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S-adenosyl-L-methionine + 5,7,4'trihydroxyisoflavone
S-adenosyl-L-homocysteine + 5,7-dihydroxy-4'-O-methylisoflavone
-
-
-
-
?
S-adenosyl-L-methionine + 7,4'-dihydroxyisoflavone
S-adenosyl-L-homocysteine + 7-hydroxy-4'-methoxylisoflavone
-
i.e. daidzein. The reaction follows an ordered BiBi mechanism with S-adenosylmethionine and S-adenosylhomocysteine as leading reaction partners
-
-
?
S-adenosyl-L-methionine + 7,4'-dihydroxyisoflavone
S-adenosyl-L-homocysteine + 7-hydroxy-4'-O-methylisoflavone
S-adenosyl-L-methionine + a 4'-hydroxyisoflavone
S-adenosyl-L-homocysteine + a 4'-methoxyisoflavone
-
-
-
-
?
S-adenosyl-L-methionine + daidzein
S-adenosyl-L-homocysteine + formononetin
S-adenosyl-L-methionine + genistein
S-adenosyl-L-homocysteine + biochanin A
S-adenosyl-L-methionine + isoformononetin
S-adenosyl-L-homocysteine + 4',7-dimethoxyisoflavone
5.2% activity compared to genistein
-
-
?
S-adenosyl-L-methionine + prunetin
S-adenosyl-L-homocysteine + 4',7-dimethoxy-5-hydroxyisoflavone
6.2% activity compared to genistein
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-
?
additional information
?
-
S-adenosyl-L-methionine + 7,4'-dihydroxyisoflavone
S-adenosyl-L-homocysteine + 7-hydroxy-4'-O-methylisoflavone
-
i.e. daidzein. Methylation is the last step in the biosynthesis of 4-methoxyisoflavones
-
-
?
S-adenosyl-L-methionine + 7,4'-dihydroxyisoflavone
S-adenosyl-L-homocysteine + 7-hydroxy-4'-O-methylisoflavone
-
i.e. daidzein. Methylation is the last step in the biosynthesis of 4'-methoxyisoflavones
-
-
?
S-adenosyl-L-methionine + daidzein
S-adenosyl-L-homocysteine + formononetin
-
-
-
-
?
S-adenosyl-L-methionine + daidzein
S-adenosyl-L-homocysteine + formononetin
48.8% activity compared to genistein
-
-
?
S-adenosyl-L-methionine + genistein
S-adenosyl-L-homocysteine + biochanin A
-
-
-
-
?
S-adenosyl-L-methionine + genistein
S-adenosyl-L-homocysteine + biochanin A
100% activity
-
-
?
additional information
?
-
-
no methylation of: p-hydroxycinnamic acid, p-hydroxybenzoic acid, 3,4-dihydroxycinnamic acid, naringenin, (5,7,4'-trihydroxyflavanone), apigenin (5,7,4'-trihydroxyflavone), luteolin (5,7,3',4'-tetrahydroxyflavone), kaempferol (3,5,7,4'-tetrahydroxyflavone), wedelolactone (5,3',4'-trihydroxy-7-methoxycoumestone)
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-
?
additional information
?
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-
the bifunctionally enzyme also catalyzes the formation of a 2,7-dihydroxy-4'-methoxyisoflavanone from a 2,4',7-trihydroxyisoflavanone (reaction of EC 2.1.1.212)
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additional information
?
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the enzyme is not able to methylate 2,7,4'-trihydroxyisoflavanone, biochanin A, formononetin, apigenin, luteolin, liquirtitigenin, kaempferol, quercetin, isoliquiritigenin, and caffeic acid
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-
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additional information
?
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the enzyme is not able to methylate 2,7,4'-trihydroxyisoflavanone, biochanin A, formononetin, apigenin, luteolin, liquirtitigenin, kaempferol, quercetin, isoliquiritigenin, and caffeic acid
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S-adenosyl-L-methionine + 7,4'-dihydroxyisoflavone
S-adenosyl-L-homocysteine + 7-hydroxy-4'-O-methylisoflavone
S-adenosyl-L-methionine + a 4'-hydroxyisoflavone
S-adenosyl-L-homocysteine + a 4'-methoxyisoflavone
-
-
-
-
?
S-adenosyl-L-methionine + daidzein
S-adenosyl-L-homocysteine + formononetin
-
-
-
-
?
S-adenosyl-L-methionine + genistein
S-adenosyl-L-homocysteine + biochanin A
-
-
-
-
?
S-adenosyl-L-methionine + 7,4'-dihydroxyisoflavone
S-adenosyl-L-homocysteine + 7-hydroxy-4'-O-methylisoflavone
-
i.e. daidzein. Methylation is the last step in the biosynthesis of 4-methoxyisoflavones
-
-
?
S-adenosyl-L-methionine + 7,4'-dihydroxyisoflavone
S-adenosyl-L-homocysteine + 7-hydroxy-4'-O-methylisoflavone
-
i.e. daidzein. Methylation is the last step in the biosynthesis of 4'-methoxyisoflavones
-
-
?
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Wengenmayer, H.; Ebel, J.; Grisebach, H.
Purification and properties of a S-adenosylmethionine: isoflavone 4-O-methyltransferase from cell suspension cultures of Cicer arietinum L
Eur. J. Biochem.
50
135-143
1974
Cicer arietinum
brenda
Li, J.; Li, C.; Gou, J.; Wang, X.; Fan, R.; Zhang, Y.
An alternative pathway for formononetin biosynthesis in Pueraria lobata
Front. Plant Sci.
7
861
2016
Pueraria montana var. lobata (A0A1L1Z441), Pueraria montana var. lobata
brenda
Mochida, K.; Sakurai, T.; Seki, H.; Yoshida, T.; Takahagi, K.; Sawai, S.; Uchiyama, H.; Muranaka, T.; Saito, K.
Draft genome assembly and annotation of Glycyrrhiza uralensis, a medicinal legume
Plant J.
89
181-194
2017
Glycyrrhiza uralensis
brenda
2.1.1.46 isoflavone 4'-O-methyltransferase
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