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Adenocarcinoma
Methyl-accepting RNA in 13762 mammary adenocarcinoma correlated with low adenine methyltransferase levels.
Adenocarcinoma
The m6A Methyltransferase METTL14-Mediated N6-Methyladenosine Modification of PTEN mRNA Inhibits Tumor Growth and Metastasis in Stomach Adenocarcinoma.
Adenocarcinoma of Lung
H3K4 Methylation Status and Lysine Specific Methyltransferase KMT2C Expression Correlate with Prognosis in Lung Adenocarcinoma.
Adenocarcinoma of Lung
m6A RNA Methylation Regulators Act as Potential Prognostic Biomarkers in Lung Adenocarcinoma.
Alzheimer Disease
Altered Expression of the m6A Methyltransferase METTL3 in Alzheimer's Disease.
Bacterial Infections
N6-Adenosine Methylation of Socs1 mRNA Is Required to Sustain the Negative Feedback Control of Macrophage Activation.
Breast Neoplasms
Identification of holocarboxylase synthetase chromatin binding sites in human mammary cell lines using the DNA adenine methyltransferase identification technology.
Breast Neoplasms
MBD3 localizes at promoters, gene bodies and enhancers of active genes.
Breast Neoplasms
Ribosome 18S m6A Methyltransferase METTL5 Promotes Translation Initiation and Breast Cancer Cell Growth.
Breast Neoplasms
The m6A methyltransferase METTL3 controls epithelial-mesenchymal transition, migration and invasion of breast cancer through the MALAT1/miR-26b/HMGA2 axis.
Breast Neoplasms
The m6A methyltransferase METTL3 promotes the stemness and malignant progression of breast cancer by mediating m6A modification on SOX2.
Carcinogenesis
Epitranscriptomics in liver disease: Basic concepts and therapeutic potential.
Carcinogenesis
Methyltransferase-like 3-induced N6-methyladenosine upregulation promotes oral squamous cell carcinoma by through p38.
Carcinogenesis
N6-methyladenosine (m6A) methyltransferase WTAP accelerates the Warburg effect of gastric cancer through regulating HK2 stability.
Carcinoma
The M6A methyltransferase METTL3 promotes the development and progression of prostate carcinoma via mediating MYC methylation.
Carcinoma
The M6A methyltransferase METTL3: acting as a tumor suppressor in renal cell carcinoma.
Carcinoma, Hepatocellular
Circular RNA circDLC1 inhibits MMP1-mediated liver cancer progression via interaction with HuR.
Carcinoma, Non-Small-Cell Lung
The mechanism of m6A methyltransferase METTL3-mediated autophagy in reversing gefitinib resistance in NSCLC cells by ?-elemene.
Carcinoma, Ovarian Epithelial
METTL3 regulates m6A in endometrioid epithelial ovarian cancer independently of METTl14 and WTAP.
Carcinoma, Renal Cell
The M6A methyltransferase METTL3: acting as a tumor suppressor in renal cell carcinoma.
Colonic Neoplasms
m6A methyltransferase METTL3 maintains colon cancer tumorigenicity by suppressing SOCS2 to promote cell proliferation.
Colorectal Neoplasms
m6A methyltransferase METTL3 suppresses colorectal cancer proliferation and migration through p38/ERK pathways.
Colorectal Neoplasms
METTL3/YTHDF2 m6A axis accelerates colorectal carcinogenesis through epigenetically suppressing YPEL5.
Decompression Sickness
Fluorescence Study of DNA Binding and Bending by EcoRI DNA Methyltransferase.
Decompression Sickness
The M.EcoRV DNA-(adenine N6)-methyltransferase uses DNA bending for recognition of an expanded EcoDam recognition site.
Diabetes Mellitus
Transoesophageal echocardiographic findings in patients with ischemic lacunar and nonlacunar stroke.
Glioblastoma
N6-methyladenosine Modulates Nonsense-mediated mRNA Decay in Human Glioblastoma.
