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IUBMB Comments Isolated from the plant Erythroxylum novogranatense . The enzyme, which is highly stereoselective, is involved in cocaine biosynthesis. The substrate, ecgonone, is unstable, and in the absence of the methyltransferase decarboxylates into tropinone.
Synonyms
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CYP81AN15
previously named CYP9
MT4
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S-adenosyl L-methionine + ecgonone = S-adenosyl-L-homocysteine + ecgonone methyl ester
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S-adenosyl-L-methionine:ecgonone O-methyltransferase
Isolated from the plant Erythroxylum novogranatense. The enzyme, which is highly stereoselective, is involved in cocaine biosynthesis. The substrate, ecgonone, is unstable, and in the absence of the methyltransferase decarboxylates into tropinone.
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S-adenosyl L-methionine + (+)-ecgonone
S-adenosyl-L-homocysteine + (+)-ecgonone methyl ester
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Substrates: -
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S-adenosyl L-methionine + ecgonone
S-adenosyl-L-homocysteine + ecgonone methyl ester
Substrates: ecgonone is 4-(1-methyl-2-pyrrolidnyl)-3-methyloxobutanoate
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additional information
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Substrates: the enzyme shows no activity with (-)-ecgonone
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S-adenosyl L-methionine + (+)-ecgonone
S-adenosyl-L-homocysteine + (+)-ecgonone methyl ester
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Substrates: -
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S-adenosyl L-methionine + ecgonone
S-adenosyl-L-homocysteine + ecgonone methyl ester
Substrates: ecgonone is 4-(1-methyl-2-pyrrolidnyl)-3-methyloxobutanoate
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UniProt
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Highest Expressing Human Cell Lines
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Cell Line Links
Gene Links
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A0A9E9NIU8_ERYCB
504
0
57247
TrEMBL
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expressed in Nicotiana benthamiana leaves
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expressed in Saccharomyces cerevisiae strain CSY1341
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Wang, Y.; Huang, J.; Tian, T.; Yan, Y.; Chen, Y.; Yang, J.; Chen, J.; Gu, Y.; Huang, S.
Discovery and engineering of the cocaine biosynthetic pathway
J. Am. Chem. Soc.
144
22000-22007
2022
Erythroxylum novogranatense
brenda
Chavez, B.G.; Srinivasan, P.; Glockzin, K.; Kim, N.; Montero Estrada, O.; Jirschitzka, J.; Rowden, G.; Shao, J.; Meinhardt, L.; Smolke, C.D.; D'Auria, J.C.
Elucidation of tropane alkaloid biosynthesis in Erythroxylum coca using a microbial pathway discovery platform
Proc. Natl. Acad. Sci. USA
119
e2215372119
2022
Erythroxylum coca (A0A9E9NIU8)
brenda
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