Information on EC 2.1.1.374 - 2-heptyl-1-hydroxyquinolin-4(1H)-one methyltransferase

for references in articles please use BRENDA:EC2.1.1.374
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IUBMB Comments
The enzyme, found in mycobacteria, is a member of a family of heterocyclic toxin methyltransferases. It is involved in defense against several antimicrobial natural compounds and drugs. 4-Hydroxyquinolin-2(1H)-one, 2-heptylquinolin-4(1H)-one, 2-heptyl-3-hydroxyquinolin-4(1H)-one (the "Pseudomonas quinolone signal", PQS) and the flavonol quercetin are also O-methylated, albeit with lower activity . The enzyme also N-methylates the bactericidal compound 3-methyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile .
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Word Map
The expected taxonomic range for this enzyme is: Mycobacteriaceae
Reaction Schemes
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2-heptyl-1-hydroxyquinolin-4(1H)-one
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2-heptyl-1-methoxyquinolin-4(1H)-one
Synonyms
rv0560c, mab_2834c, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + 2-heptyl-1-hydroxyquinolin-4(1H)-one = S-adenosyl-L-homocysteine + 2-heptyl-1-methoxyquinolin-4(1H)-one
show the reaction diagram
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