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Information on EC 2.1.1.45 - thymidylate synthase and Organism(s) Helicobacter pylori and UniProt Accession O26061

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EC Tree
     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.45 thymidylate synthase
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This record set is specific for:
Helicobacter pylori
UNIPROT: O26061 not found.
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Word Map
The taxonomic range for the selected organisms is: Helicobacter pylori
The enzyme appears in selected viruses and cellular organisms
Synonyms
thymidylate synthase, thymidylate synthetase, human ts, dtmp synthase, thymidylate synthase a, tmp synthetase, 5,10-methylenetetrahydrofolate:dump c-methyltransferase, y110a7a.4, more
SYNONYM
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dTMP synthase
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methylenetetrahydrofolate:dUMP C-methyltransferase
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thymidylate synthase A
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thymidylate synthetase
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TMP synthetase
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
dehalogenation
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methylene group transfer
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reductive methylation
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PATHWAY SOURCE
PATHWAYS
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-, -, -, -, -, -, -, -, -
SYSTEMATIC NAME
IUBMB Comments
5,10-methylenetetrahydrofolate:dUMP C-methyltransferase
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CAS REGISTRY NUMBER
COMMENTARY hide
9031-61-2
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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
5,10-methylenetetrahydrofolate + dUMP
dihydrofolate + dTMP
show the reaction diagram
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-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
10-methylfolate
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5-fluoro-2'-deoxyuridine monophosphate
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8-azapurinone deoxyribonucleoside 5'-phosphate
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N-(4-{[(2-amino-4-oxo-1,4-dihydroquinazolin-6-yl)methyl](prop-2-ynoyl)amino}benzoyl)-L-glutamic acid
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
UniProt
Manually annotated by BRENDA team
CRYSTALLIZATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
in complex with co-factor FAD and substrate dUMP at 2.5 A resolution. Structure consists of a 1.5 tetramer of ThyX with a total of 1248 residues, six FAD and six dUMP molecules in an asymmetric unit
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Zhang, X.; Zhang, J.; Guo, G.; Mao, X.; Hu, Y.; Zou, Q.
Crystal structure of a flavin-dependent thymidylate synthase from Helicobacter pylori strain 26695
Protein Pept. Lett.
19
1225-1230
2012
Helicobacter pylori (O26061)
Manually annotated by BRENDA team
Wang, K.; Wang, Q.; Chen, J.; Chen, L.; Jiang, H.; Shen, X.
Crystal structure and enzymatic characterization of thymidylate synthase X from Helicobacter pylori strain SS1
Protein Sci.
20
1398-1410
2011
Helicobacter pylori, Helicobacter pylori SS1
Manually annotated by BRENDA team