Reference on EC 2.1.1.6 - catechol O-methyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Axelrod, J.; Tomchick, R.
Enzymatic O-methylation of epinephrine and other catechols
J. Biol. Chem.
233
702-705
1958
Bos taurus, Cavia porcellus, Oryctolagus cuniculus, Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa
Huh, M.M.O.; Friedhoff, A.J.
Multiple molecular forms of catechol-O-methyltransferase. Evidence for two distinct forms, and their purification and physical characterization
J. Biol. Chem.
254
299-308
1979
Oryctolagus cuniculus, Homo sapiens, Rattus norvegicus
Borchardt, R.T.
Catechol O-methyltransferase
Methods Enzymol.
77
267-272
1981
Rattus norvegicus
Bhaird, N.N.; Tipton, K.F.
Catechol-O-methyltransferase from human placenta: purification and some properties
Biochem. Soc. Trans.
19
20S
1991
Homo sapiens
Lundstrm, K.; Tilgmann, C.; Pernen, J.; Kalkkinen, N.; Ulmanen, I.
Expression of enzymatically active rat liver and human placental catechol-O-methyltransferase in Escherichia coli; purification and partial characterization of the enzyme
Biochim. Biophys. Acta
1129
149-154
1992
Homo sapiens, Rattus norvegicus
Bertocci, B.; Garotta, G.; Da Prada, M.; Lahm, H.W.; Zurcher, G.; Virgallita, G.; Miggiano, V.
Immunoaffinity purification and partial amino acid sequence analysis of catechol-O-methyltransferase from pig liver
Biochim. Biophys. Acta
1080
103-109
1991
Homo sapiens, Sus scrofa
Gulliver, P.A.; Tipton, K.F.
The purification and properties of pig-liver catechol-O-methyl transferase
Eur. J. Biochem.
88
439-444
1978
Sus scrofa
Borchardt, R.T.; Cheng, C.F.
Purification and characterization of rat heart and brain catechol methyltransferase
Biochim. Biophys. Acta
522
49-62
1978
Rattus norvegicus
Tong, J.H.; D'Iorio, A.
Solubilization and partial purification of particulate catechol-O-methyltransferase from rat liver
Can. J. Biochem.
55
1108-1113
1977
Rattus norvegicus
Buu, N.T.; Kuchel, O.; Parent, M.T.
Competitive inhibition of catechol O-methyltransferase by RO-4-4602
Can. J. Biochem.
55
771-773
1977
Rattus norvegicus
Borchardt, R.T.; Cheng, C.F.; Thakker, D.R.
Purification of catechol-O-methyltransferase by affinity chromatography
Biochem. Biophys. Res. Commun.
63
69-77
1975
Rattus norvegicus
Raxworthy, M.J.; Gulliver, P.A.
The effect of bulk hydrogen ion concentration upon the apparent kinetic parameters of purified pig liver catechol O-methyltransferase
Biochim. Biophys. Acta
870
417-425
1986
Sus scrofa
Tilgmann, C.; Kalkkinen, N.
Purification and partial sequence analysis of the soluble catechol-O-methyltransferase from human placenta: comparison to the rat liver enzyme
Biochem. Biophys. Res. Commun.
174
995-1002
1991
Homo sapiens
Sanft, K.; Thomas, H.
Competitive inhibition of catechol-O-methyltransferase by tetrahydro-isochinoline alkaloids salsolidin and 1-carboxysalsolin
Z. Naturforsch. C
44
173-176
1989
Rattus norvegicus
Schwabe, K.P.; Flohe, L.
Catechol-O-methyltransferase, 3. Relationship between the structure of flavonoids and their ability to inhibit catechol-O-methyltransferase
Hoppe-Seyler's Z. Physiol. Chem.
353
476-482
1972
Rattus norvegicus
Coward, J.K.; Slisz, E.P.; Wu, F.Y.H.
Kinetic studies on catechol O-methyltransferase. Product inhibition and the nature of the catechol binding site
Biochemistry
12
2291-2297
1973
Rattus norvegicus
Ball, P.; Knuppen, R.; Haupt, M.; Breuer, H.
Kinetic properties of a soluble catechol O-methyltransferase of human liver
Eur. J. Biochem.
26
560-569
1972
Homo sapiens
Rivett, A.J.; Roth, J.A.
Kinetic studies on the O-methylation of dopamine by human brain membrane-bound catechol O-methyltransferase
Biochemistry
21
1740-1742
1982
Homo sapiens
Veser, J.
Kinetics and inhibition studies of catechol O-methyltransferase from the yeast Candida tropicalis
J. Bacteriol.
169
3696-3700
1987
Candida tropicalis
Veser, J.; Geywitz, P.; Thomas, H.
Purification and properties of a catechol methyltransferase of the yeast Candida tropicalis
Z. Naturforsch. C
34
709-714
1979
Candida tropicalis
Tilgmann, C.; Kalkkinen, N.
Purification and partial characterization of rat liver soluble catechol-O-methyltransferase
FEBS Lett.
264
95-99
1990
Homo sapiens, Rattus norvegicus
Lin, R.L.; Narasimhachari, N.
Specific tlc, gc, and gc-ms methods for kinetic studies with COMT
Anal. Biochem.
57
46-58
1974
Homo sapiens, Platyrrhini
Nic A'Bhaird, N.; Tipton, K.F.
Behavior and properties of catechol-O-methyltransferase from human placenta
J. Neural Transm.
32
359-368
1990
Homo sapiens
Piedrafita, F.J.; Elorriaga, C.; Fernandez-Alvarez, E.; Nieto, O.
Inhibition of catechol-O-methyltransferase by N-(3,4-dihydroxyphenyl) maleimide
J. Enzyme Inhib.
4
43-50
1990
Sus scrofa
Schultz, E.; Nissinen, E.
Inhibition of rat liver and duodenum soluble catechol-O-methyltransferase by a tight-binding inhibitor OR-462
Biochem. Pharmacol.
38
3953-3956
1989
Rattus norvegicus
Timmers, R.J.M.; Lambert, J.G.D.
Kinetic studies of catechol-O-methyltransferase from the brain of the African catfish, Clarias gariepinus
Comp. Biochem. Physiol. C Comp. Pharmacol. Toxicol.