Hypertension
The m6A methyltransferase METTL3 promotes hypoxic pulmonary arterial hypertension.
Hypertension
Transoesophageal echocardiographic findings in patients with ischemic lacunar and nonlacunar stroke.
Infections
Characterization of a DNA Adenine Methyltransferase Gene of Borrelia hermsii and Its Dispensability for Murine Infection and Persistence.
Infections
Comparative studies of the phage T2 and T4 DNA (N6-adenine)methyltransferases: amino acid changes that affect catalytic activity.
Infections
DNA adenine methylase overproduction in Yersinia pseudotuberculosis alters YopE expression and secretion and host immune responses to infection.
Infections
Enterotoxigenic Escherichia coli infection promotes enteric defensin expression via FOXO6-METTL3-m6A-GPR161 signalling axis.
Infections
Escherichia coli bacteriophage T1 DNA methyltransferase appears to interact with Escherichia coli enolase.
Infections
In vivo-selected mutations in methyl-directed mismatch repair suppress the virulence attenuation of Salmonella dam mutant strains following intraperitoneal, but not oral, infection of naïve mice.
Infections
N6-methyladenosine RNA modification suppresses antiviral innate sensing pathways via reshaping double-stranded RNA.
Infections
Rate of translocation of bacteriophage T7 DNA across the membranes of Escherichia coli.
Infections
The Helicobacter pylori HpyAXII restriction-modification system limits exogenous DNA uptake by targeting GTAC sites but shows asymmetric conservation of the DNA methyltransferase and restriction endonuclease components.
Infections
Widespread remodeling of the m6A RNA-modification landscape by a viral regulator of RNA processing and export.
Leukemia
Widespread, exceptionally high levels of histone H3 lysine 4 trimethylation largely mediate "privileged" gene expression.
Leukemia
[Research progress of histone 3 methyltransferase MLL4].
Lung Neoplasms
The m6A methyltransferase METTL3 contributes to Transforming Growth Factor-beta-induced epithelial-mesenchymal transition of lung cancer cells through the regulation of JUNB.
Lung Neoplasms
The mechanism of m6A methyltransferase METTL3-mediated autophagy in reversing gefitinib resistance in NSCLC cells by ?-elemene.
Lymphoma
m6A methyltransferase Wilms' tumor 1-associated protein facilitates cell proliferation and cisplatin resistance in NK/T cell lymphoma by regulating dual-specificity phosphatases 6 expression via m6A RNA methylation.
Melanoma
METTL3 induces PLX4032 resistance in melanoma by promoting m6A-dependent EGFR translation.
Nasopharyngeal Carcinoma
The m6A methyltransferase METTL3 aggravates the progression of nasopharyngeal carcinoma through inducing EMT by m6A-modified Snail mRNA.
Neoplasm Metastasis
Targeting Histone Methyltransferase DOT1L by a Novel Psammaplin A Analog Inhibits Growth and Metastasis of Triple-Negative Breast Cancer.
Neoplasm Metastasis
The m6A Methyltransferase METTL14-Mediated N6-Methyladenosine Modification of PTEN mRNA Inhibits Tumor Growth and Metastasis in Stomach Adenocarcinoma.
Neoplasm Metastasis
The m6A methyltransferase METTL3 controls epithelial-mesenchymal transition, migration and invasion of breast cancer through the MALAT1/miR-26b/HMGA2 axis.
Neoplasms
Associations between arsenic (+3 oxidation state) methyltransferase (AS3MT) and N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) polymorphisms, arsenic metabolism, and cancer risk in a chilean population.
Neoplasms
Connecting METTL3 and intratumoural CD33+ MDSCs in predicting clinical outcome in cervical cancer.
Neoplasms
Detection of DNA methyltransferase activity using allosteric molecular beacons.
Neoplasms
Methyl-accepting RNA in 13762 mammary adenocarcinoma correlated with low adenine methyltransferase levels.
Neoplasms
METTL3 promotes ovarian carcinoma growth and invasion through the regulation of AXL translation and epithelial to mesenchymal transition.
