Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Disease on EC 2.1.1.37 - DNA (cytosine-5-)-methyltransferase

Please use the Disease Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Aberrant Crypt Foci
Dietary arsenic affects dimethylhydrazine-induced aberrant crypt formation and hepatic global DNA methylation and DNA methyltransferase activity in rats.
Potent antitumor activity of Laccaic acid and Phenethyl isothiocyanate combination in colorectal cancer via dual inhibition of DNA methyltransferase-1 and Histone deacetylase-1.
Abortion, Spontaneous
A Single Nucleotide Polymorphism of DNA methyltransferase 3B gene is a risk factor for recurrent spontaneous abortion.
Association of DNMT3B and DNMN3L Gene Polymorphisms with Early Pregnancy Loss.
DNA methyltransferase 3A promoter polymorphism is associated with the risk of human spontaneous abortion after assisted reproduction techniques and natural conception.
[Correlation of genomic DNA methylation level with unexplained early spontaneous abortion].
Acne Vulgaris
Milk disrupts p53 and DNMT1, the guardians of the genome: implications for acne vulgaris and prostate cancer.
Acute Coronary Syndrome
Age-dependent decreases in DNA methyltransferase levels and low transmethylation micronutrient levels synergize to promote overexpression of genes implicated in autoimmunity and acute coronary syndromes.
Acute Lung Injury
Transforming Growth Factor-?1 Promotes M1 Alveolar Macrophage Polarization in Acute Lung Injury by Up-Regulating DNMT1 to Mediate the microRNA-124/PELI1/IRF5 Axis.
Adenocarcinoma
A pilot clinical trial of the cytidine deaminase inhibitor tetrahydrouridine combined with decitabine to target DNMT1 in advanced, chemorefractory pancreatic cancer.
A subgroup of pancreatic adenocarcinoma is sensitive to the 5-aza-dC DNA methyltransferase inhibitor.
Aberrant DNA methyltransferase expression in pancreatic ductal adenocarcinoma development and progression.
Association of increased DNA methyltransferase expression with carcinogenesis and poor prognosis in pancreatic ductal adenocarcinoma.
Association of the DNMT3B polymorphism with colorectal adenomatous polyps and adenocarcinoma.
CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression.
Depletion of DNA methyltransferase 1 and/or DNA methyltransferase 3b mediates growth arrest and apoptosis in lung and esophageal cancer and malignant pleural mesothelioma cells.
Different susceptibility of increased DNMT1 expression by exposure to tobacco smoke according to histology in primary non-small cell lung cancer.
DNA methyltransferase 3a modulates chemosensitivity to gemcitabine and oxaliplatin via CHK1 and AKT in p53?deficient pancreatic cancer cells.
DNMT3A overexpression is associated with aggressive behavior and enteroblastic differentiation of gastric adenocarcinoma.
DNMT3a promotes proliferation by activating the STAT3 signaling pathway and depressing apoptosis in pancreatic cancer.
DNMT3b 39179GT polymorphism and the risk of adenocarcinoma of the colon in Koreans.
Epigenetic targeting DNMT1 of pancreatic ductal adenocarcinoma using interstitial control release biodegrading polymer reduced tumor growth through hedgehog pathway inhibition.
Epigenetic up-regulation of CXCR4 and CXCL12 expression by 17 beta-estradiol and tamoxifen is associated with formation of DNA methyltransferase 3B4 splice variant in Ishikawa endometrial adenocarcinoma cells.
Epigenetic-mediated upregulation of progesterone receptor B gene in endometrial cancer cell lines.
Estrogen regulates DNA methyltransferase 3B expression in Ishikawa endometrial adenocarcinoma cells.
FXR silencing in human colon cancer by DNA methylation and KRAS signaling.
HOTAIR Induces Methylation of PCDH10, a Tumor Suppressor Gene, by Regulating DNMT1 and Sponging with miR-148b in Gastric Adenocarcinoma.
Increased DNA methyltransferase 1 (DNMT1) protein expression in precancerous conditions and ductal carcinomas of the pancreas.
Inhibition of DNA methyltransferase activity prevents tumorigenesis in a mouse model of prostate cancer.
Regulation of Human RNA Polymerase III Transcription by DNMT1 and DNMT3a DNA Methyltransferases.
Role of DNA hypomethylation in the development of the resistance to doxorubicin in human MCF-7 breast adenocarcinoma cells.
Role of DNA methylation in expression control of the IKZF3-GSDMA region in human epithelial cells.
Significance of DNA methyltransferase-1 and histone deacetylase-1 in pancreatic cancer.
Single nucleotide polymorphism in DNA methyltransferase 3B promoter and its association with gastric cardiac adenocarcinoma in North China.
Stage-specific alterations of DNA methyltransferase expression, DNA hypermethylation, and DNA hypomethylation during prostate cancer progression in the transgenic adenocarcinoma of mouse prostate model.
The Helicobacter pylori genome is modified at CATG by the product of hpyIM.
[High expression of DNMT1 was correlated with beta-catenin accumulation and malignant phynotype of lung squamous cell carcinoma and adenocarcinoma]
Adenocarcinoma of Lung
Deoxyribonucleic acid (DNA) methyltransferase contributes to p16 promoter CpG island methylation in lung adenocarcinoma with smoking.
DNMT3a expression pattern and its prognostic value in lung adenocarcinoma.
Epigenetic silencing of the RASSF1A tumor suppressor gene through HOXB3-mediated induction of DNMT3B expression.
Long Non-coding RNA LINC00628 Interacts Epigenetically with the LAMA3 Promoter and Contributes to Lung Adenocarcinoma.
Low expression of PRKCDBP promoted cisplatin resistance in lung adenocarcinoma by DNMT1 and TNF??.
Promoter methylation status of tumor suppressor genes and inhibition of expression of DNA methyltransferase 1 in non-small cell lung cancer.
STK11/LKB1 Loss of Function Is Associated with Global DNA Hypomethylation and S-Adenosyl-Methionine Depletion in Human Lung Adenocarcinoma.
Adenocarcinoma, Bronchiolo-Alveolar
Promoter methylation of glutathione S-transferase pi1 and multidrug resistance gene 1 in bronchioloalveolar carcinoma and its correlation with DNA methyltransferase 1 expression.
Adenoma
5'-Cytosine DNA-methyltransferase mRNA levels in hereditary colon carcinoma.
All Things in Moderation: Prevention of Intestinal Adenomas by DNA Hypomethylation.
Complete genetic suppression of polyp formation and reduction of CpG-island hypermethylation in Apc(Min/+) Dnmt1-hypomorphic Mice.
DNA hypomethylation contributes to genomic instability and intestinal cancer initiation.
DNA methyltransferase and alcohol dehydrogenase: gene-nutrient interactions in relation to risk of colorectal polyps.
Gene-specific DNA methylation of DNMT3B and MTHFR and colorectal adenoma risk.
Genetic and epigenetic variation in the DNMT3B and MTHFR genes and colorectal adenoma risk.
Impact of Dnmt1 deficiency, with and without low folate diets, on tumor numbers and DNA methylation in Min mice.
Inhibition of intestinal tumor formation by deletion of the DNA methyltransferase 3a.
Promoter methylation status of hMLH1, MGMT, and CDKN2A/p16 in colorectal adenomas.
Quantification of gene-specific methylation of DNMT3B and MTHFR using sequenom EpiTYPER®.
Suppression of intestinal neoplasia by deletion of Dnmt3b.
Suppression of intestinal neoplasia by DNA hypomethylation.
The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation and tumor suppressor gene hypermethylation in mice and lung cancer patients.
Tubular adenomas with minor villous changes show molecular features characteristic of tubulovillous adenomas.
Adenoma, Pleomorphic
Immunolocalization of DNMT1 and DNMT3a in salivary gland neoplasms.
Adenomatous Polyposis Coli
Clofarabine, a novel adenosine analogue, reactivates DNA methylation-silenced tumour suppressor genes and inhibits cell growth in breast cancer cells.
DNA methyltransferases messenger RNA expression and aberrant methylation of CpG islands in non-small-cell lung cancer: association and prognostic value.
Down-regulation of DNMT3b in PC3 cells effects locus-specific DNA methylation, and represses cellular growth and migration.
Epigenetic-genetic interactions in the APC/WNT, RAS/RAF, and P53 pathways in colorectal carcinoma.
piRNA-823 Is Involved in Cancer Stem Cell Regulation Through Altering DNA Methylation in Association With Luminal Breast Cancer.
The loss-of-function of DNA methyltransferase 1 by siRNA impairs the growth of non-small cell lung cancer with alleviated side effects via reactivation of RASSF1A and APC in vitro and vivo.
Adenomatous Polyps
Abnormal regulation of DNA methyltransferase expression during colorectal carcinogenesis.
Association of the DNMT3B polymorphism with colorectal adenomatous polyps and adenocarcinoma.
DNMT3B Expression Might Contribute to Abnormal Methylation of RASSF1A in Lager Colorectal Adenomatous Polyps.
Sequential DNA methylation changes are associated with DNMT3B overexpression in colorectal neoplastic progression.
Adenomyosis
Aberrant Immunoreactivity of Deoxyribonucleic Acid Methyltransferases in Adenomyosis.
Downregulation of DNA methyltransferase 3 alpha promotes cell proliferation and invasion of ectopic endometrial stromal cells in adenomyosis.
Alopecia
Progressive Alopecia Reveals Decreasing Stem Cell Activation Probability during Aging of Mice with Epidermal Deletion of DNA Methyltransferase 1.
Alzheimer Disease
Age-related formaldehyde interferes with DNA methyltransferase function, causing memory loss in Alzheimer's disease.
Association study between the DNMT3A -448A>G polymorphism and risk of Alzheimer's disease in Caucasians of Italian origin.
Chronic hypoxia facilitates Alzheimer's disease through demethylation of ?-secretase by downregulating DNA methyltransferase 3b.
DNA methylase and demethylase activities are modulated by one-carbon metabolism in Alzheimer's disease models.
DNA methyltransferase haplotype is associated with Alzheimer's disease.
DNMT1 mutation hot spot causes varied phenotypes of HSAN1 with dementia and hearing loss.
DNMT3A rs1550117 Polymorphism is Associated With Late-Onset Alzheimer's Disease in a Chinese Population.
DNMT3B promoter polymorphisms and risk of late onset Alzheimer's disease.
Lead neurotoxicity: exploring the potential impact of lead substitution in zinc-finger proteins on mental health.
Methylation analysis of multiple genes in blood DNA of Alzheimer's disease and healthy individuals.
Reduced RAN expression and disrupted transport between cytoplasm and nucleus; a key event in Alzheimer's disease pathophysiology.
The synergistic risk effect of apolipoprotein ?4 and DNA (cytosine-5-)-methyltransferase 3 beta (DNMT3B) haplotype for Alzheimer's disease.
Ameloblastoma
DNA methyltransferase expression in odontogenic cysts and tumours.
DNA methyltransferase immunohistochemical expression in odontogenic tumours.
Amnesia
Long-term memory consolidation or reconsolidation impairment induces amnesia with key characteristics that are similar to key learning characteristics.
Peculiarities of Participation of DNA Methyltransferases in the Mechanisms of Storage, Impairment, and Recovery of Conditioned Food Aversion Memory.
Processes of DNA methylation are involved in the mechanisms of amnesia induction and conditioned food aversion memory reconsolidation.
The role of DNA methylation in the mechanisms of memory reconsolidation and development of amnesia.
Amyotrophic Lateral Sclerosis
Epigenetic regulation of motor neuron cell death through DNA methylation.
Functional Restoration of Amyotrophic Lateral Sclerosis Patient-Derived Mesenchymal Stromal Cells Through Inhibition of DNA Methyltransferase.
Mitochondrial DNMT3A and DNA methylation in skeletal muscle and CNS of transgenic mouse models of ALS.
SETX (senataxin), the helicase mutated in AOA2 and ALS4, functions in autophagy regulation.
Anemia
Anemia in older adults as a geriatric syndrome: A review.
The extracellular signal-regulated kinase 1/2 modulates the intracellular localization of DNA methyltransferase 3A to regulate erythrocytic differentiation.
Anemia, Refractory
Clinical activity and safety of the dual pathway inhibitor rigosertib for higher risk myelodysplastic syndromes following DNA methyltransferase inhibitor therapy.
Clinical effectiveness of DNA methyltransferase inhibitors and lenalidomide in older patients with refractory anemia with ring sideroblasts: a population-based study in the United States.
Negative impact on clinical outcome of the mutational co-occurrence of SF3B1 and DNMT3A in refractory anemia with ring sideroblasts (RARS).
Anemia, Sickle Cell
5-Aza-4'-thio-2'-deoxycytidine, a new orally bioavailable non-toxic "best-in-class" DNMT1 depleting agent in clinical development.
Decitabine. MGI Pharma Inc/SuperGen Inc.
Aneurysm
Methylation map genes can be critical in determining the methylome of intracranial aneurysm patients.
NSun2 regulates aneurysm formation by promoting autotaxin expression and T cell recruitment.
Aortic Coarctation
DNMT3A controls miR-200b in cardiac fibroblast autophagy and cardiac fibrosis.
Aortic Valve Stenosis
Clonal Hematopoiesis-Driver DNMT3A Mutations Alter Immune Cells in Heart Failure.
Apraxias
SETX (senataxin), the helicase mutated in AOA2 and ALS4, functions in autophagy regulation.
Arteriosclerosis
NSun2 Deficiency Protects Endothelium From Inflammation via mRNA Methylation of ICAM-1.
Arthritis
Amelioration of Autoimmune Arthritis in Mice Treated With the DNA Methyltransferase Inhibitor 5'-Azacytidine.
miR-148b-3p affects the pathogenesis of adjuvant-induced arthritis rats through the direct target DNMT1.
Arthritis, Gouty
Association of DNA methyltransferase polymorphisms with susceptibility to primary gouty arthritis.
Arthritis, Rheumatoid
Amelioration of Autoimmune Arthritis in Mice Treated With the DNA Methyltransferase Inhibitor 5'-Azacytidine.
Clinical relevance of clonal hematopoiesis in the oldest-old population.
Correlation between miR-126 expression and DNA hypomethylation of CD4+ T cells in rheumatoid arthritis patients.
DNMT1 activates the canonical Wnt signaling in rheumatoid arthritis model rats via a crucial functional crosstalk between miR-152 and the DNMT1, MeCP2.
Global DNA methylation, DNMT1, and MBD2 in patients with rheumatoid arthritis.
The -283C/T polymorphism of the DNMT3B gene influences the progression of joint destruction in rheumatoid arthritis.
Ascorbic Acid Deficiency
Oral vitamin C supplementation to patients with myeloid cancer on azacitidine treatment: Normalization of plasma vitamin C induces epigenetic changes.
Asthma
5-Aza-2'-deoxycytidine inhibited PDGF-induced rat airway smooth muscle cell phenotypic switching.
DNA methyltransferase 1(DNMT1) induced the expression of suppressors of cytokine signaling3 (Socs3) in a mouse model of asthma.
Epigenetic regulation of DNMT1 gene in mouse model of asthma disease.
Expression Level of MiRNA-126 in Serum Exosomes of Allergic Asthma Patients and Lung Tissues of Asthmatic Mice.
Astrocytoma
Expression of DNA methyltransferases 1 and 3B correlates with EZH2 and this 3-marker epigenetic signature predicts outcome in glioblastomas.
Pathological classification of brain tumors.
Promoter hypermethylation-mediated down-regulation of CXCL12 in human astrocytoma.
Ataxia
Cataplexy and ataxia: red flags for the diagnosis of DNA methyltransferase 1 mutation.
Functional Characterization of DNA Methylation in the Oligodendrocyte Lineage.
SETX (senataxin), the helicase mutated in AOA2 and ALS4, functions in autophagy regulation.
Ataxia Telangiectasia
DNA methyltransferase 1 knockdown activates a replication stress checkpoint.
Atherosclerosis
Aberrant MFN2 transcription facilitates homocysteine-induced VSMCs proliferation via the increased binding of c-Myc to DNMT1 in atherosclerosis.
DNA Methylation and the Potential Role of Methyl-Containing Nutrients in Cardiovascular Diseases.
DNA methyltransferase 1 and Krüppel-like factor 4 axis regulates macrophage inflammation and atherosclerosis.
Effect of DNA Methylation in Various Diseases and the Probable Protective Role of Nutrition: A Mini-Review.
Flow-dependent regulation of genome-wide mRNA and microRNA expression in endothelial cells in vivo.
Folic Acid Supplementation Delays Atherosclerotic Lesion Development by Modulating MCP1 and VEGF DNA Methylation Levels In Vivo and In Vitro.
Full spectrum of clonal haematopoiesis-driver mutations in chronic heart failure and their associations with mortality.
Global DNA methylation not increased in chronic hemodialysis patients: a case-control study.
High-methionine diets accelerate atherosclerosis by HHcy-mediated FABP4 gene demethylation pathway via DNMT1 in ApoE(-/-) mice.
Histone Methyltransferase Enhancer of Zeste Homolog 2-Mediated ABCA1 Promoter DNA Methylation Contributes to the Progression of Atherosclerosis.
Homocysteine accelerates atherosclerosis by inhibiting scavenger receptor class B member1 via DNMT3b/SP1 pathway.
Inhibiting DNA Methylation by 5-Aza-2'-deoxycytidine ameliorates atherosclerosis through suppressing macrophage inflammation.
MicroRNA-377 Inhibits Atherosclerosis by Regulating Triglyceride Metabolism Through the DNA Methyltransferase 1 in Apolipoprotein E-Knockout Mice.
Reciprocal Regulation Between miR-148a/152 and DNA Methyltransferase 1 Is Associated with Hyperhomocysteinemia-Accelerated Atherosclerosis.
Relationship of impairment induced by intracellular S-adenosylhomocysteine accumulation with DNA methylation in human umbilical vein endothelial cells treated with 3-deazaadenosine.
Autoimmune Diseases
Association analyses of DNA methyltransferase-1 (DNMT1) polymorphisms with systemic lupus erythematosus.
Mechanism of drug-induced lupus. I. Cloned Th2 cells modified with DNA methylation inhibitors in vitro cause autoimmunity in vivo.
Natural antisense RNAs are involved in the regulation of CD45 expression in autoimmune diseases.
Ultraviolet B inhibition of DNMT1 activity via AhR activation dependent SIRT1 suppression in CD4+ T cells from systemic lupus erythematosus patients.
Azoospermia
Polymorphism in DNMT1 may modify the susceptibility to oligospermia.
Bacteremia
Genetic variation of DNA methyltransferase-3A contributes to protection against persistent MRSA bacteremia in patients.
Bacterial Infections
A colorimetric assay of DNA methyltransferase activity based on peroxidase mimicking of DNA template Ag/Pt bimetallic nanoclusters.
A colorimetric assay of DNA methyltransferase activity based on the keypad lock of duplex DNA modified meso-SiO2@Fe3O4.
A methylation-blocked cascade amplification strategy for label-free colorimetric detection of DNA methyltransferase activity.
DNA methyltransferase detection based on digestion triggering the combination of poly adenine DNA with gold nanoparticles.
Magnetic bead-liposome hybrids enable sensitive and portable detection of DNA methyltransferase activity using personal glucose meter.
Biliary Atresia
MicroRNA-29b/142-5p contribute to the pathogenesis of biliary atresia by regulating the IFN-? gene.
Blast Crisis
Absence of DNMT3A gene mutation in chronic myeloid leukemia patients in blast crisis.
Bone marrow findings in blast phase of polycythemia vera.
Long noncoding RNA MEG3 inhibits proliferation of chronic myeloid leukemia cells by sponging microRNA21.
The Long Noncoding RNA MEG3 and its Target miR-147 Regulate JAK/STAT Pathway in Advanced Chronic Myeloid Leukemia.
Bone Marrow Failure Disorders
Graft-versus-host disease after liver transplantation is associated with bone marrow failure, hemophagocytosis, and DNMT3A mutations.
Bone Neoplasms
DNMT3a contributes to the development and maintenance of bone cancer pain by silencing Kv1.2 expression in spinal cord dorsal horn.
Brain Diseases
Trimethylaurintricarboxylic acid inhibits human DNA methyltransferase 1: insights from enzymatic and molecular modeling studies.
Brain Injuries
DNA Methylation Inhibitor Zebularine Confers Stroke Protection in Ischemic Rats.
DNA methyltransferase contributes to delayed ischemic brain injury.
Effects of cerebral ischemia in mice lacking DNA methyltransferase 1 in post-mitotic neurons.
Brain Injuries, Traumatic
Traumatic brain injury induces relocalization of DNA-methyltransferase 1.
Brain Ischemia
Effects of cerebral ischemia in mice lacking DNA methyltransferase 1 in post-mitotic neurons.
Brain Neoplasms
Distinct gene expression profiles between primary breast cancers and brain metastases from pair-matched samples.
DNMTs as potential therapeutic targets in high-risk pediatric embryonal brain tumors.
Expression of DNA methylation-related proteins in metastatic breast cancer.
Fusion of TTYH1 with the C19MC microRNA cluster drives expression of a brain-specific DNMT3B isoform in the embryonal brain tumor ETMR.
Methyllysine Reader Plant Homeodomain (PHD) Finger Protein 20-like 1 (PHF20L1) Antagonizes DNA (Cytosine-5) Methyltransferase 1 (DNMT1) Proteasomal Degradation.
Repurposing Disulfiram as An Anti-Cancer Agent: Updated Review on Literature and Patents.
Sensitivity to temozolomide in brain tumor initiating cells.
The Brain Microenvironment Induces DNMT1 Suppression and Indolence of Metastatic Cancer Cells.
World Cancer Day 2021 - Perspectives in Pediatric and Adult Neuro-Oncology.
Breast Neoplasms
3,3'-Diindolylmethane Enhances Paclitaxel Sensitivity by Suppressing DNMT1-Mediated KLF4 Methylation in Breast Cancer.
3,6-Dihydroxyflavone regulates microRNA-34a through DNA methylation.
5,6-Dihydro-5'-azacytidine (DHAC) affects estrogen sensitivity in estrogen-refractory human breast carcinoma cell lines.
5-Aza-2'-deoxycytidine advances EMT of breast cancer cells by demethylating Sipa1 promoter-proximal elements.
5-aza-2'-Deoxycytidine Enhances the Radiosensitivity of Breast Cancer Cells.
5-Aza-2'-deoxycytidine induces a greater inflammatory change, at the molecular levels, in normoxic than hypoxic tumor microenvironment.
5-Aza-2'-deoxycytidine-mediated reductions in G9A histone methyltransferase and histone H3 K9 di-methylation levels are linked to tumor suppressor gene reactivation.
5-Aza-2-deoxycytidine and trichostatin A increase COUP-TFII expression in antiestrogen-resistant breast cancer cell lines.
5-AZA-dC induces epigenetic changes associated with modified glycosylation of secreted glycoproteins and increased EMT and migration in chemo-sensitive cancer cells.
?EF1 associates with DNMT1 and maintains DNA methylation of the E-cadherin promoter in breast cancer cells.
A candidate CpG SNP approach identifies a breast cancer associated ESR1-SNP.
A combination treatment with DNA methyltransferase inhibitors and suramin decreases invasiveness of breast cancer cells.
A Comparative Study on the In Vitro Effects of the DNA Methyltransferase Inhibitor 5-Azacytidine (5-AzaC) in Breast/Mammary Cancer of Different Mammalian Species.
A Meta-Analysis of the Association between DNMT1 Polymorphisms and Cancer Risk.
A novel FLI1 exonic circular RNA promotes metastasis in breast cancer by coordinately regulating TET1 and DNMT1.
A novel fluorometric oligonucleotide assay to measure O( 6)-methylguanine DNA methyltransferase, methylpurine DNA glycosylase, 8-oxoguanine DNA glycosylase and abasic endonuclease activities: DNA repair status in human breast carcinoma cells overexpressing methylpurine DNA glycosylase.
A novel MspI PCR-RFLP in the human cytosine 5-methyltransferase gene: lack of relevance for malignant lymphoproliferative disease and breast cancer.
Aberrant DNA methylation of integrin ?4 in human breast cancer.
Altered DNA methyltransferases promoter methylation and mRNA expression are associated with tamoxifen response in breast tumors.
An Evaluation of DNA Methyltransferase 1 (DNMT1) Single Nucleotide Polymorphisms and Chemotherapy-Associated Cognitive Impairment: A Prospective, Longitudinal Study.
An integrated genomic analysis of Tudor domain-containing proteins identifies PHD finger protein 20-like 1 (PHF20L1) as a candidate oncogene in breast cancer.
Array-based DNA methylation profiling for breast cancer subtype discrimination.
Association of DNMT1 and DNMT3B polymorphisms with breast cancer risk in Han Chinese women from South China.
Association of DNMT1 gene polymorphisms in exons with sporadic infiltrating ductal breast carcinoma among chinese han women in the Heilongjiang province.
Association of physical activity and polymorphisms in FGFR2 and DNA methylation related genes with breast cancer risk.
BRCA1 affects global DNA methylation through regulation of DNMT1.
Caspase 8 and maspin are downregulated in breast cancer cells due to CpG site promoter methylation.
Chinese Herbal Mixture, Tien-Hsien Liquid, Induces G2/M Cycle Arrest and Radiosensitivity in MCF-7 Human Breast Cancer Cells through Mechanisms Involving DNMT1 and Rad51 Downregulation.
circIQCH sponges miR-145 to promote breast cancer progression by upregulating DNMT3A expression.
CircRNA DNA methyltransferase 1 silence inhibits breast cancer development by regulating micoRNA-485-3p/zinc finger E-box binding homeobox 1 axis.
CLDN6-mediates SB431542 action through MMPs to regulate the invasion, migration, and EMT of breast cancer cells.
Clinicopathologic significance of DNA methyltransferase 1, 3a, and 3b overexpression in Tunisian breast cancers.
Clofarabine, a novel adenosine analogue, reactivates DNA methylation-silenced tumour suppressor genes and inhibits cell growth in breast cancer cells.
Combination Epigenetic Therapy in Advanced Breast Cancer with 5-Azacitidine and Entinostat: A Phase II National Cancer Institute/Stand Up to Cancer Study.
Comprehensive analysis of regulation of DNA methyltransferase isoforms in human breast tumors.
Comprehensive bioinformatics study reveals targets and molecular mechanism of hesperetin in overcoming breast cancer chemoresistance.
CpG island shore methylation regulates caveolin-1 expression in breast cancer.
Decitabine and suberoylanilide hydroxamic acid (SAHA) inhibit growth of ovarian cancer cell lines and xenografts while inducing expression of imprinted tumor suppressor genes, apoptosis, G2/M arrest, and autophagy.
Decreased expression of EZH2 reactivates RASSF2A by reversal of promoter methylation in breast cancer cells.
Demethylating agent 5-aza-2-deoxycytidine enhances susceptibility of breast cancer cells to anticancer agents.
Derivative of Stevioside; CPUK02; Restores ESR1 Gene Methylation in MDA-MB 231
Differential expression of the epigenetic methylation-related protein DNMT1 by breast cancer molecular subtype and stromal histology.
DNA hypermethylation near the transcription start site of collagen alpha2(I) gene occurs in both cancer cell lines and primary colorectal cancers.
DNA Methylation Affects the SP1-regulated Transcription of FOXF2 in Breast Cancer Cells.
DNA methylation and not H3K4 trimethylation dictates the expression status of miR-152 gene which inhibits migration of breast cancer cells via DNMT1/CDH1 loop.
DNA methyltransferase 1/3a overexpression in sporadic breast cancer is associated with reduced expression of estrogen receptor-alpha/breast cancer susceptibility gene 1 and poor prognosis.
DNA Methyltransferase Gene Polymorphisms for Prediction of Radiation-induced Skin Fibrosis after Treatment of Breast Cancer: a Multifactorial Genetic Approach.
DNA methyltransferase inhibition increases efficacy of adoptive cellular immunotherapy of murine breast cancer.
DNA methyltransferase inhibition upregulates MHC-I to potentiate cytotoxic T lymphocyte responses in breast cancer.
DNA methyltransferase inhibitor CDA-2 synergizes with high-dose thiotepa and paclitaxel in killing breast cancer stem cells.
DNA methyltransferase inhibitor, zebularine, delays tumor growth and induces apoptosis in a genetically engineered mouse model of breast cancer.
DNA methyltransferase inhibitors influence on the DIRAS3 and STAT3 expression and in vitro migration of ovarian and breast cancer cells.
DNMT1 genetic polymorphisms affect breast cancer risk in the central European Caucasian population.
DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis.
DNMT1: A key drug target in triple-negative breast cancer.
DNMT3a mediates paclitaxel-induced abnormal expression of LINE-1 by increasing the intragenic methylation.
DNMT3b 39179GT polymorphism and the risk of adenocarcinoma of the colon in Koreans.
DNMT3B gene amplification predicts resistance to DNA demethylating drugs.
DNMT3b overexpression contributes to a hypermethylator phenotype in human breast cancer cell lines.
Down-regulation of CXCL12 mRNA expression by promoter hypermethylation and its association with metastatic progression in human breast carcinomas.
Down-regulation of CXCR4 expression by tamoxifen is associated with DNA methyltransferase 3B up-regulation in MCF-7 breast cancer cells.
Downregulation of FOXO3a by DNMT1 promotes breast cancer stem cell properties and tumorigenesis.
Dysregulation of microRNA expression drives aberrant DNA hypermethylation in basal-like breast cancer.
Dysregulation of the epigenome in triple-negative breast cancers: Basal-like and claudin-low breast cancers express aberrant DNA hypermethylation.
E-cadherin, Snail, ZEB-1, DNMT1, DNMT3A and DNMT3B expression in normal and breast cancer tissues.
Effects of 5-Aza-CdR on the proliferation of human breast cancer cell line MCF-7 and on the expression of Apaf-1 gene.
Effects of a novel DNA methyltransferase inhibitor zebularine on human breast cancer cells.
Effects of specific DNMT-gene depletion on cancer cell transformation and breast cancer cell invasion; towards selective DNMT inhibitors.
Endoplasmic reticulum protein 29 (ERp29) confers radioresistance through the DNA repair gene, O(6)-methylguanine DNA-methyltransferase, in breast cancer cells.
Enhancement of chemotherapeutic efficacy in hypermethylator breast cancer cells through targeted and pharmacologic inhibition of DNMT3b.
Epigenetic control of phospholipase A2 receptor expression in mammary cancer cells.
Epigenetic inactivation of BRCA1 is associated with aberrant expression of CTCF and DNA methyltransferase (DNMT3B) in some sporadic breast tumours.
Epigenetic inhibition of the tumor suppressor ARHI by light at night-induced circadian melatonin disruption mediates STAT3-driven paclitaxel resistance in breast cancer.
Epigenetic modification in 4T1 mouse breast cancer model by artificial light at night and melatonin - the role of DNA-methyltransferase.
Epigenetic Modifications, Chromatin Distribution and TP53 Transcription in a Model of Breast Cancer Progression.
Epigenetic regulation of glycosylation and the impact on chemo-resistance in breast and ovarian cancer.
Epigenetic Regulation of Manganese Superoxide Dismutase Expression in Human Breast Cancer Cells.
Epigenetic repression of PDZ-LIM domain-containing protein 2: implications for the biology and treatment of breast cancer.
Epigenetic reprogramming of cancer cells via targeted DNA methylation.
Epigenetic reprogramming of epithelial mesenchymal transition in triple negative breast cancer cells with DNA methyltransferase and histone deacetylase inhibitors.
Epigenetic silencing of CREB3L1 by DNA methylation is associated with high-grade metastatic breast cancers with poor prognosis and is prevalent in triple negative breast cancers.
Epigenetic silencing of genes enhanced by collective role of reactive oxygen species and MAPK signaling downstream ERK/Snail axis: Ectopic application of hydrogen peroxide repress CDH1 gene by enhanced DNA methyltransferase activity in human breast cancer.
Epigenetic silencing of SALL2 confers tamoxifen resistance in breast cancer.
ER alpha negative breast cancer cells restore response to endocrine therapy by combination treatment with both HDAC inhibitor and DNMT inhibitor.
ER? is required for suppressing OCT4-induced proliferation of breast cancer cells via DNMT1/ISL1/ERK axis.
ER? positively regulated DNMT1 expression by binding to the gene promoter region in human breast cancer MCF-7 cells.
ER? propelled aberrant global DNA hypermethylation by activating the DNMT1 gene to enhance anticancer drug resistance in human breast cancer cells.
Evaluation of three mRNA markers for the detection of lymph node metastases.
Expression analysis of DNA methyltransferases 1, 3A, and 3B in sporadic breast carcinomas.
Expression and clinicopathological significance of DNA methyltransferase 1, 3A and 3B in tamoxifen-treated breast cancer patients.
Expression of DNA methyl-transferase (DMT) and the cell cycle in human breast cancer cells.
FEN1 mediates miR-200a methylation and promotes breast cancer cell growth via MET and EGFR signaling.
Flavonoids and Other Polyphenols Act as Epigenetic Modifiers in Breast Cancer.
Genistein inhibits DNA methylation and increases expression of tumor suppressor genes in human breast cancer cells.
Human breast cancer progression can be regulated by dominant trans-acting factors in somatic cell hybridization studies.
Hypoxia Alters the Response to Anti-EGFR Therapy by Regulating EGFR Expression and Downstream Signaling in a DNA Methylation-Specific and HIF-Dependent Manner.
Identification of DNA Methyltransferase-1 Inhibitor for Breast Cancer Therapy through Computational Fragment-Based Drug Design.
Impact of miRNAs expression modulation on the methylation status of breast cancer stem cell-related genes.
Increased protein stability causes DNA methyltransferase 1 dysregulation in breast cancer.
Individual factors define the overall effects of dietary genistein exposure on breast cancer patients.
Induction of DNMT3B by PGE2 and IL6 at Distant Metastatic Sites Promotes Epigenetic Modification and Breast Cancer Colonization.
Induction of HRR genes and inhibition of DNMT1 is associated with anthracycline anti-tumor antibiotic-tolerant breast carcinoma cells.
Induction of the estrogen receptor by ablation of DNMT1 in ER-negative breast cancer cells.
Induction of transforming growth factor-beta receptor type II expression in estrogen receptor-positive breast cancer cells through SP1 activation by 5-aza-2'-deoxycytidine.
Inhibition of DNMT1 and ERR? crosstalk suppresses breast cancer via derepression of IRF4.
Inhibition of histone deacetylases promotes ubiquitin-dependent proteasomal degradation of DNA methyltransferase 1 in human breast cancer cells.
Inhibition of histone demethylase, LSD2 (KDM1B), attenuates DNA methylation and increases sensitivity to DNMT inhibitor-induced apoptosis in breast cancer cells.
Insulin-like growth factor binding protein-3 (IGFBP-3) plays a role in the anti-tumorigenic effects of 5-Aza-2'-deoxycytidine (AZA) in breast cancer cells.
Interaction of 5-aza-2'-deoxycytidine and depsipeptide on antineoplastic activity and activation of 14-3-3sigma, E-cadherin and tissue inhibitor of metalloproteinase 3 expression in human breast carcinoma cells.
Interleukin-6-mediated epigenetic control of the VEGFR2 gene induces disorganized angiogenesis in human breast tumors.
Joint effects between urinary selenium and polymorphisms in methylation related genes on breast cancer risk.
Kindlin-2 interacts with and stabilizes DNMT1 to promote breast cancer development.
KRAS Genomic Status Predicts the Sensitivity of Ovarian Cancer Cells to Decitabine.
Lack of ADAM2, CALR3 and SAGE1 Cancer/Testis Antigen Expression in Lung and Breast Cancer.
Laminin-1 induces E-cadherin expression in 3-dimensional cultured breast cancer cells by inhibiting DNA methyltransferase 1 and reversing promoter methylation status.
Linc01638 promotes tumorigenesis in HER2+ breast cancer.
LncRNA TINCR favors tumorigenesis via STAT3-TINCR-EGFR-feedback loop by recruiting DNMT1 and acting as a competing endogenous RNA in human breast cancer.
Long non-coding RNA H19 promotes the proliferation and invasion of breast cancer through upregulating DNMT1 expression by sponging miR-152.
Long-term stability of demethylation after transient exposure to 5-aza-2'-deoxycytidine correlates with sustained RNA polymerase II occupancy.
Loss of DNA Methylation and Histone H4 Lysine 20 Trimethylation in Human Breast Cancer Cells is Associated with Aberrant Expression of DNA Methyltransferase 1, Suv4-20h2 Histone Methyltransferase and Methyl-Binding Proteins.
Loss of post-transcriptional regulation of DNMT3b by microRNAs: a possible molecular mechanism for the hypermethylation defect observed in a subset of breast cancer cell lines.
MALAT1 Promotes Tumorigenesis and Increases Cellular Sensitivity to Herceptin in HER2-positive Breast Cancer.
Metastasis-associated protein 1 is an upstream regulator of DNMT3a and stimulator of insulin-growth factor binding protein-3 in breast cancer.
Methyl-CpG-binding domain protein-2 mediates transcriptional repression associated with hypermethylated GSTP1 CpG islands in MCF-7 breast cancer cells.
Methylation and inhibition of expression of uPA by the RAS oncogene: divergence of growth control and invasion in breast cancer cells.
Methylation and miRNA effects of resveratrol on mammary tumors vs. normal tissue.
Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis.
MicroRNA-143 is downregulated in breast cancer and regulates DNA methyltransferases 3A in breast cancer cells.
MiR-221 promotes stemness of breast cancer cells by targeting DNMT3b.
miR-29b is an indicator of prognosis in breast cancer patients.
miR-29c plays a suppressive role in breast cancer by targeting the TIMP3/STAT1/FOXO1 pathway.
Mutant p53 binds to estrogen receptor negative promoter via DNMT1 and HDAC1 in MDA-MB-468 breast cancer cells.
MYC and DNMT3A-mediated DNA methylation represses microRNA-200b in triple negative breast cancer.
New insights into estrogenic regulation of O(6)-methylguanine DNA-methyltransferase (MGMT) in human breast cancer cells: Co-degradation of ER-? and MGMT proteins by fulvestrant or O(6)-benzylguanine indicates fresh avenues for therapy.
O-6-methylguanine DNA methyltransferase is a favorable biomarker with proliferation suppressive potential in Breast Cancer.
Overexpression of NSUN2 by DNA hypomethylation is associated with metastatic progression in human breast cancer.
Oxidative DNA Damage Modulates DNA Methylation Pattern in Human Breast Cancer 1 (BRCA1) Gene via the Crosstalk between DNA Polymerase ? and a de novo DNA Methyltransferase.
p53 Binds to Estrogen Receptor 1 Promoter in Human Breast Cancer Cells.
p53 inhibits the expression of p125 and the methylation of POLD1 gene promoter by downregulating the Sp1-induced DNMT1 activities in breast cancer.
Physcion 8-O-?-glucopyranoside suppresses the metastasis of breast cancer in vitro and in vivo by modulating DNMT1.
piRNA-823 Is Involved in Cancer Stem Cell Regulation Through Altering DNA Methylation in Association With Luminal Breast Cancer.
Prevalence of DNA methyltransferase in breast cancer by SNP analysis.
Prognostic value of ubiquitin E2 UBE2W and its correlation with tumor-infiltrating immune cells in breast cancer.
Pterostilbene leads to DNMT3B-mediated DNA methylation and silencing of OCT1-targeted oncogenes in breast cancer cells.
QbD Enabled Azacitidine Loaded Liposomal Nanoformulation and Its In Vitro Evaluation.
Quantitative evaluation of DNMT3B promoter methylation in breast cancer patients using differential high resolution melting analysis.
Reactivation of SYK expression by inhibition of DNA methylation suppresses breast cancer cell invasiveness.
Reactivation of Syk gene by AZA suppresses metastasis but not proliferation of breast cancer cells.
refMiR 142 5p inhibits cell invasion and migration by targeting DNMT1 in breast cancer.
Regulation of DNA methyltransferase 1 transcription in BRCA1-mutated breast cancer: a novel crosstalk between E2F1 motif hypermethylation and loss of histone H3 lysine 9 acetylation.
Restoration of the methylation status of hypermethylated gene promoters by microRNA-29b in human breast cancer: A novel epigenetic therapeutic approach.
Retinoblastoma pathway dysregulation causes DNA methyltransferase 1 overexpression in cancer via MAD2-mediated inhibition of the anaphase-promoting complex.
Retraction Note to: Physcion 8-O-?-glucopyranoside suppresses the metastasis of breast cancer in vitro and in vivo by modulating DNMT1.
Ribavirin restores ESR1 gene expression and tamoxifen sensitivity in ESR1 negative breast cancer cell lines.
RNA interference-mediated knockdown of DNA methyltransferase 1 leads to promoter demethylation and gene re-expression in human lung and breast cancer cells.
RNA interference-mediated knockdown of DNMT1 and DNMT3B induces CXCL12 expression in MCF-7 breast cancer and AsPC1 pancreatic carcinoma cell lines.
Role of gene promoter methylation regulated by TETs and DNMTs in the overexpression of HLA-G in MCF-7 cells.
Role of PTEN promoter methylation in tamoxifen-resistant breast cancer cells.
SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities.
SMAD2 Inactivation Inhibits CLDN6 Methylation to Suppress Migration and Invasion of Breast Cancer Cells.
Specific inhibition of DNMT1 by antisense oligonucleotides induces re-expression of estrogen receptor-alpha (ER) in ER-negative human breast cancer cell lines.
Stable oncogenic silencing in vivo by programmable and targeted de novo DNA methylation in breast cancer.
Stilbenoid-Mediated Epigenetic Activation of Semaphorin 3A in Breast Cancer Cells Involves Changes in Dynamic Interactions of DNA with DNMT3A and NF1C Transcription Factor.