91
399-402
1988
Clarias gariepinus
-
Rhee, J.; Myung Un, C.
Rat liver catechol-O-methyltransferase: Purification and general properties
Hanguk Saenghwahakhoe Chi
21
60-67
1988
Rattus norvegicus
-
Jeffrey, D.R.; Roth, J.A.
Purification and kinetic mechanism of human brain soluble catechol-O-methyltransferase
J. Neurochem.
44
881-885
1985
Homo sapiens
Jeffrey, D.R.; Roth, J.A.
Characterization of membrane-bound and soluble catechol-O-methyltransferase from human frontal cortex
J. Neurochem.
42
826-832
1984
Homo sapiens
Tunnicliff, G.; Ngo, T.T.
Kinetics of rat brain soluble catechol-O-methyltransferase and its inhibition by substrate analogues
Int. J. Biochem.
15
733-738
1983
Rattus norvegicus
Borchardt, R.T.; Huber, J.H.; Houston, M.
Catechol O-methyltransferase. 10. 5-Substituted 3-hydroxy-4-methoxybenzoic acids (isovanillic acids) and 5-substituted 3-hydroxy-4-methoxybenzaldehydes (isovanillins) as potential inhibitors
J. Med. Chem.
25
258-263
1982
Rattus norvegicus
Vidgren, J.; Svensson, L.A.; Liljas, A.
Crystal structure of catechol O-methyltransferase
Nature
368
354-358
1994
Homo sapiens
Ulmanen, I.; Peranen, J.; Tenhunen, J.; Tilgmann, C.; Karhunen, T.; Panula, P.; Bernasconi, L.; Aubry, J.P.; Lundstrom, K.
Expression and intracellular localization of catechol O-methyltransferase in transfected mammalian cells
Eur. J. Biochem.
243
452-459
1997
Homo sapiens, Rattus norvegicus
Percy, E.; Kaye, D.M.; Lambert, G.W.; Gruskin, S.; Esler, M.D.; Du, X.J.
Catechol-O-methyltransferase activity in CHO cells expressing norepinephrine transporter
Br. J. Pharmacol.
128
774-780
1999
Cricetulus griseus
Karhunen, T.; Tilgmann, C.; Ulmanen, I.; Julkunen, I.; Panula, P.
Distribution of catechol-O-methyltransferase enzyme in rat tissues
J. Histochem. Cytochem.
42
1079-1090
1994
Rattus norvegicus
Weinshilboum, R.M.; Otterness, D.M.; Szumlanski, C.L.
Methylation pharmacogenetics: catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase
Annu. Rev. Pharmacol. Toxicol.
39
19-52
1999
Rattus norvegicus, Homo sapiens (P21964)
Bonifacio, M.J.; Vieira-Coelho, M.A.; Borges, N.; Soares-da-Silva, P.
Kinetics of rat brain and liver solubilized membrane-bound catechol-O-methyltransferase
Arch. Biochem. Biophys.
384
361-367
2000
Rattus norvegicus
Yan, M.; Webster, L.T., Jr.; Blumer, J.L.
Kinetic interactions of dopamine and dobutamine with human catechol-O-methyltransferase and monoamine oxidase in vitro
J. Pharmacol. Exp. Ther.
301
315-321
2002
Homo sapiens
Bonifacio, M.J.; Vieira-Coelho, M.A.; Soares-da-Silva, P.
Expression and characterization of rat soluble catechol-O-methyltransferase fusion protein
Protein Expr. Purif.
23
106-112
2001
Rattus norvegicus, Rattus norvegicus S-COMT
Lotta, T.; Vidgren, J.; Tilgmann, C.; Ulmanen, I.; Melen, K.; Julkunen, I.; Taskinen, J.
Kinetics of human soluble and membrane-bound catechol O-methyltransferase: A revised mechanism and description of the thermolabile variant of the enzyme
Biochemistry
34
4202-4210
1995
Homo sapiens
Zhu, B.T.; Patel, U.K.; Cai, M.X.; Conney, A.H.
O-Methylation of tea polyphenols catalyzed by human placental cytosolic catechol-O-methyltransferase
Drug Metab. Dispos.
28
1024-1030
2000
Homo sapiens
Eshleman, A.J.; Stewart, E.; Evenson, A.K.; Mason, J.N.; Blakely, R.D.; Janowsky, A.; Neve, K.A.
Metabolism of catecholamines by catechol-O-methyltransferase in cells expressing recombinant catecholamine transporters
J. Neurochem.
69
1459-1466
1997
Homo sapiens
Tilgmann, C.; Ulmanen, I.
Purification methods of mammalian catechol-O-methyltransferases
J. Chromatogr. B
684
147-161
1996
Homo sapiens, Rattus norvegicus
Dawling, S.; Roodi, N.; Mernaugh, R.L.; Wang, X.; Parl, F.F.
Catechol-O-methyltransferase (COMT)-mediated metabolism of catechol estrogens: comparison of wild-type and variant COMT isoforms
Cancer Res.
61
6716-6722
2001
Homo sapiens
Dhar, K.; Rosazza, J.P.N.
Purification and characterization of Streptomyces griseus catechol O-methyltransferase
Appl. Environ. Microbiol.
66
4877-4882
2000
Streptomyces griseus, Streptomyces griseus S-COMT
Zhao, W.Q.; Latinwo, L.; Liu, X.X.; Lee, E.S.; Lamango, N.; Charlton, C.G.
L-Dopa upregulates the expression and activities of Methionine adenosyl transferase and catechol-O-methyltransferase
Exp. Neurol.
171
127-138
2001
Homo sapiens
Borges, N.; Vieira-Coelho, M.A.; Parada, A.; Soares-Da-Silva, P.
Rat liver catechol-O-methyltransferase kinetics and assay methodology
J. Enzyme Inhib.
13
473-483
1998
Rattus norvegicus
Zhu, B.T.; Ezell, E.L.; Liehr, J.G.
Catechol-O-methyltransferase-catalyzed rapid O-methylation of mutagenic flavonoids
J. Biol. Chem.
269
292-299
1994
Cricetinae, Sus scrofa
Zheng, Y.; Bruice, T.C.
