-
Substrates: no activity with chemotaxis receptors McpS and chemotaxis receptors McpT
Products: -
Products: -
?
additional information
?
-
Substrates: no activity with chemotaxis receptors McpS and chemotaxis receptors McpT
Products: -
Products: -
?
additional information
?
-
Substrates: no activity with chemotaxis receptors McpS and chemotaxis receptors McpT
Products: -
Products: -
?
additional information
?
-
Substrates: no activity with chemotaxis receptors McpS and chemotaxis receptors McpT
Products: -
Products: -
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + chemotaxis receptors McpS L-glutamate
S-adenosyl-L-homocysteine + chemotaxis receptors McpS L-glutamate methyl ester
S-adenosyl-L-methionine + chemotaxis receptors McpT L-glutamate
S-adenosyl-L-homocysteine + chemotaxis receptors McpT L-glutamate methyl ester
S-adenosyl-L-methionine + methyl-accepting chemotaxis protein B L-glutamate
S-adenosyl-L-homocysteine + methyl-accepting chemotaxis protein B L-glutamate methyl ester
Substrates: exklusive substrate of CheR2
Products: -
Products: -
?
S-adenosyl-L-methionine + protein L-glutamate
S-adenosyl-L-homocysteine + protein L-glutamate methyl ester
S-adenosyl-L-methionine + chemotaxis receptors McpS L-glutamate
S-adenosyl-L-homocysteine + chemotaxis receptors McpS L-glutamate methyl ester
Substrates: substrate for isoform CheR2 only
Products: -
Products: -
?
S-adenosyl-L-methionine + chemotaxis receptors McpS L-glutamate
S-adenosyl-L-homocysteine + chemotaxis receptors McpS L-glutamate methyl ester
Substrates: substrate for isoform CheR2 only
Products: -
Products: -
?
S-adenosyl-L-methionine + chemotaxis receptors McpT L-glutamate
S-adenosyl-L-homocysteine + chemotaxis receptors McpT L-glutamate methyl ester
Substrates: substrate for isoform CheR2 only
Products: -
Products: -
?
S-adenosyl-L-methionine + chemotaxis receptors McpT L-glutamate
S-adenosyl-L-homocysteine + chemotaxis receptors McpT L-glutamate methyl ester
Substrates: substrate for isoform CheR2 only
Products: -
Products: -
?
S-adenosyl-L-methionine + protein L-glutamate
S-adenosyl-L-homocysteine + protein L-glutamate methyl ester
-
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + protein L-glutamate
S-adenosyl-L-homocysteine + protein L-glutamate methyl ester
-
Substrates: sensory adaptation in bacterial chemotaxis is mediated by covalent modification of chemoreceptors. Specific glutamyl residues are methylated and demethylated in reactions catalyzed by methyltransferase CheR and methylesterase CheB. Efficient modification by either enzyme is dependent on a conserved pentapeptide sequence, NWETF or NWESF, present at the extreme carboxyl terminus of high-abundance chemoreceptors. Maximal enhancement of the reactions of adaptational modification by the pentapeptide NWETF requires that this sequence is the final residues at the carboxyl terminus of a chemoreceptor. Receptors with carboxyl-terminal extensions past the pentapeptide exhibited rates of modification lower than a wild-type receptor but higher than the low rates for receptors deleted of the pentapeptide. The effect is greater for CheB-catalyzed modifications than for CheR-catalyzed methylation
Products: -
Products: -
?
S-adenosyl-L-methionine + protein L-glutamate
S-adenosyl-L-homocysteine + protein L-glutamate methyl ester
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + protein L-glutamate
S-adenosyl-L-homocysteine + protein L-glutamate methyl ester
Substrates: -
Products: -
Products: -
?
S-adenosyl-L-methionine + protein L-glutamate
S-adenosyl-L-homocysteine + protein L-glutamate methyl ester
-
Substrates: membrane chemoreceptor proteins
Products: -
Products: -
?