Study of the Role of siRNA Mediated Promoter Methylation in DNMT3B Knockdown and Alteration of Promoter Methylation of CDH1, GSTP1 Genes in MDA-MB -453 Cell Line.
Sulforaphane Alone and in Combination with Clofarabine Epigenetically Regulates the Expression of DNA Methylation-Silenced Tumour Suppressor Genes in Human Breast Cancer Cells.
Sulforaphane causes epigenetic repression of hTERT expression in human breast cancer cell lines.
Synergistic activation of functional estrogen receptor (ER)-alpha by DNA methyltransferase and histone deacetylase inhibition in human ER-alpha-negative breast cancer cells.
Synergistic effects of combined DNA methyltransferase inhibition and MBD2 depletion on breast cancer cells; MBD2 depletion blocks 5-aza-2'-deoxycytidine-triggered invasiveness.
The Cancer/Testis Antigen Gene VCX2 Is Rarely Expressed in Malignancies but Can Be Epigenetically Activated Using DNA Methyltransferase and Histone Deacetylase Inhibitors.
The correlation between DNMT1 and ER? expression and the methylation status of ER?, and its clinical significance in breast cancer.
The DNA methyltransferase inhibitor, guadecitabine, targets tumor-induced myelopoiesis and recovers T cell activity to slow tumor growth in combination with adoptive immunotherapy in a mouse model of breast cancer.
The DNMT3B C-->T promoter polymorphism and risk of breast cancer in a British population: a case-control study.
The effect of folate-related SNPs on clinicopathological features, response to neoadjuvant treatment and survival in pre- and postmenopausal breast cancer patients.
The low-toxicity 9-cis UAB30 novel retinoid down-regulates the DNA methyltransferases and has anti-telomerase activity in human breast cancer cells.
The Metallophosphoesterase-Domain-Containing Protein 2 (MPPED2) Gene Acts as Tumor Suppressor in Breast Cancer.
The possible role of EZH2 and DNMT1 polymorphisms in sporadic triple-negative breast carcinoma in southern Chinese females.
The STAT3-DNMT1 connection.
The Study of DNA Methyltransferase-3B Promoter Variant Genotype among Iranian Sporadic Breast Cancer Patients.
Therapeutic potential of DNA methyltransferase inhibitors with immune checkpoint inhibitor therapy in breast cancer.
Transcriptome-Wide Effects of Sphingosine Kinases Knockdown in Metastatic Prostate and Breast Cancer Cells: Implications for Therapeutic Targeting.
Transcriptomics Analysis of the Tumor-Inhibitory Pathways of 6-Thioguanine in MCF-7 Cells via Silencing DNMT1 Activity.
Trichostatin A down-regulate DNA methyltransferase 1 in Jurkat T cells.
TROP2 methylation and expression in tamoxifen-resistant breast cancer.
Valproic acid, in combination with all-trans retinoic acid and 5-aza-2'-deoxycytidine, restores expression of silenced RARbeta2 in breast cancer cells.
YY1-mediated long non-coding RNA Kcnq1ot1 promotes the tumor progression by regulating PTEN via DNMT1 in triple negative breast cancer.
Zebularine Treatment Induces MAGE-A11 Expression and Improves CTL Cytotoxicity Using a Novel Identified HLA-A2-restricted MAGE-A11 Peptide.
[Apple polyphenol inhibited the proliferation and migration of breast cancer cell MDA-MB-231 mediated by UHRF1].
[Expression of melanoma-associated antigen-C2 in breast cancers and mechanism].
[Growth inhibition and demethylation by a component of natural drug, CDP, in cancer cell lines]
[miR-101 inhibits the proliferation and migration of breast cancer cells via downregulating the expression of DNA methyltransferase 3a].
[Traditional medicine CDP and promoter demethylation in breast cancer cell lines]
Bronchopulmonary Dysplasia
Attenuation of miR-17?92 Cluster in Bronchopulmonary Dysplasia.
Of mice and men: correlations between microRNA-17?92 cluster expression and promoter methylation in severe bronchopulmonary dysplasia.
Burkitt Lymphoma
De novo protein synthesis is required for lytic cycle reactivation of Epstein-Barr virus, but not Kaposi's sarcoma-associated herpesvirus, in response to histone deacetylase inhibitors and protein kinase C agonists.
Deregulation of DNMT1, DNMT3B and miR29s in Burkitt lymphoma suggests novel contribution for disease pathogenesis.
DNA methylation enzymes and PRC1 restrict B-cell Epstein-Barr virus oncoprotein expression.
DNMT3B overexpression contributes to aberrant DNA methylation and MYC-driven tumor maintenance in T-ALL and Burkitt's lymphoma.
Transcriptional activation of the Epstein-Barr virus latency C promoter after 5-azacytidine treatment: evidence that demethylation at a single CpG site is crucial.
Carcinogenesis
'Plug and play' microelectrode assisted with Y-motif-mediated primer-free cyclic signal amplification for sensitive quantitation of DNA methyltransferase activity.
3,6-Dihydroxyflavone regulates microRNA-34a through DNA methylation.
3,6-Dihydroxyflavone Suppresses Breast Carcinogenesis by Epigenetically Regulating miR-34a and miR-21.
A concern regarding the current confusion with the human homolog of mouse Np95, ICBP90/UHRF1.
A DNA methyltransferase inhibitor and all-trans retinoic acid reduce oral cavity carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide.
A folate- and methyl-deficient diet alters the expression of DNA methyltransferases and methyl CpG binding proteins involved in epigenetic gene silencing in livers of F344 rats.
A functional polymorphism in the DNA methyltransferase-3A promoter modifies the susceptibility in gastric cancer but not in esophageal carcinoma.
A novel DNMT3B subfamily, DeltaDNMT3B, is the predominant form of DNMT3B in non-small cell lung cancer.
A Novel Functional TagSNP Rs7560488 in the DNMT3A1 Promoter Is Associated with Susceptibility to Gastric Cancer by Modulating Promoter Activity.
A regulatory circuit composed of DNA methyltransferases and receptor tyrosine kinases controls lung cancer cell aggressiveness.
Aberrant methylation accounts for cell adhesion-related gene silencing during 3-methylcholanthrene and diethylnitrosamine induced multistep rat lung carcinogenesis associated with overexpression of DNA methyltransferases 1 and 3a.
Abnormal regulation of DNA methyltransferase expression during colorectal carcinogenesis.
Absence of DICER1, CTCF, RPL22, DNMT3A, TRRAP, IDH1 and IDH2 hotspot mutations in patients with various subtypes of ovarian carcinomas.
AML-Associated Mutations in DNA Methyltransferase DNMT3A.
An association between overexpression of DNA methyltransferase 3B4 and clear cell renal cell carcinoma.
An association of DNMT3b protein expression with P16INK4a promoter hypermethylation in non-smoking female lung cancer with human papillomavirus infection.
An essential role for DNA methyltransferase 3a in melanoma tumorigenesis.
Angiogenin contributes to bladder cancer tumorigenesis by DNMT3b-mediated MMP2 activation.
Association between DNA Methyltransferases 3B Gene Polymorphisms and the Susceptibility to Acute Myeloid Leukemia in Chinese Han Population.
Association of genetic polymorphisms in DNMT3A with the progression of gastric mucosal atrophy and susceptibility to gastric cancer in Japan.
Association of increased DNA methyltransferase expression with carcinogenesis and poor prognosis in pancreatic ductal adenocarcinoma.
Bioinformatics analysis of DNMT1 expression and its role in head and neck squamous cell carcinoma prognosis.
Changes in de novo DNA (cytosine-5-)-methyltransferase activity in oncogenically susceptible rat target tissues induced by N-methyl-N-nitrosourea.
Class I HDACs Are Mediators of Smoke Carcinogen-Induced Stabilization of DNMT1 and Serve as Promising Targets for Chemoprevention of Lung Cancer.
Cloning, expression and chromosome locations of the human DNMT3 gene family.
Complete genetic suppression of polyp formation and reduction of CpG-island hypermethylation in Apc(Min/+) Dnmt1-hypomorphic Mice.
De novo DNA methyltransferase activity in colorectal cancer is directed towards H3K36me3 marked CpG islands.
De novo methylation of CpG island sequences in human fibroblasts overexpressing DNA (cytosine-5-)-methyltransferase.
Decreased miR-30b-5p expression by DNMT1 methylation regulation involved in gastric cancer metastasis.
Delta DNMT3B variants regulate DNA methylation in a promoter-specific manner.
Deoxyribonucleic acid (DNA) methyltransferase contributes to p16 promoter CpG island methylation in lung adenocarcinoma with smoking.
Depletion of DNMT3A suppressed cell proliferation and restored PTEN in hepatocellular carcinoma cell.
DNA Electrochemistry Shows DNMT1 Methyltransferase Hyperactivity in Colorectal Tumors.
DNA hypermethylation on multiple CpG islands associated with increased DNA methyltransferase DNMT1 protein expression during multistage urothelial carcinogenesis.
DNA hypomethylation contributes to genomic instability and intestinal cancer initiation.
DNA methylation of multiple tumor-related genes in association with overexpression of DNA methyltransferase 1 (DNMT1) during multistage carcinogenesis of the pancreas.
DNA methyltransferase 1 expression and promoter methylation of E-cadherin in mucoepidermoid carcinoma.
DNA methyltransferase 1 knock down induces gene expression by a mechanism independent of DNA methylation and histone deacetylation.
DNA Methyltransferase 1: A Potential Gene Therapy Target for Hepatocellular Carcinoma?
DNA methyltransferase 3A promotes cell proliferation by silencing CDK inhibitor p18INK4C in gastric carcinogenesis.
DNA methyltransferase 3B expression is associated with poor outcome of stage I testicular seminoma.
DNA methyltransferase deficiency modifies cancer susceptibility in mice lacking DNA mismatch repair.
DNA methyltransferase expression and DNA methylation of CPG islands and peri-centromeric satellite regions in human colorectal and stomach cancers.
DNA methyltransferase inhibition reduces inflammation-induced colon tumorigenesis.
DNA methyltransferases 1, 3a, and 3b overexpression and clinical significance in gastroenteropancreatic neuroendocrine tumors.
DNA methyltransferases 3a and 3b are differentially expressed in the early stages of a rat liver carcinogenesis model.
DNA-based hybridization chain reaction amplification for assaying the effect of environmental phenolic hormone on DNA methyltransferase activity.
DNMT1 ablation suppresses tumorigenesis by inhibiting the self-renewal of esophageal cancer stem cells.
DNMT1 and DNMT3B regulate tumorigenicity of human prostate cancer cells by controlling RAD9 expression through targeted methylation.
DNMT1 is a component of a multiprotein DNA replication complex.
DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis.
DNMT1 overexpression predicting gastric carcinogenesis, subsequent progression and prognosis: a meta and bioinformatic analysis.
DNMT1 Regulates Epithelial-Mesenchymal Transition and Cancer Stem Cells, Which Promotes Prostate Cancer Metastasis.
DNMT1: A key drug target in triple-negative breast cancer.
Dnmt1N/+ reduces the net growth rate and multiplicity of intestinal adenomas in C57BL/6-multiple intestinal neoplasia (Min)/+ mice independently of p53 but demonstrates strong synergy with the modifier of Min 1(AKR) resistance allele.
DNMT3A -448A>G polymorphism and the risk for hepatocellular carcinoma.
Dnmt3a and Dnmt3b Associate with Enhancers to Regulate Human Epidermal Stem Cell Homeostasis.
DNMT3a epigenetic program regulates the HIF-2? oxygen-sensing pathway and the cellular response to hypoxia.
DNMT3a promotes proliferation by activating the STAT3 signaling pathway and depressing apoptosis in pancreatic cancer.
DNMT3A rs36012910 A>G polymorphism and gastric cancer susceptibility in a Chinese population.
DNMT3B C46359T and SHMT1 C1420T polymorphisms in the folate pathway in carcinogenesis of head and neck.
Dnmt3b is a haploinsufficient tumor suppressor gene in Myc-induced lymphomagenesis.
DNMT3B isoforms without catalytic activity stimulate gene body methylation as accessory proteins in somatic cells.
DNMT3B modulates the expression of cancer-related genes and downregulates the expression of the gene VAV3 via methylation.
DNMT3B overexpression by deregulation of FOXO3a-mediated transcription repression and MDM2 overexpression in lung cancer.
Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing.
DNMT3B silencing suppresses migration and invasion by epigenetically promoting miR-34a in bladder cancer.
Dose response evaluation of gene expression profiles in the skin of K6/ODC mice exposed to sodium arsenite.
Downregulation of FOXO3a by DNMT1 promotes breast cancer stem cell properties and tumorigenesis.
Dysregulation of p53/Sp1 control leads to DNA methyltransferase-1 overexpression in lung cancer.
EBV as a high infection risk factor promotes RASSF10 methylation and induces cell proliferation in EBV-associated gastric cancer.
EBV based cancer prevention and therapy in nasopharyngeal carcinoma.
Effect of a single treatment with the alkylating carcinogens dimethylnitrosamine and methyl methanesulphonate on liver regenerating after partial hepatectomy. IV. Effect on methylase-mediated methylation of DNA.
Effects on biological behavior of bladder carcinoma T24 cells via silencing DNMT1 and/or DNMT3b with shRNA In Vitro.
Epidrug Modulated Expression of MiR--152 and MiR-148a Reverse Cisplatin Resistance in Ovarian Cancer Cells: An Experimental In-vitro Study.
Epigenetic Modifications, Chromatin Distribution and TP53 Transcription in a Model of Breast Cancer Progression.
Epigenetic regulation of p62/SQSTM1 overcomes the radioresistance of head and neck cancer cells via autophagy-dependent senescence induction.
Epigenetic targeting DNMT1 of pancreatic ductal adenocarcinoma using interstitial control release biodegrading polymer reduced tumor growth through hedgehog pathway inhibition.
Epigenetic-genetic interactions in the APC/WNT, RAS/RAF, and P53 pathways in colorectal carcinoma.
Epigenetically deregulated miR-200c is involved in a negative feedback loop with DNMT3a in gastric cancer cells.
Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells.
Expression of antisense to DNA methyltransferase mRNA induces DNA demethylation and inhibits tumorigenesis.
Expression of DNA (5-cytosin)-methyltransferases (DNMTs) in hepatocellular carcinomas.
Expression of prokaryotic HhaI DNA methyltransferase is transforming and lethal to NIH 3T3 cells.
Expression pattern and clinical significance of DNA methyltransferase 3B variants in gastric carcinoma.
Folate deficiency and aberrant expression of DNA methyltransferase 1 were associated with cervical cancerization.
Gene expression and promoter polymorphisms of DNA methyltransferase 3B in nasopharyngeal carcinomas in Taiwanese people: a case-control study.
GLAD-PCR Assay of R(5mC)GY Sites in the Regulatory Region of Tumor-Suppressor Genes Associated with Gastric Cancer.
HBP1-mediated transcriptional regulation of DNA methyltransferase 1 and its impact on cell senescence.
Heat Shock Factor 1 Epigenetically Stimulates Glutaminase-1-Dependent mTOR Activation to Promote Colorectal Carcinogenesis.
Hepatitis B virus infection in hepatocellular carcinoma tissues upregulates expression of DNA methyltransferases.
Hiwi mediated tumorigenesis is associated with DNA hypermethylation.
hNaa10p contributes to tumorigenesis by facilitating DNMT1-mediated tumor suppressor gene silencing.
Human DNA methyltransferase gene DNMT1 is regulated by the APC pathway.
Human polyomavirus BKV transcriptionally activates DNA methyltransferase 1 through the pRb/E2F pathway.
Hypermethylation of RAS effector related genes and DNA methyltransferase 1 expression in endometrial carcinogenesis.
Hypomethylation and overexpression of c-jun and c-myc protooncogenes and increased DNA methyltransferase activity in dichloroacetic and trichloroacetic acid-promoted mouse liver tumors.
Hypomethylation of LIMD1 and P16 by downregulation of DNMT1 results in restriction of liver carcinogenesis by amarogentin treatment.
Identification of potential genes regulated by DNA methyltransferase 3B in a hepatocellular carcinoma cell line by RNA interference and microarray analysis.
Impact of Dnmt1 deficiency, with and without low folate diets, on tumor numbers and DNA methylation in Min mice.
Increased DNA methyltransferase 1 (DNMT1) gene expression in human lymphomas by fluorescent in situ hybridization.
Increased DNA methyltransferase 1 (DNMT1) protein expression correlates significantly with poorer tumor differentiation and frequent DNA hypermethylation of multiple CpG islands in gastric cancers.
Increased DNA methyltransferase 1 (DNMT1) protein expression in precancerous conditions and ductal carcinomas of the pancreas.
Increased DNA methyltransferase 1 protein expression in human transitional cell carcinoma of the bladder.
Increased DNA methyltransferase expression in leukaemia.
Increased DNA methyltransferase expression in rhabdomyosarcomas.
Increased expression of DNA methyltransferase 1 (DNMT1) protein in uterine cervix squamous cell carcinoma and its precursor lesion.
Increased expression of DNA methyltransferase-1 in non-neoplastic epithelium helps predict colorectal neoplasia risk in ulcerative colitis.
Inhibition of DNA methyltransferase 1 by RNA interference reverses epithelial-mesenchymal transition in highly metastatic 95D lung cancer cells by inhibiting the Wnt signaling pathway.
Inhibition of DNA methyltransferase activity prevents tumorigenesis in a mouse model of prostate cancer.
Inhibition of DNA methyltransferase by antisense oligodeoxynucleotide modifies cell characteristics in gastric cancer cell lines.
Inhibition of DNMT suppresses the stemness of colorectal cancer cells through down-regulating Wnt signaling pathway.
Interplay between DNA Methyltransferase 1 and microRNAs During Tumorigenesis.
Intestinal PPAR? Protects Against Colon Carcinogenesis via Regulation of Methyltransferases DNMT1 and PRMT6.
Kaposi's Sarcoma-Associated Herpesvirus (KSHV) vIL-6 Promotes Cell Proliferation and Migration by Upregulating DNMT1 via STAT3 Activation.
LINC00337 promotes tumor angiogenesis in colorectal cancer by recruiting DNMT1, which suppresses the expression of CNN1.
Linc01638 promotes tumorigenesis in HER2+ breast cancer.
LncRNA TINCR favors tumorigenesis via STAT3-TINCR-EGFR-feedback loop by recruiting DNMT1 and acting as a competing endogenous RNA in human breast cancer.
Long non-coding RNA BZRAP1-AS1 silencing suppresses tumor angiogenesis in hepatocellular carcinoma by mediating THBS1 methylation.
Loss of Dnmt3a and Dnmt3b does not affect epidermal homeostasis but promotes squamous transformation through PPAR-?.
Loss of MEN1 activates DNMT1 implicating DNA hypermethylation as a driver of MEN1 tumorigenesis.
Maintenance of DNA methylation: Dnmt3b joins the dance.
Mandatory fortification with folic acid in the United States is associated with increased expression of DNA methyltransferase-1 in the cervix.
Mechanisms of peroxisome proliferator-induced DNA hypomethylation in rat liver.
Methylation of RASSF1A gene promoter and the correlation with DNMT1 expression that may contribute to esophageal squamous cell carcinoma.
Methylation-independent repression of Dnmt3b contributes to oncogenic activity of Dnmt3a in mouse MYC-induced T-cell lymphomagenesis.
MicroRNA-148a is silenced by hypermethylation and interacts with DNA methyltransferase 1 in hepatocellular carcinogenesis.
MiR-137 Suppresses Triple-Negative Breast Cancer Stemness and Tumorigenesis by Perturbing BCL11A-DNMT1 Interaction.
MiR-143 inhibits cell proliferation and invasion by targeting DNMT3A in gastric cancer.
MiR-148a regulates MEG3 in gastric cancer by targeting DNA methyltransferase 1.
miR-182 induces cervical cancer cell apoptosis through inhibiting the expression of DNMT3a.
Modulation of Dnmt3b function in vitro by interactions with Dnmt3L, Dnmt3a and Dnmt3b splice variants.
Multiple sealed primers-mediated rolling circle amplification strategy for sensitive and specific detection of DNA methyltransferase activity.
Mutation of the DNA methyltransferase (DNMT) 1 gene in human colorectal cancers.
Mutational analysis of DNMT3A gene in acute leukemias and common solid cancers.
Mutations in DNA Methyltransferase (DNMT3A) Observed in Acute Myeloid Leukemia Patients Disrupt Processive Methylation.
New insights into testicular germ cell tumorigenesis from gene expression profiling.
NNK-induced DNA methyltransferase 1 in lung tumorigenesis in A/J mice and inhibitory effects of (-)-epigallocatechin-3-gallate.
NOP2/Sun RNA methyltransferase 2 promotes tumor progression via its interacting partner RPL6 in gallbladder carcinoma.
NSUN2-mediated RNA 5-methylcytosine promotes esophageal squamous cell carcinoma progression via LIN28B-dependent GRB2 mRNA stabilization.
Overexpression of DNA methyltransferase 1 (DNMT1) protein in astrocytic tumour and its correlation with O6-methylguanine-DNA methyltransferase (MGMT) expression.
Overexpression of DNA methyltransferase 1 and its biological significance in primary hepatocellular carcinoma.
Perturbed hematopoiesis in individuals with germline DNMT3A overgrowth Tatton-Brown-Rahman syndrome.
Phase 1 Study of Preoperative Chemoradiation Therapy With Temozolomide and Capecitabine in Patients With Locally Advanced Rectal Cancer.
Polymorphism of DNA Methyltransferase 3b and Association with Development and Prognosis in Gastric Cancer.
Procainamide is a specific inhibitor of DNA methyltransferase 1.
PRRX1 induced by BMP signaling decreases tumorigenesis by epigenetically regulating glioma-initiating cell properties via DNA methyltransferase 3A.
Quantitative assessment of the association between DNMT3B-579G>T polymorphism and cancer risk.
Radiation-Induced DNMT3B Promotes Radioresistance in Nasopharyngeal Carcinoma through Methylation of p53 and p21.
Reduction of pancreatic acinar cell tumor multiplicity in Dnmt1 hypomorphic mice.
Reduction of two histone marks, H3k9me3 and H3k27me3 by epidrug induces neuroendocrine differentiation in prostate cancer.
Regulatory loop between lncRNA FAS-AS1 and DNMT3b controls FAS expression in hydroquinone-treated TK6 cells and benzene-exposed workers.
Requirement of DNMT1 to orchestrate epigenomic reprogramming for NPM-ALK-driven lymphomagenesis.
Restoration of miR-101 suppresses lung tumorigenesis through inhibition of DNMT3a-dependent DNA methylation.
RGS6 is an essential tumor suppressor that prevents bladder carcinogenesis by promoting p53 activation and DNMT1 downregulation.
Risk-association of DNA methyltransferases polymorphisms with gastric cancer in the southern chinese population.
RNA interference-mediated knockdown of DNA methyltransferase 1 leads to promoter demethylation and gene re-expression in human lung and breast cancer cells.
RNF43 mutations are recurrent in Chinese patients with mucinous ovarian carcinoma but absent in other subtypes of ovarian cancer.
Role of DNA methylation in the regulation of cell function: autoimmunity, aging and cancer.
Role of MBD2 in gene regulation and tumorigenesis.
Role of MGMT as biomarker in colorectal cancer.
Single nucleotide polymorphism in DNMT3B promoter and its association with hepatocellular carcinoma in a Moroccan population.
Somatic cancer mutations in the DNMT2 tRNA methyltransferase alter its catalytic properties.
Somatic Mutation Profiling of Papillary Thyroid Carcinomas by Whole-exome Sequencing and Its Relationship with Clinical Characteristics.
Stratification and Prognostic Relevance of Jass's Molecular Classification of Colorectal Cancer.
Suppressing effects of down-regulating DNMT1 and DNMT3b expression on the growth of human cholangiocarcinoma cell line.
Targeting DNA methyltransferase in cancer.
The DNMT1/miR-34a Axis Is Involved in the Stemness of Human Osteosarcoma Cells and Derived Stem-Like Cells.
The expressions of DNA methyltransferase 1 (DNMT1) and cyclin A1 (CCNA1) in cervical carcinogenesis.
The Interplay Between miR-148a and DNMT1 Might be Exploited for Pancreatic Cancer Therapy.
The long noncoding RNA LUCAT1 promotes tumorigenesis by controlling ubiquitination and stability of DNA methyltransferase 1 in esophageal squamous cell carcinoma.
The loss-of-function of DNA methyltransferase 1 by siRNA impairs the growth of non-small cell lung cancer with alleviated side effects via reactivation of RASSF1A and APC in vitro and vivo.
The Mammalian de novo DNA Methyltransferases Dnmt3a and Dnmt3b Are Also DNA 5-Hydroxymethyl Cytosine Dehydroxymethylases.
The possible role of EZH2 and DNMT1 polymorphisms in sporadic triple-negative breast carcinoma in southern Chinese females.
The R882H substitution in the human de novo DNA methyltransferase DNMT3A disrupts allosteric regulation by the tumor supressor p53.
The RNA-binding protein HuR regulates DNA methylation through stabilization of DNMT3b mRNA.
The rs1550117 A>G variant in DNMT3A gene promoter significantly increases non-small cell lung cancer susceptibility in a Han Chinese population.
The tobacco carcinogen NNK drives accumulation of DNMT1 at the GR promoter thereby reducing GR expression in untransformed lung fibroblasts.
The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation and tumor suppressor gene hypermethylation in mice and lung cancer patients.
The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation in Laryngeal carcinoma.
Transcription of mouse DNA methyltransferase 1 (Dnmt1) is regulated by both E2F-Rb-HDAC-dependent and -independent pathways.
Transcriptome analysis of human colon Caco-2 cells exposed to sulforaphane.
Trichostatin A down-regulate DNA methyltransferase 1 in Jurkat T cells.
Up-regulation of DNA-methyltransferase 3A expression is associated with hypomethylation of intron 25 in human testicular germ cell tumors.
Up-regulation of DNMT3b contributes to HOTAIRM1 silencing via DNA hypermethylation in cells transformed by long-term exposure to hydroquinone and workers exposed to benzene.
Upregulation of DNA methyltransferase-mediated gene silencing, anchorage-independent growth, and migration of colon cancer cells by interleukin-6.
Utilization of antisense oligonucleotides to study the role of 5-cytosine DNA methyltransferase in cellular transformation and oncogenesis.
[Design of oligonucleotide inhibitors of the human DNA-methyltransferase 1]
[Effects of Dnmt1 and Dnmt3b in mucoepidermoid carcinoma of salivary glands].
[Effects of dnmt1 Gene Silencing on Cell Cycle, Proliferation, and Apoptosis of Gastric Cancer Cell Line AGS.]
[Expression of DNA methyltransferases in salivary adenoid cystic carcinoma and its association with the CpG islands methylation of tumor suppressor genes]
[High expression of DNMT1 was correlated with beta-catenin accumulation and malignant phynotype of lung squamous cell carcinoma and adenocarcinoma]
[Interaction of folate deficiency and aberrant profile of DNA methyltransferase 1 in the progression of cervix carcinogenesis].
Carcinoma
5'-Cytosine DNA-methyltransferase mRNA levels in hereditary colon carcinoma.
5,6 Dihydro-5'-azacytidine (DHAC) restores androgen responsiveness in androgen-insensitive prostate cancer cells.
A functional polymorphism in the DNA methyltransferase-3A promoter modifies the susceptibility in gastric cancer but not in esophageal carcinoma.
Aberrant DNA methyltransferase 1 expression in clear cell renal cell carcinoma development and progression.
Aberrant methylation and deacetylation of deleted in liver cancer-1 gene in prostate cancer: potential clinical applications.
Abnormal regulation of DNA methyltransferase expression during colorectal carcinogenesis.
Absence of DICER1, CTCF, RPL22, DNMT3A, TRRAP, IDH1 and IDH2 hotspot mutations in patients with various subtypes of ovarian carcinomas.
Activation of DNA methyltransferase 1 by EBV latent membrane protein 2A leads to promoter hypermethylation of PTEN gene in gastric carcinoma.
Activation of DNA methyltransferase 3a by Epstein-Barr nuclear antigen 1 in gastric carcinoma.
Activation of PAR4 Upregulates p16 through Inhibition of DNMT1 and HDAC2 Expression via MAPK Signals in Esophageal Squamous Cell Carcinoma Cells.
An association between overexpression of DNA methyltransferase 3B4 and clear cell renal cell carcinoma.
Analysis of Association Between MGMT and p53 Gene Single Nucleotide Polymorphisms and Laryngeal Cancer.
Anti-invasive effects of decitabine, a DNA methyltransferase inhibitor, through tightening of tight junctions and inhibition of matrix metalloproteinase activities in AGS human gastric carcinoma cells.
Azacitidine, as a DNMT inhibitor decreases hTERT gene expression and telomerase activity more effective compared with HDAC inhibitor in human Head and neck squamous cell carcinoma cell lines.
Bioinformatics analysis of DNMT1 expression and its role in head and neck squamous cell carcinoma prognosis.
Chemotherapy and Radiotherapy Downregulate the Activity and Expression of DNA Methyltransferase and Enhance Bcl-2/E1B-19-kDa Interacting Protein-3-Induced Apoptosis in Human Colorectal Cancer Cells.
Combined effects of DNA methyltransferase 1 and 3A polymorphisms and urinary total arsenic levels on the risk for clear cell renal cell carcinoma.
Decrease of DNA methyltransferase 1 expression relative to cell proliferation in transitional cell carcinoma.
Demethylating agent 5-aza-2'-deoxycytidine enhances susceptibility of bladder transitional cell carcinoma to Cisplatin.
Demethylating agent 5-aza-2'-deoxycytidine enhances susceptibility of renal cell carcinoma to paclitaxel.
Different susceptibility of increased DNMT1 expression by exposure to tobacco smoke according to histology in primary non-small cell lung cancer.
Differential patterns of methylation of the IFN-gamma promoter at CpG and non-CpG sites underlie differences in IFN-gamma gene expression between human neonatal and adult CD45RO- T cells.
DNA hypermethylation on multiple CpG islands associated with increased DNA methyltransferase DNMT1 protein expression during multistage urothelial carcinogenesis.
DNA methylation by DNMT1 and DNMT3b methyltransferases is driven by the MUC1-C oncoprotein in human carcinoma cells.
DNA methylation status of hMLH1, p16(INK4a), and CDH1 is not associated with mRNA expression levels of DNA methyltransferase and DNA demethylase in gastric carcinomas.
DNA methylation-mediated Klotho silencing is an independent prognostic biomarker of head and neck squamous carcinoma.
DNA methyltransferase 1 as a predictive biomarker and potential therapeutic target for chemotherapy in gastric cancer.
DNA methyltransferase 1 knock down induces gene expression by a mechanism independent of DNA methylation and histone deacetylation.
DNA methyltransferase 3B -149C/T polymorphism and the risk of laryngeal squamous cell carcinoma: a case-control study.
DNA methyltransferase inhibitor zebularine inhibits human hepatic carcinoma cells proliferation and induces apoptosis.
DNA methyltransferase inhibitor-mediated apoptosis in the Wnt/?-catenin signal pathway in a renal cell carcinoma cell line.
DNA methyltransferase inhibitors influence on the DIRAS3 and STAT3 expression and in vitro migration of ovarian and breast cancer cells.
DNMT1 ablation suppresses tumorigenesis by inhibiting the self-renewal of esophageal cancer stem cells.
DNMT1 Enhances the Radiosensitivity of HPV-Positive Head and Neck Squamous Cell Carcinomas via Downregulating SMG1.
DNMT1 mediated promoter methylation of GNAO1 in hepatoma carcinoma cells.
DNMT3A and DNMT3B mediate autocrine hGH repression of plakoglobin gene transcription and consequent phenotypic conversion of mammary carcinoma cells.
DNMT3B -579 G>T promoter polymorphism and risk of gallbladder carcinoma in North Indian population.
DNMT3B 579 G>T promoter polymorphism and risk of esophagus carcinoma in Chinese.
DNMT3b polymorphism and hereditary nonpolyposis colorectal cancer age of onset.
E6 and E7 gene silencing results in decreased methylation of tumor suppressor genes and induces phenotype transformation of human cervical carcinoma cell lines.
Effect of 5-aza-2'-deoxycytidine on Estrogen Receptor Alpha/Beta and DNA Methyltransferase 1 Genes Expression, Apoptosis Induction, and Cell Growth Prevention of the Colon Cancer HT 29 Cell Line.
Effect of age on the association between p16CDKN2A methylation and DNMT3B polymorphism in head and neck carcinoma and patient survival.
Effect of antisense DNMT3b gene eukaryotic expression plasmid on expression of the DNMT3b gene in human biliary tract carcinoma cells.
Effect of DNA Methyltransferase in Comparison to and in Combination with Histone Deacetylase Inhibitors on Hepatocellular Carcinoma HepG2 Cell Line
Effects of DNA methyltransferase 1 inhibition on esophageal squamous cell carcinoma.
Effects on biological behavior of bladder carcinoma T24 cells via silencing DNMT1 and/or DNMT3b with shRNA In Vitro.
Epigenetic regulation of chemosensitivity to 5-fluorouracil and cisplatin by zebularine in oral squamous cell carcinoma.
Epigenetic regulation of microRNA expression in renal cell carcinoma.
Epigenetic therapy regulates the expression of ALDH1 and immunologic response: Relevance to the prognosis of oral cancer.
Epigenetics and prostate cancer: defining the timing of DNA methyltransferase deregulation during prostate cancer progression.
Expression of DNMTs and genomic DNA methylation in gastric signet ring cell carcinoma.
Expression pattern and clinical significance of DNA methyltransferase 3B variants in gastric carcinoma.
Expression profiles and function of IL6 in polymorphonuclear myeloid-derived suppressor cells.
Expression profiling and clinicopathological significance of DNA methyltransferase 1, 3A and 3B in sporadic human renal cell carcinoma.
Feedback regulation of DNA methyltransferase gene expression by methylation.
Folate deficiency and aberrant expression of DNA methyltransferase 1 were associated with cervical cancerization.
FOXM1 induces a global methylation signature that mimics the cancer epigenome in head and neck squamous cell carcinoma.
Gene Polymorphisms Involved in Folate Metabolism and DNA Methylation with the Risk of Head and Neck Cancer.
Genetic and epigenetic alteration in gastric carcinogenesis.
Genetic variation in TYMS in the one-carbon transfer pathway is associated with ovarian carcinoma types in the Ovarian Cancer Association Consortium.
High DNMT1 Is Associated With Worse Local Control in Early-Stage Laryngeal Squamous Cell Carcinoma.
HPV-16 E6 upregulation of DNMT1 through repression of tumor suppressor p53.
Hypermethylation of RAS effector related genes and DNA methyltransferase 1 expression in endometrial carcinogenesis.
Hypermethylation of the progesterone receptor A in constitutive antiprogestin-resistant mouse mammary carcinomas.
Hypomethylation of L1 LINE sequences prevailing in human urothelial carcinoma.
Immunohistochemical analysis of polycomb group protein expression in advanced gastric cancer.
Immunohistochemical evaluation of Klotho and DNA methyltransferase 3a in oral squamous cell carcinomas.
Immunohistochemical expression of DNA methyltransferases 1, 3a and 3b in oral leukoplakias and squamous cell carcinomas.
Immunolocalization of DNMT1 and DNMT3a in salivary gland neoplasms.
Increased CXCR4 expression in AsPC1 pancreatic carcinoma cells with RNA interference-mediated knockdown of DNMT1 and DNMT3B.
Increased DNA methyltransferase 1 protein expression correlates significantly with intestinal histological type and gender in gastric carcinomas.
Increased DNA methyltransferase 1 protein expression in human transitional cell carcinoma of the bladder.
Increased expression of DNA methyltransferase 1 (DNMT1) protein in uterine cervix squamous cell carcinoma and its precursor lesion.
Increased NQO1 but not c-MET and survivin expression in non-small cell lung carcinoma with KRAS mutations.
Influence of gossypol acetic acid on the growth of human adenoid cystic carcinoma ACC-M cells and the expression of DNA methyltransferase 1.
Inhibition of DNA methyltransferase inhibits DNA replication.
Interleukin 6 induces cell proliferation of clear cell renal cell carcinoma by suppressing hepaCAM via the STAT3-dependent up-regulation of DNMT1 or DNMT3b.
Investigation of the expression patterns and correlation of DNA methyltransferases and class I histone deacetylases in ovarian cancer tissues.
Long noncoding RNA ATB participates in the development of renal cell carcinoma by downregulating p53 via binding to DNMT1.
Lower expression of p14ARF and p16INK4a correlates with higher DNMT3B expression in human oesophageal squamous cell carcinomas.
Methylation of RASSF1A gene promoter and the correlation with DNMT1 expression that may contribute to esophageal squamous cell carcinoma.
MG98, a second-generation DNMT1 inhibitor, in the treatment of advanced renal cell carcinoma.
miR-182 induces cervical cancer cell apoptosis through inhibiting the expression of DNMT3a.
MiR-29a is a candidate biomarker of better survival in metastatic high-grade serous carcinoma.
Missing in metastasis B, regulated by DNMT1, functions as a putative cancer suppressor in human lung giant-cell carcinoma.
Multigene methylation analysis of gastrointestinal tumors: TPEF emerges as a frequent tumor-specific aberrantly methylated marker that can be detected in peripheral blood.
Mutational analysis of DNMT3A gene in acute leukemias and common solid cancers.
Nanodiamond-mediated impairment of nucleolar activity is accompanied by oxidative stress and DNMT2 upregulation in human cervical carcinoma cells.
Natural Compounds: DNA Methyltransferase Inhibitors in Oral Squamous Cell Carcinoma.
Non-invasive detection of DNA methylation states in carcinoma and pluripotent stem cells using Raman microspectroscopy and imaging.
Novel long noncoding RNA NMR promotes tumor progression via NSUN2 and BPTF in esophageal squamous cell carcinoma.
NSUN2-mediated RNA 5-methylcytosine promotes esophageal squamous cell carcinoma progression via LIN28B-dependent GRB2 mRNA stabilization.
Over-expression of DNA methyltransferases and CDKN2A gene methylation status in squamous cell carcinoma of the oral cavity.
Over-expression of DNMT3A predicts the risk of recurrent vulvar squamous cell carcinomas.
Overexpression of maelstrom promotes bladder urothelial carcinoma cell aggressiveness by epigenetically downregulating MTSS1 through DNMT3B.
p53-mediated repression of DNA methyltransferase 1 expression by specific DNA binding.
Persistent downregulation of the pancarcinoma-associated epithelial cell adhesion molecule via active intranuclear methylation.
Phase I Trial of DNA Methyltransferase Inhibitor Guadecitabine Combined with Cisplatin and Gemcitabine for Solid Malignancies Including Urothelial Carcinoma (SPIRE).
piR-823 demonstrates tumor oncogenic activity in esophageal squamous cell carcinoma through DNA methylation induction via DNA methyltransferase 3B.
Polymorphisms of the DNMT3B gene and risk of squamous cell carcinoma of the head and neck: a case-control study.
Promoter polymorphisms of DNMT3B and the risk of head and neck squamous cell carcinoma in Taiwan: a case-control study.
Protein expression, mRNA expression and gene amplification of DNA methyltransferase 1 in endometrial tumor tissues.
Quantitative Assessment of AKAP12 Promoter Methylation in Human Prostate Cancer Using Methylation-sensitive High-resolution Melting: Correlation With Gleason Score.
Re-expression of RASSF1A by 5-Aza-CdR induced demethylation of the promoter region in human biliary tract carcinoma cells.
Regulation of DNA methyltransferase 1 by the pRb/E2F1 pathway.
Reprogramming of HeLa cells upon DNMT3L overexpression mimics carcinogenesis.
RNA interference-mediated knockdown of DNMT1 and DNMT3B induces CXCL12 expression in MCF-7 breast cancer and AsPC1 pancreatic carcinoma cell lines.
RNA methyltransferase NSUN2 promotes hypopharyngeal squamous cell carcinoma proliferation and migration by enhancing TEAD1 expression in an m5C-dependent manner.
RNF43 mutations are recurrent in Chinese patients with mucinous ovarian carcinoma but absent in other subtypes of ovarian cancer.
Role of Loss of O-Methylguanine DNA Methyltransferase (MGMT) Expression in Non-Small Cell Lung Carcinomas (NSCLCs): with Reference to the Relationship with p53 Overexpression.
Sequential DNA methylation changes are associated with DNMT3B overexpression in colorectal neoplastic progression.
Significance of DNA methyltransferase-1 and histone deacetylase-1 in pancreatic cancer.
Silencing DNA methyltransferase 1 (DNMT1) inhibits proliferation, metastasis and invasion in ESCC by suppressing methylation of RASSF1A and DAPK.
Silencing DNA methyltransferase 1 leads to the activation of the esophageal suppressor gene p16 in vitro and in vivo.
Structure-activity relationships for 4-anilinoquinoline derivatives as inhibitors of the DNA methyltransferase enzyme DNMT1.
Suppression of DNA methyltransferase 1 levels in head and neck squamous carcinoma cells using small interfering RNA results in growth inhibition and increase in Cdk inhibitor p21.
Synergic antiproliferative effect of DNA methyltransferase inhibitor in combination with anticancer drugs in gastric carcinoma.
Tamoxifen accelerates proteasomal degradation of O(6)-methylguanine DNA methyltransferase in human cancer cells.
The clinical significance of methylation of MAGE-A1 and-A3 promoters and expression of DNA methyltransferase in patients with laryngeal squamous cell carcinoma.
The involvement of promoter methylation and DNA methyltransferase-1 in the regulation of EpCAM expression in oral squamous cell carcinoma.
The long noncoding RNA LUCAT1 promotes tumorigenesis by controlling ubiquitination and stability of DNA methyltransferase 1 in esophageal squamous cell carcinoma.