A theoretical examiniation of the factors controlling the catalytic efficiency of a transmethylation enzyme: Catechol O-methyltransferase
J. Am. Chem. Soc.
119
8137-8145
1997
Rattus norvegicus
-
Chen, J.; Lipska, B.K.; Halim, N.; Ma, Q.D.; Matsumoto, M.; Melhem, S.; et al.
Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain
Am. J. Hum. Genet.
75
807-821
2004
Homo sapiens
Masuda, M.; Tsunoda, M.; Imai, K.
High-performance liquid chromatography-fluorescent assay of catechol-O-methyltransferase activity in rat brain
Anal. Bioanal. Chem.
376
1069-1073
2003
Rattus norvegicus
Tsunoda, M.; Imai, K.
An assay for determination of rat adrenal catechol-O-methyltransferase activity: comparison of spontaneously hypertensive rats and Wistar-Kyoto rats
Anal. Bioanal. Chem.
380
887-890
2004
Rattus norvegicus
Wang, S.H.; Kuo, S.C.; Chen, S.C.
High-performance liquid chromatography determination of methionine adenosyltransferase activity using catechol-O-methyltransferase-coupled fluorometric detection
Anal. Biochem.
319
13-20
2003
Homo sapiens
Chen, D.; Wang, C.Y.; Lambert, J.D.; Ai, N.; Welsh, W.J.; Yang, C.S.
Inhibition of human liver catechol-O-methyltransferase by tea catechins and their metabolites: structure-activity relationship and molecular-modeling studies
Biochem. Pharmacol.
69
1523-1531
2005
Homo sapiens
Lambert, J.D.; Chen, D.; Wang, C.Y.; Ai, N.; Sang, S.; Ho, C.T.; Welsh, W.J.; Yang, C.S.
Benzotropolone inhibitors of estradiol methylation: kinetics and in silico modeling studies
Bioorg. Med. Chem.
13
2501-2507
2005
Homo sapiens
Yao, J.; Li, Y.; Chang, M.; Wu, H.; Yang, X.; Goodman, J.E.; Liu, X.; Liu, H.; Mesecar, A.D.; Van Breemen, R.B.; Yager, J.D.; Bolton, J.L.
Catechol estrogen 4-hydroxyequilenin is a substrate and an inhibitor of catechol-O-methyltransferase
Chem. Res. Toxicol.
16
668-675
2003
Homo sapiens
Taskinen, J.; Ethell, B.T.; Pihlavisto, P.; Hood, A.M.; Burchell, B.; Coughtrie, M.W.H.
Conjugation of catechols by recombinant human sulfotransferases, UDP-glucuronosyltransferases, and soluble catechol O-methyltransferase: structure-conjugation relationships and predictive models
Drug Metab. Dispos.
31
1187-1197
2003
Homo sapiens (P21964), Homo sapiens
Lu, H.; Meng, X.; Yang, C.S.
Enzymology of methylation of tea catechins and inhibition of catechol-O-methyltransferase by (-)-epigallocatechin gallate
Drug Metab. Dispos.
31
572-579
2003
Homo sapiens, Rattus norvegicus, Sus scrofa
Nagai, M.; Conney, A.H.; Zhu, B.T.
Strong inhibitory effects of common tea catechins and bioflavonoids on the O-methylation of catechol estrogens catalyzed by human liver cytosolic catechol-O-methyltransferase
Drug Metab. Dispos.
32
497-504
2004
Homo sapiens
Bonifacio, M.J.; Vieira-Coelho, M.A.; Soares-da-Silva, P.
Kinetic inhibitory profile of BIA 3-202, a novel fast tight-binding, reversible and competitive catechol-O-methyltransferase inhibitor
Eur. J. Pharmacol.
460
163-170
2003
Rattus norvegicus
Zaccharia L.C.; Dubey, R.K.; Mi, Z.; Jackson, E.K.
Methylation of 2-hydroxyestradiol in isolated organs
Hypertension
42
82-87
2003
Rattus norvegicus
Cotton, N.J.; Stoddard, B.; Parson, W.W.
Oxidative inhibition of human soluble catechol-O-methyltransferase
J. Biol. Chem.
279
23710-23718
2004
Homo sapiens
Kim, Y.H.; Moody, J.D.; Freeman, J.P.; Brezna, B.; Engesser, K.H.; Cerniglia, C.E.
Evidence for the existence of PAH-quinone reductase and catechol-O-methyltransferase in Mycobacterium vanbaalenii PYR-1
J. Ind. Microbiol. Biotechnol.
31
507-516
2004
Mycolicibacterium vanbaalenii
Lerner, C.; Masjost, B.; Ruf, A.; Gramlich, V.; Jakob-Roetne, R.; Zurcher, G.; Borroni, E.; Diederich, F.
Bisubstrate inhibitors for the enzyme catechol-O-methyltransferase (COMT): influence of inhibitor preorganisation and linker length between the two substrate moieties on binding affinity
Org. Biomol. Chem.
1
42-49
2003
Homo sapiens
van Duursen, M.B.; Sanderson, J.T.; de Jong, P.C.; Kraaij, M.; van den Berg, M.
Phytochemicals inhibit catechol-O-methyltransferase activity in cytosolic fractions from healthy human mammary tissues: implications for catechol estrogen-induced DNA damage
Toxicol. Sci.
81
316-324
2004
Homo sapiens
Mantione, K.J.; Cadet, P.; Zhu, W.; Kream, R.M.; Sheehan, M.; Fricchione, G.L.; Goumon, Y.; Esch, T.; Stefano, G.B.
Endogenous morphine signaling via nitric oxide regulates the expression of CYP2D6 and COMT: autocrine/paracrine feedback inhibition
Addict. Biol.
13
118-123
2008
Homo sapiens
Baud, P.; Courtet, P.; Perroud, N.; Jollant, F.; Buresi, C.; Malafosse, A.
Catechol-O-methyltransferase polymorphism (COMT) in suicide attempters: a possible gender effect on anger traits
Am. J. Med. Genet. B Neuropsychiatr. Genet.
144B
1042-1047
2007
Homo sapiens
Domschke, K.; Deckert, J.; Odonovan, M.C.; Glatt, S.J.
