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Information on EC 2.1.1.60 - calmodulin-lysine N-methyltransferase and Organism(s) Homo sapiens and UniProt Accession Q7Z624

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EC Tree
     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.60 calmodulin-lysine N-methyltransferase
IUBMB Comments
One of a group of enzymes methylating proteins; see also EC 2.1.1.43 histone-lysine N-methyltransferase and EC 2.1.1.59 [cytochrome-c]-lysine N-methyltransferase.
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This record set is specific for:
Homo sapiens
UNIPROT: Q7Z624
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Word Map
The taxonomic range for the selected organisms is: Homo sapiens
The expected taxonomic range for this enzyme is: Eukaryota, Bacteria
Synonyms
cam kmt, calmodulin n-methyltransferase, calmodulin methyltransferase, camkmt, calmodulin-lysine n-methyltransferase, calmodulin lysine methyltransferase, calmodulin lysine methyl transferase, s-adenosyl-l-methionine:calmodulin-l-lysine n6-methyltransferase, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
calmodulin lysine methyltransferase
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calmodulin methyltransferase
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CaM KMT
calmodulin lysine N-methyltransferase
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-
-
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calmodulin N-methyltransferase
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-
-
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calmodulin-lysine N-methyltransferase
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methyltransferase, calmodulin (lysine)
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-
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S-adenosylmethionine:calmodulin N-methyltransferase (lysine)
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-
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
methyl group transfer
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-
-
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PATHWAY SOURCE
PATHWAYS
SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:calmodulin-L-lysine N6-methyltransferase
One of a group of enzymes methylating proteins; see also EC 2.1.1.43 histone-lysine N-methyltransferase and EC 2.1.1.59 [cytochrome-c]-lysine N-methyltransferase.
CAS REGISTRY NUMBER
COMMENTARY hide
75603-20-2
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + calmodulin L-lysine
S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine
show the reaction diagram
-
-
-
?
S-adenosyl-L-methionine + calmodulin L-lysine-115
S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine-115
show the reaction diagram
-
-
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
S-adenosyl-L-methionine + calmodulin L-lysine
S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine
show the reaction diagram
-
-
-
?
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
the absence of enzyme causes accumulation of hypomethylated calmodulin in 2p21 deletion syndrome patients
metabolism
the enzyme is the major methyltransferase of calmodulin in human cells and a Hsp90 client protein
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION?
CMKMT_HUMAN
323
0
36128
Swiss-Prot
other Location (Reliability: 1)
PDB
SCOP
CATH
UNIPROT
ORGANISM
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
36000
x * 36000, SDS-PAGE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
?
x * 36000, SDS-PAGE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
expressed in COS-7 cells
expressed in Escherichia coli BL21(DE3)-star-RIL cells
expressed in Escherichia coli
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Magnani, R.; Dirk, L.M.; Trievel, R.C.; Houtz, R.L.
Calmodulin methyltransferase is an evolutionarily conserved enzyme that trimethylates Lys-115 in calmodulin
Nat. Commun.
1
43
2010
Homo sapiens, Rattus norvegicus
Manually annotated by BRENDA team
Magen, S.; Magnani, R.; Haziza, S.; Hershkovitz, E.; Houtz, R.; Cambi, F.; Parvari, R.
Human calmodulin methyltransferase: expression, activity on calmodulin, and Hsp90 dependence
PLoS ONE
7
e52425
2012
Homo sapiens (Q7Z624), Homo sapiens, Mus musculus (Q3U2J5), Mus musculus
Manually annotated by BRENDA team
Magnani, R.; Chaffin, B.; Dick, E.; Bricken, M.L.; Houtz, R.L.; Bradley, L.H.
Utilization of a calmodulin lysine methyltransferase co-expression system for the generation of a combinatorial library of post-translationally modified proteins
Protein Expr. Purif.
86
83-88
2012
Homo sapiens (Q7Z624)
Manually annotated by BRENDA team