The Receptor Tyrosine Kinase RON and Its Isoforms as Therapeutic Targets in Ewing Sarcoma.
The role of DNA methyltransferase 3b in esophageal squamous cell carcinoma.
The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation in Laryngeal carcinoma.
Transcriptional analysis of CXCR4, DNMT3A, DNMT3B and DNMT1 gene expression in primary advanced uterine cervical carcinoma.
Trichostatin A down-regulate DNA methyltransferase 1 in Jurkat T cells.
UHRF1-mediated tumor suppressor gene inactivation in nonsmall cell lung cancer.
Uropathogenic bacteria leave a mark.
[Characteristic and clinical significance of DNA methyltransferase 3B overexpression in endometrial carcinoma].
[Clinicopathologic features and protein expression study of Epstein-Barr virus-associated gastric carcinoma in Guangzhou].
[Expression of DNA methyltransferase 1, 3A and 3B mRNA in the epithelial ovarian carcinoma]
[Gene expressions of DNA methyltransferase 1 and human leukocyte antigen-DRalpha in hepatocelluar carcinoma and their clinical significance.]
[High expression of DNMT1 was correlated with beta-catenin accumulation and malignant phynotype of lung squamous cell carcinoma and adenocarcinoma]
[Study on the combined therapy of DNA-methyltransferase inhibitor and interferon-alpha/beta for mouse spontaneously arose renal cell carcinoma, and immunological mechanism induced by the therapy]
[Synthesized small interfering RNA inhibits the expression of DNA methyltransferase 1 in salivary adenoid cystic carcinoma]
[The expression of DNMT1 in laryngeal squamous cell carcinoma and its clinical significance].
[The Study of Methylated Regulation MicroRNA in Pancreatic Carcinoma Cell and Its Effect on Cell Proliferation,Migration and Invasion].
Carcinoma in Situ
Increased DNA methyltransferase 1 protein expression in human transitional cell carcinoma of the bladder.
Carcinoma, Adenoid Cystic
ALPK1 hotspot mutation as a driver of human spiradenoma and spiradenocarcinoma.
Immunolocalization of DNMT1 and DNMT3a in salivary gland neoplasms.
Influence of gossypol acetic acid on the growth of human adenoid cystic carcinoma ACC-M cells and the expression of DNA methyltransferase 1.
[Synthesized small interfering RNA inhibits the expression of DNA methyltransferase 1 in salivary adenoid cystic carcinoma]
Carcinoma, Ductal
DNA methylation of multiple tumor-related genes in association with overexpression of DNA methyltransferase 1 (DNMT1) during multistage carcinogenesis of the pancreas.
Increased DNA methyltransferase 1 (DNMT1) protein expression in precancerous conditions and ductal carcinomas of the pancreas.
The expression patterns and correlations of claudin-6, methy-CpG binding protein 2, DNA methyltransferase 1, histone deacetylase 1, acetyl-histone H3 and acetyl-histone H4 and their clinicopathological significance in breast invasive ductal carcinomas.
Carcinoma, Embryonal
A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation.
Aza-deoxycytidine induces apoptosis or differentiation via DNMT3B and targets embryonal carcinoma cells but not their differentiated derivatives.
DNA methyltransferase-3 like protein expression in various histological types of testicular germ cell tumor.
DNMT1 and HDAC1 gene expression in impaired spermatogenesis and testicular cancer.
Genome-wide expression profiling reveals new insights into pathogenesis and progression of testicular germ cell tumors.
Meta-Analysis of Gene Expressions in Testicular Germ Cell Tumor Histologies.
Regulation of DNA methyltransferase during differentiation of F9 mouse embryonal carcinoma cells.
Carcinoma, Endometrioid
Down-regulation of miR-145 and miR-143 might be associated with DNA methyltransferase 3B overexpression and worse prognosis in endometrioid carcinomas.
Hypermethylation of RAS effector related genes and DNA methyltransferase 1 expression in endometrial carcinogenesis.
Opposite alterations of DNA methyltransferase gene expression in endometrioid and serous endometrial cancers.
[Characteristic and clinical significance of DNA methyltransferase 3B overexpression in endometrial carcinoma].
Carcinoma, Hepatocellular
Alterations in gene expression associated with the overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, during human hepatocarcinogenesis.
Anticancer drugs induce hypomethylation of the acetylcholinesterase promoter via a phosphorylated-p38-DNMT1-AChE pathway in apoptotic hepatocellular carcinoma cells.
Casticin inhibits stemness of hepatocellular carcinoma cells via disrupting the reciprocal negative regulation between DNMT1 and miR-148a-3p.
Chlorogenic Acid Decreases Malignant Characteristics of Hepatocellular Carcinoma Cells by Inhibiting DNMT1 Expression.
Correlative Analysis of DNA Methyltransferase Expression and Promoter Hypermethylation of Tumor Suppressor Genes in Hepatocellular Carcinoma.
Depletion of DNMT3A suppressed cell proliferation and restored PTEN in hepatocellular carcinoma cell.
DNA methylase activity of normal liver, regenerating liver, and a transplantable hepatocellular carcinoma.
DNA methylation controls the responsiveness of hepatoma cells to leukemia inhibitory factor.
DNA methyltransferase 1 knockdown induces silenced CDH1 gene reexpression by demethylation of methylated CpG in hepatocellular carcinoma cell line SMMC-7721.
DNA methyltransferase 1, 3a, and 3b expression in hepatitis C associated human hepatocellular carcinoma and their clinicopathological association.
DNA Methyltransferase 1: A Potential Gene Therapy Target for Hepatocellular Carcinoma?
DNA methyltransferase 3B promoter polymorphism and its susceptibility to primary hepatocellular carcinoma in the Chinese Han nationality population: a case-control study.
DNA methyltransferase 3b silencing affects locus-specific DNA methylation and inhibits proliferation, migration and invasion in human hepatocellular carcinoma SMMC-7721 and BEL-7402 cells.
DNA methyltransferase expression and DNA hypermethylation in human hepatocellular carcinoma.
DNA methyltransferase expression and DNA methylation in human hepatocellular carcinoma and their clinicopathological correlation.
DNMT1 and DNMT3b silencing sensitizes human hepatoma cells to TRAIL-mediated apoptosis via up-regulation of TRAIL-R2/DR5 and caspase-8.
DNMT1 mediated promoter methylation of GNAO1 in hepatoma carcinoma cells.
DNMT3A -448A>G polymorphism and the risk for hepatocellular carcinoma.
Down-regulated microRNA-152 induces aberrant DNA methylation in hepatitis B virus-related hepatocellular carcinoma by targeting DNA methyltransferase 1.
Dual targeting of histone methyltransferase G9a and DNA-methyltransferase 1 for the treatment of experimental hepatocellular carcinoma.
Effect of 5-aza-2'-deoxycytidine on immune-associated proteins in exosomes from hepatoma.
Effect of 5-aza-2'-deoxycytidine on p27Kip1, p21Cip1/Waf1/Sdi1, p57Kip2, and DNA methyltransferase 1 Genes Expression, Cell Growth Inhibition and Apoptosis Induction in Colon Cancer SW 480 and SW 948 Cell Lines.
Effect of Decitabine (5-aza-2'-deoxycytidine, 5-aza-CdR) in Comparison with Vorinostat (Suberoylanilide Hydroxamic Acid, SAHA) on DNMT1, DNMT3a and DNMT3b, HDAC 1-3, SOCS 1, SOCS 3, JAK2, and STAT3 Gene Expression in Hepatocellular Carcinoma HLE and LCL-PI 11 Cell Lines.
Effect of Zebularine on p16INK4a, p14ARF, p15INK4b, and DNA Methyltransferase 1 Gene Expression, Cell Growth Inhibition, and Apoptosis Induction in Human Hepatocellular Carcinoma PLC/PRF5 and Pancreatic Cancer PA-TU-8902 Cell Lines.
Epigenetic Dysregulation in Virus-Associated Neoplasms.
Epigenetic silencing of NAD(P)H:quinone oxidoreductase 1 by hepatitis B virus X protein increases mitochondrial injury and cellular susceptibility to oxidative stress in hepatoma cells.
Epigenetic upregulation of Bak by ZBP-89 inhibits the growth of hepatocellular carcinoma.
Expression of DNA (5-cytosin)-methyltransferases (DNMTs) in hepatocellular carcinomas.
Expression of proteins upregulated in hepatocellular carcinoma in patients with alcoholic hepatitis (AH) compared to non-alcoholic steatohepatitis (NASH): An immunohistochemical analysis of candidate proteins.
Genome-wide profiling of DNA methylation reveals preferred sequences of DNMTs in hepatocellular carcinoma cells.
Hepatitis C virus core protein epigenetically silences SFRP1 and enhances HCC aggressiveness by inducing epithelial-mesenchymal transition.
Identification of potential genes regulated by DNA methyltransferase 3B in a hepatocellular carcinoma cell line by RNA interference and microarray analysis.
Increased DNA methyltransferase expression is associated with an early stage of human hepatocarcinogenesis.
Increased protein expression of DNA methyltransferase (DNMT) 1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular carcinomas.
Indistinguishable physical and catalytic properties of DNA methyltransferase from normal rat liver and a transplantable rat hepatocellular carcinoma.
Influence of DNA methyltransferase 3b on FHIT expression and DNA methylation of the FHIT promoter region in hepatoma SMMC-7721 cells.
Inhibition of de novo Methyltransferase 3B is a Potential Therapy for Hepatocellular Carcinoma.
Inhibition of DNA methyltransferase activity and expression by treatment with the pan-deacetylase inhibitor panobinostat in hepatocellular carcinoma cell lines.
Integrative Epigenetic Analysis Reveals Therapeutic Targets to the DNA Methyltransferase Inhibitor Guadecitabine (SGI-110) in Hepatocellular Carcinoma.
Investigation of the Effect of 5-Aza-2'-Deoxycytidine on p15INK4, p16INK4, p18INK4, and p19INK4 Genes Expression, Cell Growth Inhibition, and Apoptosis Induction in Hepatocellular Carcinoma PLC/PRF/5 Cell Line.
lncRNA HOXB-AS3 promotes hepatoma by inhibiting p53 expression.
Long non-coding RNA HCP5 functions as a sponge of miR-29b-3p and promotes cell growth and metastasis in hepatocellular carcinoma through upregulating DNMT3A.
Long non-coding RNA RBMY2FP promotes proliferation of male hepatocellular carcinoma by directing DNA methylation and activating RBMY1A1 via DNMT1.
Long noncoding RNA DDX11-AS1 epigenetically represses LATS2 by interacting with EZH2 and DNMT1 in hepatocellular carcinoma.
Mechanistic and biological significance of DNA methyltransferase 1 upregulated by growth factors in human hepatocellular carcinoma.
Methylation mediated silencing of MicroRNA-1 gene and its role in hepatocellular carcinogenesis.
MicroRNA-200b inhibits the proliferation of hepatocellular carcinoma by targeting DNA methyltransferase 3a.
microRNA-450a targets DNA methyltransferase 3a in hepatocellular carcinoma.
miR-200b restoration and DNA methyltransferase inhibitor block lung metastasis of mesenchymal-phenotype hepatocellular carcinoma.
miR-29c-3p regulates DNMT3B and LATS1 methylation to inhibit tumor progression in hepatocellular carcinoma.
MiR-876-5p acts as an inhibitor in hepatocellular carcinoma progression by targeting DNMT3A.
MTSS1, a novel target of DNA methyltransferase 3B, functions as a tumor suppressor in hepatocellular carcinoma.
Mutation of the DNA methyltransferase (DNMT) 1 gene in human colorectal cancers.
Osteopontin alters DNA methylation through up-regulating DNMT1 and sensitizes CD133+/CD44+ cancer stem cells to 5 azacytidine in hepatocellular carcinoma.
Overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, associated with DNA hypomethylation on pericentromeric satellite regions during human hepatocarcinogenesis.
Overexpression of DNA methyltransferase 1 and its biological significance in primary hepatocellular carcinoma.
Plasma Cell Polarization to the Immunoglobulin G Phenotype in Hepatocellular Carcinomas Involves Epigenetic Alterations and Promotes Hepatoma Progression in Mice.
Promoter polymorphisms of DNA methyltransferase 3B and risk of hepatocellular carcinoma.
Putative association of DNA methyltransferase 1 (DNMT1) polymorphisms with clearance of HBV infection.
RNA methyltransferase NSUN2 promotes growth of hepatocellular carcinoma cells by regulating fizzy-related-1 in vitro and in vivo.
Role of de novo DNA methyltransferases and methyl CpG-binding proteins in gene silencing in a rat hepatoma.
S-adenosylmethionine: DNA-cytosine 5-methyltransferase from a Novikoff rat hepatoma cell line.
SALL3 interacts with DNMT3A and shows the ability to inhibit CpG island methylation in hepatocellular carcinoma.
Sera DNA Methylation of CDH1, DNMT3b and ESR1 Promoters as Biomarker for the Early Diagnosis of Hepatitis B Virus-Related Hepatocellular Carcinoma.
Significance of incorporation of DNMT1 and HLA-DR? with TNM staging in patients with hepatocellular carcinoma after curative resection.
Single nucleotide polymorphism in DNMT3B promoter and its association with hepatocellular carcinoma in a Moroccan population.
Suppression of metallothionein-I/II expression and its probable molecular mechanisms.
Telomerase reverse transcriptase regulates DNMT3B expression/aberrant DNA methylation phenotype and AKT activation in hepatocellular carcinoma.
The Effect of 5-Aza-2'-Deoxycytidine in Combination to and in Comparison with Vorinostat on DNA Methyltransferases, Histone Deacetylase 1, Glutathione S-Transferase 1 and Suppressor of Cytokine Signaling 1 Genes Expression, Cell Growth Inhibition and Apoptotic Induction in Hepatocellular LCL-PI 11 Cell Line.
Transcriptional and post-transcriptional control of DNA methyltransferase 3B is regulated by phosphatidylinositol 3 kinase/Akt pathway in human hepatocellular carcinoma cell lines.
Transfection of HCVc improves hTERT expression through STAT3 pathway by epigenetic regulation in Huh7 cells.
Trichostatin A sensitizes hepatoma cells to Taxol more than 5-Aza-dC and dexamethasone.
Ursolic acid inhibited growth of hepatocellular carcinoma HepG2 cells through AMPK?-mediated reduction of DNA methyltransferase 1.
Zinc-induced Dnmt1 expression involves antagonism between MTF-1 and nuclear receptor SHP.
ZNF479 downregulates metallothionein-1 expression by regulating ASH2L and DNMT1 in hepatocellular carcinoma.
[Effects of 5-aza-2'-deoxycytidine on the amount of exosomes and secreted immuno-associated proteins by hepatoma cells]
[High expression of DNMT3B promotes proliferation and invasion of hepatocellular carcinoma cells via Hippo signaling pathway].
[Influence of DNA methyltransferase 3b on the expression of cyclin D1 gene and methylation of its promoters in human hepatocellular carcinoma cells]
[No correlation between the sensitivity to 5-aza-dC and the global DNA methylation level in hepatocellular carcinoma cells]
[Overexpression of DNA-methyltransferases in persistency of cccDNA pool in chronic hepatitis B].
[Studies on DNA methylation in transformed mouse liver cells]
Carcinoma, Mucoepidermoid
DNA methyltransferase 1 expression and promoter methylation of E-cadherin in mucoepidermoid carcinoma.
DNA methyltransferase expression is associated with cell proliferation in salivary mucoepidermoid carcinoma.
[Effects of Dnmt1 and Dnmt3b in mucoepidermoid carcinoma of salivary glands].
Carcinoma, Neuroendocrine
DNA methyltransferases 1, 3a, and 3b overexpression and clinical significance in gastroenteropancreatic neuroendocrine tumors.
Carcinoma, Non-Small-Cell Lung
A novel DNMT3B subfamily, DeltaDNMT3B, is the predominant form of DNMT3B in non-small cell lung cancer.
Determination of O(6)-Methylguanine DNA Methyltransferase Promoter Methylation in Non-Small Cell Lung Cancer.
Different susceptibility of increased DNMT1 expression by exposure to tobacco smoke according to histology in primary non-small cell lung cancer.
DNA methyltransferases messenger RNA expression and aberrant methylation of CpG islands in non-small-cell lung cancer: association and prognostic value.
DNMT1 promotes cell proliferation via methylating hMLH1 and hMSH2 promoters in EGFR-mutated non-small cell lung cancer.
Elevated mRNA levels of DNA methyltransferase-1 as an independent prognostic factor in primary nonsmall cell lung cancer.
Expression of methylation-related genes is associated with overall survival in patients with non-small cell lung cancer.
Expression of {Delta}DNMT3B Variants and Its Association with Promoter Methylation of p16 and RASSF1A in Primary Non-Small Cell Lung Cancer.
Hypoxic-stabilized EPAS1 proteins transactivate DNMT1 and cause promoter hypermethylation and transcription inhibition of EPAS1 in non-small cell lung cancer.
Increased NQO1 but not c-MET and survivin expression in non-small cell lung carcinoma with KRAS mutations.
Inhibition of DNA methyltransferase 1 by RNA interference reverses epithelial-mesenchymal transition in highly metastatic 95D lung cancer cells by inhibiting the Wnt signaling pathway.
Inhibition of DNA methyltransferase inhibits DNA replication.
Interaction Of c-Jun And HOTAIR- Increased Expression Of p21 Converge In Polyphyllin I-Inhibited Growth Of Human Lung Cancer Cells.
LncRNA MIR210HG promotes proliferation and invasion of non-small cell lung cancer by upregulating methylation of CACNA2D2 promoter via binding to DNMT1.
Methylation of Wnt7a Is Modulated by DNMT1 and Cigarette Smoke Condensate in Non-Small Cell Lung Cancer.
Promoter methylation status of tumor suppressor genes and inhibition of expression of DNA methyltransferase 1 in non-small cell lung cancer.
Quantitative O(6)-methylguanine DNA methyltransferase methylation analysis in curatively resected non-small cell lung cancer: associations with clinical outcome.
Silibinin Synergizes with Histone Deacetylase and DNA Methyltransferase Inhibitors in Up-regulating E-cadherin Expression Together with Inhibition of Migration and Invasion of Human Non-small Cell Lung Cancer Cells.
Suppression of DNA methyltransferase 1 levels in head and neck squamous carcinoma cells using small interfering RNA results in growth inhibition and increase in Cdk inhibitor p21.
The loss-of-function of DNA methyltransferase 1 by siRNA impairs the growth of non-small cell lung cancer with alleviated side effects via reactivation of RASSF1A and APC in vitro and vivo.
The rs1550117 A>G variant in DNMT3A gene promoter significantly increases non-small cell lung cancer susceptibility in a Han Chinese population.
[Role of heterogeneous nuclear ribonucleoprotein A2/B1 protein in the pathogenesis of non-small cell lung cancer].
[The Relationship of Clinicopathology of p16 in Non-small Cell Lung Cancer and 5-nitrogen impurity-2'-deoxycytidine-nitrogen Impurity on the Influence of p16 Expression in Lung Cancer A549 Cells].
Carcinoma, Ovarian Epithelial
Clinicopathological significance and prognostic value of DNA methyltransferase 1, 3a, and 3b expressions in sporadic epithelial ovarian cancer.
Immunomodulatory action of the DNA methyltransferase inhibitor SGI-110 in epithelial ovarian cancer cells and xenografts.
[Expression of DNA methyltransferase 1, 3A and 3B mRNA in the epithelial ovarian carcinoma]
Carcinoma, Renal Cell
Aberrant DNA methyltransferase 1 expression in clear cell renal cell carcinoma development and progression.
An association between overexpression of DNA methyltransferase 3B4 and clear cell renal cell carcinoma.
Combined effects of DNA methyltransferase 1 and 3A polymorphisms and urinary total arsenic levels on the risk for clear cell renal cell carcinoma.
Decrease of DNA methyltransferase 1 expression relative to cell proliferation in transitional cell carcinoma.
Demethylating agent 5-aza-2'-deoxycytidine enhances susceptibility of renal cell carcinoma to paclitaxel.
DNA methyltransferase inhibitor-mediated apoptosis in the Wnt/?-catenin signal pathway in a renal cell carcinoma cell line.
Epigenetic regulation of microRNA expression in renal cell carcinoma.
Expression profiling and clinicopathological significance of DNA methyltransferase 1, 3A and 3B in sporadic human renal cell carcinoma.
Interleukin 6 induces cell proliferation of clear cell renal cell carcinoma by suppressing hepaCAM via the STAT3-dependent up-regulation of DNMT1 or DNMT3b.
Long noncoding RNA ATB participates in the development of renal cell carcinoma by downregulating p53 via binding to DNMT1.
MG98, a second-generation DNMT1 inhibitor, in the treatment of advanced renal cell carcinoma.
Phase II trial of DNA methyltransferase 1 inhibition with the antisense oligonucleotide MG98 in patients with metastatic renal carcinoma: a National Cancer Institute of Canada Clinical Trials Group investigational new drug study.
[Study on the combined therapy of DNA-methyltransferase inhibitor and interferon-alpha/beta for mouse spontaneously arose renal cell carcinoma, and immunological mechanism induced by the therapy]
Carcinoma, Small Cell
DNMT3b polymorphism and hereditary nonpolyposis colorectal cancer age of onset.
Carcinoma, Squamous Cell
Alteration of DNA methyltransferases contributes to 5'CpG methylation and poor prognosis in lung cancer.
Azacitidine, as a DNMT inhibitor decreases hTERT gene expression and telomerase activity more effective compared with HDAC inhibitor in human Head and neck squamous cell carcinoma cell lines.
Bioinformatics analysis of DNMT1 expression and its role in head and neck squamous cell carcinoma prognosis.
Different susceptibility of increased DNMT1 expression by exposure to tobacco smoke according to histology in primary non-small cell lung cancer.
DNA methylation-mediated Klotho silencing is an independent prognostic biomarker of head and neck squamous carcinoma.
DNA methyltransferase 1 inhibits O6-methylguanine-DNAmethyl-transferase-mediated cell growth and metastasis of hypopharyngeal squamous carcinoma.
DNMT1 Enhances the Radiosensitivity of HPV-Positive Head and Neck Squamous Cell Carcinomas via Downregulating SMG1.
Folate deficiency and aberrant expression of DNA methyltransferase 1 were associated with cervical cancerization.
FOXM1 induces a global methylation signature that mimics the cancer epigenome in head and neck squamous cell carcinoma.
Gene Polymorphisms Involved in Folate Metabolism and DNA Methylation with the Risk of Head and Neck Cancer.
High tRNA Transferase NSUN2 Gene Expression is Associated with Poor Prognosis in Head and Neck Squamous Carcinoma.
Increased expression of DNA methyltransferase 1 (DNMT1) protein in uterine cervix squamous cell carcinoma and its precursor lesion.
Loss of Dnmt3a and Dnmt3b does not affect epidermal homeostasis but promotes squamous transformation through PPAR-?.
Lower expression of p14ARF and p16INK4a correlates with higher DNMT3B expression in human oesophageal squamous cell carcinomas.
Methylation of RASSF1A gene promoter and the correlation with DNMT1 expression that may contribute to esophageal squamous cell carcinoma.
Over-expression of DNMT3A predicts the risk of recurrent vulvar squamous cell carcinomas.
Polymorphisms of the DNMT3B gene and risk of squamous cell carcinoma of the head and neck: a case-control study.
Promoter polymorphisms of DNMT3B and the risk of head and neck squamous cell carcinoma in Taiwan: a case-control study.
Reprogramming of HeLa cells upon DNMT3L overexpression mimics carcinogenesis.
Suppression of DNA methyltransferase 1 levels in head and neck squamous carcinoma cells using small interfering RNA results in growth inhibition and increase in Cdk inhibitor p21.
Transfer RNA methyltransferase gene NSUN2 mRNA expression modifies the effect of T cell activation score on patient survival in head and neck squamous carcinoma.
[High expression of DNMT1 was correlated with beta-catenin accumulation and malignant phynotype of lung squamous cell carcinoma and adenocarcinoma]
[Screening and functional analysis of microRNA expression in HPV16-positive squamous carcinoma of the cervix ?in the Uygur of southern Xinjiang].
Carcinoma, Transitional Cell
Decrease of DNA methyltransferase 1 expression relative to cell proliferation in transitional cell carcinoma.
Demethylating agent 5-aza-2'-deoxycytidine enhances susceptibility of bladder transitional cell carcinoma to Cisplatin.
Increased DNA methyltransferase 1 protein expression in human transitional cell carcinoma of the bladder.
Cardiomegaly
CRISPR-Mediated Gene Editing to Assess the Roles of Tet2 and Dnmt3a in Clonal Hematopoiesis and Cardiovascular Disease.
Hypertrophic signaling compensates for contractile and metabolic consequences of DNA methyltransferase 3A loss in human cardiomyocytes.
Cardiomyopathy, Hypertrophic, Familial
Myocardial tissue-specific Dnmt1 knockout in rats protects against pathological injury induced by Adriamycin.
Cardiovascular Diseases
A feedback loop: Interactions between Inflammatory Signals and Clonal Hematopoiesis in Cardiovascular Disease.
Clonal Hematopoiesis-Driver DNMT3A Mutations Alter Immune Cells in Heart Failure.
CRISPR-Mediated Gene Editing to Assess the Roles of Tet2 and Dnmt3a in Clonal Hematopoiesis and Cardiovascular Disease.
Effect of DNA Methylation in Various Diseases and the Probable Protective Role of Nutrition: A Mini-Review.
Genetic modifiers of folate, vitamin B-12, and homocysteine status in a cross-sectional study of the Canadian population.
Homocysteine inhibits endothelial progenitor cells proliferation via DNMT1-mediated hypomethylation of Cyclin A.
Cataplexy
A novel DNMT1 mutation associated with early onset hereditary sensory and autonomic neuropathy, cataplexy, cerebellar atrophy, scleroderma, endocrinopathy, and common variable immune deficiency.
Cataplexy and ataxia: red flags for the diagnosis of DNA methyltransferase 1 mutation.
Cataract
Expanding the phenotype of biallelic loss-of-function variants in the NSUN2 gene: Description of four individuals with juvenile cataract, chronic nephritis, or brain anomaly as novel complications.
Cell Transformation, Neoplastic
Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells.
Cerebellar Ataxia
A novel de novo exon 21 DNMT1 mutation causes cerebellar ataxia, deafness, and narcolepsy in a Brazilian patient.
A novel DNMT1 mutation associated with early onset hereditary sensory and autonomic neuropathy, cataplexy, cerebellar atrophy, scleroderma, endocrinopathy, and common variable immune deficiency.
Aberrant signature methylome by DNMT1 hot spot mutation in hereditary sensory and autonomic neuropathy 1E.
Autosomal dominant cerebellar ataxia, deafness, and narcolepsy (ADCA-DN) associated with progressive cognitive and behavioral deterioration.
Cerebellar Ataxia as a Common Clinical Presentation Associated with DNMT1 p.Y511H and a Review of the Literature.
DNMT1 mutation hot spot causes varied phenotypes of HSAN1 with dementia and hearing loss.
EIF3G is associated with narcolepsy across ethnicities.
Identification of a methylation profile for DNMT1-associated autosomal dominant cerebellar ataxia, deafness, and narcolepsy.
Identification of a novel DNMT1 mutation in a Chinese patient with hereditary sensory and autonomic neuropathy type IE.
Mutations in DNMT1 cause autosomal dominant cerebellar ataxia, deafness and narcolepsy.
Narcolepsy is a common phenotype in HSAN IE and ADCA-DN.
Novel mutation in the replication focus targeting sequence domain of DNMT1 causes hereditary sensory and autonomic neuropathy IE.
Polysomnographic and neurometabolic features may mark preclinical autosomal dominant cerebellar ataxia, deafness, and narcolepsy due to a mutation in the DNA (cytosine-5-)-methyltransferase gene, DNMT1.
Cervical Intraepithelial Neoplasia
Folate deficiency and aberrant expression of DNA methyltransferase 1 were associated with cervical cancerization.
Increased expression of DNA methyltransferase 1 (DNMT1) protein in uterine cervix squamous cell carcinoma and its precursor lesion.
Cholangiocarcinoma
DNA methyltransferase inhibitor zebularine induces human cholangiocarcinoma cell death through alteration of DNA methylation status.
Dual Targeting of G9a and DNA Methyltransferase-1 for the Treatment of Experimental Cholangiocarcinoma.
miR-29b restrains cholangiocarcinoma progression by relieving DNMT3B-mediated repression of CDKN2B expression.
Suppressing effects of down-regulating DNMT1 and DNMT3b expression on the growth of human cholangiocarcinoma cell line.
Cholangitis
Primary Biliary Cholangitis in British Columbia First Nations: Clinical features and discovery of novel genetic susceptibility loci.
Choline Deficiency
Gestational Choline Deficiency Causes Global and Igf2 Gene DNA Hypermethylation by Up-regulation of Dnmt1 Expression.
Chondrosarcoma
Epigenetic silencing of SFRP5 promotes the metastasis and invasion of chondrosarcoma by expression inhibition and Wnt signaling pathway activation.
Epigenetics: methylation-associated repression of heparan sulfate 3-O-sulfotransferase gene expression contributes to the invasive phenotype of H-EMC-SS chondrosarcoma cells.
Choriocarcinoma
Curcumol Controls Choriocarcinoma Stem-Like Cells Self-Renewal via Repression of DNA Methyltransferase (DNMT)- and Histone Deacetylase (HDAC)-Mediated Epigenetic Regulation.
DNA methyltransferase-3 like protein expression in various histological types of testicular germ cell tumor.
Production of an anti-angiogenic factor sFLT1 is suppressed via promoter hypermethylation of FLT1 gene in choriocarcinoma cells.
Colitis, Ulcerative
Immunohistochemical analysis of the DNA methyltransferase 3b expression is associated with significant improvements in the discrimination of ulcerative colitis-associated neoplastic lesions.
Increased expression of DNA methyltransferase-1 in non-neoplastic epithelium helps predict colorectal neoplasia risk in ulcerative colitis.
Inflammatory cytokines promote clonal hematopoiesis with specific mutations in ulcerative colitis patients.
Colonic Neoplasms
5-Aza-CdR Regulates RASSF1A By Inhibiting DNMT1 To Affect Colon Cancer Cell Proliferation, Migration And Apoptosis.
5-Aza-cytidine is a potent inhibitor of DNA methyltransferase 3a and induces apoptosis in HCT-116 colon cancer cells via Gadd45- and p53-dependent mechanisms.
A DNA methylation signature associated with aberrant promoter DNA hypermethylation of DNMT3B in human colorectal cancer.
A feasibility study of combined epigenetic and vaccine therapy in advanced colorectal cancer with pharmacodynamic endpoint.
A microassay for measuring cytosine DNA methyltransferase activity during tumor progression.
A novel miR-203-DNMT3b-ABCG2 regulatory pathway predisposing colorectal cancer development.
Antiproliferative effects of DNA methyltransferase 3B depletion are not associated with DNA demethylation.
Azacytidine and decitabine induce gene-specific and non-random DNA demethylation in human cancer cell lines.
Black raspberry-derived anthocyanins demethylate tumor suppressor genes through the inhibition of DNMT1 and DNMT3B in colon cancer cells.
Calcium-sensing receptor silencing in colorectal cancer is associated with promoter hypermethylation and loss of acetylation on histone 3.
Cell and stage of transformation-specific effects of folate deficiency on methionine cycle intermediates and DNA methylation in an in vitro model.
Combination of gefitinib and DNA methylation inhibitor decitabine exerts synergistic anti-cancer activity in colon cancer cells.
Correction to "5-aza-Cytidine Is a Potent Inhibitor of DNA Methyltransferase 3a and Induces Apoptosis in HCT-116 Colon Cancer Cells via Gadd45- and p53-Dependent Mechanisms".
CpG island hypermethylation is maintained in human colorectal cancer cells after RNAi-mediated depletion of DNMT1.
De novo CpG island methylation in human cancer cells.
Different involvement of DNA methylation and histone deacetylation in the expression of solute-carrier transporters in 4 colon cancer cell lines.
DLEC1 is a functional 3p22.3 tumour suppressor silenced by promoter CpG methylation in colon and gastric cancers.
DNA Methylation Regulates MicroRNA Expression.
DNA methyltransferase 1 is essential for initiation of the colon cancers.
DNMT1 and DNMT3B modulate distinct polycomb-mediated histone modifications in colon cancer.
DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells.
DNMT1 modulates gene expression without its catalytic activity partially through its interactions with histone-modifying enzymes.
DNMT1 Stability Is Regulated by Proteins Coordinating Deubiquitination and Acetylation-Driven Ubiquitination.
DNMT1-associated long non-coding RNAs regulate global gene expression and DNA methylation in colon cancer.
DNMT3b 39179GT polymorphism and the risk of adenocarcinoma of the colon in Koreans.
DNMT3B expression might contribute to CpG island methylator phenotype in colorectal cancer.
Effect of 5-Aza-2'-Deoxycytidine in Comparison to Valproic Acid and Trichostatin A on Histone Deacetylase 1, DNA Methyltransferase 1, and CIP/KIP Family (p21, p27, and p57) Genes Expression, Cell Growth Inhibition, and Apoptosis Induction in Colon Cancer SW480 Cell Line.
Effect of 5-aza-2'-deoxycytidine on Estrogen Receptor Alpha/Beta and DNA Methyltransferase 1 Genes Expression, Apoptosis Induction, and Cell Growth Prevention of the Colon Cancer HT 29 Cell Line.
Effect of 5-aza-2'-deoxycytidine on p27Kip1, p21Cip1/Waf1/Sdi1, p57Kip2, and DNA methyltransferase 1 Genes Expression, Cell Growth Inhibition and Apoptosis Induction in Colon Cancer SW 480 and SW 948 Cell Lines.
Effect of Zebularine in Comparison to and in Combination with Trichostatin A on CIP/KIP Family (p21Cip1/Waf1/Sdi1, p27Kip1, and p57Kip2), DNMTs (DNMT1, DNMT3a, and DNMT3b), Class I HDACs (HDACs 1, 2, 3) and Class II HDACs (HDACs 4, 5, 6) Gene Expression, Cell Growth Inhibition and Apoptosis Induction in Colon Cancer LS 174T Cell Line.
Effects of DNA methylation on expression of tumor suppressor genes and proto-oncogene in human colon cancer cell lines.
Emergent issues in the genetics of intestinal neoplasia.
Epigenetic mechanisms involved in differential MDR1 mRNA expression between gastric and colon cancer cell lines and rationales for clinical chemotherapy.
Fenofibrate Exerts Antitumor Effects in Colon Cancer via Regulation of DNMT1 and CDKN2A.
Frequent Increased Gene Copy Number and High Protein Expression of tRNA (Cytosine-5-)-Methyltransferase (NSUN2) in Human Cancers.
FXR silencing in human colon cancer by DNA methylation and KRAS signaling.
Genes methylated by DNA methyltransferase 3b are similar in mouse intestine and human colon cancer.
Green tea polyphenol epigallocatechin 3-gallate, contributes to the degradation of DNMT3A and HDAC3 in HCT 116 human colon cancer cells.
High expression of the DNA methyltransferase gene characterizes human neoplastic cells and progression stages of colon cancer.
High-resolution analysis of the 5'-end transcriptome using a next generation DNA sequencer.
Hinokitiol induces DNA demethylation via DNMT1 and UHRF1 inhibition in colon cancer cells.
HOXB13, a target of DNMT3B, is methylated at an upstream CpG island, and functions as a tumor suppressor in primary colorectal tumors.
Human cytomegalovirus infection is sensitive to the host cell DNA methylation state and alters global DNA methylation capacity.
Identification of long-range epigenetic silencing on chromosome 15q25 and its clinical implication in gastric cancer.
Increased cytosine DNA-methyltransferase activity during colon cancer progression.
Increased DNA methyltransferase expression is associated with an early stage of human hepatocarcinogenesis.
Inhibition of the extracellular signal-regulated kinase/mitogen-activated protein kinase pathway decreases DNA methylation in colon cancer cells.
Intestinal PPAR? Protects Against Colon Carcinogenesis via Regulation of Methyltransferases DNMT1 and PRMT6.
Investigation of the Effect of Zebularine in Comparison to and in Combination with Trichostatin A on p21Cip1/Waf1/ Sdi1, p27Kip1, p57Kip2, DNA Methyltransferases and Histone Deacetylases in Colon Cancer LS 180 Cell Line.
Limited up-regulation of DNA methyltransferase in human colon cancer reflecting increased cell proliferation.
Mechanisms of inactivation of the receptor tyrosine kinase EPHB2 in colorectal tumors.
MiR-339 and especially miR-766 reactivate the expression of tumor suppressor genes in colorectal cancer cell lines through DNA methyltransferase 3B gene inhibition.
Mitoxantrone mediates demethylation and reexpression of cyclin d2, estrogen receptor and 14.3.3sigma in breast cancer cells.
PHF21B as a candidate tumor suppressor gene in head and neck squamous cell carcinomas.
Re: Schneider-Stock R, Diab-Assef M, Rohrbeck A, Foltzer-Jourdainne C, Boltze C, Hartig R, Schönfeld P, Roessner A, and Gali-Muhtasib H (2005) 5-aza-Cytidine Is a Potent Inhibitor of DNA Methyltransferase 3a and Induces Apoptosis in HCT-116 Colon Cancer Cells via Gadd45- and p53-Dependent Mechanisms. J Pharmacol Exp Ther February 2005 312:525-536; doi:10.1124/jpet.104.074195.
Regulation of hMSH2 and hMLH1 expression in the human colon cancer cell line SW1116 by DNA methyltransferase 1.
Regulation of UGT1A1 and HNF1 transcription factor gene expression by DNA methylation in colon cancer cells.
Role and mechanism of organic cation transporter 3 in oxaliplatin treatment of colon cancer in vitro and in vivo.
Silencing of the DNA mismatch repair gene MLH1 induced by hypoxic stress in a pathway dependent on the histone demethylase LSD1.
Synergistic Effect of Epigenetic Inhibitors Decitabine and Suberoylanilide Hydroxamic Acid on Colorectal Cancer in vitro.
Targeted bisulfite sequencing by solution hybrid selection and massively parallel sequencing.
The depletion of DNA Methyltransferase-1 and the epigenetic effects of 5-Aza-2'Deoxycytidine (Decitabine) are differentially regulated by cell cycle progression.
The DNMT1-associated lincRNA DACOR1 reprograms genome-wide DNA methylation in colon cancer.
The immunomodulatory anticancer agent, RRx-001, induces an interferon response through epigenetic induction of viral mimicry.
Theaflavin-Containing Black Tea Extract: A Potential DNA Methyltransferase Inhibitor in Human Colon Cancer Cells and Ehrlich Ascites Carcinoma-Induced Solid Tumors in Mice.
Upregulation of DNA methyltransferase-mediated gene silencing, anchorage-independent growth, and migration of colon cancer cells by interleukin-6.
Wnt signaling pathway upregulates DNMT1 to trigger NHERF1 promoter hypermethylation in colon cancer.
[Effect and mechanism of DNMT inhibitor on the reversal of multidrug resistance in human colon cancer cell line sw620/L-OHP].
[Effect of eukaryotic expression plasmid DNA methyltransferase gene on methylation status and transcription level of DNA mismatch repair genes in human colon cancer cell line]
[Regulation of histone acetylation on the expression of cell cycle-associated genes in human colon cancer cell lines]
Colorectal Neoplasms
A DNA methylation signature associated with aberrant promoter DNA hypermethylation of DNMT3B in human colorectal cancer.
A protein interaction between beta-catenin and Dnmt1 regulates Wnt Signaling and DNA methylation in colorectal cancer cells.
Aberrant methylation of miR-124 upregulates DNMT3B in colorectal cancer to accelerate invasion and migration.
Abnormal regulation of DNA methyltransferase expression during colorectal carcinogenesis.
Association of DNMT3B -283 T > C and -579 G > T polymorphisms with decreased cancer risk: evidence from a meta-analysis.
Association of interindividual differences in p14(ARF) promoter methylation with single nucleotide polymorphism in primary colorectal cancer.
Association of the DNMT3A -448A>G polymorphism with genetic susceptibility to colorectal cancer.
Association of the SUV39H1 histone methyltransferase with the DNA methyltransferase 1 at mRNA expression level in primary colorectal cancer.
Chemotherapy and Radiotherapy Downregulate the Activity and Expression of DNA Methyltransferase and Enhance Bcl-2/E1B-19-kDa Interacting Protein-3-Induced Apoptosis in Human Colorectal Cancer Cells.
Circ_0084615 is an oncogenic circular RNA in colorectal cancer and promotes DNMT3A expression via repressing miR-599.
Colon cancer stemness as a reversible epigenetic state: Implications for anticancer therapies.
Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells.
CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression.
CpG island hypermethylation is maintained in human colorectal cancer cells after RNAi-mediated depletion of DNMT1.
CpG methylation is maintained in human cancer cells lacking DNMT1.
Curvature-Mediated Surface Accessibility Enables Ultrasensitive Electrochemical Human Methyltransferase Analysis.
De novo DNA methyltransferase activity in colorectal cancer is directed towards H3K36me3 marked CpG islands.
Decoupling of DNA methylation and activity of intergenic LINE-1 promoters in colorectal cancer.
Deep proteomic analysis of Dnmt1 mutant/hypomorphic colorectal cancer cells reveals dysregulation of epithelial-mesenchymal transition and subcellular re-localization of Beta-Catenin.
Different effects of epigenetic modifiers on the cytotoxicity induced by 5-fluorouracil, irinotecan or oxaliplatin in colon cancer cells.
Differential requirement for DNA methyltransferase 1 in maintaining human cancer cell gene promoter hypermethylation.
Discovery of epigenetically silenced genes by methylated DNA immunoprecipitation in colon cancer cells.