Meta-analysis of COMT val158met in panic disorder: ethnic heterogeneity and gender specificity
Am. J. Med. Genet. B Neuropsychiatr. Genet.
144B
667-673
2007
Homo sapiens
Pelayo-Teran, J.M.; Crespo-Facorro, B.; Carrasco-Marin, E.; Perez-Iglesias, R.; Mata, I.; Arranz, M.J.; Leyva-Cobian, F.; Vazquez-Barquero, J.L.
Catechol-O-methyltransferase Val158Met polymorphism and clinical characteristics in first episode non-affective psychosis
Am. J. Med. Genet. B Neuropsychiatr. Genet.
147B
550-556
2008
Homo sapiens
Halleland, H.; Lundervold, A.J.; Halmy, A.; Haavik, J.; Johansson, S.
Association between catechol O-methyltransferase (COMT) haplotypes and severity of hyperactivity symptoms in adults
Am. J. Med. Genet. B Neuropsychiatr. Genet.
150B
403-410
2009
Homo sapiens
Barnett, J.H.; Heron, J.; Ring, S.M.; Golding, J.; Goldman, D.; Xu, K.; Jones, P.B.
Gender-specific effects of the catechol-O-methyltransferase Val108/158Met polymorphism on cognitive function in children
Am. J. Psychiatry
164
142-149
2007
Homo sapiens
Ozkan-Ariksoysal, D.; Tezcanli, B.; Kosova, B.; Ozsoz, M.
Design of electrochemical biosensor systems for the detection of specific DNA sequences in PCR-amplified nucleic acids related to the catechol-O-methyltransferase Val108/158Met polymorphism based on intrinsic guanine signal
Anal. Chem.
80
588-596
2008
Homo sapiens
Hirano, Y.; Tsunoda, M.; Shimosawa, T.; Fujita, T.; Funatsu, T.
Measurement of catechol-O-methyltransferase activity in the brain of Dahl salt-sensitive rats
Biol. Pharm. Bull.
30
2178-2180
2007
Rattus norvegicus
Lehmann, L.; Jiang, L.; Wagner, J.
Soy isoflavones decrease the catechol-O-methyltransferase-mediated inactivation of 4-hydroxyestradiol in cultured MCF-7 cells
Carcinogenesis
29
363-370
2008
Homo sapiens
Bai, H.W.; Shim, J.Y.; Yu, J.; Zhu, B.T.
Biochemical and molecular modeling studies of the O-methylation of various endogenous and exogenous catechol substrates catalyzed by recombinant human soluble and membrane-bound catechol-O-methyltransferases
Chem. Res. Toxicol.
20
1409-1425
2007
Homo sapiens
Zoccolella, S.; Iliceto, G.; deMari, M.; Livrea, P.; Lamberti, P.
Management of L-Dopa related hyperhomocysteinemia: catechol-O-methyltransferase (COMT) inhibitors or B vitamins? Results from a review
Clin. Chem. Lab. Med.
45
1607-1613
2007
Homo sapiens
Bonifacio, M.J.; Palma, P.N.; Almeida, L.; Soares-da-Silva, P.
Catechol-O-methyltransferase and its inhibitors in Parkinsons disease
CNS Drug Rev.
13
352-379
2007
Oryctolagus cuniculus, Homo sapiens, Mus musculus, Sus scrofa, Rattus norvegicus (P22734)
Apud, J.A.; Weinberger, D.R.
Treatment of cognitive deficits associated with schizophrenia: potential role of catechol-O-methyltransferase inhibitors
CNS Drugs
21
535-557
2007
Homo sapiens
Zahid, M.; Saeed, M.; Lu, F.; Gaikwad, N.; Rogan, E.; Cavalieri, E.
Inhibition of catechol-O-methyltransferase increases estrogen-DNA adduct formation
Free Radic. Biol. Med.
43
1534-1540
2007
Homo sapiens
Hirano, Y.; Tsunoda, M.; Shimosawa, T.; Matsui, H.; Fujita, T.; Funatsu, T.
Suppression of catechol-O-methyltransferase activity through blunting of alpha2-adrenoceptor can explain hypertension in Dahl salt-sensitive rats
Hypertens. Res.
30
269-278
2007
Homo sapiens, Rattus norvegicus
Cheon, K.A.; Jun, J.Y.; Cho, D.Y.
Association of the catechol-O-methyltransferase polymorphism with methylphenidate response in a classroom setting in children with attention-deficit hyperactivity disorder
Int. Clin. Psychopharmacol.
23
291-298
2008
Homo sapiens
Hirose, Y.; Tsutsui, T.W.; Ohno, M.; Barrett, J.C.; Tsutsui, T.
Effects of a catechol-O-methyltransferase inhibitor on catechol estrogen-induced cellular transformation, chromosome aberrations and apoptosis in Syrian hamster embryo cells
Int. J. Cancer
120
1627-1633
2007
Mesocricetus auratus
Savitz, J.B.; van der Merwe, L.; Newman, T.K.; Solms, M.; Stein, D.J.; Ramesar, R.S.
The relationship between childhood abuse and dissociation. Is it influenced by catechol-O-methyltransferase (COMT) activity?
Int. J. Neuropsychopharmacol.
11
149-161
2008
Homo sapiens
Lorentzon, M.; Eriksson, A.L.; Nilsson, S.; Mellstroem, D.; Ohlsson, C.
Association between physical activity and BMD in young men is modulated by catechol-O-methyltransferase (COMT) genotype: the GOOD study
J. Bone Miner. Res.
22
1165-1172
2007
Homo sapiens
Passarinha, L.A.; Bonifacio, M.J.; Soares-da-Silva, P.; Queiroz, J.A.
A new approach on the purification of recombinant human soluble catechol-O-methyltransferase from an Escherichia coli extract using hydrophobic interaction chromatography
J. Chromatogr. A
1177
287-296
2008
Homo sapiens
Stolk, L.; van Meurs, J.B.; Jhamai, M.; Arp, P.P.; van Leeuwen, J.P.; Hofman, A.; de Jong, F.H.; Pols, H.A.; Uitterlinden, A.G.
