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IUBMB Comments The enzyme, present in egg-laying vertebrates, is involved in biosynthesis of the UV absorbing compound gadusol. It is a bifunctional enzyme that also catalyses EC 1.3.1.126 , 2-epi -5-epi -valiolone dehydrogenase.
Reaction Schemes
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demethylgadusol
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gadusol
Synonyms MT-Ox , MT-Ox protein, zgc:113054 ,
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desmethyl gadusol O-methyltransferase
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S-adenosyl-L-methionine + demethylgadusol = S-adenosyl-L-homocysteine + gadusol
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S-adenosyl-L-methionine:demethylgadusol 2-O-methyltransferase
The enzyme, present in egg-laying vertebrates, is involved in biosynthesis of the UV absorbing compound gadusol. It is a bifunctional enzyme that also catalyses EC 1.3.1.126, 2-epi-5-epi-valiolone dehydrogenase.
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2-epi-5-epivaliolone + S-adenosyl-L-methionine
gadusol + S-adenosyl-L-homocysteine
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Substrates: -
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S-adenosyl-L-methionine + 2-epi-5-epivaliolone
S-adenosyl-L-homocysteine + gadusol
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Substrates: conversion of 2-epi-5-epivaliolone to gadusol by the enzyme takes place via oxidation of the C-2 or C-3 OH, followed by enolization and methylation of the resulting C-2 OH
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S-adenosyl-L-methionine
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brenda
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brenda
Highest Expressing Human Cell Lines
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Cell Line Links
Gene Links
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Ni-NTA column chromatography
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expressed in Escherichia coli
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expressed in Saccharomyces cerevisiae and Escherichia coli BL21 Gold (DE3) pLysS cells
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Osborn, A.R.; Almabruk, K.H.; Holzwarth, G.; Asamizu, S.; LaDu, J.; Kean, K.M.; Karplus, P.A.; Tanguay, R.L.; Bakalinsky, A.T.; Mahmud, T.
De novo synthesis of a sunscreen compound in vertebrates
eLife
4
e05919
2015
Danio rerio
brenda
Brotherton, C.A.; Balskus, E.P.
Shedding light on sunscreen biosynthesis in zebrafish
eLife
4
e07961
2015
Danio rerio
brenda
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