DNA Electrochemistry Shows DNMT1 Methyltransferase Hyperactivity in Colorectal Tumors.
DNA methylation down-regulates CDX1 gene expression in colorectal cancer cell lines.
DNA methylation-dependent repression of PDZ-LIM domain-containing protein 2 in colon cancer and its role as a potential therapeutic target.
DNA Methyltransferase Inhibitors Improve the Effect of Chemotherapeutic Agents in SW48 and HT-29 Colorectal Cancer Cells.
DNA methyltransferases expression in normal tissues and various human cancer cell lines, xenografts and tumors.
DNA-methyltransferase 3B 39179 G > T polymorphism and risk of sporadic colorectal cancer in a subset of Iranian population.
DNMT1 and DNMT3b cooperate to silence genes in human cancer cells.
DNMT1 maintains the methylation of miR-152-3p to regulate TMSB10 expression, thereby affecting the biological characteristics of colorectal cancer cells.
DNMT3A -448A>G polymorphism and cancer risk: a meta-analysis.
DNMT3A -448A>G polymorphism and the risk for hepatocellular carcinoma.
DNMT3a plays a role in switches between doxorubicin-induced senescence and apoptosis of colorectal cancer cells.
DNMT3B -149 C>T and -579 G>T Polymorphisms and Risk of Gastric and Colorectal Cancer: a Meta-analysis.
DNMT3b -149C/T promoter variants and methylation of colorectal cancer-associated genes.
DNMT3B expression might contribute to CpG island methylator phenotype in colorectal cancer.
DNMT3b polymorphism and hereditary nonpolyposis colorectal cancer age of onset.
Doxorubicin inhibits DNMT1, resulting in conditional apoptosis.
Effects of Amino Acid Substitution Polymorphisms of two DNA Methyltransferases on Susceptibility to Sporadic Colorectal Cancer.
Effects of Decitabine on Invasion and Exosomal Expression of miR-200c and miR-141 in Oxaliplatin-Resistant Colorectal Cancer Cells.
Effects of Zebularine on Invasion Activity and Intracellular Expression Level of let-7b in Colorectal Cancer Cells.
Elevated Dnmt3a activity promotes polyposis in Apc(Min) mice by relaxing extracellular restraints on Wnt signaling.
Epigenetic regulation of X-linked cancer/germline antigen genes by DNMT1 and DNMT3b.
Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer.
Expression of human DNA methyltransferase 1 in colorectal cancer tissues and their corresponding distant normal tissues.
Frequent Increased Gene Copy Number and High Protein Expression of tRNA (Cytosine-5-)-Methyltransferase (NSUN2) in Human Cancers.
Gene-specific DNA methylation of DNMT3B and MTHFR and colorectal adenoma risk.
Genetic disruption of cytosine DNA methyltransferase enzymes induces chromosomal instability in human cancer cells.
Genetic modifiers of folate, vitamin B-12, and homocysteine status in a cross-sectional study of the Canadian population.
Genetic Polymorphism of DNA Methyltransferase 3A rs1550117 A>G and Risk of Cancer: A Meta-analysis.
Genetic polymorphism of DNA methyltransferase 3B 149 C>T and risk of colorectal cancer: a meta-analysis.
Genetic unmasking of epigenetically silenced tumor suppressor genes in colon cancer cells deficient in DNA methyltransferases.
Genetic Variants of Methyl Metabolizing Enzymes and Epigenetic Regulators: Associations with Promoter CpG Island Hypermethylation in Colorectal Cancer.
Genetic variation in the promoter of DNMT3B is associated with the risk of colorectal cancer.
HOXB13, a target of DNMT3B, is methylated at an upstream CpG island, and functions as a tumor suppressor in primary colorectal tumors.
Hsa_circ_0040809 regulates colorectal cancer development by upregulating methyltransferase DNMT1 via targeting miR-515-5p.
IL-6-induced DNMT1 activity mediates SOCS3 promoter hypermethylation in ulcerative colitis-related colorectal cancer.
Impairment of DYRK2 by DNMT1?mediated transcription augments carcinogenesis in human colorectal cancer.
Improved microsatellite instability detection in colorectal cancer patients by a combination of fourteen markers especially DNMT3a, DCD, and MT1X.
Inhibition of DNA methyltransferase induces G2 cell cycle arrest and apoptosis in human colorectal cancer cells via inhibition of JAK2/STAT3/STAT5 signaling.
Inhibition of DNA methyltransferase induces G2 cell cycle arrest and apoptosis in human colorectal cancer cells via inhibition of JAK2/STAT3/STAT5 signalling.
Inhibition of intestinal tumor formation by deletion of the DNA methyltransferase 3a.
Label-free electrochemical detection of human methyltransferase from tumors.
LINC00337 promotes tumor angiogenesis in colorectal cancer by recruiting DNMT1, which suppresses the expression of CNN1.
LncRNA HIF1A-AS2 positively affects the progression and EMT formation of colorectal cancer through regulating miR-129-5p and DNMT3A.
Long noncoding RNA LINC00630 promotes radio-resistance by regulating BEX1 gene methylation in colorectal cancer cells.
Loss of imprinting in colorectal cancer linked to hypomethylation of H19 and IGF2.
Luteolin induces apoptosis in BE colorectal cancer cells by downregulating calpain, UHRF1, and DNMT1 expressions.
Mechanisms of colon cancer prevention with and beyond COX-2 inhibition.
Methylation of O-6-methylguanine DNA methyltransferase characterizes a subset of colorectal cancer with low-level DNA microsatellite instability.
MGMT and MLH1 promoter methylation versus APC, KRAS and BRAF gene mutations in colorectal cancer: indications for distinct pathways and sequence of events.
MicroRNA-342 inhibits colorectal cancer cell proliferation and invasion by directly targeting DNA methyltransferase 1.
miR-124 and miR-506 inhibit colorectal cancer progression by targeting DNMT3B and DNMT1.
MiR-339 and especially miR-766 reactivate the expression of tumor suppressor genes in colorectal cancer cell lines through DNA methyltransferase 3B gene inhibition.
MiR-410 is overexpressed in liver and colorectal tumors and enhances tumor cell growth by silencing FHL1 via a direct/indirect mechanism.
Multigene methylation analysis of gastrointestinal tumors: TPEF emerges as a frequent tumor-specific aberrantly methylated marker that can be detected in peripheral blood.
Multiproteomic and Transcriptomic Analysis of Oncogenic ?-Catenin Molecular Networks.
Mutation and expression analysis of the IDH1, IDH2, DNMT3A, and MYD88 genes in colorectal cancer.
Mutation of the DNA methyltransferase (DNMT) 1 gene in human colorectal cancers.
Myeloid-Derived Suppressor Cells Produce IL-10 to Elicit DNMT3b-Dependent IRF8 Silencing to Promote Colitis-Associated Colon Tumorigenesis.
NUSAP1 gene silencing inhibits cell proliferation, migration and invasion through inhibiting DNMT1 gene expression in human colorectal cancer.
Potent antitumor activity of Laccaic acid and Phenethyl isothiocyanate combination in colorectal cancer via dual inhibition of DNA methyltransferase-1 and Histone deacetylase-1.
Procainamide is a specific inhibitor of DNA methyltransferase 1.
Prognostic potential of DNA methylation and transcript levels of HIF1A and EPAS1 in colorectal cancer.
Promoter methylation analysis of WNT/?-catenin pathway regulators and its association with expression of DNMT1 enzyme in colorectal cancer.
Promoter methylation status of hMLH1, MGMT, and CDKN2A/p16 in colorectal adenomas.
Promoter polymorphisms of DNMT3B and the risk of colorectal cancer in Chinese: a case-control study.
Protein expression trends of DNMT1 in gastrointestinal diseases: From benign to precancerous lesions to cancer.
Quantitative assessment of AKAP12 promoter methylation in colorectal cancer using methylation-sensitive high resolution melting: Correlation with dukes' stage.
Relationship between gene body DNA methylation and intragenic H3K9me3 and H3K36me3 chromatin marks.
Role of MGMT as biomarker in colorectal cancer.
Simultaneous silencing Aurora-A and UHRF1 inhibits colorectal cancer cell growth through regulating expression of DNMT1 and STAT1.
Suppression of intestinal neoplasia by DNA hypomethylation.
The -149C>T polymorphism of DNMT3B is not associated with colorectal cancer risk: Evidence from a meta-analysis based on case-control studies.
The Curcumin Analog CH-5 Exerts Anticancer Effects in Human Osteosarcoma Cells via Modulation of Transcription Factors p53/Sp1.
The role of a ginseng saponin metabolite as a DNA methyltransferase inhibitor in colorectal cancer cells.
Unique methylation pattern of oncostatin m receptor gene in cancers of colorectum and other digestive organs.
Upregulation of DNA methyltransferase-mediated gene silencing, anchorage-independent growth, and migration of colon cancer cells by interleukin-6.
Zebularine inhibits tumorigenesis and stemness of colorectal cancer via p53-dependent endoplasmic reticulum stress.
[Relationship of DNMT3b expression and SEPT9 methylation in theprogression of colorectal carcinogenesis].
Colorectal Neoplasms, Hereditary Nonpolyposis
DNMT3b polymorphism and hereditary nonpolyposis colorectal cancer age of onset.
Common Variable Immunodeficiency
A novel DNMT1 mutation associated with early onset hereditary sensory and autonomic neuropathy, cataplexy, cerebellar atrophy, scleroderma, endocrinopathy, and common variable immune deficiency.
Communicable Diseases
Genotyping of DNA using sequence-specific methyltransferases followed by immunochemical detection.
Congenital Abnormalities
DNA methyltransferase 3a mediates developmental thermal plasticity.
Corneal Injuries
Rapamycin ameliorates corneal injury after alkali burn through methylation modification in mouse TSC1 and mTOR genes.
Coronary Artery Disease
Risk-Association of DNMT1 Gene Polymorphisms with Coronary Artery Disease in Chinese Han Population.
Coronary Disease
Atherosclerosis and clonal hematopoyesis: A new risk factor.
Clinical relevance of clonal hematopoiesis in the oldest-old population.
Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease.
COVID-19
SARS-CoV-2 Infection-Induced Promoter Hypomethylation as an Epigenetic Modulator of Heat Shock Protein A1L (HSPA1L) Gene.
Cryptorchidism
The Mechanism of Environmental Endocrine Disruptors (DEHP) Induces Epigenetic Transgenerational Inheritance of Cryptorchidism.
Cutis Laxa
Epigenetic silencing of lysyl oxidase-like-1 through DNA hypermethylation in an autosomal recessive cutis laxa case.
Cystic Fibrosis
ALTERATION IN THE CYTOKINE SECRETION PATTERN IN T CELLS OF PATIENTS WITH CYSTIC FIBROSIS CAUSED BY DNA METHYLTRANSFERASE INHIBITOR 5-AZACITIDINE.
Cytomegalovirus Retinitis
Antisense therapy in clinical oncology: preclinical and clinical experiences.
Deafness
A novel de novo exon 21 DNMT1 mutation causes cerebellar ataxia, deafness, and narcolepsy in a Brazilian patient.
A novel DNMT1 mutation associated with early onset hereditary sensory and autonomic neuropathy, cataplexy, cerebellar atrophy, scleroderma, endocrinopathy, and common variable immune deficiency.
Aberrant signature methylome by DNMT1 hot spot mutation in hereditary sensory and autonomic neuropathy 1E.
Autosomal dominant cerebellar ataxia, deafness, and narcolepsy (ADCA-DN) associated with progressive cognitive and behavioral deterioration.
Cerebellar Ataxia as a Common Clinical Presentation Associated with DNMT1 p.Y511H and a Review of the Literature.
DNMT1 mutation hot spot causes varied phenotypes of HSAN1 with dementia and hearing loss.
EIF3G is associated with narcolepsy across ethnicities.
Identification of a methylation profile for DNMT1-associated autosomal dominant cerebellar ataxia, deafness, and narcolepsy.
Local delivery of arsenic trioxide nanoparticles for hepatocellular carcinoma treatment.
Mutations in DNMT1 cause autosomal dominant cerebellar ataxia, deafness and narcolepsy.
Narcolepsy is a common phenotype in HSAN IE and ADCA-DN.
Novel mutation in the replication focus targeting sequence domain of DNMT1 causes hereditary sensory and autonomic neuropathy IE.
Polysomnographic and neurometabolic features may mark preclinical autosomal dominant cerebellar ataxia, deafness, and narcolepsy due to a mutation in the DNA (cytosine-5-)-methyltransferase gene, DNMT1.
Deficiency Diseases
DNA hypomethylation, cancer, the immunodeficiency, centromeric region instability, facial anomalies syndrome and chromosomal rearrangements.
Dehydration
Epigenetic control of the vasopressin promoter explains physiological ability to regulate vasopressin transcription in dehydration and salt loading states in the rat.
Dementia
A novel DNMT1 mutation associated with early onset hereditary sensory and autonomic neuropathy, cataplexy, cerebellar atrophy, scleroderma, endocrinopathy, and common variable immune deficiency.
Aberrant signature methylome by DNMT1 hot spot mutation in hereditary sensory and autonomic neuropathy 1E.
Association study between the DNMT3A -448A>G polymorphism and risk of Alzheimer's disease in Caucasians of Italian origin.
DNA Methylation in Neurodegenerative and Cerebrovascular Disorders.
DNA methyltransferase 1 mutations and mitochondrial pathology: is mtDNA methylated?
DNMT1 links aberrant DNA methylation to hereditary sensory neuropathy.
DNMT1 mutation hot spot causes varied phenotypes of HSAN1 with dementia and hearing loss.
EIF3G is associated with narcolepsy across ethnicities.
Lack of association between DNMT1 gene polymorphisms and noise-induced hearing loss in a Chinese population.
Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss.
Narcolepsy is a common phenotype in HSAN IE and ADCA-DN.
Demyelinating Diseases
Efficient Remyelination Requires DNA Methylation.
Dermatitis, Atopic
Social defeat stress exacerbates atopic dermatitis through downregulation of DNA methyltransferase 1 and upregulation of C-C motif chemokine receptor 7 in skin dendritic cells.
Diabetes Complications
Overexpression of Dnmt3a ameliorates diabetic muscle atrophy by modulating Pten/Akt pathway.
Diabetes Mellitus
Overexpression of Dnmt3a ameliorates diabetic muscle atrophy by modulating Pten/Akt pathway.
Diabetes Mellitus, Type 2
Author Correction: NT5C2 methylation regulatory interplay between DNMT1 and insulin receptor in type 2 diabetes.
Inhibition of DNA methyltransferase 1 increases nuclear receptor subfamily 4 group A member 1 expression and decreases blood glucose in type 2 diabetes.
NT5C2 methylation regulatory interplay between DNMT1 and insulin receptor in type 2 diabetes.
Diabetic Angiopathies
Transient High Glucose Causes Persistent Vascular Dysfunction and Delayed Wound Healing by the DNMT1-Mediated Ang-1/NF-?B Pathway.
Diabetic Nephropathies
Cissus quadrangularis extract attenuates diabetic nephropathy by altering SIRT1/DNMT1 axis.
DNA methyltransferase 1 may be a therapy target for attenuating diabetic nephropathy and podocyte injury.
High glucose-induced cytoplasmic translocation of Dnmt3a contributes to CTGF hypo-methylation in mesangial cells.
Zhang L, Zhang Q, Liu S, et al. DNA methyltransferase 1 may be a therapy target for attenuating diabetic nephropathy and podocyte injury. Kidney Int. 2017;92:140-153.
Diabetic Retinopathy
5-aza-2'-deoxycytidine in the regulation of antioxidant enzymes in retinal endothelial cells and rat diabetic retina.
Curcumin Modulates DNA Methyltransferase Functions in a Cellular Model of Diabetic Retinopathy.
Epigenetic modifications and diabetic retinopathy.
Diphtheria
Folding funnels and conformational transitions via hinge-bending motions.
dna (cytosine-5-)-methyltransferase deficiency
5-aza-2'-deoxycytidine induces alterations in murine spermatogenesis and pregnancy outcome.
A necessary role of DNMT3A in endurance exercise by suppressing ALDH1L1-mediated oxidative stress.
Abnormalities of the DNA methylation mark and its machinery: an emerging cause of neurologic dysfunction.
Bronchial epithelial DNA methyltransferase 3b dampens pulmonary immune responses during Pseudomonas aeruginosa infection.
Compromised oocyte quality and assisted reproduction contribute to sex-specific effects on offspring outcomes and epigenetic patterning.
Cooperation between EZH2, NSPc1-mediated histone H2A ubiquitination and Dnmt1 in HOX gene silencing.
Deletion of the de novo DNA methyltransferase Dnmt3a promotes lung tumor progression.
DNA hypomethylation perturbs the function and survival of CNS neurons in postnatal animals.
DNA hypomethylation, cancer, the immunodeficiency, centromeric region instability, facial anomalies syndrome and chromosomal rearrangements.
DNA methylation, through DNMT1, has an essential role in the development of gastrointestinal smooth muscle cells and disease.
DNA methyltransferase 1 (Dnmt1) mutation affects Snrpn imprinting in the mouse male germ line.
DNA methyltransferase 1 and Krüppel-like factor 4 axis regulates macrophage inflammation and atherosclerosis.
DNA Methyltransferase 1 Is Indispensable for Development of the Hippocampal Dentate Gyrus.
DNA methyltransferase 3a limits the expression of interleukin-13 in T helper 2 cells and allergic airway inflammation.
DNA methyltransferase deficiency modifies cancer susceptibility in mice lacking DNA mismatch repair.
Dnmt1 deficiency leads to enhanced microsatellite instability in mouse embryonic stem cells.
Dnmt1 deficiency promotes CAG repeat expansion in the mouse germline.
DNMT1 deficiency triggers mismatch repair defects in human cells through depletion of repair protein levels in a process involving the DNA damage response.
Dnmt1 is required for proximal-distal patterning of the lung endoderm and for restraining alveolar type 2 cell fate.
DNMT1 maintains metabolic fitness of adipocytes through acting as an epigenetic safeguard of mitochondrial dynamics.
Dnmt1 overexpression causes genomic hypermethylation, loss of imprinting, and embryonic lethality.
Dnmt1-dependent DNA methylation is essential for photoreceptor terminal differentiation and retinal neuron survival.
Dnmt3 and G9a cooperate for tissue-specific development in zebrafish.
Dnmt3a deficiency in the skin causes focal, canonical DNA hypomethylation and a cellular proliferation phenotype.
Dnmt3b ablation impairs fracture repair through upregulation of Notch pathway.
DNMT3B deficiency alters mitochondrial biogenesis and ?-ketoglutarate levels in human embryonic stem cells.
Dnmt3b Deficiency in Myf5+-Brown Fat Precursor Cells Promotes Obesity in Female Mice.
DNMT3B deficiency presenting as severe combined immune deficiency: A case report.
Effects of NSUN2 deficiency on the mRNA 5-methylcytosine modification and gene expression profile in HEK293 cells.
Epigenetic alteration of microRNAs in DNMT3B-mutated patients of ICF syndrome.
Epigenetic and therapeutic implications of dnmt3b in temporomandibular joint osteoarthritis.
Epigenetic regulation of macrophage polarization and inflammation by DNA methylation in obesity.
Epigenetic regulation of macrophage polarization by DNA methyltransferase 3b.
Immunodeficiency, centromeric region instability, facial anomalies syndrome (ICF).
Impact of Dnmt1 deficiency, with and without low folate diets, on tumor numbers and DNA methylation in Min mice.
Loss of DNMT1o disrupts imprinted X chromosome inactivation and accentuates placental defects in females.
Loss of Dnmt3a and endogenous Kras(G12D/+) cooperate to regulate hematopoietic stem and progenitor cell functions in leukemogenesis.
Loss of Dnmt3b accelerates MLL-AF9 leukemia progression.
Loss of inherited genomic imprints in mice leads to severe disruption in placental lipid metabolism.
Maternal Exposure to High-Fat Diet Induces Long-Term Derepressive Chromatin Marks in the Heart.
Methylation of the FSHD syndrome-linked subtelomeric repeat in normal and FSHD cell cultures and tissues.
Myocardial tissue-specific Dnmt1 knockout in rats protects against pathological injury induced by Adriamycin.
Neuronal Dnmt1 Deficiency Attenuates Diet-Induced Obesity in Mice.
Neuronal Nsun2 deficiency produces tRNA epitranscriptomic alterations and proteomic shifts impacting synaptic signaling and behavior.
NSun2 Deficiency Protects Endothelium From Inflammation via mRNA Methylation of ICAM-1.
NSun2 regulates aneurysm formation by promoting autotaxin expression and T cell recruitment.
Quantitative analysis of associations between DNA hypermethylation, hypomethylation, and DNMT RNA levels in ovarian tumors.
Reduced rates of gene loss, gene silencing, and gene mutation in Dnmt1-deficient embryonic stem cells.
Regulation of somatic cell reprogramming through inducible mir-302 expression.
Role of DNMT3B in the regulation of early neural and neural crest specifiers.
Selective demethylation and altered gene expression are associated with ICF syndrome in human-induced pluripotent stem cells and mesenchymal stem cells.
The extracellular signal-regulated kinase 1/2 modulates the intracellular localization of DNA methyltransferase 3A to regulate erythrocytic differentiation.
The histone chaperone CAF-1 cooperates with the DNA methyltransferases to maintain Cd4 silencing in cytotoxic T cells.
Virus-mediated Dnmt1 and Dnmt3a deletion disrupts excitatory synaptogenesis and synaptic function in primary cultured hippocampal neurons.
DNA Repair-Deficiency Disorders
Hypersensitivity to radiation-induced non-apoptotic and apoptotic death in cell lines from patients with the ICF chromosome instability syndrome.
Down Syndrome
DNMT3B promoter polymorphisms and maternal risk of birth of a child with Down syndrome.
Maternal risk for down syndrome and polymorphisms in the promoter region of the DNMT3B gene: A case-control study.
Dwarfism
Gain-of-function DNMT3A mutations cause microcephalic dwarfism and hypermethylation of Polycomb-regulated regions.
The DNMT3A PWWP domain is essential for the normal DNA methylation landscape in mouse somatic cells and oocytes.
Ecchymosis
Lobular neutrophilic panniculitis associated with DNA methyltransferase inhibitors in the treatment of myeloid disease.
Embryo Loss
Generation of chimeric mice with spermatozoa fully derived from embryonic stem cells using a triple-target CRISPR method for Nanos3†.
Encephalomyelitis
Opposing roles of STAT4 and Dnmt3a in Th1 gene regulation.
Encephalomyelitis, Autoimmune, Experimental
Opposing roles of STAT4 and Dnmt3a in Th1 gene regulation.
Endodermal Sinus Tumor
DNA methyltransferase-3 like protein expression in various histological types of testicular germ cell tumor.
Endometrial Hyperplasia
Hypermethylation of RAS effector related genes and DNA methyltransferase 1 expression in endometrial carcinogenesis.
Endometrial Neoplasms
5-Aza-2'-deoxycytidine is a potent inhibitor of DNA methyltransferase 3B and induces apoptosis in human endometrial cancer cell lines with the up-regulation of hMLH1.
Differential Expression and Clinical Significance of DNA Methyltransferase 3B (DNMT3B), Phosphatase and Tensin Homolog (PTEN) and Human MutL Homologs 1 (hMLH1) in Endometrial Carcinomas.
Direct monitoring of breast and endometrial cancer cell epigenetic response to DNA methyltransferase and histone deacetylase inhibitors.
DNA methylation and DNA methyltransferase (DNMT1) activity pattern in endometrial carcinoma.
DNMT Inhibitors and HDAC Inhibitors Regulate E-Cadherin and Bcl-2 Expression in Endometrial Carcinoma in vitro and in vivo.
DNMT1 regulates human endometrial carcinoma cell proliferation.
Down-regulation of miR-145 and miR-143 might be associated with DNA methyltransferase 3B overexpression and worse prognosis in endometrioid carcinomas.
Down-regulation of the progesterone receptor by the methylation of progesterone receptor gene in endometrial cancer cells.
Epigenetic considerations for endometrial cancer prevention, diagnosis and treatment.
Estrogen regulates DNA methyltransferase 3B expression in Ishikawa endometrial adenocarcinoma cells.
Histone deacetylase inhibitors decrease DNA methyltransferase-3B messenger RNA stability and down-regulate de novo DNA methyltransferase activity in human endometrial cells.
Hypermethylation of RAS effector related genes and DNA methyltransferase 1 expression in endometrial carcinogenesis.
LINC00470 Stimulates Methylation of PTEN to Facilitate the Progression of Endometrial Cancer by Recruiting DNMT3a Through MYC.
Loss of exosomal miR-148b from cancer-associated fibroblasts promotes endometrial cancer cell invasion and cancer metastasis.
Opposite alterations of DNA methyltransferase gene expression in endometrioid and serous endometrial cancers.
Piwil1 causes epigenetic alteration of PTEN gene via upregulation of DNA methyltransferase in type I endometrial cancer.
RG108 induces the apoptosis of endometrial cancer Ishikawa cell lines by inhibiting the expression of DNMT3B and demethylation of HMLH1.
SOX17, ?-catenin and CyclinD1 expression in the endometrioid adenocarcinoma and influence of 5-AZA on expression.
TCF3 is epigenetically silenced by EZH2 and DNMT3B and functions as a tumor suppressor in endometrial cancer.
Up-regulation of DNA methyltransferase 3B expression in endometrial cancers.
[Characteristic and clinical significance of DNA methyltransferase 3B overexpression in endometrial carcinoma].
Endometriosis
A review of aberrant DNA methylation and epigenetic agents targeting DNA methyltransferase in endometriosis.
Aberrant expression and localization of deoxyribonucleic acid methyltransferase 3B in endometriotic stromal cells.
Aberrant expression of deoxyribonucleic acid methyltransferases DNMT1, DNMT3A, and DNMT3B in women with endometriosis.
Association between DNMT3L polymorphic variants and the risk of endometriosis-associated infertility.
Coordination of AUF1 and miR-148a destabilizes DNA methyltransferase 1 mRNA under hypoxia in endometriosis.
Integrated Bioinformatics Analysis Reveals Function and Regulatory Network of miR-200b-3p in Endometriosis.
Polymorphic variants of DNMT3A and the risk of endometriosis.
[Expression of DNMT1, DNMT3a, and DNMT3b in eutopic endometrium].
Enterovirus Infections
Coxsackievirus B Type 4 Infection in ? Cells Downregulates the Chaperone Prefoldin URI to Induce a MODY4-like Diabetes via Pdx1 Silencing.
Epilepsy
DNA methyltransferase isoforms expression in the temporal lobe of epilepsy patients with a history of febrile seizures.
Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis.
Identification of De Novo DNMT3A Mutations That Cause West Syndrome by Using Whole-Exome Sequencing.
Increased Expression of DNA methyltransferase 1 and 3a in Human Temporal Lobe Epilepsy.
Methyl-CpG-Binding Domain Protein 3 Promotes Seizures by Recruiting Methyltransferase DNMT1 to Enhance TREM2 Methylation.
Epilepsy, Temporal Lobe
Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis.
Increased Expression of DNA methyltransferase 1 and 3a in Human Temporal Lobe Epilepsy.
Epstein-Barr Virus Infections
Association between human papillomavirus and Epstein - Barr virus DNA and gene promoter methylation of RB1 and CDH1 in the cervical lesions: a transversal study.
Correlation between DNA methyltransferases expression and Epstein-Barr virus, JC polyomavirus and Helicobacter pylori infections in gastric carcinomas.
Epigenetic and Transcriptional Changes Which Follow Epstein-Barr Virus Infection of Germinal Center B Cells and Their Relevance to the Pathogenesis of Hodgkin's Lymphoma.
Identifying Key Genes for Nasopharyngeal Carcinoma by Prioritized Consensus Differentially Expressed Genes Caused by Aberrant Methylation.
Increased DNA methyltransferase 1 (DNMT1) protein expression correlates significantly with poorer tumor differentiation and frequent DNA hypermethylation of multiple CpG islands in gastric cancers.
Esophageal Neoplasms
Aberrant Methylation-Mediated Silencing of lncRNA MEG3 Functions as a ceRNA in Esophageal Cancer.
Benzo[a]pyrene diol epoxide suppresses retinoic acid receptor-beta2 expression by recruiting DNA (cytosine-5-)-methyltransferase 3A.
Depletion of DNA methyltransferase 1 and/or DNA methyltransferase 3b mediates growth arrest and apoptosis in lung and esophageal cancer and malignant pleural mesothelioma cells.
DNMT1 ablation suppresses tumorigenesis by inhibiting the self-renewal of esophageal cancer stem cells.
DNMT3B 579 G>T promoter polymorphism and risk of esophagus carcinoma in Chinese.
Epigenetic modulation combined with PD-1/PD-L1 blockade enhances immunotherapy based on MAGE-A11 antigen-specific CD8+T cells against esophageal carcinoma.
High expression of DNA methyltransferase 1 in Kazakh esophageal epithelial cells may promote malignant transformation induced by N-methyl-N'-nitro-N-nitrosoguanidine.
Methylation of RASSF1A gene promoter and the correlation with DNMT1 expression that may contribute to esophageal squamous cell carcinoma.
miR-148a-3p Suppresses the Proliferation and Invasion of Esophageal Cancer by Targeting DNMT1.
Single nucleotide polymorphisms of one-carbon metabolism and cancers of the esophagus, stomach, and liver in a Chinese population.
The role of DNA methyltransferase 3b in esophageal squamous cell carcinoma.
Esophageal Squamous Cell Carcinoma
Activation of PAR4 Upregulates p16 through Inhibition of DNMT1 and HDAC2 Expression via MAPK Signals in Esophageal Squamous Cell Carcinoma Cells.
DNMT1 ablation suppresses tumorigenesis by inhibiting the self-renewal of esophageal cancer stem cells.
Effects of DNA methyltransferase 1 inhibition on esophageal squamous cell carcinoma.
Methylation of RASSF1A gene promoter and the correlation with DNMT1 expression that may contribute to esophageal squamous cell carcinoma.
Novel long noncoding RNA NMR promotes tumor progression via NSUN2 and BPTF in esophageal squamous cell carcinoma.
NSUN2-mediated RNA 5-methylcytosine promotes esophageal squamous cell carcinoma progression via LIN28B-dependent GRB2 mRNA stabilization.
piR-823 demonstrates tumor oncogenic activity in esophageal squamous cell carcinoma through DNA methylation induction via DNA methyltransferase 3B.
Silencing DNA methyltransferase 1 (DNMT1) inhibits proliferation, metastasis and invasion in ESCC by suppressing methylation of RASSF1A and DAPK.
Silencing DNA methyltransferase 1 leads to the activation of the esophageal suppressor gene p16 in vitro and in vivo.
The long noncoding RNA LUCAT1 promotes tumorigenesis by controlling ubiquitination and stability of DNA methyltransferase 1 in esophageal squamous cell carcinoma.
The role of DNA methyltransferase 3b in esophageal squamous cell carcinoma.
Essential Hypertension
Polymorphism of the DNA methyltransferase 1 gene is associated with the susceptibility to essential hypertension in male.
Fatty Liver
Intestinal FGF15/19 physiologically repress hepatic lipogenesis in the late fed-state by activating SHP and DNMT3A.
MicroRNA-29a Disrupts DNMT3b to Ameliorate Diet-Induced Non-Alcoholic Steatohepatitis in Mice.
Fetal Alcohol Spectrum Disorders
High dietary folate in pregnant mice leads to pseudo-MTHFR deficiency and altered methyl metabolism, with embryonic growth delay and short-term memory impairment in offspring.
Fetal Growth Retardation
Effects of Folic Acid on DNMT1, GAP43, and VEGFR1 in Intrauterine Growth Restriction Filial Rats.
Epigenetic regulation of placental glucose transporters mediates maternal cadmium-induced fetal growth restriction.
Fibroadenoma
DNA methyltransferase 1/3a overexpression in sporadic breast cancer is associated with reduced expression of estrogen receptor-alpha/breast cancer susceptibility gene 1 and poor prognosis.
Fibrosarcoma
DNA hypermethylation near the transcription start site of collagen alpha2(I) gene occurs in both cancer cell lines and primary colorectal cancers.
Retention of unmethylated CpG island alleles in human diploid fibroblast x fibrosarcoma hybrids expressing high levels of DNA methyltransferase.
Frontotemporal Dementia
DNMT1 mutation hot spot causes varied phenotypes of HSAN1 with dementia and hearing loss.
SETX (senataxin), the helicase mutated in AOA2 and ALS4, functions in autophagy regulation.
Gallbladder Neoplasms
c?Jun suppresses the expression of WNT inhibitory factor 1 through transcriptional regulation and interaction with DNA methyltransferase 1 in gallbladder cancer.
NOP2/Sun RNA methyltransferase 2 promotes tumor progression via its interacting partner RPL6 in gallbladder carcinoma.
Ganglioneuroblastoma
Tatton-Brown-Rahman syndrome: Six individuals with novel features.
Gastritis
Protein expression trends of DNMT1 in gastrointestinal diseases: From benign to precancerous lesions to cancer.
Gastritis, Atrophic
Protein expression trends of DNMT1 in gastrointestinal diseases: From benign to precancerous lesions to cancer.
Gastrointestinal Diseases
Protein expression trends of DNMT1 in gastrointestinal diseases: From benign to precancerous lesions to cancer.
Gastrointestinal Stromal Tumors
Expression of DNMTs and MBD2 in GIST.
GATA2 Deficiency
Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation.
Genetic Diseases, Inborn
'Plug and play' microelectrode assisted with Y-motif-mediated primer-free cyclic signal amplification for sensitive quantitation of DNA methyltransferase activity.
Coupling hybridization chain reaction with DNAzyme recycling for enzyme-free and dual amplified sensitive fluorescent detection of methyltransferase activity.
Defective de novo methylation of viral and cellular DNA sequences in ICF syndrome cells.
DNA Methyltransferase Activity Assays: Advances and Challenges.
Modulation of Dnmt3b function in vitro by interactions with Dnmt3L, Dnmt3a and Dnmt3b splice variants.
Selective demethylation and altered gene expression are associated with ICF syndrome in human-induced pluripotent stem cells and mesenchymal stem cells.
Structural basis of specific DNA binding by the transcription factor ZBTB24.
The DNA methyltransferases of mammals.
[Diversity of hereditary pathology in the population of Marii El Republic and its differentiation with respect to gene frequencies for hereditary diseases]
[Genetic epidemiological study of Bashkortostan Republic: the effect of genetic structure of population on the load of monogenic hereditary diseases]
[Medico-genetic study of residents of Marii El republic: burden of hereditary diseases in four regions of the republic]
Germinoma
Methylator phenotype of malignant germ cell tumours in children identifies strong candidates for chemotherapy resistance.
Glioblastoma
A 4-miRNAs signature predicts survival in glioblastoma multiforme patients.
A five-miRNA signature with prognostic and predictive value for MGMT promoter-methylated glioblastoma patients.
A methylation-specific and SYBR-green-based quantitative polymerase chain reaction technique for O6-methylguanine DNA methyltransferase promoter methylation analysis.
Aldehyde dehydrogenase 1A1--a new mediator of resistance to temozolomide in glioblastoma.
Association of molecular marker O(6)Methylguanine DNA methyltransferase and concomitant chemoradiotherapy with survival in Southern Chinese glioblastoma patients.
c-Jun-N-terminal phosphorylation regulates DNMT1 expression and genome wide methylation in gliomas.
Combination treatment with doxorubicin and microRNA-21 inhibitor synergistically augments anticancer activity through upregulation of tumor suppressing genes.
Comprehensive analysis of MGMT promoter methylation: correlation with MGMT expression and clinical response in GBM.
Correlation of apparent diffusion coefficient values measured by diffusion MRI and MGMT promoter methylation semiquantitatively analyzed with MS-MLPA in patients with glioblastoma multiforme.
Distinct demographic profile and molecular markers of primary CNS tumor in 1873 adolescent and young adult patient population.
DNMT3A co-mutation in an IDH1-mutant glioblastoma.
Effect of O6-Substitued Guanine Analogs on O6-Methylguanine DNA-Methyltransferase Expression and Glioblastoma Cells Viability.
Efficiency and safety of O?-methylguanine DNA methyltransferase (MGMT(P140K))-mediated in vivo selection in a humanized mouse model.
Endoplasmic reticulum stress-inducing drugs sensitize glioma cells to temozolomide through downregulation of MGMT, MPG, and Rad51.
Epigallocatechin Gallate Preferentially Inhibits O6-Methylguanine DNA-Methyltransferase Expression in Glioblastoma Cells Rather than in Nontumor Glial Cells.
FM19G11 inhibits O6 -methylguanine DNA-methyltransferase expression under both hypoxic and normoxic conditions.
Genetic and environmental determinants of O6-methylguanine DNA-methyltransferase (MGMT) gene methylation: a 10-year longitudinal study of Danish twins.
Glycogen synthase kinase 3? inhibition sensitizes human glioblastoma cells to temozolomide by affecting O6-methylguanine DNA methyltransferase promoter methylation via c-Myc signaling.
High incidence of low O(6)-methylguanine DNA methyltransferase expression in invasive macroadenomas of Cushing's disease.
IDH mutations predict longer survival and response to temozolomide in secondary glioblastoma.
Immunohistochemical evaluation of O(6) -methylguanine DNA methyltransferase (MGMT) expression in 117 cases of glioblastoma.
Intratumoral heterogeneity identified at the epigenetic, genetic and transcriptional level in glioblastoma.
Intratumoral homogeneity of MGMT promoter hypermethylation as demonstrated in serial stereotactic specimens from anaplastic astrocytomas and glioblastomas.
Is the prognostic significance of O6-methylguanine- DNA methyltransferase promoter methylation equally important in glioblastomas of patients from different continents? A systematic review with meta-analysis.
Lentiviral MGMT(P140K)-mediated in vivo selection employing a ubiquitous chromatin opening element (A2UCOE) linked to a cellular promoter.
Loss of pericentromeric DNA methylation pattern in human glioblastoma is associated with altered DNA methyltransferases expression and involves the stem cell compartment.
MEK-ERK signaling dictates DNA-repair gene MGMT expression and temozolomide resistance of stem-like glioblastoma cells via the MDM2-p53 axis.
Methylation of O6-methylguanine DNA methyltransferase and loss of heterozygosity on 19q and/or 17p are overlapping features of secondary glioblastomas with prolonged survival.
MGMT-Independent Temozolomide Resistance in Pediatric Glioblastoma Cells Associated with a PI3-Kinase-Mediated HOX/Stem Cell Gene Signature.
miR-148-3p Inhibits Growth of Glioblastoma Targeting DNA Methyltransferase-1 (DNMT1).
miR-29s inhibit the malignant behavior of U87MG glioblastoma cell line by targeting DNMT3A and 3B.
Mutant TP53 enhances the resistance of glioblastoma cells to temozolomide by up-regulating O(6)-methylguanine DNA-methyltransferase.
Newly Synthesized DNA Methyltransferase Inhibitors as Radiosensitizers for Human Lung Cancer and Glioblastoma Cells.
O (6)-Methylguanine DNA methyltransferase determined by promoter hypermethylation and immunohistochemical expression is correlated with progression-free survival in patients with glioblastoma.
O(6)-Methylguanine DNA methyltransferase expression in tumor cells predicts outcome of radiotherapy plus concomitant and adjuvant temozolomide therapy in patients with primary glioblastoma.
O(6)-methylguanine DNA-methyltransferase methylation status can change between first surgery for newly diagnosed glioblastoma and second surgery for recurrence: clinical implications.
O6-Methylguanine DNA methyltransferase protein expression in tumor cells predicts outcome of temozolomide therapy in glioblastoma patients.
O6-Methylguanine DNA Methyltransferase Status Does Not Predict Response or Resistance to Alkylating Agents in Well-Differentiated Pancreatic Neuroendocrine Tumors.
Outlining involvement of stem cell program in regulation of O6-methylguanine DNA methyltransferase and development of temozolomide resistance in glioblastoma: An Editorial Highlight for 'Transcriptional control of O6 -methylguanine DNA methyltransferase expression and temozolomide resistance in glioblastoma' on page 780.
Pathological findings and prognostic factors in recurrent glioblastomas.
Phase 1 Study of Preoperative Chemoradiation Therapy With Temozolomide and Capecitabine in Patients With Locally Advanced Rectal Cancer.
Predictive biomarkers investigated in glioblastoma.
Promoter methylation and silencing of the tissue factor pathway inhibitor-2 (TFPI-2), a gene encoding an inhibitor of matrix metalloproteinases in human glioma cells.
Radiosensitization of Glioblastoma Cells by a Novel DNA Methyltransferase-inhibiting Phthalimido-Alkanamide Derivative.
RCC2 promotes proliferation and radio-resistance in glioblastoma via activating transcription of DNMT1.
Recurrent Glioblastoma: Combination of High Cerebral Blood Flow with MGMT Promoter Methylation Is Associated with Benefit from Low-Dose Temozolomide Rechallenge at First Recurrence.
Regulation of the leucocyte chemoattractant receptor FPR in glioblastoma cells by cell differentiation.
Should biomarkers be used to design personalized medicine for the treatment of glioblastoma?
Specific Inhibition of DNMT3A/ISGF3? Interaction Increases the Temozolomide Efficiency to Reduce Tumor Growth.
Status of O? -methylguanine-DNA methyltransferase [MGMT] gene promoter methylation among patients with glioblastomas from India.
The Changes in MGMT Promoter Methylation Status in Initial and Recurrent Glioblastomas.
The Clinical Implications of Inconsistently Methylated Results from Glioblastoma MGMT Testing by Replicate Methylation-Specific PCR.
Treatment considerations for MGMT-unmethylated glioblastoma.