The catechol-O-methyltransferase Met158 low-activity allele and association with nonvertebral fracture risk in elderly men
J. Clin. Endocrinol. Metab.
92
3206-3212
2007
Homo sapiens
Rutherford, K.; Le Trong, I.; Stenkamp, R.E.; Parson, W.W.
Crystal structures of human 108V and 108M catechol O-methyltransferase
J. Mol. Biol.
380
120-130
2008
Sus scrofa, Homo sapiens (P21964), Homo sapiens, Rattus norvegicus (P22734)
Yavich, L.; Forsberg, M.M.; Karayiorgou, M.; Gogos, J.A.; Maennistoe, P.T.
Site-specific role of catechol-O-methyltransferase in dopamine overflow within prefrontal cortex and dorsal striatum
J. Neurosci.
27
10196-10209
2007
Mus musculus
Tan, H.Y.; Chen, Q.; Goldberg, T.E.; Mattay, V.S.; Meyer-Lindenberg, A.; Weinberger, D.R.; Callicott, J.H.
Catechol-O-methyltransferase Val158Met modulation of prefrontal-parietal-striatal brain systems during arithmetic and temporal transformations in working memory
J. Neurosci.
27
13393-13401
2007
Homo sapiens
Williams-Gray, C.H.; Hampshire, A.; Robbins, T.W.; Owen, A.M.; Barker, R.A.
Catechol O-methyltransferase Val158Met genotype influences frontoparietal activity during planning in patients with Parkinsons disease
J. Neurosci.
27
4832-4838
2007
Homo sapiens
Papaleo, F.; Crawley, J.N.; Song, J.; Lipska, B.K.; Pickel, J.; Weinberger, D.R.; Chen, J.
Genetic dissection of the role of catechol-O-methyltransferase in cognition and stress reactivity in mice
J. Neurosci.
28
8709-8723
2008
Homo sapiens (P21964), Homo sapiens
Lu, F.; Zahid, M.; Saeed, M.; Cavalieri, E.L.; Rogan, E.G.
Estrogen metabolism and formation of estrogen-DNA adducts in estradiol-treated MCF-10F cells. The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin induction and catechol-O-methyltransferase inhibition
J. Steroid Biochem. Mol. Biol.
105
150-158
2007
Homo sapiens
Helkamaa, T.; Reenilae, I.; Tuominen, R.K.; Soinila, S.; Vaeaenaenen, A.; Tilgmann, C.; Rauhala, P.
Increased catechol-O-methyltransferase activity and protein expression in OX-42-positive cells in the substantia nigra after lipopolysaccharide microinfusion
Neurochem. Int.
51
412-423
2007
Rattus norvegicus
Babovic, D.; OTuathaigh, C.M.; OConnor, A.M.; OSullivan, G.J.; Tighe, O.; Croke, D.T.; Karayiorgou, M.; Gogos, J.A.; Cotter, D.; Waddington, J.L.
Phenotypic characterization of cognition and social behavior in mice with heterozygous versus homozygous deletion of catechol-O-methyltransferase
Neuroscience
155
1021-1029
2008
Homo sapiens, Mus musculus
Nackley, A.G.; Tan, K.S.; Fecho, K.; Flood, P.; Diatchenko, L.; Maixner, W.
Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta 2- and beta 3-adrenergic receptors
Pain
128
199-208
2007
Rattus norvegicus
Ronkainen, P.H.; Poellaenen, E.; Toermaekangas, T.; Tiainen, K.; Koskenvuo, M.; Kaprio, J.; Rantanen, T.; Sipilae, S.; Kovanen, V.
Catechol-O-methyltransferase gene polymorphism is associated with skeletal muscle properties in older women alone and together with physical activity
PLoS ONE
3
e1819
2008
Homo sapiens
Crespo-Facorro, B.; Roiz-Santianez, R.; Pelayo-Teran, J.M.; Perez-Iglesias, R.; Carrasco-Marin, E.; Mata, I.; Gonzalez-Mandly, A.; Jorge, R.; Vazquez-Barquero, J.L.
Low-activity allele of catechol-O-methyltransferase (COMTL) is associated with increased lateral ventricles in patients with first episode non-affective psychosis
Prog. Neuropsychopharmacol. Biol. Psychiatry
31
1514-1518
2007
Homo sapiens (P21964), Homo sapiens
Roussos, P.; Giakoumaki, S.G.; Rogdaki, M.; Pavlakis, S.; Frangou, S.; Bitsios, P.
Prepulse inhibition of the startle reflex depends on the catechol O-methyltransferase Val158Met gene polymorphism
Psychol. Med.
38
1651-1658
2008
Homo sapiens
Wentz, M.J.; Shi, S.Q.; Shi, L.; Salama, S.A.; Harirah, H.M.; Fouad, H.; Garfield, R.E.; Al-Hendy, A.
Treatment with an inhibitor of catechol-O-methyltransferase activity reduces preterm birth and impedes cervical resistance to stretch in pregnant rats
Reproduction
134
831-839
2007
Rattus norvegicus
Tsuji, E.; Okazaki, K.; Takeda, K.
Crystal structures of rat catechol-O-methyltransferase complexed with coumarine-based inhibitor
Biochem. Biophys. Res. Commun.
378
494-497
2009
Rattus norvegicus (P22734)
Overbye, A.; Seglen, P.O.
Phosphorylated and non-phosphorylated forms of catechol O-methyltransferase in rat liver, brain and other tissues
Biochem. J.
417
535-545
2009
Rattus norvegicus
Doyle, A.; Yager, J.
Catechol-O-methyltransferase: Effects of the val108met polymorphism on protein turnover in human cells
Biochim. Biophys. Acta
1780
27-33
2008
Homo sapiens
Rutherford, K.; Alphandery, E.; McMillan, A.; Daggett, V.; Parson, W.W.
The V108M mutation decreases the structural stability of catechol O-methyltransferase
Biochim. Biophys. Acta
1784
1098-1105
2008
Homo sapiens (P21964), Homo sapiens
Reenilae, I.; Rauhala, P.
Simultaneous analysis of catechol-O-methyl transferase activity, S-adenosylhomocysteine and adenosine
Biomed. Chromatogr.
24
294-300
2010
Rattus norvegicus
Huo, C.; Yang, H.; Cui, Q.C.; Dou, Q.P.; Chan, T.H.