Neoplasms
Role of m6A methyltransferase component VIRMA in multiple human cancers (Review).
Neoplasms
The loss of RNA N6-adenosine methyltransferase Mettl14 in tumor-associated macrophages promotes CD8+ T cell dysfunction and tumor growth.
Neoplasms
The m6A Methyltransferase METTL14-Mediated N6-Methyladenosine Modification of PTEN mRNA Inhibits Tumor Growth and Metastasis in Stomach Adenocarcinoma.
Neoplasms
The m6A methyltransferase METTL3 controls epithelial-mesenchymal transition, migration and invasion of breast cancer through the MALAT1/miR-26b/HMGA2 axis.
Neoplasms
The M6A methyltransferase METTL3: acting as a tumor suppressor in renal cell carcinoma.
Neoplasms
You Get a Modification, and You Get a Modification
Everyone Gets a Modification!
Osteoporosis
Mettl3-mediated m6A RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis.
Osteoporosis
Regulatory Role of RNA N6-Methyladenosine Modification in Bone Biology and Osteoporosis.
Osteosarcoma
The m6A methyltransferase METTL3 promotes osteosarcoma progression by regulating the m6A level of LEF1.
Ovarian Neoplasms
A newly defined risk signature, consisting of three m6A RNA methylation regulators, predicts the prognosis of ovarian cancer.
Pancreatic Neoplasms
m6A Methyltransferase METTL14-Mediated Upregulation of Cytidine Deaminase Promoting Gemcitabine Resistance in Pancreatic Cancer.
Prostatic Neoplasms
Genome-wide analysis of ETV1 targets: Insights into the role of ETV1 in tumor progression.
Prostatic Neoplasms
m6A methyltransferase METTL3 promotes the progression of prostate cancer via m6A-modified LEF1.
Prostatic Neoplasms
RNA m6A Methyltransferase METTL3 Promotes The Growth Of Prostate Cancer By Regulating Hedgehog Pathway.
Pulmonary Arterial Hypertension
The m6A methyltransferase METTL3 promotes hypoxic pulmonary arterial hypertension.
Relapsing Fever
Characterization of a DNA Adenine Methyltransferase Gene of Borrelia hermsii and Its Dispensability for Murine Infection and Persistence.
Retinoblastoma
m6A methyltransferase METTL3 promotes retinoblastoma progression via PI3K/AKT/mTOR pathway.
Salmonella Infections
Cross-protective immunity conferred by a DNA adenine methylase deficient Salmonella enterica serovar Typhimurium vaccine in calves challenged with Salmonella serovar Newport.
Salmonella Infections
Development of a Salmonella cross-protective vaccine for food animal production systems.
Seminoma
The m6A methyltransferase METTL3 regulates autophagy and sensitivity to cisplatin by targeting ATG5 in seminoma.
site-specific dna-methyltransferase (adenine-specific) deficiency
A role for the bacterial GATC methylome in antibiotic stress survival.
Stomach Neoplasms
Effect of histone modifications on hMLH1 alternative splicing in gastric cancer.
Stomach Neoplasms
Knockdown of m6A methyltransferase METTL3 in gastric cancer cells results in suppression of cell proliferation.
Stomach Neoplasms
m6A Methyltransferase 3 Promotes the Proliferation and Migration of Gastric Cancer Cells through the m6A Modification of YAP1.
Stomach Neoplasms
METTL16 promotes cell proliferation by up-regulating cyclin D1 expression in gastric cancer.
Stomach Neoplasms
N6-methyladenosine (m6A) methyltransferase WTAP accelerates the Warburg effect of gastric cancer through regulating HK2 stability.
Stomach Neoplasms
The m6A methyltransferase METTL14 inhibits the proliferation, migration, and invasion of gastric cancer by regulating the PI3K/AKT/mTOR signaling pathway.
Stroke, Lacunar
Transoesophageal echocardiographic findings in patients with ischemic lacunar and nonlacunar stroke.