[Standards and new developments in the chemotherapy of glioblastomas]
Glioma
20(S)-ginsenoside-Rg3 reverses temozolomide resistance and restrains epithelial-mesenchymal transition progression in glioblastoma.
A new tumor suppressor LncRNA ADAMTS9-AS2 is regulated by DNMT1 and inhibits migration of glioma cells.
c-Jun-N-terminal phosphorylation regulates DNMT1 expression and genome wide methylation in gliomas.
Clinical and Molecular Characteristics of Thalamic Gliomas: Retrospective Report of 26 Cases.
Concurrent hypermethylation of DNMT1, MGMT and EGFR genes in progression of gliomas.
Demystifying demethylator sensitivity in gliomas: role for TERT and DNMT1.
Disruption of Dnmt1/PCNA/UHRF1 interactions promotes tumorigenesis from human and mice glial cells.
DNA methyltransferase levels and altered CpG methylation in the total genome and in the GSTP1 gene in human glioma cells transfected with sense and antisense DNA methyltransferase cDNA.
DNMT1 Mediated CAHM Repression Promotes Glioma Invasion via SPAK/JNK Pathway.
DNMT1 mediates chemosensitivity by reducing methylation of miRNA-20a promoter in glioma cells.
DNMT3L interacts with transcription factors to target DNMT3L/DNMT3B to specific DNA sequences: role of the DNMT3L/DNMT3B/p65-NF?B complex in the (de-)methylation of TRAF1.
Downregulation of KLF13 through DNMT1-mediated hypermethylation promotes glioma cell proliferation and invasion.
Drug-resistance gene expression and progression of astrocytic tumors.
Epigenetic downregulation of STAT6 increases HIF-1? expression via mTOR/S6K/S6, leading to enhanced hypoxic viability of glioma cells.
Epigenetic modification of miR-141 regulates SKA2 by an endogenous 'sponge' HOTAIR in glioma.
Epigenetic regulation of DNA methyltransferases: DNMT1 and DNMT3B in gliomas.
Epigenetic repression of long non-coding RNA MEG3 mediated by DNMT1 represses the p53 pathway in gliomas.
Erratum to: Epigenetic regulation of DNA methyltransferases: DNMT1 and DNMT3B in gliomas.
Expression and prognostic characteristics of m5 C regulators in low-grade glioma.
Frequent promoter hypermethylation and low expression of the MGMT gene in oligodendroglial tumors.
Genome-wide analysis of epigenetic silencing identifies BEX1 and BEX2 as candidate tumor suppressor genes in malignant glioma.
Impact on prognosis of the regional distribution of MGMT methylation with respect to the CpG island methylator phenotype and age in glioma patients.
Interferon-? Induces Loss of Spherogenicity and Overcomes Therapy Resistance of Glioblastoma Stem Cells.
Isocitrate dehydrogenase 1 Gene Mutation Is Associated with Prognosis in Clinical Low-Grade Gliomas.
Long Noncoding RNA LINC00467 Promotes Glioma Progression through Inhibiting P53 Expression via Binding to DNMT1.
Long noncoding RNA NEAT1 promotes progression of glioma as a ceRNA by sponging miR-185-5p to stimulate DNMT1/mTOR signaling.
Methylation-induced downregulation and tumor-suppressive role of microRNA-98 in glioma through targeting Sal-like protein 4.
Methylation-related chromatin structure is associated with exclusion of transcription factors from and suppressed expression of the O-6-methylguanine DNA methyltransferase gene in human glioma cell lines.
MicroRNA-129-5p inhibits human glioma cell proliferation and induces cell cycle arrest by directly targeting DNMT3A.
miR-148-3p Inhibits Growth of Glioblastoma Targeting DNA Methyltransferase-1 (DNMT1).
miR-152 regulated glioma cell proliferation and apoptosis via Runx2 mediated by DNMT1.
MiR-221/222 target the DNA methyltransferase MGMT in glioma cells.
NSun2 promotes cell migration through methylating autotaxin mRNA.
O6 -methylguanine DNA methyltransferase gene promoter methylation in high-grade gliomas: a review of current status.
Pathological classification of brain tumors.
PDCD4 gene silencing in gliomas is associated with 5'CpG island methylation and unfavorable prognosis.
Polycomb group expression signatures in the malignant progression of gliomas.
Prognostic markers in gliomas.
Quantitative analysis of O(6)-methylguanine DNA methyltransferase (MGMT) promoter methylation in patients with low-grade gliomas.
Regulation of human glioma cell apoptosis and invasion by miR-152-3p through targeting DNMT1 and regulating NF2 : MiR-152-3p regulate glioma cell apoptosis and invasion.
Regulation of the leucocyte chemoattractant receptor FPR in glioblastoma cells by cell differentiation.
Relationship between MGMT gene expression and treatment effectiveness and prognosis in glioma.
Repression of Dok7 expression mediated by DNMT1 promotes glioma cells proliferation.
Silencing DNA methyltransferase (DNMT) enhances glioma chemosensitivity.
Synergistic induction of NY-ESO-1 antigen expression by a novel histone deacetylase inhibitor, valproic acid, with 5-aza-2'-deoxycytidine in glioma cells.
TERT and DNMT1 expression predict sensitivity to decitabine in gliomas.
TGF-?-mediated repression of MST1 by DNMT1 promotes glioma malignancy.
The Role of DNA Methylation in ST6Gal1 Expression in Gliomas.
Treatment of anaplastic glioma.
Tumor-suppressive miR148a is silenced by CpG island hypermethylation in IDH1-mutant gliomas.
Upregulation of CYP17A1 by Sp1-mediated DNA demethylation confers temozolomide resistance through DHEA-mediated protection in glioma.
World Cancer Day 2021 - Perspectives in Pediatric and Adult Neuro-Oncology.
Gliosarcoma
O(6)-methylguanine DNA methyltransferase status determined by promoter methylation and immunohistochemistry in gliosarcoma and their clinical implications.
Glomerulonephritis, IGA
Defective activation of the MAPK/ERK pathway, leading to PARP1 and DNMT1 dysregulation, is a common defect in IgA nephropathy and Henoch-Schönlein purpura.
Glucose Intolerance
Dnmt3a is an epigenetic mediator of adipose insulin resistance.
Obesity-induced DNA hypermethylation of the adiponectin gene mediates insulin resistance.
Glycogen Storage Disease
Whole exome sequencing unravels disease-causing genes in consanguineous families in Qatar.
Goiter
[Human thyroid gland DNA methylase in nodular and diffuse goiter]
Gonadal Dysgenesis
DNA analysis of a patient with two different marker chromosomes using Y-specific DNA probes.
Graft vs Host Disease
Graft-versus-host disease after liver transplantation is associated with bone marrow failure, hemophagocytosis, and DNMT3A mutations.
Hallux Valgus
Further delineation of autosomal recessive intellectual disability syndrome caused by homozygous variant of the NSUN2 gene in a chinese pedigree.
Head and Neck Neoplasms
A novel C/T polymorphism in the core promoter of human de novo cytosine DNA methyltransferase 3B6 is associated with prognosis in head and neck cancer.
Association of DNMT3B -283 T > C and -579 G > T polymorphisms with decreased cancer risk: evidence from a meta-analysis.
DNMT3B C46359T and SHMT1 C1420T polymorphisms in the folate pathway in carcinogenesis of head and neck.
EPHA3 Contributes to Epigenetic Suppression of PTEN in Radioresistant Head and Neck Cancer.
Gene Polymorphisms Involved in Folate Metabolism and DNA Methylation with the Risk of Head and Neck Cancer.
HPV Infection Leaves a DNA Methylation Signature in Oropharyngeal Cancer Affecting Both Coding Genes and Transposable Elements.
Polymorphism of DNA methyltransferase 3B -149C/T and cancer risk: a meta-analysis.
Hearing Loss
A Patient With DNMT1 Gene Mutation Presenting With Polyneuropathy, Hearing Loss, and Personality Changes.
Aberrant signature methylome by DNMT1 hot spot mutation in hereditary sensory and autonomic neuropathy 1E.
DNA methyltransferase 1 mutations and mitochondrial pathology: is mtDNA methylated?
DNMT1 links aberrant DNA methylation to hereditary sensory neuropathy.
DNMT1 mutation hot spot causes varied phenotypes of HSAN1 with dementia and hearing loss.
Identification of a novel DNMT1 mutation in a Chinese patient with hereditary sensory and autonomic neuropathy type IE.
Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss.
Narcolepsy is a common phenotype in HSAN IE and ADCA-DN.
Hearing Loss, Noise-Induced
DNMT1 and DNMT3A haplotypes associated with noise-induced hearing loss in Chinese workers.
Lack of association between DNMT1 gene polymorphisms and noise-induced hearing loss in a Chinese population.
The DNA methylation inhibitor RG108 protects against noise-induced hearing loss.
[Association between SNPs in DNMT1 and noise-induced hearing loss in Chinese Han population].
[Association of DNMT3a's single nucleotide polymorphisms with susceptibility to noise-induced hearing loss in Chinese workers].
Hearing Loss, Sensorineural
Lack of association between DNMT1 gene polymorphisms and noise-induced hearing loss in a Chinese population.
Heart Defects, Congenital
Association of DNMT1 Gene Polymorphisms with Congenital Heart Disease in Child Patients.
Heart Failure
A long noncoding RNA CHAIR protects the heart from pathological stress.
Association of Mutations Contributing to Clonal Hematopoiesis With Prognosis in Chronic Ischemic Heart Failure.
Clonal haematopoiesis in chronic ischaemic heart failure: prognostic role of clone size for DNMT3A- and TET2-driver gene mutations.
Clonal Hematopoiesis-Driver DNMT3A Mutations Alter Immune Cells in Heart Failure.
Experimental heart failure modelled by the cardiomyocyte-specific loss of an epigenome modifier, DNMT3B.
Full spectrum of clonal haematopoiesis-driver mutations in chronic heart failure and their associations with mortality.
Histone deacetylase 3 suppresses the expression of SHP-1 via deacetylation of DNMT1 to promote heart failure.
Supplemental Association of Clonal Hematopoiesis With Incident Heart Failure.
Heart Septal Defects, Ventricular
Roles for Dnmt3b in mammalian development: a mouse model for the ICF syndrome.
Hemangioma
MiR-206 promotes extracellular matrix accumulation and relieves infantile hemangioma through targeted inhibition of DNMT3A.
Hemangiosarcoma
Multiomic analysis and immunoprofiling reveal distinct subtypes of human angiosarcoma.
Hematologic Diseases
5-Aza-2'-deoxycytidine causes replication lesions that require Fanconi anemia-dependent homologous recombination for repair.
Dnmt3a restrains mast cell inflammatory responses.
Screening for mutation R882 in the DNMT3A gene in Chinese patients with hematological disease.
Systematic profiling of DNMT3A variants reveals protein instability mediated by the DCAF8 E3 ubiquitin ligase adaptor.
[Analysis of DNMT3a mutation in childhood acute myeloid leukemia].
Hematologic Neoplasms
A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells.
A phase 1 and pharmacodynamic study of decitabine in combination with carboplatin in patients with recurrent, platinum-resistant, epithelial ovarian cancer.
A primer for epigenetics of hematological malignancies.
Abnormal RNA splicing and genomic instability after induction of DNMT3A mutations by CRISPR/Cas9 gene editing.
Activation of a Subset of Evolutionarily Young Transposable Elements and Innate Immunity Are Linked to Clinical Responses to 5-Azacytidine.
Alterations to DNMT3A in Hematologic Malignancies.
Antineoplastic activity of the DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine in anaplastic large cell lymphoma.
Approaches to target the genome and its epigenome in cancer.
Azacytidine induces cell cycle arrest and suppression of neuroendocrine markers in carcinoids.
BCOR gene alterations in hematological diseases.
Biological background of the genomic variations of cf-DNA in healthy individuals.
Characterization of decomposition products and preclinical and low dose clinical pharmacokinetics of decitabine (5-aza-2'-deoxycytidine) by a new liquid chromatography/tandem mass spectrometry quantification method.
Combination therapy with DNA methyltransferase inhibitors in hematologic malignancies.
Cost-effective screening of DNMT3A coding sequence identifies somatic mutation in pediatric T-cell acute lymphoblastic leukemia.
Decitabine--bedside to bench.
Decitabine. MGI Pharma Inc/SuperGen Inc.
Decitabine: development of a DNA methyltransferase inhibitor for hematological malignancies.
Decreases in different Dnmt3b activities drive distinct development of hematologic malignancies in mice.
Demethylation of DNA by decitabine in cancer chemotherapy.
Differential effects of epigenetic modifiers on the expansion and maintenance of human cord blood stem/progenitor cells.
DNA methylation in normal and malignant hematopoiesis.
DNA Methylation-Targeted Drugs.
DNA methyltransferase expression in triple-negative breast cancer predicts sensitivity to decitabine.
DNA Methyltransferase Inhibition Promotes Th1 Polarization in Human CD4+CD25high FOXP3+ Regulatory T Cells but Does Not Affect Their Suppressive Capacity.
DNA methyltransferases in hematologic malignancies.
DNA methyltransferases in hematological malignancies.
Dnmt3a deletion cooperates with the Flt3/ITD mutation to drive leukemogenesis in a murine model.
DNMT3A in Leukemia.
Dnmt3a Is a Haploinsufficient Tumor Suppressor in CD8+ Peripheral T Cell Lymphoma.
DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias.
Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation.
Dual targeting of epigenetic therapy in cancer.
Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies.
Efficacy and safety of extended dosing schedules of CC-486 (oral azacitidine) in patients with lower-risk myelodysplastic syndromes.
Epigenetic biomarkers for human cancer: The time is now.
Epigenetic dysregulation in myelodysplastic syndromes.
Epigenetic modifiers in normal and malignant hematopoiesis.
Epigenetic pathways in macrophages emerge as novel targets in atherosclerosis.
Epigenetic therapy and chemosensitization in solid malignancy.
Epigenetic therapy of cancer stem and progenitor cells by targeting DNA methylation machineries.
Epigenetic therapy of hematological malignancies: where are we now?
Epigenetics as a Therapeutic Target in Breast Cancer.
Induction of a CD8+ T-cell response to the MAGE cancer testis antigen by combined treatment with azacitidine and sodium valproate in patients with acute myeloid leukemia and myelodysplasia.
Inhibition of DNMT1 and ERR? crosstalk suppresses breast cancer via derepression of IRF4.
Landmark analysis of DNMT3A mutations in hematological malignancies.
Loss of Dnmt3b accelerates MLL-AF9 leukemia progression.
MiR-10a and HOXB4 are overexpressed in atypical myeloproliferative neoplasms.
Mutation and expression analysis of the IDH1, IDH2, DNMT3A, and MYD88 genes in colorectal cancer.
Mutational analysis of DNMT3A gene in acute leukemias and common solid cancers.
Mutational and transcriptomic profiling of acute leukemia of ambiguous lineage reveals obscure but clinically important lineage bias.
Mutations in the DNA methyltransferase gene DNMT3A cause an overgrowth syndrome with intellectual disability.
Perturbed hematopoiesis in individuals with germline DNMT3A overgrowth Tatton-Brown-Rahman syndrome.
Promoter Hypomethylation and Expression Is Conserved in Mouse Chronic Lymphocytic Leukemia Induced by Decreased or Inactivated Dnmt3a.
Rapid detection of DNMT3A R882 mutations in hematologic malignancies using a novel bead-based suspension assay with BNA(NC) probes.
Sequential acquisition of mutations in myelodysplastic syndromes.
Somatic RHOA mutation in angioimmunoblastic T cell lymphoma.
Targeting DNA methylation for treating triple-negative breast cancer.
Targeting epigenetics for the treatment of prostate cancer: recent progress and future directions.
TET2 and DNMT3A Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors.
The extracellular signal-regulated kinase 1/2 modulates the intracellular localization of DNA methyltransferase 3A to regulate erythrocytic differentiation.
The role of vitamin C in epigenetic cancer therapy.
The spectrum of DNMT3A variants in Tatton-Brown-Rahman syndrome overlaps with that in hematologic malignancies.
[Epigenetic cancer drugs and their role in anticancer therapy].
[Genomic aberrations in myelodysplastic syndromes and related disorders].
[Predisposition and progression of myelodysplastic syndromes].
Hemoglobinopathies
In vitro and in vivo induction of fetal hemoglobin with a reversible and selective DNMT1 inhibitor.
Hepatitis
Epigenetic modification induced by hepatitis B virus X protein via interaction with de novo DNA methyltransferase DNMT3A.
Hepatitis B
Down-regulated microRNA-152 induces aberrant DNA methylation in hepatitis B virus-related hepatocellular carcinoma by targeting DNA methyltransferase 1.
Epigenetic modification induced by hepatitis B virus X protein via interaction with de novo DNA methyltransferase DNMT3A.
Expression of DNA methyltransferase 1 is activated by hepatitis B virus X protein via a regulatory circuit involving the p16INK4a-cyclin D1-CDK 4/6-pRb-E2F1 pathway.
Glucocorticoid-induced S-adenosylmethionine enhances the interferon signaling pathway by restoring STAT1 protein methylation in hepatitis B virus-infected cells.
Hepatitis B virus can be inhibited by DNA methyltransferase 3a via specific zinc-finger-induced methylation of the X promoter.
Hepatitis B virus X protein represses E-cadherin expression via activation of DNA methyltransferase 1.
Hepatitis B virus X protein upregulates DNA methyltransferase 3A/3B and enhances SOCS-1CpG island methylation.
miR-101 is down-regulated by the hepatitis B virus x protein and induces aberrant DNA methylation by targeting DNA methyltransferase 3A.
Overexpression of DNA methyltransferase 1 and its biological significance in primary hepatocellular carcinoma.
Sera DNA Methylation of CDH1, DNMT3b and ESR1 Promoters as Biomarker for the Early Diagnosis of Hepatitis B Virus-Related Hepatocellular Carcinoma.
Hepatitis B, Chronic
DNMT1 modulation in chronic hepatitis B patients and hypothetic influence on mitochondrial DNA methylation status during long-term nucleo(t)side analogs therapy.
Impact of hepatitis virus and aging on DNA methylation in human hepatocarcinogenesis.
Sera DNA Methylation of CDH1, DNMT3b and ESR1 Promoters as Biomarker for the Early Diagnosis of Hepatitis B Virus-Related Hepatocellular Carcinoma.
Hepatitis C
DNA methyltransferase 1, 3a, and 3b expression in hepatitis C associated human hepatocellular carcinoma and their clinicopathological association.
Hepatitis C virus core protein downregulates E-cadherin expression via activation of DNA methyltransferase 1 and 3b.
Ribavirin restores ESR1 gene expression and tamoxifen sensitivity in ESR1 negative breast cancer cell lines.
Hepatitis, Chronic
DNA methyltransferase expression and DNA methylation in human hepatocellular carcinoma and their clinicopathological correlation.
Expression of mRNA for DNA methyltransferases and methyl-CpG-binding proteins and DNA methylation status on CpG islands and pericentromeric satellite regions during human hepatocarcinogenesis.
Increased DNA methyltransferase expression is associated with an early stage of human hepatocarcinogenesis.
Increased protein expression of DNA methyltransferase (DNMT) 1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular carcinomas.
Overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, associated with DNA hypomethylation on pericentromeric satellite regions during human hepatocarcinogenesis.
Hepatoblastoma
Epigenetic reprogramming modulates malignant properties of human liver cancer.
Methylation of episomal plasmids as a barrier to transient gene expression via a synthetic delivery vector.
Hepatomegaly
Dnmt3a regulates myeloproliferation and liver-specific expansion of hematopoietic stem and progenitor cells.
The effect of phenobarbital on the methylation level of the p16 promoter region in rat liver.
Hereditary Sensory and Autonomic Neuropathies
DNA methyltransferase 1 mutations and mitochondrial pathology: is mtDNA methylated?
DNMT1 links aberrant DNA methylation to hereditary sensory neuropathy.
Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss.
Narcolepsy is a common phenotype in HSAN IE and ADCA-DN.
Novel mutation in the replication focus targeting sequence domain of DNMT1 causes hereditary sensory and autonomic neuropathy IE.
Hereditary Sensory and Motor Neuropathy
Genetic and phenotypic characterization of complex hereditary spastic paraplegia.
Herpes Simplex
Effect of methylation on expression of microinjected genes.
Herpes Zoster
Expression patterns of dnmt3aa, dnmt3ab, and dnmt4 during development and fin regeneration in zebrafish.
Hidradenitis
Lobular neutrophilic panniculitis associated with DNA methyltransferase inhibitors in the treatment of myeloid disease.
Hirschsprung Disease
Epigenetic factors Dnmt1 and Uhrf1 coordinate intestinal development.
Involvement of DNMT3B in the pathogenesis of Hirschsprung disease and its possible role as a regulator of neurogenesis in the human enteric nervous system.
Overexpression of DNMT3b target genes during Enteric Nervous System development contribute to the onset of Hirschsprung disease.
HIV Infections
Epigenetic regulation of RCAN1 expression in kidney disease and its role in podocyte injury.
HIV infection of human regulatory T cells downregulates Foxp3 expression by increasing DNMT3b levels and DNA methylation in the FOXP3 gene.
Hyperalgesia
DNMT3a methylation in neuropathic pain.
Hyperandrogenism
Prevalence of Prediabetes Risk in Offspring Born to Mothers with Hyperandrogenism.
Hypereosinophilic Syndrome
Imatinib causes epigenetic alterations of PTEN gene via upregulation of DNA methyltransferases and polycomb group proteins.
Hyperglycemia
Regulation of MDA-MB-231 cell proliferation by GSK-3? involves epigenetic modifications under high glucose conditions.
Transient High Glucose Causes Persistent Vascular Dysfunction and Delayed Wound Healing by the DNMT1-Mediated Ang-1/NF-?B Pathway.
Hyperhomocysteinemia
Reciprocal Regulation Between miR-148a/152 and DNA Methyltransferase 1 Is Associated with Hyperhomocysteinemia-Accelerated Atherosclerosis.
[Effects and related mechanism of 5-aza-2'-deoxycytidine on endothelial function in rats with hyperhomocysteinemia].
Hyperlipidemias
DNMT1 maintains metabolic fitness of adipocytes through acting as an epigenetic safeguard of mitochondrial dynamics.
Hypersensitivity
Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation.
Contribution of DNMT1 to Neuropathic Pain Genesis Partially through Epigenetically Repressing Kcna2 in Primary Afferent Neurons.
DNMT3a contributes to the development and maintenance of bone cancer pain by silencing Kv1.2 expression in spinal cord dorsal horn.
Epigenetic control of hypersensitivity in chronic inflammatory pain by the de novo DNA methyltransferase Dnmt3a2.
Genome-wide redistribution of MeCP2 in dorsal root ganglia after peripheral nerve injury.
High DNA methyltransferase 3B expression mediates 5-aza-deoxycytidine hypersensitivity in testicular germ cell tumors.
Nerve Injury-Induced Chronic Pain Is Associated with Persistent DNA Methylation Reprogramming in Dorsal Root Ganglion.
Reciprocal epigenetic remodeling controls testicular cancer hypersensitivity to hypomethylating agents and chemotherapy.
Refractory testicular germ cell tumors are highly sensitive to the second generation DNA methylation inhibitor guadecitabine.
Hypertension
Association of Mutations Contributing to Clonal Hematopoiesis With Prognosis in Chronic Ischemic Heart Failure.
Epigenetic regulation of aortic remodeling in hyperhomocysteinemia.
Hypertension, Pulmonary
DNA methyltransferase 3B deficiency unveils a new pathological mechanism of pulmonary hypertension.
Hyperthyroidism
Alterations of Global DNA Methylation and DNA Methyltransferase Expression in T and B Lymphocytes from Patients with Newly Diagnosed Autoimmune Thyroid Diseases After Treatment: A Follow-Up Study.
Hypertrophy, Right Ventricular
DNA methyltransferase 3B deficiency unveils a new pathological mechanism of pulmonary hypertension.
Hypothyroidism
MTHFR GENE C677T POLYMORPHISM AND LEVELS OF DNA METHYLTRASFERASES IN SUBCLINICAL HYPOTHYROIDISM.
Immune System Diseases
Two siblings with immunodeficiency, facial abnormalities and chromosomal instability without mutation in DNMT3B gene but liability towards malignancy; a new chromatin disorder delineation?
Infections
An association of DNMT3b protein expression with P16INK4a promoter hypermethylation in non-smoking female lung cancer with human papillomavirus infection.
Association of Clonal Hematopoiesis of Indeterminate Potential With Inflammatory Gene Expression in Patients With Severe Degenerative Aortic Valve Stenosis or Chronic Postischemic Heart Failure.
Association of genetic polymorphisms in DNMT3A with the progression of gastric mucosal atrophy and susceptibility to gastric cancer in Japan.
Bronchial epithelial DNA methyltransferase 3b dampens pulmonary immune responses during Pseudomonas aeruginosa infection.
Chronic infection drives Dnmt3a-loss-of-function clonal hematopoiesis via IFN? signaling.
Correlation between DNA methyltransferases expression and Epstein-Barr virus, JC polyomavirus and Helicobacter pylori infections in gastric carcinomas.
CpG distribution and methylation pattern in porcine parvovirus.
Crosstalk between histone modification and DNA methylation orchestrates the epigenetic regulation of the costimulatory factors, Tim?3 and galectin?9, in cervical cancer.
Cytosine methylation by DNMT2 facilitates stability and survival of HIV-1 RNA in the host cell during infection.
Distinct Roles of Two DNA Methyltransferases from Cryphonectria parasitica in Fungal Virulence, Responses to Hypovirus Infection, and Viral Clearance.
DNA Methylation Fluctuation Induced by Virus Infection Differs between MD-resistant and -susceptible Chickens.
DNA methyltransferase inhibitors increase baculovirus-mediated gene expression in mammalian cells when applied before infection.
DNA methyltransferases 1 and 3B are required for hepatitis C virus infection in cell culture.
DNMT gene expression and methylome in Marek's disease resistant and susceptible chickens prior to and following infection by MDV.
DNMT3a rs1550117 polymorphism association with increased risk of Helicobacter pylori infection.
Enterovirus 71 Suppresses miR-17-92 Cluster Through Up-Regulating Methylation of the miRNA Promoter.
Escherichia coli bacteriophage T1 DNA methyltransferase appears to interact with Escherichia coli enolase.
Expression of DNMTs and MBD2 in GIST.
Genome-wide non-CpG methylation of the host genome during M. tuberculosis infection.
Global and Complement Gene-Specific DNA Methylation in Grass Carp after Grass Carp Reovirus (GCRV) Infection.
Haemophagocytic lymphohistiocytosis occurred during induction chemotherapy in an acute monocytic leukemia patient with FLT3-ITD and DNMT3A mutations.
Hematopoietic Stem Cell Transplantation Corrects the Immunologic Abnormalities Associated With Immunodeficiency Centromeric Instability Facial Dysmorphism Syndrome.
Hepatitis B virus infection in hepatocellular carcinoma tissues upregulates expression of DNA methyltransferases.
Hepatitis B virus inhibits liver regeneration via epigenetic regulation of urokinase-type plasminogen activator.
Hepatitis B virus replication induces methylation of both host and viral DNA.
Hepatitis B Virus X Protein Stimulates Virus Replication Via DNA Methylation of the C-1619 in Covalently Closed Circular DNA.
Hepatitis C virus represses E-cadherin expression via DNA methylation to induce epithelial to mesenchymal transition in human hepatocytes.
Host gene expression analysis in Sri Lankan melioidosis patients.
Human cytomegalovirus infection is sensitive to the host cell DNA methylation state and alters global DNA methylation capacity.
Hypomethylation of host cell DNA synthesized after infection or transformation of cells by herpes simplex virus.
Identification of a Minimal 3-Transcript Signature to Differentiate Viral from Bacterial Infection from Best Genome-Wide Host RNA Biomarkers: A Multi-Cohort Analysis.
Increased cytomegalovirus replication by 5-Azacytidine and viral-induced cytoplasmic expression of DNMT?1 in medulloblastoma and endothelial cells.
Infection of lymphoid cells by integration-defective human immunodeficiency virus type 1 increases de novo methylation.
Infection with human immunodeficiency virus type 1 upregulates DNA methyltransferase, resulting in de novo methylation of the gamma interferon (IFN-gamma) promoter and subsequent downregulation of IFN-gamma production.
Inhibition of breast cancer cell growth in vitro and in vivo: effect of restoration of Wwox expression.
Inhibition of DNA methyltransferase activity prevents tumorigenesis in a mouse model of prostate cancer.
Modulation of epigenetic factors during the early stages of HIV-1 infection in CD4+ T cells in vitro.
MOLECULAR MECHANISMS OF HSDS INVERSIONS IN THE COD LOCUS OF STREPTOCOCCUS PNEUMONIAE.
Polymorphisms of the DNA methyltransferase 1 associated with reduced risks of Helicobacter pylori infection and increased risks of gastric atrophy.
Putative association of DNA methyltransferase 1 (DNMT1) polymorphisms with clearance of HBV infection.
Role of B-cell proliferation in the establishment of gammaherpesvirus latency.
The de novo methyltransferases DNMT3a and DNMT3b target the murine gammaherpesvirus immediate-early gene 50 promoter during establishment of latency.
The DNA methyltransferase DNMT3A associates with viral proteins and impacts HSV-1 infection.
The phage growth limitation system in Streptomyces coelicolor A(3)2 is a toxin/antitoxin system, comprising enzymes with DNA methyltransferase, protein kinase and ATPase activity.
The presence of a methylation fingerprint of Helicobacter pylori infection in human gastric mucosae.
Tissue-specific induced DNA methyltransferase 1 (Dnmt1) in endocrine pancreas by RCAS-TVA-based somatic gene transfer system promotes ?-cell proliferation.
Uropathogenic bacteria leave a mark.
Uropathogenic E. coli infection provokes epigenetic downregulation of CDKN2A (p16INK4A) in uroepithelial cells.
[Overexpression of DNA-methyltransferases in persistency of cccDNA pool in chronic hepatitis B].
Infertility
Associations of MTHFR DNMT3b 4977 bp deletion in mtDNA and GSTM1 deletion, and aberrant CpG island hypermethylation of GSTM1 in non-obstructive infertility in Indian men.
Meiotic and epigenetic defects in Dnmt3L-knockout mouse spermatogenesis.
Polymorphic variants of DNMT3A and the risk of endometriosis.
Infertility, Male
Association between single-nucleotide polymorphisms of DNMT3L and infertility with azoospermia in Chinese men.
Associations of MTHFR DNMT3b 4977 bp deletion in mtDNA and GSTM1 deletion, and aberrant CpG island hypermethylation of GSTM1 in non-obstructive infertility in Indian men.
Expression of NOL1/NOP2/sun domain (Nsun) RNA methyltransferase family genes in early mouse embryogenesis.
Idiopathic male infertility and polymorphisms in the DNA methyltransferase genes involved in epigenetic marking.
Polymorphism in DNMT1 may modify the susceptibility to oligospermia.
Transcriptional alterations of genes related to fertility decline in male rats induced by chronic sleep restriction.
Inflammatory Bowel Diseases
Human cytomegalovirus infection is sensitive to the host cell DNA methylation state and alters global DNA methylation capacity.
Influenza, Human
Epigenetic changes mediated by microRNA miR29 activate cyclooxygenase 2 and lambda-1 interferon production during viral infection.
Epigenetic modification is regulated by the interaction of influenza A virus nonstructural protein-1 with the de novo DNA methyltransferase DNMT3B and subsequent transport to the cytoplasm for K48-linked polyubiquitination.
Insulin Resistance
DNMT3a and TET2 in adipocyte insulin sensitivity.
Dnmt3a is an epigenetic mediator of adipose insulin resistance.
Epigenetic regulation of macrophage polarization and inflammation by DNA methylation in obesity.
Epigenetic regulation of macrophage polarization by DNA methyltransferase 3b.
How does obesity lead to insulin resistance?
Hypermethylation of Hepatic Mitochondrial ND6 Provokes Systemic Insulin Resistance.
Interleukin-6 determines protein stabilization of DNA methyltransferases and alters DNA promoter methylation of genes associated with insulin signaling and angiogenesis.
Obesity-induced DNA hypermethylation of the adiponectin gene mediates insulin resistance.
TET2 facilitates PPAR? agonist-mediated gene regulation and insulin sensitization in adipocytes.
Intellectual Disability
A Novel Single-Nucleotide Deletion (c.1020delA) in NSUN2 Causes Intellectual Disability in an Emirati Child.
Acromegaly in the setting of Tatton-Brown-Rahman Syndrome.
Acute myeloid leukaemia in a case with Tatton-Brown-Rahman syndrome: the peculiar DNMT3A R882 mutation.
DNA methyltransferase 3B (DNMT3B) mutations in ICF syndrome lead to altered epigenetic modifications and aberrant expression of genes regulating development, neurogenesis and immune function.
Expanding the phenotype of biallelic loss-of-function variants in the NSUN2 gene: Description of four individuals with juvenile cataract, chronic nephritis, or brain anomaly as novel complications.
Expression of NOL1/NOP2/sun domain (Nsun) RNA methyltransferase family genes in early mouse embryogenesis.
First identified Korean family with Tatton-Brown-Rahman Syndrome caused by the novel DNMT3A variant c.118G>C p.(Glu40Gln).
Frequencies of Six (Five Novel) STR Markers Linked to TUSC3 (MRT7) or NSUN2 (MRT5) Genes Used for Homozygosity Mapping of Recessive Intellectual Disability.
Further delineation of autosomal recessive intellectual disability syndrome caused by homozygous variant of the NSUN2 gene in a chinese pedigree.
Identification of De Novo DNMT3A Mutations That Cause West Syndrome by Using Whole-Exome Sequencing.
Mapping and significance of the mRNA methylome.
Mutation in NSUN2, which encodes an RNA methyltransferase, causes autosomal-recessive intellectual disability.
Mutations in NSUN2 cause autosomal-recessive intellectual disability.
Mutations in the DNA methyltransferase gene DNMT3A cause an overgrowth syndrome with intellectual disability.
Novel DNMT3A Germline Variant in a Patient with Multiple Paragangliomas and Papillary Thyroid Carcinoma.
NSun2-mediated cytosine-5 methylation of vault noncoding RNA determines its processing into regulatory small RNAs.
Tatton-Brown-Rahman syndrome with a novel DNMT3A mutation presented severe intellectual disability and autism spectrum disorder.
The Tatton-Brown-Rahman Syndrome: A clinical study of 55 individuals with de novo constitutive DNMT3A variants.
Intervertebral Disc Degeneration
DNMT3B decreases extracellular matrix degradation and alleviates intervertebral disc degeneration through TRPA1 methylation to inhibit the COX2/YAP axis.
Intestinal Neoplasms
DNA hypomethylation contributes to genomic instability and intestinal cancer initiation.
DNMT3B Oncogenic Activity in Human Intestinal Cancer Is Not Linked to CIMP or BRAFV600E Mutation.
Ischemic Attack, Transient
Effects of Transient Cerebral Ischemia on the Expression of DNA Methyltransferase 1 in the Gerbil Hippocampal CA1 Region.
Ischemic Stroke
The Emerging Role of Epigenetics in Cerebral Ischemia.
Keloid
Methylation of secreted frizzled-related protein 1 (SFRP1) promoter downregulates Wnt/?-catenin activity in keloids.
The Expression of DNMT1 in Pathologic Scar Fibroblasts and the Effect of 5-aza-2-Deoxycytidine on Cytokines of Pathologic Scar Fibroblasts.
[Expression and significance of DNMT1 in human keloid fibroblast].
Kidney Diseases
Dnmt3a and Dnmt3b-Decommissioned Fetal Enhancers are Linked to Kidney Disease.
Kidney Failure, Chronic
Matrix stiffness determines the phenotype of vascular smooth muscle cell in vitro and in vivo: Role of DNA methyltransferase 1.
Kidney Neoplasms
Aberrant DNA methyltransferase 1 expression in clear cell renal cell carcinoma development and progression.
Klatskin Tumor
si-DNMT1 restore tumor suppressor genes expression through the reversal of DNA hypermethylation in cholangiocarcinoma.
Laryngeal Neoplasms
The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation in Laryngeal carcinoma.
Leiomyoma
5-aza-2'-deoxycitidine inhibits cell proliferation, extracellular matrix formation and Wnt/?-catenin pathway in human uterine leiomyomas.
Aberrant DNA methylation status in human uterine leiomyoma.
Cross-talk between miR-29c and transforming growth factor-?3 is mediated by an epigenetic mechanism in leiomyoma.
DNA hypomethylation and imbalanced expression of DNA methyltransferases (DNMT1, 3A, and 3B) in human uterine leiomyoma.
Mechanisms underlying aberrant expression of miR-29c in uterine leiomyoma.
Leiomyosarcoma
Temozolomide in advanced and recurrent uterine leiomyosarcoma and correlation with o6-methylguanine DNA methyltransferase expression: a case series.
Treatment with epigenetic agents profoundly inhibits tumor growth in leiomyosarcoma.
Leukemia
8a, a New Acridine Antiproliferative and Pro-Apoptotic Agent Targeting HDAC1/DNMT1.
?-Arrestin1 promotes the self-renewal of the leukemia-initiating cell-enriched subpopulation in B-lineage acute lymphoblastic leukemia related to DNMT1 activity.
A Model System for Studying the DNMT3A Hotspot Mutation (DNMT3AR882) Demonstrates a Causal Relationship between Its Dominant-Negative Effect and Leukemogenesis.
Aberrant DNA methylation-induced gene inactivation is associated with the diagnosis and/or therapy of T-cell leukemias.
Abnormal promoter DNA methylation in juvenile myelomonocytic leukemia is not caused by mutation in DNMT3A.
Activation of HLA-G expression by 5-aza-2 - deoxycytidine in malignant hematopoetic cells isolated from leukemia patients.
Activation of the p53 DNA damage response pathway after inhibition of DNA methyltransferase by 5-aza-2'-deoxycytidine.
Acute leukemia in adolescents and young adults.
Acute Myeloid Leukemia With Recurrent Genetic Abnormalities Other Than Translocations.
Bcor deficiency perturbs erythro-megakaryopoiesis and cooperates with Dnmt3a loss in acute erythroid leukemia onset in mice.
Cancer cells express aberrant DNMT3B transcripts encoding truncated proteins.
CDK6 Is a Potential Prognostic Biomarker in Acute Myeloid Leukemia.
Chinese Herbal Mixture, Tien-Hsien Liquid, Induces G2/M Cycle Arrest and Radiosensitivity in MCF-7 Human Breast Cancer Cells through Mechanisms Involving DNMT1 and Rad51 Downregulation.
Chronic myelomonocytic leukemia with double-mutations in DNMT3A and FLT3-ITD treated with decitabine and sorafenib.
Ciprofloxacin has antifibrotic effects in scleroderma fibroblasts via downregulation of Dnmt1 and upregulation of Fli1.
Clonal hematopoiesis and associated diseases: A review of recent findings.
Clonal hematopoiesis: Pre-cancer PLUS.
Codelivery of Genistein and miRNA-29b to A549 Cells Using Aptamer-Hybrid Nanoparticle Bioconjugates.
Combination of a hypomethylating agent and inhibitors of PARP and HDAC traps PARP1 and DNMT1 to chromatin, acetylates DNA repair proteins, down-regulates NuRD and induces apoptosis in human leukemia and lymphoma cells.
Consequences of combining siRNA-mediated DNA methyltransferase 1 depletion with 5-aza-2'-deoxycytidine in human leukemic KG1 cells.
De novo methylation of MMLV provirus in embryonic stem cells: CpG versus non-CpG methylation.
Decitabine, a DNA methyltransferase inhibitor, induces apoptosis in human leukemia cells through intracellular reactive oxygen species generation.
Decreases in different Dnmt3b activities drive distinct development of hematologic malignancies in mice.
Design, synthesis and biological evaluation of 4-amino-N- (4-aminophenyl)benzamide analogues of quinoline-based SGI-1027 as inhibitors of DNA methylation.
Development and validation of a gas chromatography/mass spectrometry method for the assessment of genomic DNA methylation.
Differentiation therapy in poor risk myeloid malignancies: Results of a dose finding study of the combination bryostatin-1 and GM-CSF.
DNA damage response as a prognostic indicator in metastatic breast cancer via mutational analysis.
DNA methyl transferase I acts as a negative regulator of allergic skin inflammation.
DNA methylation as a pathogenic event and as a therapeutic target in AML.
DNA methylation changes in hematologic malignancies: biologic and clinical implications.
DNA Methylation-Targeted Drugs.
DNA methyltransferase 1-mediated CpG methylation of the miR-150-5p promoter contributes to fibroblast growth factor receptor 1-driven leukemogenesis.
DNA methyltransferase inhibition induces mouse embryonic stem cell differentiation into endothelial cells.
DNA methyltransferase inhibitor RG108 and histone deacetylase inhibitors cooperate to enhance NB4 cell differentiation and E-cadherin re-expression by chromatin remodeling.
DNA methyltransferases in hematologic malignancies.
DNA-methylation analysis identifies the E-cadherin gene as a potential marker of disease progression in patients with monoclonal gammopathies.
DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells.
DNMT3A Arg882 mutation drives chronic myelomonocytic leukemia through disturbing gene expression/DNA methylation in hematopoietic cells.
DNMT3A in Leukemia.
DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias.
DNMT3A mutation is a poor prognosis biomarker in AML: Results of a meta-analysis of 4500 AML patients.
DNMT3A mutational analysis in primary myelofibrosis, chronic myelomonocytic leukemia and advanced phases of myeloproliferative neoplasms.
DNMT3A mutations are associated with inferior overall and leukemia-free survival in chronic myelomonocytic leukemia.
DNMT3A mutations in acute myeloid leukemia.
DNMT3A mutations mediate the epigenetic reactivation of the leukemogenic factor MEIS1 in acute myeloid leukemia.