Proteasome inhibition in human breast cancer cells with high catechol-O-methyltransferase activity by green tea polyphenol EGCG analogs
Bioorg. Med. Chem.
18
1252-1258
2010
Homo sapiens
Kaeenmaeki, M.; Tammimaeki, A.; Garcia-Horsman, J.A.; Myoehaenen, T.; Schendzielorz, N.; Karayiorgou, M.; Gogos, J.A.; Maennistoe, P.T.
Importance of membrane-bound catechol-O-methyltransferase in L-DOPA metabolism: a pharmacokinetic study in two types of Comt gene modified mice
Br. J. Pharmacol.
158
1884-1894
2009
Mus musculus
Ross, J.R.; Riley, J.; Taegetmeyer, A.B.; Sato, H.; Gretton, S.; du Bois, R.M.; Welsh, K.I.
Genetic variation and response to morphine in cancer patients: catechol-O-methyltransferase and multidrug resistance-1 gene polymorphisms are associated with central side effects
Cancer
112
1390-1403
2008
Homo sapiens
Meyer, M.R.; Maurer, H.H.
Enantioselectivity in the methylation of the catecholic phase I metabolites of methylenedioxy designer drugs and their capability to inhibit catechol-O-methyltransferase-catalyzed dopamine 3-methylation
Chem. Res. Toxicol.
22
1205-1211
2009
Homo sapiens
Ho, P.W.; Chu, A.C.; Kwok, K.H.; Liu, H.F.; Kung, M.H.; Ramsden, D.B.; Ho, S.L.
Effects of plasticisers and related compounds on the expression of the soluble form of catechol-O-methyltransferase in MCF-7 cells
Curr. Drug Metab.
9
276-279
2008
Homo sapiens
Ho, P.W.; Garner, C.E.; Ho, J.W.; Leung, K.C.; Chu, A.C.; Kwok, K.H.; Kung, M.H.; Burka, L.T.; Ramsden, D.B.; Ho, S.L.
Estrogenic phenol and catechol metabolites of PCBs modulate catechol-O-methyltransferase expression via the estrogen receptor: potential contribution to cancer risk
Curr. Drug Metab.
9
304-309
2008
Homo sapiens
Salih, S.; Salama, S.; Fadl, A.; Nagamani, M.; Al-Hendy, A.
Expression and cyclic variations of catechol-O-methyl transferase in human endometrial stroma
Fertil. Steril.
90
789-797
2008
Homo sapiens
Salama, S.A.; Kamel, M.; Awad, M.; Nasser, A.H.; Al-Hendy, A.; Botting, S.; Arrastia, C.
Catecholestrogens induce oxidative stress and malignant transformation in human endometrial glandular cells: protective effect of catechol-O-methyltransferase
Int. J. Cancer
123
1246-1254
2008
Homo sapiens
Zeng, B.Y.; Balfour, R.H.; Jackson, M.J.; Rose, S.; Jenner, P.
Expression of catechol-O-methyltransferase in the brain and periphery of normal and MPTP-treated common marmosets
J. Neural Transm.
117
45-51
2010
Callithrix jacchus
Zhu, B.T.; Wang, P.; Nagai, M.; Wen, Y.; Bai, H.W.
Inhibition of human catechol-O-methyltransferase (COMT)-mediated O-methylation of catechol estrogens by major polyphenolic components present in coffee
J. Steroid Biochem. Mol. Biol.
113
65-74
2009
Homo sapiens
Tsuji, E.; Okazaki, K.; Isaji, M.; Takeda, K.
Crystal structures of the apo and holo form of rat catechol-O-methyltransferase
J. Struct. Biol.
165
133-139
2009
Rattus norvegicus (P22734)
Yasuda, S.; Yasuda, T.; Hui, Y.; Liu, M.Y.; Suiko, M.; Sakakibara, Y.; Liu, M.C.
Concerted action of the cytosolic sulfotransferase, SULT1A3, and catechol-O-methyltransferase in the metabolism of dopamine in SK-N-MC human neuroblastoma cells
Neurosci. Res.
64
273-279
2009
Homo sapiens
Meyers, B.; DAgostino, A.; Walker, J.; Kritzer, M.
Gonadectomy and hormone replacement exert region- and enzyme isoform-specific effects on monoamine oxidase and catechol-O-methyltransferase activity in prefrontal cortex and neostriatum of adult male rats
Neuroscience
165
850-862
2010
Rattus norvegicus
Sand, P.; Korte, G.; Domani, M.; Konstandin, N.; Karl, A.; Wagner, K.; Dinnbier, M.
Alternatively spliced human catechol-O-methyltransferase (COMT) rationalizes lack of Val158Met effects on pain tolerance
Pain
136
445-446
2008
Homo sapiens (A3F6Y9), Homo sapiens
Salama, S.A.; Kamel, M.W.; Botting, S.; Salih, S.M.; Borahay, M.A.; Hamed, A.A.; Kilic, G.S.; Saeed, M.; Williams, M.Y.; Diaz-Arrastia, C.R.
Catechol-O-methyltransferase expression and 2-methoxyestradiol affect microtubule dynamics and modify steroid receptor signaling in leiomyoma cells
PLoS ONE
4
e7356
2009
Homo sapiens
Du, X.; Schwander, M.; Moresco, E.M.; Viviani, P.; Haller, C.; Hildebrand, M.S.; Pak, K.; Tarantino, L.; Roberts, A.; Richardson, H.; Koob, G.; Najmabadi, H.; Ryan, A.F.; Smith, R.J.; Mueller, U.; Beutler, B.
A catechol-O-methyltransferase that is essential for auditory function in mice and humans
Proc. Natl. Acad. Sci. USA
105
14609-14614
2008
Homo sapiens, Mus musculus
Ellermann, M.; Lerner, C.; Burgy, G.; Ehler, A.; Bissantz, C.; Jakob-Roetne, R.; Paulini, R.; Allemann, O.; Tissot, H.; Gruenstein, D.; Stihle, M.; Diederich, F.; Rudolph, M.G.
Catechol-O-methyltransferase in complex with substituted 3-deoxyribose bisubstrate inhibitors
Acta Crystallogr. Sect. D
68
253-260
2012
Rattus norvegicus (P22734)
Li, D.; Du, X.; Zhao, X.; Wang, J.
