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Information on EC 2.1.1.378 - [methyl-Co(III) glycine betaine-specific corrinoid protein]-tetrahydrofolate methyltransferase

for references in articles please use BRENDA:EC2.1.1.378

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IUBMB Comments

This enzyme, characterized from the anaerobic bacterium Desulfitobacterium hafniense Y51, catalyses a similar reaction to that of EC 2.1.1.258, 5-methyltetrahydrofolate—corrinoid/iron-sulfur protein Co-methyltransferase, but in the opposite direction, transferring a methyl group from a methylated corrinoid protein to tetrahydrofolate. The corrinoid protein is specifically methylated by EC 2.1.1.376, glycine betaine—corrinoid protein Co-methyltransferase.

The expected taxonomic range for this enzyme is: Desulfitobacterium hafniense
Reaction Schemes
hide
a [methyl-Co(III) glycine betaine-specific corrinoid protein]
+
tetrahydrofolate
=
a [Co(I) glycine betaine-specific corrinoid protein]
+
5-methyltetrahydrofolate
a [methyl-Co(III) glycine betaine-specific corrinoid protein]
+
=
a [Co(I) glycine betaine-specific corrinoid protein]
+

Synonyms
methylcobalamin:tetrahydrofolate methyltransferase, dsy3157, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a [methyl-Co(III) glycine betaine-specific corrinoid protein] + tetrahydrofolate = a [Co(I) glycine betaine-specific corrinoid protein] + 5-methyltetrahydrofolate
show the reaction diagram
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-
-
-
PATHWAY SOURCE
PATHWAYS
MetaCyc
glycine betaine degradation IV
Highest Expressing Human Cell Lines
Cell Line Links Gene Links