Dnmt3a protects active chromosome domains against cancer-associated hypomethylation.
Do AML patients with DNMT3A exon 23 mutations benefit from idarubicin as compared to daunorubicin? A single center experience.
DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia.
Downregulation of miR-217 correlates with resistance of ph(+) leukemia cells to ABL tyrosine kinase inhibitors.
Dynamics of DNMT3A mutation and prognostic relevance in patients with primary myelodysplastic syndrome.
Early T-cell precursor acute lymphoblastic leukemia with KRAS and DNMT3A mutations and unexpected monosomy 7.
Effects of DNA Methylation on Leukemia Cell Proliferation.
Effects of TET2 mutations on DNA methylation in chronic myelomonocytic leukemia.
Epigenetic analysis of patients with T-ALL identifies poor outcomes and a hypomethylating agent-responsive subgroup.
Epigenetic Perturbations by Arg882-Mutated DNMT3A Potentiate Aberrant Stem Cell Gene-Expression Program and Acute Leukemia Development.
Epigenetic regulation of the human telomerase reverse transciptase gene: A potential therapeutic target for the treatment of leukemia (Review).
Erlotinib antagonizes ABC transporters in acute myeloid leukemia.
Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia.
Exosomal DNMT1 mRNA transcript is elevated in acute lymphoblastic leukemia which might reprograms leukemia progression.
Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia.
Gene expression profiling of the DNMT3A R882 mutation in acute leukemia.
Haemophagocytic lymphohistiocytosis occurred during induction chemotherapy in an acute monocytic leukemia patient with FLT3-ITD and DNMT3A mutations.
Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains.
Harmine, a Novel DNA Methyltransferase 1 Inhibitor in the Leukemia Cell Line.
Hepatic leukemia factor is a novel leukemic stem cell regulator in DNMT3A, NPM1, and FLT3-ITD triple-mutated AML.
High expression of FLT3 is a risk factor in leukemia.
Homocysteine suppresses the expression of the collagen cross-linker lysyl oxidase involving IL-6, Fli1, and epigenetic DNA methylation.
IDH1/2 but not DNMT3A mutations are suitable targets for minimal residual disease monitoring in acute myeloid leukemia patients: a study by the Acute Leukemia French Association.
Imatinib causes epigenetic alterations of PTEN gene via upregulation of DNA methyltransferases and polycomb group proteins.
In vivo activity of murine de novo methyltransferases, Dnmt3a and Dnmt3b.
Influence of Histone Deacetylase Inhibitors and DNA-Methyltransferase Inhibitors on the NK Cell-Mediated Lysis of Pediatric B-Lineage Leukemia.
Inhibition of DNA methylation in L1210 leukemic cells by 5-aza-2'-deoxycytidine as a possible mechanism of chemotherapeutic action.
Leukemia cutis with IDH1, DNMT3A and NRAS mutations conferring resistance to venetoclax plus 5-azacytidine in refractory AML.
Long-term serial xenotransplantation of juvenile myelomonocytic leukemia recapitulates human disease in Rag2-/-?c-/- mice.
Long-term stability of demethylation after transient exposure to 5-aza-2'-deoxycytidine correlates with sustained RNA polymerase II occupancy.
Loss of Dnmt3a and Dnmt3b does not affect epidermal homeostasis but promotes squamous transformation through PPAR-?.
Loss of Dnmt3b accelerates MLL-AF9 leukemia progression.
Methylation silencing of the Apaf-1 gene in acute leukemia.
Methylation-independent repression of Dnmt3b contributes to oncogenic activity of Dnmt3a in mouse MYC-induced T-cell lymphomagenesis.
Methyltransferase DNMT3B in leukemia.
miR-126 promotes the growth and proliferation of leukemia stem cells by targeting DNA methyltransferase 1.
miR-9 plays a role in IL-10-mediated expression of E-cadherin in acute myelogenous leukemia cells.
Mitoxantrone, etoposide and cytarabine following epigenetic priming with decitabine in adults with relapsed/refractory acute myeloid leukemia or other high-grade myeloid neoplasms: a phase 1/2 study.
Mixed-phenotype acute leukemia (MPAL) exhibits frequent mutations in DNMT3A and activated signaling genes.
Modeling and targeting of erythroleukemia by hematopoietic genome editing.
Multicolor Flow Cytometry and Multi-Gene Next Generation Sequencing are Complementary and Highly Predictive for Relapse in Acute Myeloid Leukemia Following Allogeneic Transplant.
Mutant DNA methylation regulators endow hematopoietic stem cells with the preleukemic stem cell property, a requisite of leukemia initiation and relapse.
Mutational analysis of DNMT3A gene in acute leukemias and common solid cancers.
Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2 and DNMT3A.
Mutations in DNMT3A and loss of RKIP are independent events in acute monocytic leukemia.
New approaches to the treatment of myelodysplasia.
Novel Mutations in a Lethal Case of Lymphomatous Adult T Cell Lymphoma with Cryptic Myocardial Involvement.
Overexpression of Arginase 1 is linked to DNMT3A and TET2 mutations in lower-grade myelodysplastic syndromes and chronic myelomonocytic leukemia.
Overexpression of microRNA-143 inhibits growth and induces apoptosis in human leukemia cells.
Palliative chemotherapy followed by methylation inhibitor in high-risk acute myeloid leukemia: An in vitro and clinical study.
Panobinostat treatment depletes EZH2 and DNMT1 levels and enhances decitabine mediated de-repression of JunB and loss of survival of human acute leukemia cells.
Perinatal Programming of Adult Rat Germ Cell Death After Exposure to Xenoestrogens: Role of microRNA miR-29 Family in the Down-Regulation of DNA Methyltransferases and Mcl-1.
Pharmacokinetic evaluation of decitabine for the treatment of leukemia.
PHF6 and DNMT3A mutations are enriched in distinct subgroups of mixed phenotype acute leukemia with T-lineage differentiation.
PML-RARA requires DNA methyltransferase 3A to initiate acute promyelocytic leukemia.
Progesterone receptor gene inactivation and CpG island hypermethylation in human leukemia cancer cells.
Prognostic significance of DNA methyltransferase 3A mutations in cytogenetically normal acute myeloid leukemia: a study by the Acute Leukemia French Association.
Promoter Hypomethylation and Expression Is Conserved in Mouse Chronic Lymphocytic Leukemia Induced by Decreased or Inactivated Dnmt3a.
Rare occurrence of DNMT3A mutations in myelodysplastic syndromes.
Reactivation of epigenetically silenced genes by DNA methyltransferase inhibitors: basic concepts and clinical applications.
Regulation of DNA methylation and tumor suppression gene expression by miR-29b in leukemia patients and related mechanisms.
Retinoic acid targets DNA-methyltransferases and histone deacetylases during APL blast differentiation in vitro and in vivo.
Runx1 Regulation of Pu.1 Corepressor/Coactivator Exchange Identifies Specific Molecular Targets for Leukemia Differentiation Therapy.
Silencing of CHD5 gene by promoter methylation in leukemia.
Sowing the Seeds of Clonal Hematopoiesis.
Spliceosomal gene mutations are frequent events in the diverse mutational spectrum of chronic myelomonocytic leukemia but largely absent in juvenile myelomonocytic leukemia.
STAT5A regulates DNMT3A in CD34(+)/CD38(-) AML cells.
TET2 and DNMT3A Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors.
The Gene Expression Profile and DNA Methylation Pattern of CDH1 and DNMT1 Genes in Acute Promyelocytic Leukemia (APL).
The Impact of DNA Methylation in Hematopoietic Malignancies.
The role of autophagy in targeted therapy for acute myeloid leukemia.
The role of human equilibrative nucleoside transporter 1 on the cellular transport of the DNA methyltransferase inhibitors 5-azacytidine and CP-4200 in human leukemia cells.
Therapeutic Delivery of MicroRNA-29b by Cationic Lipoplexes for Lung Cancer.
Thymoquinone exerts potent growth-suppressive activity on leukemia through DNA hypermethylation reversal in leukemia cells.
Tissue-Biased Expansion of DNMT3A-Mutant Clones in a Mosaic Individual Is Associated with Conserved Epigenetic Erosion.
Tocotrienol-rich fraction from annatto ameliorates expression of lysyl oxidase in human osteoblastic MG-63 cells.
Total synthesis of the proposed structures of the DNA methyl transferase inhibitors peyssonenynes, and structural revision of peyssonenyne B.
Trichostatin A down-regulate DNA methyltransferase 1 in Jurkat T cells.
Two Novel Methods for Rapid Detection and Quantification of DNMT3A R882 Mutations in Acute Myeloid Leukemia.
Xiao W, Bharadwaj M, Levine M, et al. PHF6 and DNMT3A mutations are enriched in distinct subgroups of mixed phenotype acute leukemia with T-lineage differentiation. Blood Adv. 2018;2(23):3526-3539.
YTHDF2 is a potential target of AML1/ETO-HIF1? loop-mediated cell proliferation in t(8;21) AML.
ZNF479 downregulates metallothionein-1 expression by regulating ASH2L and DNMT1 in hepatocellular carcinoma.
[Clinical significance of the expression of DNA methyltransferase genes (DNMT) in acute leukemia patients.]
[Functional role of DNMT3A mutation in acute myeloid leukemia].
[Prognostic Value of Recurrent Molecular Genetics and Epigenetics Abnormity in T Lymphoblastic Lymphoma / Leukemia -Review].
[The C46359T polymorphism of DNMT3B promoter gene and pathogenesis of acute leukemia]
[The expression of DNA methyltransferase DNMT1, 3A and 3B in acute leukemia and myelodysplastic syndrome]
[The re-expression of p15(INK4B) gene in leukemia cells induced by in vitro DNA methyltransferase and histone deacetylase inhibition]
Leukemia, Biphenotypic, Acute
Gene expression profiling of the DNMT3A R882 mutation in acute leukemia.
Leukemia, Erythroblastic, Acute
A potent cell-active allosteric inhibitor of murine DNA cytosine C5 methyltransferase.
Effect of aphidicolin on DNA methyltransferase in the nucleus.
Growth-dependent expression of multiple species of DNA methyltransferase in murine erythroleukemia cells.
In vitro methylation of the 5'-flanking regions of the mouse beta-globin gene.
Inhibition of DNA methyltransferase and induction of Friend erythroleukemia cell differentiation by 5-azacytidine and 5-aza-2'-deoxycytidine.
Interaction of DNA methyltransferase and other non-histone proteins isolated from Friend erythroleukemia cell nuclei with 5-azacytosine residues in DNA.
Interleukin-6 regulation of the human DNA methyltransferase (HDNMT) gene in human erythroleukemia cells.
Localization of DNA methyltransferase in the chromatin of Friend erythroleukemia cells.
Naturally occurring methylation inhibitor: DNA hypomethylation and hemoglobin synthesis in human K562 cells.
Peptide mapping of the murine DNA methyltransferase reveals a major phosphorylation site and the start of translation.
Purification and stabilization of mouse DNA methyltransferase.
Two DNA methyltransferases from murine erythroleukemia cells: purification, sequence specificity, and mode of interaction with DNA.
Leukemia, Hairy Cell
Decreases in different Dnmt3b activities drive distinct development of hematologic malignancies in mice.
Leukemia, Large Granular Lymphocytic
Concurrent STAT3, DNMT3A, and TET2 mutations in T-LGL leukemia with molecularly distinct clonal hematopoiesis of indeterminate potential.
Leukemia, Lymphocytic, Chronic, B-Cell
Dnmt3a Is a Haploinsufficient Tumor Suppressor in CD8+ Peripheral T Cell Lymphoma.
Loss of Dnmt3a induces CLL and PTCL with distinct methylomes and transcriptomes in mice.
Promoter Hypomethylation and Expression Is Conserved in Mouse Chronic Lymphocytic Leukemia Induced by Decreased or Inactivated Dnmt3a.
Leukemia, Monocytic, Acute
Effects of DNA Methylation on Leukemia Cell Proliferation.
Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia.
Haemophagocytic lymphohistiocytosis occurred during induction chemotherapy in an acute monocytic leukemia patient with FLT3-ITD and DNMT3A mutations.
Mutations in DNMT3A and loss of RKIP are independent events in acute monocytic leukemia.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
A carrier-mediated prodrug approach to improve the oral absorption of antileukemic drug decitabine.
Absence of DNMT3A gene mutation in chronic myeloid leukemia patients in blast crisis.
Depleting long noncoding RNA HOTAIR attenuates chronic myelocytic leukemia progression by binding to DNA methyltransferase 1 and inhibiting PTEN gene promoter methylation.
DNA Methyltransferase 1 Drives Transcriptional Down-Modulation of ? Catenin Antagonist Chibby1 Associated With the BCR-ABL1 Gene of Chronic Myeloid Leukemia.
DNA methyltransferase 1 mediated aberrant methylation and silencing of SHP-1 gene in chronic myelogenous leukemia cells.
Effects of DNA Methylation on Leukemia Cell Proliferation.
Exome sequencing reveals DNMT3A and ASXL1 variants associate with progression of chronic myeloid leukemia after tyrosine kinase inhibitor therapy.
Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia.
Imatinib causes epigenetic alterations of PTEN gene via upregulation of DNA methyltransferases and polycomb group proteins.
Leukemia, Myeloid
5-Aza-2'-Deoxycytidine and DNA Methyltransferase Inhibitors in the Treatment of Myeloid Leukemias and Myelodysplastic Syndromes: Biological Aspects and Clinical Results. Proceedings of a workshop. Rome, Italy, November 3, 1991.
A Novel t(8;14)(q24;q11) Rearranged Human Cell Line as a Model for Mechanistic and Drug Discovery Studies of NOTCH1-Independent Human T-Cell Leukemia.
A WIMSical approach to decoding DNA methylation in myeloid leukemia.
Constrained analogues of procaine as novel small molecule inhibitors of DNA methyltransferase-1.
Dnmt1 links BCR-ABLp210 to epigenetic tumor stem cell priming in myeloid leukemia.
DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias.
Human concentrative nucleoside transporter 1-mediated uptake of 5-azacytidine enhances DNA demethylation.
Quantitative determination of decitabine incorporation into DNA and its effect on mutation rates in human cancer cells.
Leukemia, Myeloid, Acute
5-Aza-4'-thio-2'-deoxycytidine, a new orally bioavailable non-toxic "best-in-class" DNMT1 depleting agent in clinical development.
A case of familial transmission of the newly described DNMT3A-Overgrowth Syndrome.
A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells.
A mutational and expressional analysis of DNMT3A in acute myeloid leukemia cytogenetic subgroups.
A phase I biological study of MG98, an oligodeoxynucleotide antisense to DNA methyltransferase 1, in patients with high-risk myelodysplasia and acute myeloid leukemia.
A vicious loop of fatty acid-binding protein 4 and DNA methyltransferase 1 promotes acute myeloid leukemia and acts as a therapeutic target.
Abnormal RNA splicing and genomic instability after induction of DNMT3A mutations by CRISPR/Cas9 gene editing.
Acute myeloid leukemia cells exhibit selective down-regulation of DNMT3A isoform 2.
Acute myeloid leukemia derived from lympho-myeloid clonal hematopoiesis.
Acute Myeloid Leukemia with Del(9q) is Characterized by Frequent Mutations of NPM1, DNMT3A, WT1 and Low Expression of TLE4.
Acute myeloid leukemia with DNMT3A mutations.
Acute myeloid leukemia-associated DNMT3A p.Arg882His mutation in a patient with Tatton-Brown-Rahman overgrowth syndrome as a constitutional mutation.
Adult acute myeloid leukemia with trisomy 11 as the sole abnormality is characterized by the presence of five distinct gene mutations: MLL-PTD, DNMT3A, U2AF1, FLT3-ITD and IDH2.
Age-Related Prognostic Impact of Different Types of DNMT3A Mutations in Adults With Primary Cytogenetically Normal Acute Myeloid Leukemia.
Allogeneic hematopoietic stem cell transplantation could improve survival of cytogenetically normal adult acute myeloid leukemia patients with DNMT3A mutations.
AML-Associated Mutations in DNA Methyltransferase DNMT3A.
An miRNA-DNMT1 Axis Is Involved in Azacitidine Resistance and Predicts Survival in Higher-Risk Myelodysplastic Syndrome and Low Blast Count Acute Myeloid Leukemia.
Association between DNMT3A mutations and prognosis of adults with de novo acute myeloid leukemia: a systematic review and meta-analysis.
Association between increased mutation rates in DNMT3A and FLT3-ITD and poor prognosis of patients with acute myeloid leukemia.
ASXL1 and DNMT3A mutation in a cytogenetically normal B3 thymoma.
Azacitidine-Induced Pericarditis: A Case Series.
Bioinformatics Analysis Identifies Key Genes and Pathways in Acute Myeloid Leukemia Associated with DNMT3A Mutation.
Biological and clinical influences of NPM1 in acute myeloid leukemia patients with DNMT3A mutations.
Biologico-clinical significance of DNMT3A variants expression in acute myeloid leukemia.
Bortezomib induces DNA hypomethylation and silenced gene transcription by interfering with Sp1/NF-kappaB-dependent DNA methyltransferase activity in acute myeloid leukemia.
Case Report: Refusal of an Veno-Arterial Extracorporeal Membrane Oxygenation Due to Malignant Disease? - An Extremely Rare Form of Cardiac Involvement in Acute Myeloid Leukemia.
CBFB-MYH11 Fusion Sequesters RUNX1 in Cytoplasm to Prevent DNMT3A Recruitment to Target Genes in AML.
Characteristics of DNMT3A mutations in acute myeloid leukemia.
Characterization of DNA demethylation effects induced by 5-Aza-2'-deoxycytidine in patients with myelodysplastic syndrome.
Clinical and biological implications of IDH1/2 in acute myeloid leukemia with DNMT3Amut.
Clinical Effect of Combined Mutations in DNMT3A, FLT3-ITD, and NPM1 Among Egyptian Acute Myeloid Leukemia Patients.
Clinical Features and MicroRNA Expression Patterns Between AML Patients With DNMT3A R882 and Frameshift Mutations.
Clinical features of de novo acute myeloid leukemia with concurrent DNMT3A, FLT3 and NPM1 mutations.
Clinical impact of DNMT3A mutations in younger adult patients with acute myeloid leukemia: results of the AML Study Group (AMLSG).
Clonal haematopoiesis and risk of acute myeloid leukemia.
Co-occurrence of DNMT3A, NPM1, FLT3 mutations identifies a subset of acute myeloid leukemia with adverse prognosis.
Comparative examination of various PCR-based methods for DNMT3A and IDH1/2 mutations identification in acute myeloid leukemia.
Comparison of high-resolution melting analysis with direct sequencing for the detection of recurrent mutations in DNA methyltransferase 3A and isocitrate dehydrogenase 1 and 2 genes in acute myeloid leukemia patients.
Concomitant inhibition of DNA methyltransferase and BCL-2 protein function synergistically induce mitochondrial apoptosis in acute myelogenous leukemia cells.
Conditional knockin of Dnmt3a R878H initiates acute myeloid leukemia with mTOR pathway involvement.
Continuation of a Levonorgestrel Intrauterine Device During Hematopoietic Stem Cell Transplant: A Case Report.
Cooperating gene mutations in childhood acute myeloid leukemia with special reference on mutations of ASXL1, TET2, IDH1, IDH2 and DNMT3A.
Cooperation of Dnmt3a R878H with Nras G12D promotes leukemogenesis in knock-in mice: a pilot study.
CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression.
Curcumin down-regulates DNA methyltransferase 1 and plays an anti-leukemic role in acute myeloid leukemia.
Decitabine Downregulates TIGAR to Induce Apoptosis and Autophagy in Myeloid Leukemia Cells.
Decreased DNA methylation in acute myeloid leukemia patients with DNMT3A mutations and prognostic implications of DNA methylation.
Depletion of ZBTB38 potentiates the effects of DNA demethylating agents in cancer cells via CDKN1C mRNA up-regulation.
Detection of high-frequency and novel DNMT3A mutations in acute myeloid leukemia by high-resolution melting curve analysis.
DNA methylation and hydroxymethylation patterns in acute myeloid leukemia patients with mutations in DNMT3A and IDH1/2 and their combinations.
DNA methylation in normal and malignant hematopoiesis.
DNA Methylation-Targeted Drugs.
DNA methyltransferase inhibitors in acute myeloid leukemia: Discovery, design and first therapeutic experiences.
DNA methyltransferases in hematological malignancies.
DNMT Inhibitors Increase Methylation in the Cancer Genome.
DNMT3A (R882) mutation features and prognostic effect in acute myeloid leukemia in Coexistent with NPM1 and FLT3 mutations.
DNMT3A and IDH mutations in acute myeloid leukemia and other myeloid malignancies: associations with prognosis and potential treatment strategies.
DNMT3A Arg882 mutation drives chronic myelomonocytic leukemia through disturbing gene expression/DNA methylation in hematopoietic cells.
Dnmt3a haploinsufficiency transforms Flt3-ITD myeloproliferative disease into a rapid, spontaneous, and fully-penetrant acute myeloid leukemia.
DNMT3A in Leukemia.
DNMT3A intragenic hypomethylation is associated with adverse prognosis in acute myeloid leukemia.
Dnmt3a loss and Idh2 neomorphic mutations mutually potentiate malignant hematopoiesis.
Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation.
DNMT3A mutant transcript levels persist in remission and do not predict outcome in patients with acute myeloid leukemia.
DNMT3A mutation leads to leukemic extramedullary infiltration mediated by TWIST1.
DNMT3A Mutation-Induced CDK1 Overexpression Promotes Leukemogenesis by Modulating the Interaction between EZH2 and DNMT3A.
DNMT3A Mutational Status Affects the Results of Dose-Escalated Induction Therapy in Acute Myelogenous Leukemia.
DNMT3A mutations and clinical features in Chinese patients with acute myeloid leukemia.
DNMT3A mutations and response to the hypomethylating agent decitabine in acute myeloid leukemia.
DNMT3A mutations are rare in childhood acute myeloid leukemia.
DNMT3A mutations at R882 hotspot are only found in major clones of acute myeloid leukemia.
DNMT3A mutations in acute myeloid leukemia.
DNMT3A mutations in acute myeloid leukemia: impact on low-risk patients with CEBPA mutations.
DNMT3A mutations in acute myeloid leukemia: stability during disease evolution and clinical implications.
DNMT3A mutations in Chinese childhood acute myeloid leukemia.
DNMT3a mutations in high-risk myelodysplastic syndrome parallel those found in acute myeloid leukemia.
DNMT3A Mutations in Patients with Acute Myeloid Leukemia in South Brazil.
DNMT3A mutations mediate the epigenetic reactivation of the leukemogenic factor MEIS1 in acute myeloid leukemia.
DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling.
DNMT3A R882 mutation is associated with elevated expression of MAFB and M4/M5 immunophenotype of acute myeloid leukemia blasts.
DNMT3A R882 Mutation with FLT3-ITD Positivity Is an Extremely Poor Prognostic Factor in Patients with Normal-Karyotype Acute Myeloid Leukemia after Allogeneic Hematopoietic Cell Transplantation.
DNMT3A R882 mutations in patients with cytogenetically normal acute myeloid leukemia and myelodysplastic syndrome.
DNMT3A R882H mutation in acute myeloid leukemia cell line SET-2.
Dnmt3a regulates myeloproliferation and liver-specific expansion of hematopoietic stem and progenitor cells.
DNMT3A, TET2, and JAK2 mutations in polycythemia vera following long-term remission of secondary acute myeloid leukemia.
Dnmt3b Methylates DNA by a Noncooperative Mechanism, and Its Activity Is Unaffected by Manipulations at the Predicted Dimer Interface.
Do age-associated DNA methylation changes increase the risk of malignant transformation?
Do AML patients with DNMT3A exon 23 mutations benefit from idarubicin as compared to daunorubicin? A single center experience.
Dominating the Negative: How DNMT3A Mutations Contribute to AML Pathogenesis.
DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia.
Droplet digital polymerase chain reaction for DNMT3A and IDH1/2 mutations to improve early detection of acute myeloid leukemia relapse after allogeneic hematopoietic stem cell transplantation.
Dynamics of DNMT3A mutation and prognostic relevance in patients with primary myelodysplastic syndrome.
Effect of DNMT3A variant allele frequency and double mutation on clinicopathologic features of patients with de novo AML.
Epigenetic aberrations in myeloid malignancies (Review).
Epigenetic landscape analysis of lncRNAs in acute myeloid leukemia with DNMT3A mutations.
Epigenetic modifiers: basic understanding and clinical development.
Epimutations mimic genomic mutations of DNMT3A in acute myeloid leukemia.
Evaluation of DNMT3A genetic polymorphisms as outcome predictors in AML patients.
Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia.
Expression of myeloperoxidase in acute myeloid leukemia blasts mirrors the distinct DNA methylation pattern involving the downregulation of DNA methyltransferase DNMT3B.
Expression Profiles of DNA Methylation and Demethylation Machinery Components in Pediatric Myelodysplastic Syndrome: Clinical Implications.
FLT3-ITD Compared with DNMT3A R882 Mutation Is a More Powerful Independent Inferior Prognostic Factor in Adult Acute Myeloid Leukemia Patients After Allogeneic Hematopoietic Stem Cell Transplantation: A Retrospective Cohort Study
FLT3-ITD with DNMT3A R882 double mutation is a poor prognostic factor in Chinese patients with acute myeloid leukemia after chemotherapy or allogeneic hematopoietic stem cell transplantation.
FLT3-ITD, NPM1, and DNMT3A Gene Mutations and Risk Factors in Normal Karyotype Acute Myeloid Leukemia and Myelodysplastic Syndrome Patients in Upper Northern Thailand
Frequency, onset and clinical impact of somatic DNMT3A mutations in therapy-related and secondary acute myeloid leukemia.
Functional Analysis of DNMT3A DNA Methyltransferase Mutations Reported in Patients with Acute Myeloid Leukemia.
Functional and epigenetic phenotypes of humans and mice with DNMT3A Overgrowth Syndrome.
Further delineation of neuropsychiatric findings in Tatton-Brown-Rahman syndrome due to disease-causing variants in DNMT3A: seven new patients.
GADD45A methylation predicts poor overall survival in acute myeloid leukemia and is associated with IDH1/2 and DNMT3A mutations.
Gene expression profiling of the DNMT3A R882 mutation in acute leukemia.
Gene mutation and AML pathogenesis.
Gene mutation patterns and their prognostic impact in a cohort of 1185 patients with acute myeloid leukemia.
Genetic and Epigenetic Perturbations by DNMT3A-R882 Mutants Impaired Apoptosis through Augmentation of PRDX2 in Myeloid Leukemia Cells.
Genomic and epigenomic predictors of response to guadecitabine in relapsed/refractory acute myelogenous leukemia.
Genomic markers of midostaurin drug sensitivity in FLT3 mutated and FLT3 wild-type acute myeloid leukemia patients.
Haploinsufficiency for DNA methyltransferase 3A predisposes hematopoietic cells to myeloid malignancies.
Hepatic leukemia factor is a novel leukemic stem cell regulator in DNMT3A, NPM1, and FLT3-ITD triple-mutated AML.
High DNA methyltransferase DNMT3B levels: a poor prognostic marker in acute myeloid leukemia.
High DNA-methyltransferase 3B expression predicts poor outcome in acute myeloid leukemia, especially among patients with co-occurring NPM1 and FLT3 mutations.
High frequency of additional gene mutations in acute myeloid leukemia with MLL partial tandem duplication: DNMT3A mutation is associated with poor prognosis.
HOTAIR suppresses PTEN via DNMT3b and confers drug resistance in acute myeloid leukemia.
Hypomethylating Agents in the Treatment of Myelodysplastic Syndromes and Myeloid Leukemia.
Identification of Two DNMT3A Mutations Compromising Protein Stability and Methylation Capacity in Acute Myeloid Leukemia.
IDH1/2 but not DNMT3A mutations are suitable targets for minimal residual disease monitoring in acute myeloid leukemia patients: a study by the Acute Leukemia French Association.
Impact of the variant allele frequency of ASXL1, DNMT3A, JAK2, TET2, TP53, and NPM1 on the outcomes of patients with newly diagnosed acute myeloid leukemia.
Incidence and Prognostic Impact of DNMT3A Mutations in Korean Normal Karyotype Acute Myeloid Leukemia Patients.
Incidence and Prognostic Influence of DNMT3A Mutations in Acute Myeloid Leukemia.
Increased DNA methylation of Dnmt3b targets impairs leukemogenesis.
Influence of DNMT3A R882 mutations on AML prognosis determined by the allele ratio in Chinese patients.
Inhibition of DNA methyltransferase activates tumor necrosis factor alpha-induced monocytic differentiation in acute myeloid leukemia cells.
Inhibitors of DNA methylation in the treatment of hematological malignancies and MDS.
Interplay of RUNX1/MTG8 and DNA methyltransferase 1 in acute myeloid leukemia.
Investigation of screening method for DNMT3A mutations by high-resolution melting analysis in acute myeloid leukemia.
Lack of association of IDH1, IDH2 and DNMT3A mutations with outcome in older patients with acute myeloid leukemia treated with hypomethylating agents.
Landscape of Tumor Suppressor Mutations in Acute Myeloid Leukemia.
Leukemic mutations in the methylation-associated genes DNMT3A and IDH2 are rare events in pediatric AML: a report from the Children's Oncology Group.
Low frequency of mutations in Chinese with acute myeloid leukemia: Different disease or different aetiology?
Low-Dose Azacitidine with DNMT1 Level Monitoring to Treat Post-Transplantation Acute Myelogenous Leukemia or Myelodysplastic Syndrome Relapse.
MicroRNA -29b induces global DNA hypomethylation and tumor suppressor gene re-expression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1.
Molecular Evaluation of DNMT3A and IDH1/2 Gene Mutation: Frequency, Distribution Pattern and Associations with Additional Molecular Markers in Normal Karyotype Indian Acute Myeloid Leukemia Patients.
MUC1-C induces DNA methyltransferase 1 and represses tumor suppressor genes in acute myeloid leukemia.
Mutant DNMT3A clone evading chemotherapy and infiltrating central nervous system in a patient with molecularly good-risk acute myeloid leukemia.
Mutant DNMT3A in acute myeloid leukemia: guilty of inducing genetic instability?
Mutant DNMT3A: a marker of poor prognosis in acute myeloid leukemia.
Mutation Analysis of Isocitrate Dehydrogenase (IDH1/2) and DNA Methyltransferase 3A (DNMT3A) in Thai Patients with Newly Diagnosed Acute Myeloid Leukemia
Mutation profiling of 19 candidate genes in acute myeloid leukemia suggests significance of DNMT3A mutations.
Mutational analysis of DNMT3A gene in acute leukemias and common solid cancers.
Mutations in DNA Methyltransferase (DNMT3A) Observed in Acute Myeloid Leukemia Patients Disrupt Processive Methylation.
Mutations in DNMT3A and loss of RKIP are independent events in acute monocytic leukemia.
Mutations in DNMT3A, U2AF1, and EZH2 identify intermediate-risk acute myeloid leukemia patients with poor outcome after CR1.
Mutations in TET2 and DNMT3A genes are associated with changes in global and gene-specific methylation in acute myeloid leukemia.
Mutations in the DNA methyltransferase gene DNMT3A cause an overgrowth syndrome with intellectual disability.
Mutations in the DNMT3A DNA methyltransferase in AML patients cause both loss and gain of function and differential regulation by protein partners.
Mutations in the DNMT3A exon 23 independently predict poor outcome in older patients with acute myeloid leukemia: a SWOG report.
Next-generation sequencing of acute myeloid leukemia identifies the significance of TP53, U2AF1, ASXL1, and TET2 mutations.
Next-generation sequencing-based multigene mutational screening for acute myeloid leukemia using MiSeq: applicability for diagnostics and disease monitoring.
Noncanonical immune response to the inhibition of DNA methylation by Staufen1 via stabilization of endogenous retrovirus RNAs.
Novel approaches for myelodysplastic syndromes: beyond hypomethylating agents.
Novel DNMT3A Germline Variant in a Patient with Multiple Paragangliomas and Papillary Thyroid Carcinoma.
Novel impact of the DNMT3A R882H mutation on GSH metabolism in a K562 cell model established by TALENs.
On the potential role of DNMT1 in acute myeloid leukemia and myelodysplastic syndromes: not another mutated epigenetic driver.
Opposing effects of acute versus chronic inhibition of p53 on decitabine's efficacy in myeloid neoplasms.
Oral Azacitidine and Cedazuridine Approximate Parenteral Azacitidine Efficacy in Murine Model.
p53 and TDG are dominant in regulating the activity of the human de novo DNA methyltransferase DNMT3A on nucleosomes.
Persistent DNMT3A mutation burden in DNMT3A mutated adult cytogenetically normal acute myeloid leukemia patients in long-term remission.
Pharmacokinetic evaluation of decitabine for the treatment of leukemia.
PML-RARA requires DNA methyltransferase 3A to initiate acute promyelocytic leukemia.
Preliminary study on the role of miR?148a and DNMT1 in the pathogenesis of acute myeloid leukemia.
Prognostic and biologic significance of DNMT3B expression in older patients with cytogenetically normal primary acute myeloid leukemia.
Prognostic Impact of Concurrent DNMT3A, FLT3 and NPM1 Gene Mutations in Acute Myeloid Leukemia Patients.
Prognostic impact of DNMT3A mutation in acute myeloid leukemia with mutated NPM1.
Prognostic impact of DNMT3A mutations in patients with intermediate cytogenetic risk profile acute myeloid leukemia.
Prognostic significance of DNA methyltransferase 3A mutations in cytogenetically normal acute myeloid leukemia: a study by the Acute Leukemia French Association.
Prognostic significance of DNMT3A mutations in patients with acute myeloid leukemia.
Proteomic analysis identifies differentially expressed proteins in AML1/ETO acute myeloid leukemia cells treated with DNMT inhibitors azacitidine and decitabine.
Quantitative detection of DNMT3A R882H mutation in acute myeloid leukemia.
Rapid detection of DNMT3A R882 codon mutations allows early identification of poor risk patients with acute myeloid leukemia.
Rare occurrence of DNMT3A mutations in myelodysplastic syndromes.
Recurrent DNMT3A mutations in patients with myelodysplastic syndromes.
Recurrent DNMT3A R882 mutations in Chinese patients with acute myeloid leukemia and myelodysplastic syndrome.
Remethylation of Dnmt3a-/- hematopoietic cells is associated with partial correction of gene dysregulation and reduced myeloid skewing.
Retinoid-Sensitive Epigenetic Regulation of the Hoxb Cluster Maintains Normal Hematopoiesis and Inhibits Leukemogenesis.
Role of DNMT3A, TET2, and IDH1/2 mutations in pre-leukemic stem cells in acute myeloid leukemia.
Screening for mutation R882 in the DNMT3A gene in Chinese patients with hematological disease.
SHP2 inhibition reduces leukemogenesis in models of combined genetic and epigenetic mutations.
Silencing long non-coding RNA HOTAIR exerts anti-oncogenic effect on human acute myeloid leukemia via demethylation of HOXA5 by inhibiting Dnmt3b.
Silylation of Deoxynucleotide Analog Yields an Orally Available Drug with Antileukemia Effects.
Simpson's Paradox and the Impact of Different DNMT3A Mutations on Outcome in Younger Adults With Acute Myeloid Leukemia.
Simultaneous inhibition of DNA methyltransferase and histone deacetylase induces p53-independent apoptosis via down-regulation of Mcl-1 in acute myelogenous leukemia cells.
Structural basis for impairment of DNA methylation by the DNMT3A R882H mutation.
Study on the Immune Escape Mechanism of Acute Myeloid Leukemia With DNMT3A Mutation.
Synergistic inhibitory effects of low-dose decitabine in combination with bortezomib in the AML cell line Kasumi-1.
Tcl1 protein functions as an inhibitor of de novo DNA methylation in B-cell chronic lymphocytic leukemia (CLL).
The acute myeloid leukemia variant DNMT3A Arg882His is a DNMT3B-like enzyme.
The combination of FLT3 and DNA methyltransferase inhibition is synergistically cytotoxic to FLT3/ITD acute myeloid leukemia cells.
The DNA demethylating agent decitabine activates the TRAIL pathway and induces apoptosis in acute myeloid leukemia.
The DNA methylation inhibitor induces telomere dysfunction and apoptosis of leukemia cells that is attenuated by telomerase over-expression.
The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells.
The DNMT3A R882H mutant displays altered flanking sequence preferences.
The influence of DNMT3A and DNMT3B gene polymorphisms on acute myeloid leukemia risk in a Moroccan population.
The prevalence and clinical profiles of FLT3-ITD, FLT3-TKD, NPM1, C-KIT, DNMT3A, and CEBPA mutations in a cohort of patients with de novo acute myeloid leukemia from southwest China.
The R882H DNMT3A Mutation Associated with AML Dominantly Inhibits Wild-Type DNMT3A by Blocking Its Ability to Form Active Tetramers.
The R882H substitution in the human de novo DNA methyltransferase DNMT3A disrupts allosteric regulation by the tumor supressor p53.
The role of autophagy in targeted therapy for acute myeloid leukemia.
The spectrum of DNMT3A variants in Tatton-Brown-Rahman syndrome overlaps with that in hematologic malignancies.
Two Novel Methods for Rapid Detection and Quantification of DNMT3A R882 Mutations in Acute Myeloid Leukemia.
Variants of DNMT3A cause transcript-specific DNA methylation patterns and affect hematopoiesis.
[Analysis of prognosis of acute myeloid leukemia patients based on genetic mutations].
[Clonal haematopoiesis: A concise review].
[Detection of DNMT3a mutation in acute myelogenous leukemia and its clinical significance].
[DNMT3A gene mutations in acute myeloid leukemia].
[Effect of FLT3-ITD with DNMT3A R882 double-mutation on the prognosis of acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation].
[Effects of DNMT3A gene mutations on prognosis of patients with acute myeloid leukemia: a meta-analysis].
[Expression of DNMT gene in bone marrow of patients with acute myelogenous leukemia and its significance].
[Functional role of DNMT3A mutation in acute myeloid leukemia].
[Identification of novel pathogenic gene mutations in pediatric acute myeloid leukemia by whole-exome resequencing].
[Outcomes of refractory or relapsed DNMT3A + cytogenetically normal acute myeloid leukemia patients followed the therapy including decitabine combined with CAG or CAG-like regimen].
[The clinical characteristics and prognoses of de novo acute myeloid leukemia patients with DNA methyltransferase 3A gene mutations].
Leukemia, Myelomonocytic, Chronic
Acute Myeloid Leukemia With Recurrent Genetic Abnormalities Other Than Translocations.
Chronic myelomonocytic leukemia with double-mutations in DNMT3A and FLT3-ITD treated with decitabine and sorafenib.
DNA Methylation-Targeted Drugs.
DNMT3A Arg882 mutation drives chronic myelomonocytic leukemia through disturbing gene expression/DNA methylation in hematopoietic cells.
DNMT3A mutational analysis in primary myelofibrosis, chronic myelomonocytic leukemia and advanced phases of myeloproliferative neoplasms.
DNMT3A mutations are associated with inferior overall and leukemia-free survival in chronic myelomonocytic leukemia.
Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2 and DNMT3A.
Overexpression of Arginase 1 is linked to DNMT3A and TET2 mutations in lower-grade myelodysplastic syndromes and chronic myelomonocytic leukemia.
Spliceosomal gene mutations are frequent events in the diverse mutational spectrum of chronic myelomonocytic leukemia but largely absent in juvenile myelomonocytic leukemia.
Leukemia, Myelomonocytic, Juvenile
Abnormal promoter DNA methylation in juvenile myelomonocytic leukemia is not caused by mutation in DNMT3A.
Long-term serial xenotransplantation of juvenile myelomonocytic leukemia recapitulates human disease in Rag2-/-?c-/- mice.
Spliceosomal gene mutations are frequent events in the diverse mutational spectrum of chronic myelomonocytic leukemia but largely absent in juvenile myelomonocytic leukemia.
Leukemia, Plasma Cell
DNA-methylation analysis identifies the E-cadherin gene as a potential marker of disease progression in patients with monoclonal gammopathies.
Leukemia, Promyelocytic, Acute
Chinese Herbal Mixture, Tien-Hsien Liquid, Induces G2/M Cycle Arrest and Radiosensitivity in MCF-7 Human Breast Cancer Cells through Mechanisms Involving DNMT1 and Rad51 Downregulation.
Differentiation therapy in poor risk myeloid malignancies: Results of a dose finding study of the combination bryostatin-1 and GM-CSF.
Do AML patients with DNMT3A exon 23 mutations benefit from idarubicin as compared to daunorubicin? A single center experience.
PML-RARA requires DNA methyltransferase 3A to initiate acute promyelocytic leukemia.
Retinoic acid targets DNA-methyltransferases and histone deacetylases during APL blast differentiation in vitro and in vivo.
The Gene Expression Profile and DNA Methylation Pattern of CDH1 and DNMT1 Genes in Acute Promyelocytic Leukemia (APL).
The role of autophagy in targeted therapy for acute myeloid leukemia.
Leukemia, T-Cell
Epigenetic analysis of patients with T-ALL identifies poor outcomes and a hypomethylating agent-responsive subgroup.
Leukemia-Lymphoma, Adult T-Cell
North American ATLL has a distinct mutational and transcriptional profile and responds to epigenetic therapies.
Leukocytosis
Effect of DNMT3A variant allele frequency and double mutation on clinicopathologic features of patients with de novo AML.
Leukoplakia
Immunohistochemical expression of DNA methyltransferases 1, 3a and 3b in oral leukoplakias and squamous cell carcinomas.
Leukoplakia, Oral
Immunohistochemical expression of DNA methyltransferases 1, 3a and 3b in oral leukoplakias and squamous cell carcinomas.