S-adenosyl-L-methionine + protein L-glutamate
S-adenosyl-L-homocysteine + protein L-glutamate methyl ester
-
Substrates: enzyme is essential for maintaining the appropriate rate constants and levels of the regulator of the chemotactic response
Products: -
Products: -
?
S-adenosyl-L-methionine + protein L-glutamate
S-adenosyl-L-homocysteine + protein L-glutamate methyl ester
-
Substrates: anti-bovine serum albumin antibody can be carboxylmethylated via spleen PCMT to a level similar to gamma-globulinglobulin. This carboxylmethylation increased the hydrophobicity of the anti-bovine serum albumin antibody up to 11.4%, and enhances the antigen-binding activity of this antibody up to 24.6%. Protein carboxylmethylation may reversibly regulate the antibody-mediated immunological events via the Fc region
Products: -
Products: -
?
S-adenosyl-L-methionine + protein L-glutamate
S-adenosyl-L-homocysteine + protein L-glutamate methyl ester
-
Substrates: adaptation in bacterial chemotaxis involves reversible methylation of specific glutamate residues within the cytoplasmic domains of methyl-accepting chemotaxis proteins. Fifteen sites of methylation are identified within the cytoplasmic domains of four different chemoreceptors. The results establish a consensus sequence for chemoreceptor methylation sites in Thermotoga maritima that is distinct from the previously identified consensus sequence
Products: -
Products: -
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
METALS and IONS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Ca2+
Mg2+
Ca2+
-
activates, Ca2+ is somewhat more effective than Mg2+, optimum: 5 mM Ca2+
Ca2+
-
Ca2+, Mn2+, Cu2+, Zn2+, Co2+, Fe2+, Fe3+ and Mg2+ at 2 mM have no effect on enzyme activity of methyltransferase I
Ca2+
-
Ca2+, Mn2+, Cu2+, Zn2+, Co2+, Fe2+, Fe3+ and Mg2+ at 2 mM have no effect on enzyme activity of methyltransferase I
Ca2+
-
Ca2+, Mn2+, Cu2+, Zn2+, Co2+, Fe2+, Fe3+ and Mg2+ at 2 mM have no effect on enzyme activity of methyltransferase I
Mg2+
-
activates, Ca2+ is somewhat more effective than Mg2+, optimum: 5 mM Ca2+
Mg2+
-
Ca2+, Mn2+, Cu2+, Zn2+, Co2+, Fe2+, Fe3+ and Mg2+ at 2 mM have no effect on enzyme activity of methyltransferase I
Mg2+
-
Ca2+, Mn2+, Cu2+, Zn2+, Co2+, Fe2+, Fe3+ and Mg2+ at 2 mM have no effect on enzyme activity of methyltransferase I
Mg2+
-
Ca2+, Mn2+, Cu2+, Zn2+, Co2+, Fe2+, Fe3+ and Mg2+ at 2 mM have no effect on enzyme activity of methyltransferase I
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
p-chloromercuribenzoate
-
0.4 mM, 40% inhibition, can be reversed by 12 mM 2-mercaptoethanol
S-adenosyl-L-homocysteine
-
D-isomer is inactive
S-adenosyl-L-homocysteine
-
competitive vs. S-adenosyl-L-methionine
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Breast Neoplasms
Prognostic value of HER2 status on circulating tumor cells in advanced-stage breast cancer patients with HER2-negative tumors.
Carcinoma
Characterization of the Enzymatic Activity of SETDB1 and Its 1:1 Complex with ATF7IP.
Carcinoma
Evolutionary Expression of HER2 Conferred by Chromosome Aneuploidy on Circulating Gastric Cancer Cells Contributes to Developing Targeted and Chemotherapeutic Resistance.
Carcinoma, Hepatocellular
PRMT6 Regulates RAS/RAF Binding and MEK/ERK-Mediated Cancer Stemness Activities in Hepatocellular Carcinoma through CRAF Methylation.
Cholestasis
Lobe-specific heterogeneity in asymmetric dimethylarginine and matrix metalloproteinase levels in a rat model of obstructive cholestasis.
