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The expected taxonomic range for this enzyme is: Bacteria, Eukaryota
Synonyms
adenine-n6 methyltransferase, yfic protein, more
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adenine-N6 methyltransferase
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S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N6-methyladenine
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methyl group transfer
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S-adenosyl-L-methionine:tRNA (adenine-N6-)-methyltransferase
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S-adenosyl-L-methionine + adenine 37 in tRNA1Val(cmo5UAC)
S-adenosyl-L-homocysteine + N6-methyladenine 37 in tRNA1Val(cmo5UAC)
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Substrates: the enzyme specifically methylates adenosine at position 37 of tRNA1Val(cmo5UAC)
Products: -
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S-adenosyl-L-methionine + adenine in tRNA
S-adenosyl-L-homocysteine + N6-methyladenine in tRNA
S-adenosyl-L-methionine + adenine in tRNA
S-adenosyl-L-homocysteine + N6-methyladenine in tRNA
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Substrates: -
Products: -
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S-adenosyl-L-methionine + adenine in tRNA
S-adenosyl-L-homocysteine + N6-methyladenine in tRNA
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Substrates: methyl group acceptor is yeast tRNA, poor acceptors are E. coli or mycoplasma tRNAs
Products: -
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S-adenosyl-L-methionine + adenine in tRNA
S-adenosyl-L-homocysteine + N6-methyladenine in tRNA
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Substrates: -
Products: -
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strains BW25141 and JW2559
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brenda
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brenda
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brenda
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brenda
Highest Expressing Human Cell Lines
Cell Line Links
Gene Links
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physiological function
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the yfiC gene confers a growth advantage under conditions of osmotic and oxidative stress
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J9FSH0_9ZZZZ
118
0
12735
TrEMBL
other Location (Reliability: 4)
A0A7C9A5R7_OPUST
128
0
13970
TrEMBL
other Location (Reliability: 1)
A1Z759_DROME
412
0
46057
TrEMBL
other Location (Reliability: 2)
A0A7C9A3D6_OPUST
193
0
21563
TrEMBL
other Location (Reliability: 2)
U5Q2A6_9BACT
268
0
29856
TrEMBL
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I6CIB5_SHIFL
51
0
5991
TrEMBL
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Q8MR50_DROME
394
0
43984
TrEMBL
other Location (Reliability: 2)
A0A6N3QYT0_SHIFL
51
0
5991
TrEMBL
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Ni-NTA agarose column chromatography
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expressed in Escherichia coli AG1 cells
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Sharma, O.K.
Differences in the transfer RNA methyltransferases from normal rat liver and Novikoff hepatoma
Biochim. Biophys. Acta
299
415-427
1973
Rattus norvegicus
brenda
Golovina, A.Y.; Sergiev, P.V.; Golovin, A.V.; Serebryakova, M.V.; Demina, I.; Govorun, V.M.; Dontsova, O.A.
The yfiC gene of E. coli encodes an adenine-N6 methyltransferase that specifically modifies A37 of tRNA1Val(cmo5UAC)
RNA
15
1134-1141
2009
Escherichia coli
brenda
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