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Information on EC 2.1.1.57 - methyltransferase cap1

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EC Tree
     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.57 methyltransferase cap1
IUBMB Comments
This enzyme catalyses the methylation of the ribose on the first transcribed nucleotide of mRNA or snRNA molecules. This methylation event is known as cap1, and occurs in all mRNAs and snRNAs of higher eukaryotes, including insects, vertebrates and their viruses. The human enzyme can also methylate mRNA molecules that lack methylation on the capping 5'-triphosphoguanosine .
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Word Map
The enzyme appears in viruses and cellular organisms
Synonyms
nsp16, 2'-o-methyltransferase, 2'-o-mtase, cmtr1, ns5 mtase, 2'-o mtase, (nucleoside-2'-o-)-methyltransferase, nonstructural protein 16, 2'-o methyltransferase, isg95, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + a 5'-(N7-methyl 5'-triphosphoguanosine)-(ribonucleotide)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N7-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleotide)-[mRNA]
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PATHWAY SOURCE
PATHWAYS
MetaCyc