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As well as licodione [1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-1,3-propanedione], the 2''-hydroxy-derivative and isoliquiritigenin can act as acceptors, but more slowly.
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The enzyme appears in viruses and cellular organisms
methyltransferase, licodione 2'-O-, more
S-adenosyl-L-methionine + licodione = S-adenosyl-L-homocysteine + 2'-O-methyllicodione
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