Li-Fraumeni Syndrome
Epigenetic and functional analysis of IGFBP3 and IGFBPrP1 in cellular immortalization.
Lichen Planus, Oral
DNMT3B (C46359T) polymorphisms and immunoexpression of DNMT3b and DNMT1 proteins in oral lichen planus.
Liposarcoma
miR-193b-regulated signaling networks serve as tumor suppressors in liposarcoma and promote adipogenesis in adipose-derived stem cells.
Liver Cirrhosis
Angiogenic factor with G patch and FHA domains 1 (Aggf1) regulates liver fibrosis by modulating TGF-? signaling.
DNMT1 controls LncRNA H19/ERK signal pathway in hepatic stellate cell activation and fibrosis.
Epigenetic mechanisms and metabolic reprogramming in fibrogenesis: dual targeting of G9a and DNMT1 for the inhibition of liver fibrosis.
Epigenetic silencing of LncRNA ANRIL enhances liver fibrosis and HSC activation through activating AMPK pathway.
LncRNA-SNHG7/miR-29b/DNMT3A axis affects activation, autophagy and proliferation of hepatic stellate cells in liver fibrosis.
Methylation of RCAN1.4 mediated by DNMT1 and DNMT3b enhances hepatic stellate cell activation and liver fibrogenesis through Calcineurin/NFAT3 signaling.
Repression of Smad7 mediated by DNMT1 determines hepatic stellate cell activation and liver fibrosis in rats.
Salvianolic acid B-induced microRNA-152 inhibits liver fibrosis by attenuating DNMT1-mediated Patched1 methylation.
Sennoside A prevents liver fibrosis by binding DNMT1 and suppressing DNMT1-mediated PTEN hypermethylation in HSC activation and proliferation.
Sera DNA Methylation of CDH1, DNMT3b and ESR1 Promoters as Biomarker for the Early Diagnosis of Hepatitis B Virus-Related Hepatocellular Carcinoma.
The interaction between microRNA-152 and DNA methyltransferase-1 as an epigenetic prognostic biomarker in HCV-induced liver cirrhosis and HCC patients.
Liver Cirrhosis, Biliary
Primary Biliary Cholangitis in British Columbia First Nations: Clinical features and discovery of novel genetic susceptibility loci.
Liver Diseases
Expression of proteins upregulated in hepatocellular carcinoma in patients with alcoholic hepatitis (AH) compared to non-alcoholic steatohepatitis (NASH): An immunohistochemical analysis of candidate proteins.
Intestinal FGF15/19 physiologically repress hepatic lipogenesis in the late fed-state by activating SHP and DNMT3A.
Mechanism of drug-induced lupus. I. Cloned Th2 cells modified with DNA methylation inhibitors in vitro cause autoimmunity in vivo.
Liver Neoplasms
Antiproliferative Effects of Epigenetic Modifier Drugs Through E-cadherin Up-regulation in Liver Cancer Cell Lines.
Arsenic trioxide inhibits DNA methyltransferase and restores methylation-silenced genes in human liver cancer cells.
Correlative Analysis of DNA Methyltransferase Expression and Promoter Hypermethylation of Tumor Suppressor Genes in Hepatocellular Carcinoma.
DNA methyltransferase 3b silencing affects locus-specific DNA methylation and inhibits proliferation, migration and invasion in human hepatocellular carcinoma SMMC-7721 and BEL-7402 cells.
Expanding the Structural Diversity of DNA Methyltransferase Inhibitors.
Human hepatic cancer stem cells are characterized by common stemness traits and diverse oncogenic pathways.
LncRNA SNHG1 promotes liver cancer development through inhibiting p53 expression via binding to DNMT1.
miR-30a-3p inhibits the proliferation of liver cancer cells by targeting DNMT3a through the PI3K/AKT signaling pathway.
Overexpression of miR-450 affects the biological behavior of HepG2 cells by targeting DNMT3a.
The DNMT1/miR-34a/FOXM1 Axis Contributes to Stemness of Liver Cancer Cells.
[Growth inhibition and demethylation by a component of natural drug, CDP, in cancer cell lines]
Lung Injury
DNA methyltransferase inhibitor alleviates bleomycin-induced pulmonary inflammation.
Regulatory T Cell DNA Methyltransferase Inhibition Accelerates Resolution of Lung Inflammation.
Lung Neoplasms
?-elemene inhibited expression of DNA methyltransferase 1 through activation of ERK1/2 and AMPK? signalling pathways in human lung cancer cells: the role of Sp1.
? DNMT3B4-del Contributes to Aberrant DNA Methylation Patterns in Lung Tumorigenesis.
A novel DNMT3B subfamily, DeltaDNMT3B, is the predominant form of DNMT3B in non-small cell lung cancer.
A novel polymorphism in human cytosine DNA-methyltransferase-3B promoter is associated with an increased risk of lung cancer.
A regulatory circuit composed of DNA methyltransferases and receptor tyrosine kinases controls lung cancer cell aggressiveness.
Activation of SAPK/JNK mediated the inhibition and reciprocal interaction of DNA methyltransferase 1 and EZH2 by ursolic acid in human lung cancer cells.
An association of DNMT3b protein expression with P16INK4a promoter hypermethylation in non-smoking female lung cancer with human papillomavirus infection.
Association of DNMT3B -283T>C polymorphism with risk of lung and gastric cancer: a case-control study and a meta-analysis.
Associations of DNMT3B -149C>T and -2437T>A polymorphisms and lung cancer risk in Chinese population.
Cancer-type regulation of MIG-6 expression by inhibitors of methylation and histone deacetylation.
Chinese herbal medicine Xiaoji decoction inhibited growth of lung cancer cells through AMPK?-mediated inhibition of Sp1 and DNA methyltransferase 1.
Cigarette smoke induces demethylation of prometastatic oncogene synuclein-gamma in lung cancer cells by downregulation of DNMT3B.
Class I HDACs Are Mediators of Smoke Carcinogen-Induced Stabilization of DNMT1 and Serve as Promising Targets for Chemoprevention of Lung Cancer.
Combination of azacitidine and trichostatin A decreased the tumorigenic potential of lung cancer cells.
Combinations of DNA methyltransferase and histone deacetylase inhibitors induce DNA damage in small cell lung cancer cells: correlation of resistance with IFN-stimulated gene expression.
Corrigendum to "An association of DNMT3b protein expression with P16INK4a promoter hypermethylation in non-smoking female lung cancer with human papillomavirus infection" [Cancer Lett. 226 (1) (2005 Aug 8) 77-84].
Cucurbitacin B Alters the Expression of Tumor-Related Genes by Epigenetic Modifications in NSCLC and Inhibits NNK-Induced Lung Tumorigenesis.
Decitabine reverses TGF-?1-induced epithelial-mesenchymal transition in non-small-cell lung cancer by regulating miR-200/ZEB axis.
Decreased miRNA-148a is associated with lymph node metastasis and poor clinical outcomes and functions as a suppressor of tumor metastasis in non-small cell lung cancer.
Deletion of the de novo DNA methyltransferase Dnmt3a promotes lung tumor progression.
Delta DNMT3B variants regulate DNA methylation in a promoter-specific manner.
Depletion of DNA methyltransferase 1 and/or DNA methyltransferase 3b mediates growth arrest and apoptosis in lung and esophageal cancer and malignant pleural mesothelioma cells.
Determination of O(6)-Methylguanine DNA Methyltransferase Promoter Methylation in Non-Small Cell Lung Cancer.
Different susceptibility of increased DNMT1 expression by exposure to tobacco smoke according to histology in primary non-small cell lung cancer.
Disabled-2 and Axin are concurrently colocalized and underexpressed in lung cancers.
Dissecting epigenetic silencing complexity in the mouse lung cancer suppressor gene Cadm1.
DNA methyltransferase 3b contributes to oncogenic transformation induced by SV40T antigen and activated Ras.
DNA methyltransferase inhibition reverses epigenetically embedded phenotypes in lung cancer preferentially affecting polycomb target genes.
DNA methyltransferases messenger RNA expression and aberrant methylation of CpG islands in non-small-cell lung cancer: association and prognostic value.
DNMT Inhibitors Increase Methylation in the Cancer Genome.
DNMT1 promotes cell proliferation via methylating hMLH1 and hMSH2 promoters in EGFR-mutated non-small cell lung cancer.
Dnmt3a protects active chromosome domains against cancer-associated hypomethylation.
DNMT3B overexpression by deregulation of FOXO3a-mediated transcription repression and MDM2 overexpression in lung cancer.
DNMT3b polymorphism and hereditary nonpolyposis colorectal cancer age of onset.
DNMT3B polymorphisms and risk of primary lung cancer.
Downregulation of DNMT3A by miR-708-5p Inhibits Lung Cancer Stem Cell-like Phenotypes through Repressing Wnt/?-catenin Signaling.
Downregulation of RECK by promoter methylation correlates with lymph node metastasis in non-small cell lung cancer.
Dysregulation of p53/Sp1 control leads to DNA methyltransferase-1 overexpression in lung cancer.
Elevated mRNA levels of DNA methyltransferase-1 as an independent prognostic factor in primary nonsmall cell lung cancer.
Enhanced growth inhibition by combined DNA methylation/HDAC inhibitors in lung tumor cells with silenced CDKN2A.
Epigenetic Inactivation of the Tumor Suppressor IRX1 Occurs Frequently in Lung Adenocarcinoma and Its Silencing Is Associated with Impaired Prognosis.
Epigenetic mechanisms for silencing glutathione S-transferase m2 expression by hypermethylated specificity protein 1 binding in lung cancer.
Epigenetic Therapeutics and Their Impact in Immunotherapy of Lung Cancer.
Epigenetic-Based Biomarkers in the Malignant Transformation of BEAS-2B Cells Induced by Coal Tar Pitch Extract.
Essential role of DNA methyltransferase 1-mediated transcription of insulin-like Growth Factor 2 in Resistance to Histone Deacetylase Inhibitors.
Exploration of the relationship between DNA methyltransferase 1 and lung cancer screening.
Expression of methylation-related genes is associated with overall survival in patients with non-small cell lung cancer.
Expression of {Delta}DNMT3B Variants and Its Association with Promoter Methylation of p16 and RASSF1A in Primary Non-Small Cell Lung Cancer.
Genetic variations in epigenetic genes are predictors of recurrence in stage I or II non-small cell lung cancer patients.
Global identification of genes targeted by DNMT3b for epigenetic silencing in lung cancer.
H3K27me3 induces multidrug resistance in small cell lung cancer by affecting HOXA1 DNA methylation via regulation of the lncRNA HOTAIR.
Hypoxic-stabilized EPAS1 proteins transactivate DNMT1 and cause promoter hypermethylation and transcription inhibition of EPAS1 in non-small cell lung cancer.
Identification of DBCCR1 as a suppressor in the development of lung cancer that is associated with increased DNA methyltransferase 1.
IL-6 enriched lung cancer stem-like cell population by inhibition of cell cycle regulators via DNMT1 upregulation.
Increased cytosine DNA-methyltransferase activity is target-cell-specific and an early event in lung cancer.
Increased NQO1 but not c-MET and survivin expression in non-small cell lung carcinoma with KRAS mutations.
Inhibition of DNA methylation and histone deacetylation prevents murine lung cancer.
Inhibition of DNA methyltransferase 1 by RNA interference reverses epithelial-mesenchymal transition in highly metastatic 95D lung cancer cells by inhibiting the Wnt signaling pathway.
Inhibition of EZH2 via activation of SAPK/JNK and reduction of p65 and DNMT1 as a novel mechanism in inhibition of human lung cancer cells by polyphyllin I.
Integrated analysis of miRNAs and DNA methylation identifies miR-132-3p as a tumor suppressor in lung adenocarcinoma.
Interaction Of c-Jun And HOTAIR- Increased Expression Of p21 Converge In Polyphyllin I-Inhibited Growth Of Human Lung Cancer Cells.
Interplay between menin and K-Ras in regulating lung adenocarcinoma.
Lactate-fueled oxidative metabolism drives DNA methyltransferase 1-mediated transcriptional co-activator with PDZ binding domain protein activation.
LncRNA MIR210HG promotes proliferation and invasion of non-small cell lung cancer by upregulating methylation of CACNA2D2 promoter via binding to DNMT1.
LncRNA NEAT1 Interacted With DNMT1 to Regulate Malignant Phenotype of Cancer Cell and Cytotoxic T Cell Infiltration via Epigenetic Inhibition of p53, cGAS, and STING in Lung Cancer.
Long non-coding RNA AFAP1-AS1 plays an oncogenic role in promoting cell migration in non-small cell lung cancer.
Long noncoding RNA LINC00337 accelerates the non-small-cell lung cancer progression through inhibiting TIMP2 by recruiting DNMT1.
Loss of Dnmt3a and Dnmt3b does not affect epidermal homeostasis but promotes squamous transformation through PPAR-?.
MDM2 Overexpression Deregulates the Transcriptional Control of RB/E2F Leading to DNA Methyltransferase 3A Overexpression in Lung Cancer.
Methylation of RILP in lung cancer promotes tumor cell proliferation and invasion.
Methylation of Wnt7a Is Modulated by DNMT1 and Cigarette Smoke Condensate in Non-Small Cell Lung Cancer.
MicroRNA-101 suppresses progression of lung cancer through the PTEN/AKT signaling pathway by targeting DNA methyltransferase 3A.
MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B.
MicroRNA-30a-3p inhibits the progression of lung cancer via the PI3K/AKT by targeting DNA methyltransferase 3a.
miR-185 and miR-29a are similarly expressed in the bronchoalveolar lavage cells in IPF and lung cancer but common targets DNMT1 and COL1A1 show disease specific patterns.
miRSNPs of miR1274 and miR3202 Genes that Target MeCP2 and DNMT3b Are Associated with Lung Cancer Risk: A Study Conducted on MassARRAY Genotyping.
Mithramycin A inhibits DNA methyltransferase and metastasis potential of lung cancer cells.
Mutational analysis of DNMT3A gene in acute leukemias and common solid cancers.
Newly Synthesized DNA Methyltransferase Inhibitors as Radiosensitizers for Human Lung Cancer and Glioblastoma Cells.
No evidence of correlation between the single nucleotide polymorphism of DNMT3B promoter and gastric cancer risk in a Japanese population.
O6-Methylguanine-DNA methyltransferase hypermethylation modulated by 17beta-estradiol in lung cancer cells.
P16 methylation increases the sensitivity of cancer cells to the CDK4/6 inhibitor palbociclib.
Peperomin E reactivates silenced tumor suppressor genes in lung cancer cells via inhibition of DNA methyltransferase.
Polymorphisms in the DNA methyltransferase 3b gene and prostate cancer risk.
Prognostic significance of folate metabolism polymorphisms for lung cancer.
Promoter methylation status of tumor suppressor genes and inhibition of expression of DNA methyltransferase 1 in non-small cell lung cancer.
Quantitative O(6)-methylguanine DNA methyltransferase methylation analysis in curatively resected non-small cell lung cancer: associations with clinical outcome.
Restoration of miR-101 suppresses lung tumorigenesis through inhibition of DNMT3a-dependent DNA methylation.
RNA interference-mediated knockdown of DNA methyltransferase 1 leads to promoter demethylation and gene re-expression in human lung and breast cancer cells.
SGI-110 and entinostat therapy reduces lung tumor burden and reprograms the epigenome.
Silencing of miR-137 by aberrant promoter hypermethylation in surgically resected lung cancer.
Silibinin Synergizes with Histone Deacetylase and DNA Methyltransferase Inhibitors in Up-regulating E-cadherin Expression Together with Inhibition of Migration and Invasion of Human Non-small Cell Lung Cancer Cells.
Structural optimization of non-nucleoside DNA methyltransferase inhibitor as anti-cancer agent.
Targeting EP4 downstream c-Jun through ERK1/2-mediated reduction of DNMT1 reveals novel mechanism of solamargine-inhibited growth of lung cancer cells.
TGF-? induced EMT and stemness characteristics are associated with epigenetic regulation in lung cancer.
The DNA Methyltransferase 3B -149 Genetic Polymorphism Modulates Lung Cancer Risk from Smoking
The DNA Methyltransferase DNMT1 and Tyrosine-Protein Kinase KIT Cooperatively Promote Resistance to 5-Aza-2'-deoxycytidine (Decitabine) and Midostaurin (PKC412) in Lung Cancer Cells.
The DNMT3B -579 G>T promoter polymorphism and risk of lung cancer.
The DNMT3B -579G>T Polymorphism Is Significantly Associated With the Risk of Gastric Cancer but not Lung Cancer in Chinese Population.
The expression patterns and correlations of chibby, ?-catenin, and DNA methyltransferase-1 and their clinicopathological significance in lung cancers.
The inhibitory activity of gallic acid against DNA methylation: application of gallic acid on epigenetic therapy of human cancers.
The loss-of-function of DNA methyltransferase 1 by siRNA impairs the growth of non-small cell lung cancer with alleviated side effects via reactivation of RASSF1A and APC in vitro and vivo.
The Nonsteroidal Anti-Inflammatory Drug NS398 Reactivates SPARC Expression via Promoter Demethylation to Attenuate Invasiveness of Lung Cancer Cells.
The rs1550117 A>G variant in DNMT3A gene promoter significantly increases non-small cell lung cancer susceptibility in a Han Chinese population.
The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation and tumor suppressor gene hypermethylation in mice and lung cancer patients.
The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation in Laryngeal carcinoma.
Thyroid cancer 1 (C8orf4) shows high expression, no mutation and reduced methylation level in lung cancers, and its expression correlates with ?-catenin and DNMT1 expression and poor prognosis.
Unique Role for a DNA Methyltransferase Isoform in Lung Cancer.
Upregulation of SPP1 Is a Marker for Poor Lung Cancer Prognosis and Contributes to Cancer Progression and Cisplatin Resistance.
USP24 induces IL-6 in tumor-associated microenvironment by stabilizing p300 and ?-TrCP and promotes cancer malignancy.
[Expression and significance of DNA methyltransferase in sera of patients with lung cancer].
[High expression of DNMT1 was correlated with beta-catenin accumulation and malignant phynotype of lung squamous cell carcinoma and adenocarcinoma]
[Lung cancer and its epigenetics association with chronic obstructive pulmonary disease].
[Protein expressions of HDAC1 and DNMT1 in non-small-cell lung cancer and its clinical significance].
[Role of heterogeneous nuclear ribonucleoprotein A2/B1 protein in the pathogenesis of non-small cell lung cancer].
[The Relationship of Clinicopathology of p16 in Non-small Cell Lung Cancer and 5-nitrogen impurity-2'-deoxycytidine-nitrogen Impurity on the Influence of p16 Expression in Lung Cancer A549 Cells].
Lupus Erythematosus, Systemic
A correlation study on the effects of DNMT1 on methylation levels in CD4(+) T cells of SLE patients.
Analysis of associations between the patterns of global DNA hypomethylation and expression of DNA methyltransferase in patients with systemic lupus erythematosus.
Association analyses of DNA methyltransferase-1 (DNMT1) polymorphisms with systemic lupus erythematosus.
Associations between aberrant DNA methylation and transcript levels of DNMT1 and MBD2 in CD4+T cells from patients with systemic lupus erythematosus.
Decreased Expression of Serine/Arginine-Rich Splicing Factor 1 in T Cells From Patients With Active Systemic Lupus Erythematosus Accounts for Reduced Expression of RasGRP1 and DNA Methyltransferase 1.
Effect of 5-azacytidine and procainamide on CD3-zeta chain expression in Jurkat T cells.
Genetic variants of DNMT3A and systemic lupus erythematosus susceptibility.
Global DNA methylation, DNMT1, and MBD2 in patients with systemic lupus erythematosus.
Mesenchymal Stem Cells Activate the MEK/ERK Signaling Pathway and Enhance DNA Methylation via DNMT1 in PBMC from Systemic Lupus Erythematosus.
MicroRNA-126 regulates DNA methylation in CD4(+) T cells and contributes to systemic lupus erythematosus by targeting DNA methyltransferase 1.
MicroRNA-126 regulates DNA methylation in CD4+ T cells and contributes to systemic lupus erythematosus by targeting DNA methyltransferase 1.
MicroRNA-29b contributes to DNA hypomethylation of CD4+ T cells in systemic lupus erythematosus by indirectly targeting DNA methyltransferase 1.
Obesity promotes the global hypomethylation of CD4+ T cells in patients with systemic lupus erythematosus via downregulating DNMT1.
Possible role of DNA hypomethylation in the induction of SLE: relationship to the transcription of human endogenous retroviruses.
Prevalence of ZAP-70, LAT, SLP-76, and DNA methyltransferase 1 expression in CD4+ T cells of patients with systemic lupus erythematosus.
RFX1 regulates CD70 and CD11a expression in lupus T cells by recruiting the histone methyltransferase SUV39H1.
Transcript levels of DNA methyltransferases DNMT1, DNMT3A and DNMT3B in CD4+ T cells from patients with systemic lupus erythematosus.
Ultraviolet B enhances DNA hypomethylation of CD4+ T cells in systemic lupus erythematosus via inhibiting DNMT1 catalytic activity.
Ultraviolet B inhibition of DNMT1 activity via AhR activation dependent SIRT1 suppression in CD4+ T cells from systemic lupus erythematosus patients.
Lyme Disease
Characterization of a DNA Adenine Methyltransferase Gene of Borrelia hermsii and Its Dispensability for Murine Infection and Persistence.
Lymphatic Metastasis
Aberrant DNA methyltransferase 1 expression in clear cell renal cell carcinoma development and progression.
Clinical significance of the expression of DNA methyltransferase proteins in gastric cancer.
Clinicopathological significance and prognostic value of DNA methyltransferase 1, 3a, and 3b expressions in sporadic epithelial ovarian cancer.
Disabled-2 and Axin are concurrently colocalized and underexpressed in lung cancers.
DNA methyltransferase 1 inhibits O6-methylguanine-DNAmethyl-transferase-mediated cell growth and metastasis of hypopharyngeal squamous carcinoma.
DNA methyltransferase 1/3a overexpression in sporadic breast cancer is associated with reduced expression of estrogen receptor-alpha/breast cancer susceptibility gene 1 and poor prognosis.
DNA methyltransferase expression and DNA methylation of CPG islands and peri-centromeric satellite regions in human colorectal and stomach cancers.
DNMT3A overexpression is associated with aggressive behavior and enteroblastic differentiation of gastric adenocarcinoma.
Downregulation of microRNA-29c is associated with hypermethylation of tumor-related genes and disease outcome in cutaneous melanoma.
Effects of DNA methyltransferase 1 inhibition on esophageal squamous cell carcinoma.
Epigenetics and prostate cancer: defining the timing of DNA methyltransferase deregulation during prostate cancer progression.
Expression of ribonucleotide reductase M2 subunit in gastric cancer and effects of RRM2 inhibition in vitro.
Reactivation of the homeotic tumor suppressor gene CDX2 by 5-aza-2'-deoxycytidine-induced demethylation inhibits cell proliferation and induces caspase-independent apoptosis in gastric cancer cells.
Single nucleotide polymorphism in DNA methyltransferase 3B promoter and its association with gastric cardiac adenocarcinoma in North China.
[Expression of DNA methyltransferase 1, 3A and 3B mRNA in the epithelial ovarian carcinoma]
[Expression of DNMT3b in human bladder cancer tissue and its correlation with clinical prognosis].
[High expression of DNMT1 was correlated with beta-catenin accumulation and malignant phynotype of lung squamous cell carcinoma and adenocarcinoma]
Lymphocytic Choriomeningitis
DNA methylation by DNA methyltransferase 1 is critical for effector CD8 T cell expansion.
Lymphoma
6-Thioguanine and zebularine down-regulate DNMT1 and globally demethylate canine malignant lymphoid cells.
Activation and transposition of endogenous retroviral elements in hypomethylation induced tumors in mice.
An essential role for Dnmt1 in the prevention and maintenance of MYC-induced T-cell lymphomas.
Angioimmunoblastic T-cell lymphoma and myelodysplastic syndrome with mutations in TET2, DNMT3 and CUX1 - azacitidine induces only lymphoma remission.
Antineoplastic activity of the DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine in anaplastic large cell lymphoma.
Black raspberry-derived anthocyanins demethylate tumor suppressor genes through the inhibition of DNMT1 and DNMT3B in colon cancer cells.
Combination of a hypomethylating agent and inhibitors of PARP and HDAC traps PARP1 and DNMT1 to chromatin, acetylates DNA repair proteins, down-regulates NuRD and induces apoptosis in human leukemia and lymphoma cells.
Comprehensive analysis of clinical, pathological, and genomic characteristics of follicular helper T-cell derived lymphomas.
Detection of the circulating tumor DNAs in angioimmunoblastic T- cell lymphoma.
Dna methyltransferase 1 (DNMT1) gene activity in human lymphomas correlates with aberrant p53 gene expression.
DNA methyltransferase 1-mediated CpG methylation of the miR-150-5p promoter contributes to fibroblast growth factor receptor 1-driven leukemogenesis.
DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells.
Dnmt3a Is a Haploinsufficient Tumor Suppressor in CD8+ Peripheral T Cell Lymphoma.
Dnmt3a loss and Idh2 neomorphic mutations mutually potentiate malignant hematopoiesis.
Downregulation of miR-152 contributes to DNMT1-mediated silencing of SOCS3/SHP-1 in non-Hodgkin lymphoma.
Effects of R type and S type ginsenoside Rg3 on DNA methylation in human hepatocarcinoma cells.
Effects of SAHA and EGCG on Growth Potentiation of Triple-Negative Breast Cancer Cells.
Epigenetic biomarkers for human cancer: The time is now.
Exhausting circ_0136474 and Restoring miR-766-3p Attenuate Chondrocyte Oxidative Injury in IL-1?-Induced Osteoarthritis Progression Through Regulating DNMT3A.
Increased DNA methyltransferase 1 (DNMT1) gene expression in human lymphomas by fluorescent in situ hybridization.
Loss of Dnmt3a induces CLL and PTCL with distinct methylomes and transcriptomes in mice.
Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis.
Methylation-independent repression of Dnmt3b contributes to oncogenic activity of Dnmt3a in mouse MYC-induced T-cell lymphomagenesis.
Mutational analysis of DNMT3A gene in acute leukemias and common solid cancers.
Mutations found in cell-free DNAs of patients with malignant lymphoma at remission can derive from clonal hematopoiesis.
Myeloproliferative neoplasms: Current molecular biology and genetics.
Promoter Hypomethylation and Expression Is Conserved in Mouse Chronic Lymphocytic Leukemia Induced by Decreased or Inactivated Dnmt3a.
Properly substituted analogues of BIX-01294 lose inhibition of G9a histone methyltransferase and gain selective anti-DNA methyltransferase 3A activity.
Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas.
Somatic RHOA mutation in angioimmunoblastic T cell lymphoma.
Targeted next generation sequencing of breast implant-associated anaplastic large cell lymphoma reveals mutations in JAK/STAT signalling pathway genes, TP53 and DNMT3A.
The antitumor effects of arsenic trioxide in mantle cell lymphoma via targeting Wnt/??catenin pathway and DNA methyltransferase-1.
The Impact of DNA Methylation in Hematopoietic Malignancies.
[Current standard in diagnostic and therapy of peripheral T-cell lymphoma].
Lymphoma, B-Cell
AID assists DNMT1 to attenuate BCL6 expression through DNA methylation in diffuse large B-cell lymphoma cell lines.
Decreases in different Dnmt3b activities drive distinct development of hematologic malignancies in mice.
DNA methyltransferase deficiency modifies cancer susceptibility in mice lacking DNA mismatch repair.
DNA methyltransferase DNMT3b protein overexpression as a prognostic factor in patients with diffuse large B-cell lymphomas.
DNMT1 is associated with cell cycle and DNA replication gene sets in diffuse large B-cell lymphoma.
DNMT1 is predictive of survival and associated with Ki-67 expression in R-CHOP-treated diffuse large B-cell lymphomas.
Dnmt3b is a haploinsufficient tumor suppressor gene in Myc-induced lymphomagenesis.
Effects of R type and S type ginsenoside Rg3 on DNA methylation in human hepatocarcinoma cells.
Exhausting circ_0136474 and Restoring miR-766-3p Attenuate Chondrocyte Oxidative Injury in IL-1?-Induced Osteoarthritis Progression Through Regulating DNMT3A.
Hypermethylation of the DNA repair gene O(6)-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphoma.
Is inactivation of O(6)-methylguanine DNA methyltransferase still a favorable prognostic factor of patients with diffuse large B-cell lymphoma in the era of R-CHOP chemotherapy?
Overexpression of DNA methyltransferase 1 as a negative independent prognostic factor in primary gastrointestinal diffuse large B-cell lymphoma treated with CHOP-like regimen and rituximab.
Targeting the cancer epigenome: synergistic therapy with bromodomain inhibitors.
Triplet Therapy with PD-1 Blockade, Histone Deacetylase Inhibitor, and DNA Methyltransferase Inhibitor Achieves Radiological Response in Refractory Double-Expressor Diffuse Large B-cell Lymphoma with 17p Deletion.
Lymphoma, Large B-Cell, Diffuse
AID assists DNMT1 to attenuate BCL6 expression through DNA methylation in diffuse large B-cell lymphoma cell lines.
DNMT1 is associated with cell cycle and DNA replication gene sets in diffuse large B-cell lymphoma.
Hypermethylation of the DNA repair gene O(6)-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphoma.
Is inactivation of O(6)-methylguanine DNA methyltransferase still a favorable prognostic factor of patients with diffuse large B-cell lymphoma in the era of R-CHOP chemotherapy?
Overexpression of DNA methyltransferase 1 as a negative independent prognostic factor in primary gastrointestinal diffuse large B-cell lymphoma treated with CHOP-like regimen and rituximab.
Triplet Therapy with PD-1 Blockade, Histone Deacetylase Inhibitor, and DNA Methyltransferase Inhibitor Achieves Radiological Response in Refractory Double-Expressor Diffuse Large B-cell Lymphoma with 17p Deletion.
Lymphoma, Large-Cell, Anaplastic
Antineoplastic activity of the DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine in anaplastic large cell lymphoma.
Targeted next generation sequencing of breast implant-associated anaplastic large cell lymphoma reveals mutations in JAK/STAT signalling pathway genes, TP53 and DNMT3A.
Lymphoma, Mantle-Cell
The antitumor effects of arsenic trioxide in mantle cell lymphoma via targeting Wnt/??catenin pathway and DNA methyltransferase-1.
Lymphoma, Non-Hodgkin
Biochemical fractionation reveals association of DNA methyltransferase (Dnmt) 3b with Dnmt1 and that of Dnmt 3a with a histone H3 methyltransferase and Hdac1.
Downregulation of miR-152 contributes to DNMT1-mediated silencing of SOCS3/SHP-1 in non-Hodgkin lymphoma.
Inhibitors of histone deacetylase and DNA methyltransferase synergistically activate the methylated metallothionein I promoter by activating the transcription factor MTF-1 and forming an open chromatin structure.
Physical and functional interaction of DNA methyltransferase 3A with Mbd3 and Brg1 in mouse lymphosarcoma cells.
Suppression of metallothionein-I/II expression and its probable molecular mechanisms.
Lymphoma, T-Cell
A Survey of Somatic Mutations in 41 Genes in a Cohort of T-Cell Lymphomas Identifies Frequent Mutations in Genes Involved in Epigenetic Modification.
An essential role for Dnmt1 in the prevention and maintenance of MYC-induced T-cell lymphomas.
Angioimmunoblastic T-cell lymphoma and myelodysplastic syndrome with mutations in TET2, DNMT3 and CUX1 - azacitidine induces only lymphoma remission.
Clonal hematopoiesis in angioimmunoblastic T-cell lymphoma with divergent evolution to myeloid neoplasms.
Combined oral 5-azacytidine and romidepsin are highly effective in patients with PTCL: a multicenter phase 2 study.
DNMT3A(R882H) mutant and Tet2 inactivation cooperate in the deregulation of DNA methylation control to induce lymphoid malignancies in mice.
Epigenetic alterations in hematopoietic malignancies.
Identification of cell-type-specific mutations in nodal T-cell lymphomas.
Methylation-independent repression of Dnmt3b contributes to oncogenic activity of Dnmt3a in mouse MYC-induced T-cell lymphomagenesis.
Multi-gene epigenetic silencing of tumor suppressor genes in T-cell lymphoma cells; delayed expression of the p16 protein upon reversal of the silencing.
Recurrent mutations in epigenetic regulators, RHOA and FYN kinase in peripheral T cell lymphomas.
TET2 and DNMT3A mutations in human T-cell lymphoma.
The pathological features of angioimmunoblastic T-cell lymphomas with IDH2R172 mutations.
Lymphoma, T-Cell, Cutaneous
Decreases in different Dnmt3b activities drive distinct development of hematologic malignancies in mice.
Effects of SAHA and EGCG on Growth Potentiation of Triple-Negative Breast Cancer Cells.
Methylation status of the p15, p16 and MGMT promoter genes in primary cutaneous T-cell lymphomas.
Lymphoma, T-Cell, Peripheral
Dnmt3a Is a Haploinsufficient Tumor Suppressor in CD8+ Peripheral T Cell Lymphoma.
Epigenetic modifiers: basic understanding and clinical development.
Identification of cell-type-specific mutations in nodal T-cell lymphomas.
Lymphoproliferative Disorders
Chronic lymphoproliferative disorder of NK cells with TNFAIP3 and DNMT3A mutations.
Epigenetic biomarkers for human cancer: The time is now.
Macrophage Activation Syndrome
Association of Clonal Hematopoiesis of Indeterminate Potential With Inflammatory Gene Expression in Patients With Severe Degenerative Aortic Valve Stenosis or Chronic Postischemic Heart Failure.
Malaria
A novel class of selective non-nucleoside inhibitors of human DNA methyltransferase 3A.
Mastocytoma
DNA methyltransferase polypeptides in mouse and human cells.
Isolation and characterization of proteins that stimulate the activity of mammalian DNA methyltransferase.
Mouse DNA-cytosine-5-methyltransferase: sequence specificity of the methylation reaction and electron microscopy of enzyme-DNA complexes.
Purification and characterization of mammalian DNA methyltransferases by use of monoclonal antibodies.
Reduced methyl group acceptance of 1-beta-D-arabinofuranosylcytosine-containing DNA polymers.
Structure of mouse DNA (cytosine-5-)-methyltransferase.
Mastocytosis
Epigenetic Changes in Neoplastic Mast Cells and Potential Impact in Mastocytosis.
Single Nucleotide Polymorphism Array Lesions, TET2, DNMT3A, ASXL1 and CBL Mutations Are Present in Systemic Mastocytosis.
Mastocytosis, Systemic
Single Nucleotide Polymorphism Array Lesions, TET2, DNMT3A, ASXL1 and CBL Mutations Are Present in Systemic Mastocytosis.
Medulloblastoma
Biallelic epigenetic inactivation of the RASSF1A tumor suppressor gene in medulloblastoma development.
Effects of epigenetic modificators in combination with small molecule inhibitors of receptor tyrosine kinases on medulloblastoma growth.
Epigenetic deregulation of multiple S100 gene family members by differential hypomethylation and hypermethylation events in medulloblastoma.
Erratum to: The DNA methyltransferase inhibitor zebularine exerts antitumor effects and reveals BATF2 as a poor prognostic marker for childhood medulloblastoma.
Global analysis of the medulloblastoma epigenome identifies disease-subgroup-specific inactivation of COL1A2.
High expression of DNA methyltransferases in primary human medulloblastoma.
Identification of tumour-specific epigenetic events in medulloblastoma development by hypermethylation profiling.
MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-Enhancers at Tumor Suppressor Genes.
The DNA methyltransferase inhibitor zebularine exerts antitumor effects and reveals BATF2 as a poor prognostic marker for childhood medulloblastoma.
The first case report of medulloblastoma associated with Tatton-Brown-Rahman syndrome.
Melanoma
A gene expression signature identifying transient DNMT1 depletion as a causal factor of cancer-germline gene activation in melanoma.
A novel temozolomide analog, NEO212, with enhanced activity against MGMT-positive melanoma in vitro and in vivo.
An essential role for DNA methyltransferase 3a in melanoma tumorigenesis.
Berberine induces apoptosis in human multiple myeloma cell line U266 through hypomethylation of p53 promoter.
Cancer-type regulation of MIG-6 expression by inhibitors of methylation and histone deacetylation.
Comparative proteomics of human embryonic stem cells and embryonal carcinoma cells.
Correction: Ras and Rac1, frequently mutated in melanomas, are activated by superoxide anion, modulate Dnmt1 level and are causally related to melanocyte malignant transformation.
Cytotoxicity, DNA damage, and apoptosis induced by new fotemustine analogs on human melanoma cells in relation to O6-methylguanine DNA-methyltransferase expression.
Dissecting the role of RNA modification regulatory proteins in melanoma.
DNA methylation-induced E-cadherin silencing is correlated with the clinicopathological features of melanoma.
DNMT1 and DNMT3B genetic polymorphisms affect the clinical course and outcome of melanoma patients.
DNMT3b Modulates Melanoma Growth by Controlling Levels of mTORC2 Component RICTOR.
Downregulation of microRNA-29c is associated with hypermethylation of tumor-related genes and disease outcome in cutaneous melanoma.
DSS1 promoter hypomethylation and overexpression predict poor prognosis in melanoma and squamous cell carcinoma patients.
Epigenetic impacts of ascorbate on human metastatic melanoma cells.
Epigenetic regulation by decitabine of melanoma differentiation in vitro and in vivo.
Epigenetic regulation of the transcription factor Foxa2 directs differential elafin expression in melanocytes and melanoma cells.
Epigenetic silencing of TET2 and TET3 induces an EMT-like process in melanoma.
Expression of DNA Methyltransferase 1 Is a Hallmark of Melanoma, Correlating with Proliferation and Response to B-Raf and Mitogen-Activated Protein Kinase Inhibition in Melanocytic Tumors.
Genetic variants in RORA and DNMT1 associated with cutaneous melanoma survival.
Impact of DNA methyltransferases on the epigenetic regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor expression in malignant melanoma.
Induction of HLA-G expression in a melanoma cell line OCM-1A following the treatment with 5-aza-2'-deoxycytidine.
KRAS Genomic Status Predicts the Sensitivity of Ovarian Cancer Cells to Decitabine.
Metallothionein 1E is methylated in malignant melanoma and increases sensitivity to cisplatin-induced apoptosis.
Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis.
MGMT promoter methylation is associated with temozolomide response and prolonged progression-free survival in disseminated cutaneous melanoma.
MiR-211 is epigenetically regulated by DNMT1 mediated methylation and inhibits EMT of melanoma cells by targeting RAB22A.
O(6)-methylguanine DNA-methyltransferase (MGMT) overexpression in melanoma cells induces resistance to nitrosoureas and temozolomide but sensitizes to mitomycin C.
Promoter hypermethylation of the O(6)-methylguanine DNA methyltransferase gene and microsatellite instability in metastatic melanoma.
Randomized trial of the combination of lomeguatrib and temozolomide compared with temozolomide alone in chemotherapy naive patients with metastatic cutaneous melanoma.
Rare Stochastic Expression of O6-Methylguanine- DNA Methyltransferase (MGMT) in MGMT-Negative Melanoma Cells Determines Immediate Emergence of Drug-Resistant Populations upon Treatment with Temozolomide In Vitro and In Vivo.
Ras and Rac1, frequently mutated in melanomas, are activated by superoxide anion, modulate Dnmt1 level and are causally related to melanocyte malignant transformation.
Regulation of high molecular weight-melanoma associated antigen (HMW-MAA) gene expression by promoter DNA methylation in human melanoma cells.
Signature of VDR miRNAs and epigenetic modulation of vitamin D signaling in melanoma cell lines.
Spitz nevi and Spitzoid melanomas: exome sequencing and comparison with conventional melanocytic nevi and melanomas.
SUV39H1/DNMT3A-dependent methylation of the RB1 promoter stimulates PIN1 expression and melanoma development.
Synergistic silencing by promoter methylation and reduced AP-2? transactivation of the proapoptotic HRK gene confers apoptosis resistance and enhanced tumor growth.
Temozolomide chemoresistance heterogeneity in melanoma with different treatment regimens: DNA damage accumulation contribution.
TET2 and DNMT3A mutations and exceptional response to 4'-thio-2'-deoxycytidine in human solid tumor models.
The Brain Microenvironment Induces DNMT1 Suppression and Indolence of Metastatic Cancer Cells.
The Cancer/Testis Antigen Gene VCX2 Is Rarely Expressed in Malignancies but Can Be Epigenetically Activated Using DNA Methyltransferase and Histone Deacetylase Inhibitors.
Transient down-regulation of DNMT1 methyltransferase leads to activation and stable hypomethylation of MAGE-A1 in melanoma cells.
Trichostatin A and 5-aza-2'-deoxycytidine switch S1P from an inhibitor to a stimulator of motility through epigenetic regulation of S1P receptors.
Unbiased High-Throughput Drug Combination Pilot Screening Identifies Synergistic Drug Combinations Effective against Patient-Derived and Drug-Resistant Melanoma Cell Lines.
Melanoma, Experimental
Dnmt3a is required for the tumor stemness of B16 melanoma cells.
Melanosis
DNA Methyltransferases in Malar Melasma and Their Modification by Sunscreen in Combination with 4% Niacinamide, 0.05% Retinoic Acid, or Placebo.
Melioidosis
Host gene expression analysis in Sri Lankan melioidosis patients.
Memory Disorders
Age-related formaldehyde interferes with DNA methyltransferase function, causing memory loss in Alzheimer's disease.
Hippocampal chromatin-modifying enzymes are pivotal for scopolamine-induced synaptic plasticity gene expression changes and memory impairment.