Expression, purification and activity assay of the recombinant protein of Catechol-O-Methyltransferase from chinese white shrimp (Fenneropenaeus chinensis)
Am. J. Biochem. Biotechnol.
6
148-154
2010
Penaeus chinensis
-
Rautio, J.; Leppaenen, J.; Lehtonen, M.; Laine, K.; Koskinen, M.; Pystynen, J.; Savolainen, J.; Sairanen, M.
Design, synthesis and in vitro/in vivo evaluation of orally bioavailable prodrugs of a catechol-O-methyltransferase inhibitor
Bioorg. Med. Chem. Lett.
20
2614-2616
2010
Homo sapiens
Ellermann, M.; Paulini, R.; Jakob-Roetne, R.; Lerner, C.; Borroni, E.; Roth, D.; Ehler, A.; Schweizer, W.B.; Schlatter, D.; Rudolph, M.G.; Diederich, F.
Molecular recognition at the active site of catechol-O-methyltransferase (COMT): adenine replacements in bisubstrate inhibitors
Chemistry
17
6369-6381
2011
Rattus norvegicus
Skopec, M.M.; Dearing, M.D.
Differential expression and activity of catechol-O-methyl transferase (COMT) in a generalist (Neotoma albigula) and juniper specialist (Neotoma stephensi) woodrat
Comp. Biochem. Physiol. C
154
383-390
2011
Neotoma stephensi, Neotoma albigula
Zhu, B.T.; Wu, K.Y.; Wang, P.; Cai, M.X.; Conney, A.H.
O-methylation of catechol estrogens by human placental catechol-o-methyltransferase: interindividual differences in sensitivity to heat inactivation and to inhibition by dietary polyphenols
Drug Metab. Dispos.
38
1892-1899
2010
Homo sapiens
Kiss, L.E.; Ferreira, H.S.; Torrao, L.; Bonifacio, M.J.; Palma, P.N.; Soares-da-Silva, P.; Learmonth, D.A.
Discovery of a long-acting, peripherally selective inhibitor of catechol-O-methyltransferase
J. Med. Chem.
53
3396-3411
2010
Rattus norvegicus
Yalcin, D.; Bayraktar, O.
Inhibition of catechol-O-methyltransferase (COMT) by some plant-derived alkaloids and phenolics
J. Mol. Catal. B
64
162-166
2010
Sus scrofa domesticus
-
Myoehaenen, T.T.; Schendzielorz, N.; Maennistoe, P.T.
Distribution of catechol-O-methyltransferase (COMT) proteins and enzymatic activities in wild-type and soluble COMT deficient mice
J. Neurochem.
113
1632-1643
2010
Mus musculus
Robinson, R.G.; Smith, S.M.; Wolkenberg, S.E.; Kandebo, M.; Yao, L.; Gibson, C.R.; Harrison, S.T.; Polsky-Fisher, S.; Barrow, J.C.; Manley, P.J.; Mulhearn, J.J.; Nanda, K.K.; Schubert, J.W.; Trotter, B.W.; Zhao, Z.; Sanders, J.M.; Smith, R.F.; McLoughlin, D.; Sharma, S.; Hall, D.L.; Walker, T.L.; Kershner, J.L.; , B.
Characterization of non-nitrocatechol pan and isoform specific catechol-O-methyltransferase inhibitors and substrates
ACS Chem. Neurosci.
3
129-140
2012
Homo sapiens, Rattus norvegicus
Kurogi, K.; Alazizi, A.; Liu, M.Y.; Sakakibara, Y.; Suiko, M.; Sugahara, T.; Liu, M.C.
Concerted actions of the catechol O-methyltransferase and the cytosolic sulfotransferase SULT1A3 in the metabolism of catecholic drugs
Biochem. Pharmacol.
84
1186-1195
2012
Homo sapiens
Pedro, A.; Pereira, P.; Bonifacio, M.; Queiroz, J.; Passarinha, L.
Purification of membrane-bound catechol-O-methyltransferase by arginine-affinity chromatography
Chromatographia
78
1339-1348
2015
Homo sapiens
-
Weinert, C.; Wiese, S.; Rawel, H.; Esatbeyoglu, T.; Winterhalter, P.; Homann, T.; Kulling, S.
Methylation of catechins and procyanidins by rat and human catechol-o-methyltransferase: Metabolite profiling and molecular modeling studies
Drug Metab. Dispos.
40
353-359
2012
Homo sapiens, Rattus norvegicus
Lorenz, M.; Paul, F.; Moobed, M.; Baumann, G.; Zimmermann, B.F.; Stangl, K.; Stangl, V.
The activity of catechol-O-methyltransferase (COMT) is not impaired by high doses of epigallocatechin-3-gallate (EGCG) in vivo
Eur. J. Pharmacol.
740
645-651
2014
Homo sapiens
Rajesh, S.; Kiruthika, J.; Ponniah, A.G.; Shekhar, M.S.
Identification, cloning and expression analysis of catechol-O-methyltransferase (COMT) gene from shrimp, Penaeus monodon and its relevance to salinity stress
Fish Shellfish Immunol.
32
693-699
2012
Penaeus monodon (G5D6Q3), Penaeus monodon
Silva, R.; Ferreira, S.; Bonifacio, M.J.; Dias, J.M.; Queiroz, J.A.; Passarinha, L.A.
Optimization of fermentation conditions for the production of human soluble catechol-O-methyltransferase by Escherichia coli using artificial neural network
J. Biotechnol.
160
161-168
2012
Homo sapiens
Garcia-Meseguer, R.; Zinovjev, K.; Roca, M.; Ruiz-Pernia, J.J.; Tunon, I.
Linking electrostatic effects and protein motions in enzymatic catalysis. A theoretical analysis of catechol O-methyltransferase
J. Phys. Chem. B
119
873-882
2015
Rattus norvegicus (P22734)
Moskovitz, J.; Walss-Bass, C.; Cruz, D.A.; Thompson, P.M.; Hairston, J.; Bortolato, M.
