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The taxonomic range for the selected organisms is: Bacillus subtilis
The enzyme appears in selected viruses and cellular organisms
Synonyms
thymidylate synthase, thymidylate synthetase, human ts, dtmp synthase, thymidylate synthase a, tmp synthetase, y110a7a.4, 5,10-methylenetetrahydrofolate:dump c-methyltransferase,
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methylenetetrahydrofolate:dUMP C-methyltransferase
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thymidylate synthetase
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methylene group transfer
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reductive methylation
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-, -, -, -, -, -, -, -, -
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5,10-methylenetetrahydrofolate:dUMP C-methyltransferase
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5,10-methylenetetrahydrofolate + dUMP
dihydrofolate + dTMP
5,10-methylenetetrahydrofolate + dUMP
dihydrofolate + dTMP
5,10-methylenetetrahydrofolate + dUMP
dihydrofolate + dTMP
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?, r
5,10-methylenetetrahydrofolate + dUMP
dihydrofolate + dTMP
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r
5,10-methylenetetrahydrofolate + dUMP
dihydrofolate + dTMP
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?
5,10-methylenetetrahydrofolate + dUMP
dihydrofolate + dTMP
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r
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5,10-methylenetetrahydrofolate + dUMP
dihydrofolate + dTMP
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?
5,10-methylenetetrahydrofolate + dUMP
dihydrofolate + dTMP
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?
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5-fluoro-2'-deoxyuridylic acid
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-
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0.000001
5-fluoro-2'-deoxyuridylic acid
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Uniprot
brenda
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50
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fairly stable, incubation for 10 min results in loss of 50% enzyme activity
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2 different thymidilate synthases, bsTS-A and bsTS-B
contains 2 genes for thymidilate synthase, ThyA and ThyB
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Belfort, M.; Moelleken, A.; Maley, G.F.; Maley, F.
Purification and properties of T4 phage thymidylate synthetase produced by the cloned gene in an amplification vector
J. Biol. Chem.
258
2045-2051
1983
Bacillus subtilis, Escherichia coli, Escherichia coli B / ATCC 11303, Escherichia phage T2, Lacticaseibacillus casei, Rattus norvegicus, Tequatrovirus T4
brenda
Carlson, J.H.; Hill, S.A.
Identification and characterization of thymidylate synthase from Neisseria gonorrhoeae
FEMS Microbiol. Lett.
151
225-230
1997
Bacillus subtilis, Haemophilus influenzae, Neisseria gonorrhoeae, Neisseria gonorrhoeae MS11
brenda
Stout, T.J.; Schellenberger, U.; Santi, D.V.; Stroud, R.M.
Crystal structures of a unique thermal-stable thymidylate synthase from Bacillus subtilis
Biochemistry
37
14736-14747
1998
Lacticaseibacillus casei, Lactococcus lactis, Bacillus phage phi3T, Escherichia coli (P0A884), Escherichia coli, Bacillus subtilis (P0CI79), Bacillus subtilis
brenda
Fox, K.M.; Maley, F.; Garibian, A.; Changchien, L.M.; Van Roey, P.
Crystal structure of thymidylate synthase A from Bacillus subtilis
Protein Sci.
8
538-544
1999
Bacillus subtilis, Escherichia coli
brenda
Changchien, L.M.; Garibian, A.; Frasca, V.; Lobo, A.; Maley, G.F.; Maley, F.
High-Level expression of Escherichia coli and Bacillus subtilis thymidylate synthases
Protein Expr. Purif.
19
265-270
2000
Bacillus subtilis, Escherichia coli
brenda