Choline Deficiency
The effects of ethionine administration and choline deficiency on protein carboxymethylase activity in mouse pancreas.
Diabetes Insipidus
High-protein carboxymethylase activity and low endogenous methyl acceptor proteins in posterior pituitary lobe of rats lacking neurophysin-vasopressin (Brattleboro rats).
Leukemia
DOT1L inhibitor EPZ-5676 displays synergistic antiproliferative activity in combination with standard of care drugs and hypomethylating agents in MLL-rearranged leukemia cells.
Leukemia
Mechanisms of Pinometostat (EPZ-5676) Treatment-Emergent Resistance in MLL-Rearranged Leukemia.
Lymphoma
EPZ011989, A Potent, Orally-Available EZH2 Inhibitor with Robust in Vivo Activity.
Melanoma
Characterization of the Enzymatic Activity of SETDB1 and Its 1:1 Complex with ATF7IP.
Neoplasms
A concordant expression pattern of fatty acid synthase and membranous human epidermal growth factor receptor 2 exists in gastric cancer and is associated with a poor prognosis in gastric adenocarcinoma patients.
Neoplasms
Biological processes and signal transduction pathways regulated by the protein methyltransferase SETD7 and their significance in cancer.
Neoplasms
Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors.
Neoplasms
Development of novel SUV39H2 inhibitors that exhibit growth suppressive effects in mouse xenograft models and regulate the phosphorylation of H2AX.
Neoplasms
EPZ011989, A Potent, Orally-Available EZH2 Inhibitor with Robust in Vivo Activity.
Neoplasms
In Situ Proteome Profiling and Bioimaging Applications of Small-Molecule Affinity-Based Probes Derived From DOT1L Inhibitors.
Neoplasms
Mimicking H3 Substrate Arginine in the Design of G9a Lysine Methyltransferase Inhibitors for Cancer Therapy: A Computational Study for Structure-Based Drug Design.
Neoplasms
PRMT6 Regulates RAS/RAF Binding and MEK/ERK-Mediated Cancer Stemness Activities in Hepatocellular Carcinoma through CRAF Methylation.
Neoplasms
Prognostic value of HER2 status on circulating tumor cells in advanced-stage breast cancer patients with HER2-negative tumors.
Neoplasms
Protein methyltransferase inhibitors as precision cancer therapeutics: a decade of discovery.
Neoplasms
RIZ1 is epigenetically inactivated by promoter hypermethylation in thyroid carcinoma.
Neoplasms
Smyd3 Is a Transcriptional Potentiator of Multiple Cancer-Promoting Genes and Required for Liver and Colon Cancer Development.
Neuroblastoma
Characterization of protein carboxyl-O-methyltransferase in the spontaneous in vivo murine C-1300 neuroblastoma.
Neuroblastoma
Protein carboxyl-O-methyltransferase activity in cultured C-1300 neuroblastoma cells.
Retinoblastoma
Altered expression of retinoblastoma protein-interacting zinc finger gene, RIZ, in human leukaemia.
Retinoblastoma
Modulation of RIZ gene expression is associated to estradiol control of MCF-7 breast cancer cell proliferation.
Sarcoma, Avian
Selective methylation of rous sarcoma virus glycoproteins by protein methylase II.
Subacute Combined Degeneration
Correlation between inhibition of myelin basic protein (arginine) methyltransferase by sinefungin and lack of compact myelin formation in cultures of cerebral cells from embryonic mice.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
0.01
S-adenosyl-L-methionine
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
6.5 - 8.5
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
6 - 8
-
approx. 30% of maximal activity at pH 6.0, approx. 65% of maximal activity at pH 8.0
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
-
the enzyme is mostly expressed in the root endodermis and cortex
brenda
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
Highest Expressing Human Cell Lines
Cell Line LinksPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
metabolism
physiological function
malfunction
enzyme gene disruption results in loss of motility and significantly impairs symbiotic competency with the liverwort Blasia pusilla