Thyroid Neoplasms
Progression of Thyroid Carcinoma Is Promoted by the m6A Methyltransferase METTL3 Through Regulating m6A Methylation on TCF1.
Tuberculosis
DNA methylation impacts gene expression and ensures hypoxic survival of Mycobacterium tuberculosis.
Typhoid Fever
Cross-protective immunity conferred by a DNA adenine methylase deficient Salmonella enterica serovar Typhimurium vaccine in calves challenged with Salmonella serovar Newport.
Typhoid Fever
Innate interferon response in macrophage and epithelial cells infected with wild-type compared to DNA adenine methylase and flagellin mutant Salmonella enterica serovar Typhimurium.
Typhoid Fever
Salmonella DNA adenine methylase mutants elicit protective immune responses to homologous and heterologous serovars in chickens.
Typhoid Fever
Tissue selectivity of interferon-stimulated gene expression in mice infected with Dam(+) versus Dam(-) Salmonella enterica serovar Typhimurium strains.
Urinary Bladder Neoplasms
The m6A methyltransferase METTL3 promotes bladder cancer progression via AFF4/NF-?B/MYC signaling network.
Vesicular Stomatitis
N6-methyladenosine RNA modification suppresses antiviral innate sensing pathways via reshaping double-stranded RNA.
Wilms Tumor
m6A methyltransferase Wilms' tumor 1-associated protein facilitates cell proliferation and cisplatin resistance in NK/T cell lymphoma by regulating dual-specificity phosphatases 6 expression via m6A RNA methylation.
Wilms Tumor
Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase.
Wilms Tumor
miR-550-1 functions as a tumor suppressor in acute myeloid leukemia via the hippo signaling pathway.
Wilms Tumor
N6-methyladenosine (m6A) methyltransferase WTAP accelerates the Warburg effect of gastric cancer through regulating HK2 stability.
Wilms Tumor
Wilms' tumour 1-associating protein inhibits endothelial cell angiogenesis by m6A-dependent epigenetic silencing of desmoplakin in brain arteriovenous malformation.
Wilms Tumor
WTAP promotes myocardial ischemia/reperfusion injury by increasing endoplasmic reticulum stress via regulating m6A modification of ATF4 mRNA.
Wolf-Hirschhorn Syndrome
Wolf-Hirschhorn Syndrome Candidate 1 (whsc1) Functions as a Tumor Suppressor by Governing Cell Differentiation.
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Hattman, S.
DNA-[adenine] methylation in lower eukaryotes
Biochemistry (Moscow)
70
550-558
2005
Anopheles gambiae, Arabidopsis thaliana, Caenorhabditis elegans, Chlamydomonas reinhardtii, Chlorella sp., Drosophila melanogaster, Homo sapiens, Leishmania major, Oxytricha fallax, Paramecium aurelia, Peridinium triquetrum, Plasmodium falciparum, Plasmodium knowlesi, Plasmodium yoelii, Saccharomyces cerevisiae, Schizosaccharomyces pombe, Stylonychia mytilus, Tetrahymena thermophila
brenda
Ren, X.; Aleshin, M.; Jo, W.J.; Dills, R.; Kalman, D.A.; Vulpe, C.D.; Smith, M.T.; Zhang, L.
Involvement of N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) in arsenic biomethylation and its role in arsenic-induced toxicity
Environ. Health Perspect.
119
771-777
2011
Homo sapiens (Q9Y5N5), Homo sapiens
brenda
Woodcock, C.; Yu, D.; Hajian, T.; Li, J.; Huang, Y.; Dai, N.; Correa, I.J.; Wu, T.; Vedadi, M.; Zhang, X.; Cheng, X.
Human MettL3-MettL14 complex is a sequence-specific DNA adenine methyltransferase active on single-strand and unpaired DNA in vitro
Cell Discov.
5
63
2019
Homo sapiens
brenda
2.1.1.72 site-specific DNA-methyltransferase (adenine-specific)
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The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). 
