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Information on EC 2.1.1.70 - 8-hydroxyfuranocoumarin 8-O-methyltransferase

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IUBMB Comments
Converts xanthotoxol into xanthotoxin, which has therapeutic potential in the treatment of psoriasis as it has photosensitizing and antiproliferative activities . Methylates the 8-hydroxy group of some hydroxy- and methylcoumarins, but has little activity on non-coumarin phenols (see also EC 2.1.1.69, 5-hydroxyfuranocoumarin 5-O-methyltransferase).
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The enzyme appears in viruses and cellular organisms
Synonyms
furanocoumarin 8-methyltransferase, furanocoumarin 8-O-methyl-transferase, methyltransferase, xanthotoxol, XMT, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + an 8-hydroxyfurocoumarin = S-adenosyl-L-homocysteine + an 8-methoxyfurocoumarin
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S-adenosyl-L-methionine + xanthotoxol = S-adenosyl-L-homocysteine + xanthotoxin
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