The enzymatic activities of brain catechol-O-methyltransferase (COMT) and methionine sulphoxide reductase are correlated in a COMT Val/Met allele-dependent fashion
Neuropathol. Appl. Neurobiol.
41
941-951
2015
Homo sapiens
Zhu, X.; Jia, Y.H.
Inhibition of catechol-O-methyltransferase (COMT) by myricetin, dihydromyricetin, and myricitrin
Pharmazie
69
183-186
2014
Homo sapiens
Magina, S.; Vieira-Coelho, M.A.; Serrao, M.P.; Kosmus, C.; Moura, E.; Moura, D.
Ultraviolet B radiation differentially modifies catechol-O-methyltransferase activity in keratinocytes and melanoma cells
Photodermatol. Photoimmunol. Photomed.
28
137-141
2012
Homo sapiens
Mageroy, M.; Tieman, D.; Floystad, A.; Taylor, M.; Klee, H.
A Solanum lycopersicum catechol-O-methyltransferase involved in synthesis of the flavor molecule guaiacol
Plant J.
69
1043-1051
2012
Solanum lycopersicum
Sparta, M.; Alexandrova, A.N.
How metal substitution affects the enzymatic activity of catechol-O-methyltransferase
PLoS ONE
7
e47172
2012
Homo sapiens (P21964)
Schendzielorz, N.; Oinas, J.P.; Myoehaenen, T.T.; Reenilae, I.; Raasmaja, A.; Maennistoe, P.T.
Catechol-O-methyltransferase (COMT) protein expression and activity after dopaminergic and noradrenergic lesions of the rat brain
PLoS ONE
8
e61392
2013
Rattus norvegicus
Hursel, R.; Janssens, P.L.; Bouwman, F.G.; Mariman, E.C.; Westerterp-Plantenga, M.S.
The role of catechol-O-methyl transferase Val(108/158)Met polymorphism (rs4680) in the effect of green tea on resting energy expenditure and fat oxidation: a pilot study
PLoS ONE
9
e106220
2014
Homo sapiens
Suriguga, M.; Li, X.F.; Li, Y.; Yu, C.H.; Li, Y.R.; Yi, Z.C.
The role of catechol-O-methyltransferase in catechol-enhanced erythroid differentiation of K562 cells
Toxicol. Appl. Pharmacol.
273
635-643
2013
Homo sapiens
Qi, Q.; Cao, L.; Li, F.; Wang, H.; Liu, H.; Hao, H.; Hao, K.
Salvianolic acid B as a substrate and weak catechol-O-methyltransferase inhibitor in rats
Xenobiotica
45
820-827
2015
Rattus norvegicus
Harrison, S.T.; Poslusney, M.S.; Mulhearn, J.J.; Zhao, Z.; Kett, N.R.; Schubert, J.W.; Melamed, J.Y.; Allison, T.J.; Patel, S.B.; Sanders, J.M.; Sharma, S.; Smith, R.F.; Hall, D.L.; Robinson, R.G.; Sachs, N.A.; Hutson, P.H.; Wolkenberg, S.E.; Barrow, J.C.
Synthesis and evaluation of heterocyclic catechol mimics as inhibitors of catechol-O-methyltransferase (COMT)
ACS Med. Chem. Lett.
6
318-323
2015
Homo sapiens (P21964)
Law, B.J.; Bennett, M.R.; Thompson, M.L.; Levy, C.; Shepherd, S.A.; Leys, D.; Micklefield, J.
Effects of active-site modification and quaternary structure on the regioselectivity of catechol-O-methyltransferase
Angew. Chem. Int. Ed. Engl.
55
2683-2687
2016
Rattus norvegicus (P22734)
Poor, M.; Zrinyi, Z.; K?szegi, T.
Structure related effects of flavonoid aglycones on cell cycle progression of HepG2 cells Metabolic activation of fisetin and quercetin by catechol-O-methyltransferase (COMT)
Biomed. Pharmacother.
83
998-1005
2016
Homo sapiens (P21964)
Zhao, Z.; Harrison, S.T.; Schubert, J.W.; Sanders, J.M.; Polsky-Fisher, S.; Zhang, N.R.; McLoughlin, D.; Gibson, C.R.; Robinson, R.G.; Sachs, N.A.; Kandebo, M.; Yao, L.; Smith, S.M.; Hutson, P.H.; Wolkenberg, S.E.; Barrow, J.C.
Synthesis and optimization of N-heterocyclic pyridinones as catechol-O-methyltransferase (COMT) inhibitors
Bioorg. Med. Chem. Lett.
26
2952-2956
2016
Homo sapiens (P21964)
Pedro, A.; Pereira, P.; Bonifacio, M.; Queiroz, J.; Passarinha, L.
Purification of membrane-bound catechol-O-methyltransferase by arginine-affinity chromatography
Chromatographia
78
1339-1348
2015
Homo sapiens (P21964)
-
Wang, Q.; Teng, M.; Li, X.
Functional and structural characterization of a novel catechol-O-methyltransferase from Schizosaccharomyces pombe
IUBMB Life
71
330-339
2019
Schizosaccharomyces pombe (O42898), Schizosaccharomyces pombe, Schizosaccharomyces pombe ATCC 24843 (O42898)
Buchler, I.; Akuma, D.; Au, V.; Carr, G.; de Leon, P.; DePasquale, M.; Ernst, G.; Huang, Y.; Kimos, M.; Kolobova, A.; Poslusney, M.; Wei, H.; Swinnen, D.; Montel, F.; Moureau, F.; Jigorel, E.; Schulze, M.E.D.; Wood, M.; Barrow, J.C.
Optimization of 8-hydroxyquinolines as inhibitors of catechol O-methyltransferase
J. Med. Chem.
61
9647-9665
2018
Homo sapiens (P21964)
Ikeda, M.; Iijima, H.; Shinoda, I.; Iwamoto, H.; Takeda, Y.
Inhibitory effect of bovine lactoferrin on catechol-O-methyltransferase
Molecules
22
1373
2017
Homo sapiens (P21964)
Patra, N.; Ioannidis, E.I.; Kulik, H.J.
Computational investigation of the interplay of substrate positioning and reactivity in catechol O-methyltransferase
PLoS ONE
11
e0161868
2016
Homo sapiens (P21964)
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