Prolonged febrile seizures induce inheritable memory deficits in rats through DNA methylation.
Virus-mediated Dnmt1 and Dnmt3a deletion disrupts excitatory synaptogenesis and synaptic function in primary cultured hippocampal neurons.
Meningioma
Radiation-induced hypomethylation triggers urokinase plasminogen activator transcription in meningioma cells.
The role and regulatory mechanism of IL-1? on the methylation of the NF2 gene in benign meningiomas and leptomeninges.
Menopause, Premature
Premature Menopause, Clonal Hematopoiesis, and Coronary Artery Disease in Postmenopausal Women.
Mesothelioma
Asbestos Induces Epigenetic Repression of Ras Association Domain-Containing Protein 1, p16 Kinase 4a Inhibitor, and p14 Alternative Reading Frame in Normal Human Mesothelial Cells.
Decitabine, differently from DNMT1 silencing, exerts its antiproliferative activity through p21 upregulation in malignant pleural mesothelioma (MPM) cells.
Depletion of DNA methyltransferase 1 and/or DNA methyltransferase 3b mediates growth arrest and apoptosis in lung and esophageal cancer and malignant pleural mesothelioma cells.
Mesothelioma, Malignant
Asbestos Induces Epigenetic Repression of Ras Association Domain-Containing Protein 1, p16 Kinase 4a Inhibitor, and p14 Alternative Reading Frame in Normal Human Mesothelial Cells.
Decitabine, differently from DNMT1 silencing, exerts its antiproliferative activity through p21 upregulation in malignant pleural mesothelioma (MPM) cells.
Depletion of DNA methyltransferase 1 and/or DNA methyltransferase 3b mediates growth arrest and apoptosis in lung and esophageal cancer and malignant pleural mesothelioma cells.
Somatic Epigenetic Silencing of RIPK3 Inactivates Necroptosis and Contributes to Chemoresistance in Malignant Mesothelioma.
Zebularine exerts its antiproliferative activity through S phase delay and cell death in human malignant mesothelioma cells.
Metabolic Syndrome
Botanicals as epigenetic modulators for mechanisms contributing to development of metabolic syndrome.
Microcephaly
Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders.
Cytosine-5 RNA Methylation Regulates Neural Stem Cell Differentiation and Motility.
Monoclonal Gammopathy of Undetermined Significance
DNA-methylation analysis identifies the E-cadherin gene as a potential marker of disease progression in patients with monoclonal gammopathies.
Mouth Neoplasms
A novel melatonin-regulated lncRNA suppresses TPA-induced oral cancer cell motility through replenishing PRUNE2 expression.
MicroRNA-486-3p functions as a tumor suppressor in oral cancer by targeting DDR1.
MiR-30a and miR-379 modulate retinoic acid pathway by targeting DNA methyltransferase 3B in oral cancer.
Significance of DNMT3b in Oral Cancer.
Mucopolysaccharidosis I
Whole exome sequencing unravels disease-causing genes in consanguineous families in Qatar.
Multiple Endocrine Neoplasia
Tissue-specific induced DNA methyltransferase 1 (Dnmt1) in endocrine pancreas by RCAS-TVA-based somatic gene transfer system promotes ?-cell proliferation.
Multiple Endocrine Neoplasia Type 1
Tissue-specific induced DNA methyltransferase 1 (Dnmt1) in endocrine pancreas by RCAS-TVA-based somatic gene transfer system promotes ?-cell proliferation.
Multiple Myeloma
5-Azacytidine, a DNA methyltransferase inhibitor, induces ATR-mediated DNA double-strand break responses, apoptosis, and synergistic cytotoxicity with doxorubicin and bortezomib against multiple myeloma cells.
Design and Synthesis of Novel Epigenetic Inhibitors Targeting Histone Deacetylases, DNA Methyltransferase 1, and Lysine Methyltransferase G9a with In Vivo Efficacy in Multiple Myeloma.
DNA methylation inhibition in myeloma: Experience from a phase 1b study of low-dose continuous azacitidine in combination with lenalidomide and low-dose dexamethasone in relapsed or refractory multiple myeloma.
DNA methyltransferase inhibitors upregulate CD38 protein expression and enhance daratumumab efficacy in multiple myeloma.
DNA-methylation analysis identifies the E-cadherin gene as a potential marker of disease progression in patients with monoclonal gammopathies.
Epigenetic treatment of multiple myeloma mediates tumor intrinsic and extrinsic immunomodulatory effects.
HDAC3 regulates DNMT1 expression in multiple myeloma: therapeutic implications.
In vivo treatment with epigenetic modulating agents induces transcriptional alterations associated with prognosis and immunomodulation in multiple myeloma.
Knockdown of DNA methyltransferase-1 inhibits proliferation and derepresses tumor suppressor genes in myeloma cells.
Methylation of the Promoter Region of the Tight Junction Protein-1 by DNMT1 Induces EMT-like Features in Multiple Myeloma.
Mutational analysis of DNMT3A gene in acute leukemias and common solid cancers.
Myeloid-derived suppressor cells endow stem-like qualities to multiple myeloma cells by inducing piRNA-823 expression and DNMT3B activation.
The role of DNA damage and repair in decitabine-mediated apoptosis in multiple myeloma.
Muscular Atrophy
DNA methyltransferase 3a and mitogen-activated protein kinase signaling regulate the expression of fibroblast growth factor-inducible 14 (Fn14) during denervation-induced skeletal muscle atrophy.
Overexpression of Dnmt3a ameliorates diabetic muscle atrophy by modulating Pten/Akt pathway.
Reduced Dnmt3a increases Gdf5 expression with suppressed satellite cell differentiation and impaired skeletal muscle regeneration.
Muscular Atrophy, Spinal
SETX (senataxin), the helicase mutated in AOA2 and ALS4, functions in autophagy regulation.
Muscular Dystrophies
Hypomethylation is restricted to the D4Z4 repeat array in phenotypic FSHD.
Muscular Dystrophy, Facioscapulohumeral
A Pediatric Review of Facioscapulohumeral Muscular Dystrophy.
SMCHD1 regulates a limited set of gene clusters on autosomal chromosomes.
Myasthenia Gravis
Association of the DNMT3B -579G>T polymorphism with risk of thymomas in patients with myasthenia gravis.
Downregulation of DNMT3a expression by RNAi and its effect on NF-?Bs expression of thymic epithelial cells.
Myelodysplastic Syndromes
5-Aza-2'-Deoxycytidine and DNA Methyltransferase Inhibitors in the Treatment of Myeloid Leukemias and Myelodysplastic Syndromes: Biological Aspects and Clinical Results. Proceedings of a workshop. Rome, Italy, November 3, 1991.
5-Aza-4'-thio-2'-deoxycytidine, a new orally bioavailable non-toxic "best-in-class" DNMT1 depleting agent in clinical development.
5-Azacytidine Transiently Restores Dysregulated Erythroid Differentiation Gene Expression in TET2-Deficient Erythroleukemia Cells.
A carrier-mediated prodrug approach to improve the oral absorption of antileukemic drug decitabine.
Acquired elliptocytosis as presenting sign of a myelodysplastic syndrome associated with deletion of chromosome 20 and mutations in TET2, DNMT3A, and U2AF1.
An miRNA-DNMT1 Axis Is Involved in Azacitidine Resistance and Predicts Survival in Higher-Risk Myelodysplastic Syndrome and Low Blast Count Acute Myeloid Leukemia.
Angioimmunoblastic T-cell lymphoma and myelodysplastic syndrome with mutations in TET2, DNMT3 and CUX1 - azacitidine induces only lymphoma remission.
Azacitidine-Induced Pericarditis: A Case Series.
Azacytidine causes complex DNA methylation responses in myeloid leukemia.
Cedazuridine/decitabine: from preclinical to clinical development in myeloid malignancies.
Characterization of DNA demethylation effects induced by 5-Aza-2'-deoxycytidine in patients with myelodysplastic syndrome.
Chromatin Regulation by HP1? Contributes to Survival of 5-Azacytidine-Resistant Cells.
Clinical activity and safety of the dual pathway inhibitor rigosertib for higher risk myelodysplastic syndromes following DNA methyltransferase inhibitor therapy.
Clinical Advances in Hypomethylating Agents Targeting Epigenetic Pathways.
Comparison of 7-day azacitidine and 5-day decitabine for treating myelodysplastic syndrome.
Comparison of SF3B1/DNMT3A Comutations With DNMT3A or SF3B1 Mutation Alone in Myelodysplastic Syndrome and Clonal Cytopenia of Undetermined Significance.
Decitabine. MGI Pharma Inc/SuperGen Inc.
Depletion of ZBTB38 potentiates the effects of DNA demethylating agents in cancer cells via CDKN1C mRNA up-regulation.
Developmental DNA methyltransferase inhibitors in the treatment of gynecologic cancers.
Differentiation therapy in poor risk myeloid malignancies: Results of a dose finding study of the combination bryostatin-1 and GM-CSF.
DNA methylation changes following 5-azacitidine treatment in patients with myelodysplastic syndrome.
DNA Methylation-Targeted Drugs.
DNA methyltransferase and histone deacetylase inhibitors in the treatment of myelodysplastic syndromes.
DNA methyltransferase inhibitors in myelodysplastic syndrome.
DNA Methyltransferase Inhibitors in Myeloid Cancer: Clonal Eradication or Clonal Differentiation?
DNMT Inhibitors Increase Methylation in the Cancer Genome.
Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation.
DNMT3A mutations are rare in childhood acute myeloid leukaemia, myelodysplastic syndromes and juvenile myelomonocytic leukaemia.
DNMT3a mutations in high-risk myelodysplastic syndrome parallel those found in acute myeloid leukemia.
DNMT3A R882 mutations in patients with cytogenetically normal acute myeloid leukemia and myelodysplastic syndrome.
Dnmt3a regulates myeloproliferation and liver-specific expansion of hematopoietic stem and progenitor cells.
Dynamics of DNMT3A mutation and prognostic relevance in patients with primary myelodysplastic syndrome.
Effects of a novel DNA methyltransferase inhibitor zebularine on human breast cancer cells.
Effects of DNA methyltransferase inhibitors (DNMTIs) on MDS-derived cell lines.
Epigenetic biomarkers for human cancer: The time is now.
Epigenetic modifiers: basic understanding and clinical development.
Epigenetic therapy of cancer stem and progenitor cells by targeting DNA methylation machineries.
Epigenomic networking in drug development: from pathogenic mechanisms to pharmacogenomics.
Expression levels of DNA methyltransferase genes do not correlate with p15INK4B gene methylation in myelodysplastic syndromes.
Factors influencing epigenetic mechanisms and related diseases.
FLT3-ITD, NPM1, and DNMT3A Gene Mutations and Risk Factors in Normal Karyotype Acute Myeloid Leukemia and Myelodysplastic Syndrome Patients in Upper Northern Thailand
Hydralazine and magnesium valproate as epigenetic treatment for myelodysplastic syndrome. Preliminary results of a phase-II trial.
Hypomethylating Agents in the Treatment of Myelodysplastic Syndromes and Myeloid Leukemia.
Identification of novel DNA methylation inhibitors via a two-component reporter gene system.
IDH mutations are closely associated with mutations of DNMT3A, ASXL1 and SRSF2 in patients with myelodysplastic syndromes and are stable during disease evolution.
Impact of molecular mutations on treatment response to DNMT inhibitors in myelodysplasia and related neoplasms.
Increased CDA expression/activity in males contributes to decreased cytidine analog half-life and likely contributes to worse outcomes with 5-azacytidine or decitabine therapy.
Inhibitors of DNA methylation: beyond myelodysplastic syndromes.
Intragenic hypomethylation of DNMT3A in patients with myelodysplastic syndrome.
Long-term stability of demethylation after transient exposure to 5-aza-2'-deoxycytidine correlates with sustained RNA polymerase II occupancy.
Longitudinal Analysis of DNA Methylation in CD34+ Hematopoietic Progenitors in Myelodysplastic Syndrome.
Low-Dose Azacitidine with DNMT1 Level Monitoring to Treat Post-Transplantation Acute Myelogenous Leukemia or Myelodysplastic Syndrome Relapse.
MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation.
Mutations in genes affecting DNA methylation enhances responses to decitabine in patients with myelodysplastic syndrome.
New ways to use DNA methyltransferase inhibitors for the treatment of myelodysplastic syndrome.
Noncanonical immune response to the inhibition of DNA methylation by Staufen1 via stabilization of endogenous retrovirus RNAs.
Novel approaches for myelodysplastic syndromes: beyond hypomethylating agents.
On the potential role of DNMT1 in acute myeloid leukemia and myelodysplastic syndromes: not another mutated epigenetic driver.
Opposing effects of acute versus chronic inhibition of p53 on decitabine's efficacy in myeloid neoplasms.
Optimizing therapy with methylation inhibitors in myelodysplastic syndromes: dose, duration, and patient selection.
Oral Azacitidine and Cedazuridine Approximate Parenteral Azacitidine Efficacy in Murine Model.
Overexpression of Arginase 1 is linked to DNMT3A and TET2 mutations in lower-grade myelodysplastic syndromes and chronic myelomonocytic leukemia.
Persistence of DNMT3A mutations at long-term remission in adult patients with AML.
Pharmacokinetic evaluation of decitabine for the treatment of leukemia.
Phase I and II study of azacitidine in Japanese patients with myelodysplastic syndromes.
Phase II study of targeted therapy with temozolomide in acute myeloid leukaemia and high-risk myelodysplastic syndrome patients pre-screened for low O(6) -methylguanine DNA methyltransferase expression.
Prognostic value of DNMT3A mutations in myelodysplastic syndromes: a meta-analysis.
Proteomic analysis identifies differentially expressed proteins in AML1/ETO acute myeloid leukemia cells treated with DNMT inhibitors azacitidine and decitabine.
QbD Enabled Azacitidine Loaded Liposomal Nanoformulation and Its In Vitro Evaluation.
Rare mutations in DNMT3A in myeloproliferative neoplasms and myelodysplastic syndromes.
Rare occurrence of DNMT3A mutations in myelodysplastic syndromes.
Real-time nanoscale proteomic analysis of the novel multi-kinase pathway inhibitor rigosertib to measure the response to treatment of cancer.
Recurrent DNMT3A mutations in patients with myelodysplastic syndromes.
Recurrent DNMT3A R882 mutations in Chinese patients with acute myeloid leukemia and myelodysplastic syndrome.
Silylation of Deoxynucleotide Analog Yields an Orally Available Drug with Antileukemia Effects.
Six (or more) drugs in search of a mechanism: DNA methyltransferase and histone deacetylase inhibitors in the treatment of myelodysplastic syndromes.
Targeted TET oxidase activity through methyl-CpG-binding domain extensively suppresses cancer cell proliferation.
Tcl1 protein functions as an inhibitor of de novo DNA methylation in B-cell chronic lymphocytic leukemia (CLL).
TERT and DNMT1 expression predict sensitivity to decitabine in gliomas.
The clinical use of DNA methyltransferase inhibitors in myelodysplastic syndromes.
The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells.
The effects of 5-azacytidine on the function and number of regulatory T-cells and T-effectors in myelodysplastic syndrome.
The role of autophagy in targeted therapy for acute myeloid leukemia.
The role of RASSF1A methylation in cancer.
Treatment of myelodysplastic syndrome with a DNA methyltransferase inhibitor: lack of evidence for induction of chromosomal instability.
Up-regulation of DNA methyltransferases DNMT1, 3A, and 3B in myelodysplastic syndrome.
Utility of DNA methyltransferase inhibitors for the treatment of myelodysplastic syndromes.
[Clonal haematopoiesis: A concise review].
[Epigenetic cancer drugs and their role in anticancer therapy].
[The expression of DNA methyltransferase DNMT1, 3A and 3B in acute leukemia and myelodysplastic syndrome]
Myocardial Infarction
Clonal hematopoiesis of indeterminate potential-associated mutations and risk of comorbidities in patients with myelodysplastic syndrome.
DNA methylation regulates ?-smooth muscle actin expression during cardiac fibroblast differentiation.
Narcolepsy
A novel de novo exon 21 DNMT1 mutation causes cerebellar ataxia, deafness, and narcolepsy in a Brazilian patient.
A novel DNMT1 mutation associated with early onset hereditary sensory and autonomic neuropathy, cataplexy, cerebellar atrophy, scleroderma, endocrinopathy, and common variable immune deficiency.
Aberrant signature methylome by DNMT1 hot spot mutation in hereditary sensory and autonomic neuropathy 1E.
Autosomal dominant cerebellar ataxia, deafness, and narcolepsy (ADCA-DN) associated with progressive cognitive and behavioral deterioration.
Cerebellar Ataxia as a Common Clinical Presentation Associated with DNMT1 p.Y511H and a Review of the Literature.
DNA methyltransferase 1 mutations and mitochondrial pathology: is mtDNA methylated?
DNMT1 mutation hot spot causes varied phenotypes of HSAN1 with dementia and hearing loss.
EIF3G is associated with narcolepsy across ethnicities.
Genetic association, seasonal infections and autoimmune basis of narcolepsy.
Identification of a methylation profile for DNMT1-associated autosomal dominant cerebellar ataxia, deafness, and narcolepsy.
Mutations in DNMT1 cause autosomal dominant cerebellar ataxia, deafness and narcolepsy.
Narcolepsy is a common phenotype in HSAN IE and ADCA-DN.
Novel mutation in the replication focus targeting sequence domain of DNMT1 causes hereditary sensory and autonomic neuropathy IE.
Polysomnographic and neurometabolic features may mark preclinical autosomal dominant cerebellar ataxia, deafness, and narcolepsy due to a mutation in the DNA (cytosine-5-)-methyltransferase gene, DNMT1.
The autoimmune basis of narcolepsy.
Nasal Polyps
The Role of Epigenetics in the Chronic Sinusitis with Nasal Polyp.
Nasopharyngeal Carcinoma
Activation of DNA methyltransferase 1 by EBV LMP1 Involves c-Jun NH(2)-terminal kinase signaling.
Crucifera sulforaphane (SFN) inhibits the growth of nasopharyngeal carcinoma through DNA methyltransferase 1 (DNMT1)/Wnt inhibitory factor 1 (WIF1) axis.
DNMT1 mediates metabolic reprogramming induced by Epstein-Barr virus latent membrane protein 1 and reversed by grifolin in nasopharyngeal carcinoma.
Gene expression and promoter polymorphisms of DNA methyltransferase 3B in nasopharyngeal carcinomas in Taiwanese people: a case-control study.
Inhibition of DNA methyltransferase as a novel therapeutic strategy to overcome acquired resistance to dual PI3K/mTOR inhibitors.
Interplay of DNA methyltransferase 1 and EZH2 through inactivation of Stat3 contributes to ?-elemene-inhibited growth of nasopharyngeal carcinoma cells.
MiR-152 functioning as a tumor suppressor that interacts with DNMT1 in nasopharyngeal carcinoma.
MiR-29c regulates the expression of miR-34c and miR-449a by targeting DNA methyltransferase 3a and 3b in nasopharyngeal carcinoma.
O(6) -methylguanine DNA methyltransferase repairs platinum-DNA adducts following cisplatin treatment and predicts prognoses of nasopharyngeal carcinoma.
Radiation-Induced DNMT3B Promotes Radioresistance in Nasopharyngeal Carcinoma through Methylation of p53 and p21.
Neoplasm Metastasis
A novel FLI1 exonic circular RNA promotes metastasis in breast cancer by coordinately regulating TET1 and DNMT1.
Aberrant DNA methyltransferase 1 expression in clear cell renal cell carcinoma development and progression.
Alterations of metastasis-related genes identified using an oligonucleotide microarray of genistein-treated HCC1395 breast cancer cells.
An essential role for DNA methyltransferase 3a in melanoma tumorigenesis.
Chlorogenic Acid Decreases Malignant Characteristics of Hepatocellular Carcinoma Cells by Inhibiting DNMT1 Expression.
circ0093740 Promotes Tumor Growth and Metastasis by Sponging miR-136/145 and Upregulating DNMT3A in Wilms Tumor.
Clinical significance of the expression of DNA methyltransferase proteins in gastric cancer.
Clinicopathological significance and prognostic value of DNA methyltransferase 1, 3a, and 3b expressions in sporadic epithelial ovarian cancer.
Decreased miR-30b-5p expression by DNMT1 methylation regulation involved in gastric cancer metastasis.
Deep MicroRNA sequencing reveals downregulation of miR-29a in neuroblastoma central nervous system metastasis.
Deregulation between miR-29b/c and DNMT3A is associated with epigenetic silencing of the CDH1 gene, affecting cell migration and invasion in gastric cancer.
DNA methyltransferase 1 inhibits O6-methylguanine-DNAmethyl-transferase-mediated cell growth and metastasis of hypopharyngeal squamous carcinoma.
DNA methyltransferase 1/3a overexpression in sporadic breast cancer is associated with reduced expression of estrogen receptor-alpha/breast cancer susceptibility gene 1 and poor prognosis.
DNA methyltransferase 3A isoform b contributes to repressing E-cadherin through cooperation of DNA methylation and H3K27/H3K9 methylation in EMT-related metastasis of gastric cancer.
DNA methyltransferase expression and DNA methylation of CPG islands and peri-centromeric satellite regions in human colorectal and stomach cancers.
DNMT1 Regulates Epithelial-Mesenchymal Transition and Cancer Stem Cells, Which Promotes Prostate Cancer Metastasis.
DNMT1: A key drug target in triple-negative breast cancer.
Dnmt3a is required for the tumor stemness of B16 melanoma cells.
DNMT3A overexpression is associated with aggressive behavior and enteroblastic differentiation of gastric adenocarcinoma.
Downregulation of microRNA-29c is associated with hypermethylation of tumor-related genes and disease outcome in cutaneous melanoma.
Effects of Decitabine on Invasion and Exosomal Expression of miR-200c and miR-141 in Oxaliplatin-Resistant Colorectal Cancer Cells.
Effects of DNA methyltransferase 1 inhibition on esophageal squamous cell carcinoma.
Epigenetic Regulation of CXCL12 Plays a Critical Role in Mediating Tumor Progression and the Immune Response In Osteosarcoma.
Epigenetic regulation of HGF/Met receptor axis is critical for the outgrowth of bone metastasis from breast carcinoma.
Epigenetic silencing of PTPRR activates MAPK signaling, promotes metastasis and serves as a biomarker of invasive cervical cancer.
Epigenetic silencing of TET2 and TET3 induces an EMT-like process in melanoma.
Epigenetics and prostate cancer: defining the timing of DNA methyltransferase deregulation during prostate cancer progression.
Expression of DNA methylation-related proteins in metastatic breast cancer.
Expression of human DNA methyltransferase 1 in colorectal cancer tissues and their corresponding distant normal tissues.
Expression of ribonucleotide reductase M2 subunit in gastric cancer and effects of RRM2 inhibition in vitro.
EZH2-DNMT1-mediated epigenetic silencing of miR-142-3p promotes metastasis through targeting ZEB2 in nasopharyngeal carcinoma.
FOXC1 promotes HCC proliferation and metastasis by Upregulating DNMT3B to induce DNA Hypermethylation of CTH promoter.
Functions and Epigenetic Regulation of Wwox in Bone Metastasis from Breast Carcinoma: Comparison with Primary Tumors.
GAD1 Upregulation Programs Aggressive Features of Cancer Cell Metabolism in the Brain Metastatic Microenvironment.
Grifolin directly targets ERK1/2 to epigenetically suppress cancer cell metastasis.
Human breast cancer progression can be regulated by dominant trans-acting factors in somatic cell hybridization studies.
IL-8 suppresses E-cadherin expression in nasopharyngeal carcinoma cells by enhancing E-cadherin promoter DNA methylation.
Inhibition of DNA methyltransferase 1 by RNA interference reverses epithelial-mesenchymal transition in highly metastatic 95D lung cancer cells by inhibiting the Wnt signaling pathway.
Inhibition of DNA methyltransferase activity prevents tumorigenesis in a mouse model of prostate cancer.
lncRNA H19 regulates epithelial-mesenchymal transition and metastasis of bladder cancer by miR-29b-3p as competing endogenous RNA.
Long non-coding RNA HCP5 functions as a sponge of miR-29b-3p and promotes cell growth and metastasis in hepatocellular carcinoma through upregulating DNMT3A.
Loss of Chromatin Remodeling Proteins and/or CDKN2A Associates With Metastasis of Pancreatic Neuroendocrine Tumors and Reduced Patient Survival Times.
Loss of exosomal miR-148b from cancer-associated fibroblasts promotes endometrial cancer cell invasion and cancer metastasis.
Manipulation of prostate cancer metastasis by locus-specific modification of the CRMP4 promoter region using chimeric TALE DNA methyltransferase and demethylase.
Methylation-Induced Silencing of ALDH2 Facilitates Lung Adenocarcinoma Bone Metastasis by Activating the MAPK Pathway.
MicroRNA-330-3p promotes cell invasion and metastasis in non-small cell lung cancer through GRIA3 by activating MAPK/ERK signaling pathway.
miR-200b restoration and DNA methyltransferase inhibitor block lung metastasis of mesenchymal-phenotype hepatocellular carcinoma.
miR-492 promotes chemoresistance to CDDP and metastasis by targeting inhibiting DNMT3B and induces stemness in gastric cancer.
Missing in metastasis B, regulated by DNMT1, functions as a putative cancer suppressor in human lung giant-cell carcinoma.
Mithramycin A inhibits DNA methyltransferase and metastasis potential of lung cancer cells.
Modulation of E-cadherin expression by K-Ras; involvement of DNA methyltransferase-3b.
MTSS1, a novel target of DNA methyltransferase 3B, functions as a tumor suppressor in hepatocellular carcinoma.
Mutations in DNMT3A and loss of RKIP are independent events in acute monocytic leukemia.
Novel long noncoding RNA NMR promotes tumor progression via NSUN2 and BPTF in esophageal squamous cell carcinoma.
NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation.
Opposing roles of Dnmt1 in early- and late-stage murine prostate cancer.
Over-expression of DNMT3A predicts the risk of recurrent vulvar squamous cell carcinomas.
Physcion 8-O-?-glucopyranoside suppresses the metastasis of breast cancer in vitro and in vivo by modulating DNMT1.
Promoter polymorphisms of DNMT3B and the risk of head and neck squamous cell carcinoma in Taiwan: a case-control study.
Reactivation of the homeotic tumor suppressor gene CDX2 by 5-aza-2'-deoxycytidine-induced demethylation inhibits cell proliferation and induces caspase-independent apoptosis in gastric cancer cells.
Retraction Note to: Physcion 8-O-?-glucopyranoside suppresses the metastasis of breast cancer in vitro and in vivo by modulating DNMT1.
Silencing DNA methyltransferase 1 (DNMT1) inhibits proliferation, metastasis and invasion in ESCC by suppressing methylation of RASSF1A and DAPK.
Silencing of the Metastasis Suppressor RECK by RAS Oncogene Is Mediated by DNA Methyltransferase 3b-Induced Promoter Methylation.
Targeted inhibition of genome-wide DNA methylation analysis in epigenetically modulated phenotypes in lung cancer.
The expression and clinical significance of DNA methyltransferase proteins in human gastric cancer.
The Interplay Between miR-148a and DNMT1 Might be Exploited for Pancreatic Cancer Therapy.
The long noncoding RNA LUCAT1 promotes tumorigenesis by controlling ubiquitination and stability of DNA methyltransferase 1 in esophageal squamous cell carcinoma.
The role of DNA methyltransferase 3b in esophageal squamous cell carcinoma.
Transcriptional repression of SOCS3 mediated by IL-6/STAT3 signaling via DNMT1 promotes pancreatic cancer growth and metastasis.
[Expression of DNMT3b in human bladder cancer tissue and its correlation with clinical prognosis].
[High expression of DNMT1 was correlated with beta-catenin accumulation and malignant phynotype of lung squamous cell carcinoma and adenocarcinoma]
[High expression of DNMT3B promotes proliferation and invasion of hepatocellular carcinoma cells via Hippo signaling pathway].
Neoplasm, Residual
DNMT3A mutant transcript levels persist in remission and do not predict outcome in patients with acute myeloid leukemia.
DNMT3A mutations and prognostic significance in childhood acute lymphoblastic leukemia.
DNMT3A mutations in acute myeloid leukemia: stability during disease evolution and clinical implications.
IDH1/2 but not DNMT3A mutations are suitable targets for minimal residual disease monitoring in acute myeloid leukemia patients: a study by the Acute Leukemia French Association.
Integrated epigenetic and genetic analysis identifies markers of prognostic significance in pediatric acute myeloid leukemia.
Limited role for extended maintenance temozolomide for newly diagnosed glioblastoma.
Persistence of DNMT3A mutations at long-term remission in adult patients with AML.
Predictive factors for the sensitivity of radiotherapy and prognosis of esophageal squamous cell carcinoma.
Two Novel Methods for Rapid Detection and Quantification of DNMT3A R882 Mutations in Acute Myeloid Leukemia.
Neoplasms
3,6-Dihydroxyflavone regulates microRNA-34a through DNA methylation.
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone Induces Retinoic Acid Receptor ? Hypermethylation through DNA Methyltransferase 1 Accumulation in Esophageal Squamous Epithelial Cells.
5,6 Dihydro-5'-azacytidine (DHAC) restores androgen responsiveness in androgen-insensitive prostate cancer cells.
5-Aza-2'-deoxycytidine induces a greater inflammatory change, at the molecular levels, in normoxic than hypoxic tumor microenvironment.
5-Aza-2'-deoxycytidine-induced genome rearrangements are mediated by DNMT1.
5-Aza-4'-thio-2'-deoxycytidine, a new orally bioavailable non-toxic "best-in-class" DNMT1 depleting agent in clinical development.
5-Azacytidine inhibits aflatoxin biosynthesis in Aspergillus flavus
5-Azacytidine prevents cisplatin induced nephrotoxicity and potentiates anticancer activity of cisplatin by involving inhibition of metallothionein, pAKT and DNMT1 expression in chemical induced cancer rats.
A catalytic dependent role for DNMT3B in tumor suppression.
A colorimetric assay of DNA methyltransferase activity based on peroxidase mimicking of DNA template Ag/Pt bimetallic nanoclusters.
A colorimetric assay of DNA methyltransferase activity based on the keypad lock of duplex DNA modified meso-SiO2@Fe3O4.
A Comparative Study on the In Vitro Effects of the DNA Methyltransferase Inhibitor 5-Azacytidine (5-AzaC) in Breast/Mammary Cancer of Different Mammalian Species.
A comprehensive analysis of radiosensitization targets; functional inhibition of DNA methyltransferase 3B radiosensitizes by disrupting DNA damage regulation.
A Comprehensive Prognostic and Immune Analysis of SLC41A3 in Pan-Cancer.
A concern regarding the current confusion with the human homolog of mouse Np95, ICBP90/UHRF1.
A DNA aptamer for binding and inhibition of DNA methyltransferase 1.
A DNA as a Substrate and an Enzyme: Direct Profiling of Methyltransferase Activity by Cytosine Methylation of a DNAzyme.
A DNA methylation signature associated with aberrant promoter DNA hypermethylation of DNMT3B in human colorectal cancer.
A dual amplification fluorescent strategy for sensitive detection of DNA methyltransferase activity based on strand displacement amplification and DNAzyme amplification.
A feedback loop: Interactions between Inflammatory Signals and Clonal Hematopoiesis in Cardiovascular Disease.
A high-throughput screen of pharmacologically active compounds for inhibitors of UHRF1 reveals epigenetic activity of anthracycline derivative chemotherapeutic drugs.
A Human Adult Stem Cell Signature Marks Aggressive Variants across Epithelial Cancers.
A long intergenic non-coding RNA regulates nuclear localization of DNA methyl transferase-1.
A mass balance and disposition study of the DNA methyltransferase inhibitor zebularine (NSC 309132) and three of its metabolites in mice.
A Meta-Analysis of the Association between DNMT1 Polymorphisms and Cancer Risk.
A methylation-blocked cascade amplification strategy for label-free colorimetric detection of DNA methyltransferase activity.
A microassay for measuring cytosine DNA methyltransferase activity during tumor progression.
A microchip electrophoretic assay for DNA methyltransferase activity based on methylation-sensitive endonuclease Dpn?.
A miR-199a/miR-214 self-regulatory network via PSMD10, TP53 and DNMT1 in testicular germ cell tumor.
A Model System for Studying the DNMT3A Hotspot Mutation (DNMT3AR882) Demonstrates a Causal Relationship between Its Dominant-Negative Effect and Leukemogenesis.
A multifactorial signature of DNA sequence and polycomb binding predicts aberrant CpG island methylation.
A New Class of Quinoline-Based DNA Hypomethylating Agents Reactivates Tumor Suppressor Genes by Blocking DNA Methyltransferase 1 Activity and Inducing Its Degradation.
A new tumor suppressor LncRNA ADAMTS9-AS2 is regulated by DNMT1 and inhibits migration of glioma cells.
A Novel 85-Gene Expression Signature Predicts Unfavorable Prognosis in Acute Myeloid Leukemia.
A novel DNA biosensor for the ultrasensitive detection of DNA methyltransferase activity based on a high-density "hot spot" SERS substrate and rolling circle amplification strategy.
A novel DNA methyltransferase I-derived peptide eluted from soluble HLA-A*0201 induces peptide-specific, tumor-directed cytotoxic T cells.
A Novel DNMT3B Splice Variant Expressed in Tumor and Pluripotent Cells Modulates Genomic DNA Methylation Patterns and Displays Altered DNA Binding.
A Novel Functional TagSNP Rs7560488 in the DNMT3A1 Promoter Is Associated with Susceptibility to Gastric Cancer by Modulating Promoter Activity.
A novel label-free fluorescence strategy for methyltransferase activity assay based on dsDNA-templated copper nanoparticles coupled with an endonuclease-assisted signal transduction system.
A novel polymorphism in human cytosine DNA-methyltransferase-3B promoter is associated with an increased risk of lung cancer.
A novel signal-off photoelectrochemical biosensor for M.SssI MTase activity assay based on GQDs@ZIF-8 polyhedra as signal quencher.
A novel somatic MAPK1 mutation in primary ovarian mixed germ cell tumors.
A novel temozolomide analog, NEO212, with enhanced activity against MGMT-positive melanoma in vitro and in vivo.
A phase 1 and pharmacodynamic study of decitabine in combination with carboplatin in patients with recurrent, platinum-resistant, epithelial ovarian cancer.
A phase 1 trial of the oral DNA methyltransferase inhibitor CC-486 and the histone deacetylase inhibitor romidepsin in advanced solid tumors.
A phase I pharmacokinetic and pharmacodynamic study of the DNA methyltransferase 1 inhibitor MG98 administered twice weekly.
A pilot clinical trial of oral tetrahydrouridine/decitabine for noncytotoxic epigenetic therapy of chemoresistant lymphoid malignancies.
A potential role for epigenetic modulatory drugs in the enhancement of cancer/germ-line antigen vaccine efficacy.
A Potential Role for Epigenetic Modulatory Drugs in the Enhancement of Cancer/Germ-Line Antigen Vaccine Efficacy.
A primer for epigenetics of hematological malignancies.
A prospective study of duration of smoking cessation and colorectal cancer risk by epigenetics-related tumor classification.
A recombinant reporter system for monitoring reactivation of an endogenously DNA hypermethylated gene.
A regulatory circuit composed of DNA methyltransferases and receptor tyrosine kinases controls lung cancer cell aggressiveness.
A regulatory circuit of miR-148a/152 and DNMT1 in modulating cell transformation and tumor angiogenesis through IGF-IR and IRS1.
A robust and rapid liquid chromatography tandem mass spectrometric method for the quantitative analysis of 5-azacytidine.
A signal-on fluorescence based biosensing platform for highly sensitive detection of DNA methyltransferase enzyme activity and inhibition.
A STUDY OF THE RELATIONSHIP BETWEEN LEVELS OF METHYLTRANSFERASES IN PERIPHERAL BLOOD MONONUCLEAR CELLS AND CHARACTERISTICS OF TUMOR IN PATIENTS WITH DUCTAL INVASIVE CARCINOMA OF BREAST.
A subgroup of pancreatic adenocarcinoma is sensitive to the 5-aza-dC DNA methyltransferase inhibitor.
A superstructure-based electrochemical assay for signal-amplified detection of DNA methyltransferase activity.
A Systematic Pan-Cancer Analysis of Genetic Heterogeneity Reveals Associations with Epigenetic Modifiers.
Aberrant DNA hypermethylation patterns lead to transcriptional silencing of tumor suppressor genes in UVB-exposed skin and UVB-induced skin tumors of mice.
Aberrant DNA methylation-induced gene inactivation is associated with the diagnosis and/or therapy of T-cell leukemias.
Aberrant DNA methyltransferase 1 expression in clear cell renal cell carcinoma development and progression.
Aberrant epigenetic modifications in hepatocarcinogenesis induced by hepatitis B virus X protein.
Aberrant Epigenetic Modifications of LPHN2 Function as a Potential Cisplatin-specific Biomarker for Human Gastrointestinal Cancer.
Aberrant Methylation-Mediated Silencing of lncRNA MEG3 Functions as a ceRNA in Esophageal Cancer.
Abnormal regional hypermethylation in cancer cells.
Abnormal regulation of DNA methyltransferase expression during colorectal carcinogenesis.
Abnormal RNA splicing and genomic instability after induction of DNMT3A mutations by CRISPR/Cas9 gene editing.
Absence of DICER1, CTCF, RPL22, DNMT3A, TRRAP, IDH1 and IDH2 hotspot mutations in patients with various subtypes of ovarian carcinomas.
Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation.
Acquired Mitochondrial Abnormalities, Including Epigenetic Inhibition of Superoxide Dismutase 2, in Pulmonary Hypertension and Cancer: Therapeutic Implications.
Activated leukocyte cell adhesion molecule is expressed in neuroepithelial neoplasms and decreases with tumor malignancy, matrix metalloproteinase 2 expression, and absence of IDH1R132H mutation.
Activated MEK/ERK Pathway Drives Widespread and Coordinated Overexpression of UHRF1 and DNMT1 in Cancer cells.
Activation and transposition of endogenous retroviral elements in hypomethylation induced tumors in mice.
Activation of DNA methyltransferase 1 by EBV latent membrane protein 2A leads to promoter hypermethylation of PTEN gene in gastric carcinoma.
Activation of DNA methyltransferase 1 by EBV LMP1 Involves c-Jun NH(2)-terminal kinase signaling.
Activation of mammalian DNA methyltransferase by cleavage of a Zn binding regulatory domain.
Activation of silenced tumor suppressor genes in prostate cancer cells by a novel energy restriction-mimetic agent.
Activation of the p53 DNA damage response pathway after inhibition of DNA methyltransferase by 5-aza-2'-deoxycytidine.
Acute myeloid leukaemia in a case with Tatton-Brown-Rahman syndrome: the peculiar DNMT3A R882 mutation.
ADAMTS8 is frequently down-regulated in colorectal cancer and functions as a tumor suppressor.
Administration of metformin alleviates atherosclerosis by promoting H2S production via regulating CSE expression.
Adoptive transfer of immature myeloid cells lacking NF-?B p50 (p50-IMC) impedes the growth of MHC-matched high-risk neuroblastoma.
Age and gender affect DNMT3a and DNMT3b expression in human liver.
Age-related clonal haemopoiesis is associated with increased epigenetic age.
AID assists DNMT1 to attenuate BCL6 expression through DNA methylation in diffuse large B-cell lymphoma cell lines.
AID downregulation is a novel function of the DNMT inhibitor 5-aza-deoxycytidine.
Alteration of DNA methyltransferases contributes to 5'CpG methylation and poor prognosis in lung cancer.
Alterations of DNA methylation and clinicopathological diversity of human cancers.
Alterations of regulatory factors and DNA methylation pattern in thyroid cancer.
Alterations to DNMT3A in Hematologic Malignancies.
Altered DNA methyltransferases promoter methylation and mRNA expression are associated with tamoxifen response in breast tumors.
Altered methylation of multiple genes in carcinogenesis of the prostate.
AML-Associated Mutations in DNA Methyltransferase DNMT3A.
An Effective Epigenetic-PARP inhibitor Combination Therapy for Breast and Ovarian Cancers Independent of BRCA-mutations.
An epigenetic regulator-related score (EpiScore) predicts survival in patients with diffuse large B cell lymphoma and identifies patients who may benefit from epigenetic therapy.
An essential role for DNA methyltransferase 3a in melanoma tumorigenesis.
An essential role for DNA methyltransferase DNMT3B in cancer cell survival.
An essential role for Dnmt1 in the prevention and maintenance of MYC-induced T-cell lymphomas.
An improved synthesis of psammaplin A.
An integrated epigenetic and genetic analysis of DNA methyltransferase genes (DNMTs) in tumor resistant and susceptible chicken lines.
An ultrasensitive high throughput screen for DNA methyltransferase 1-targeted molecular probes.
Analysis of the PD-1 Ligands Among Gastrointestinal Cancer Patients: Focus on Cancer Immunity.
Anti-invasive effects of decitabine, a DNA methyltransferase inhibitor, through tightening of tight junctions and inhibition of matrix metalloproteinase activities in AGS human gastric carcinoma cells.
Anti-neoplastic and demethylating activity of a newly synthetized flavanone-derived compound in Renal Cell Carcinoma cell lines.
Anticancer agents based on vulnerable components in a signalling pathway.
Anticancer drugs induce hypomethylation of the acetylcholinesterase promoter via a phosphorylated-p38-DNMT1-AChE pathway in apoptotic hepatocellular carcinoma cells.
Anticancer potential of naturally occurring immunoepigenetic modulators: A promising avenue?
Antiproliferative effects of DNA methyltransferase 3B depletion are not associated with DNA demethylation.
Antroquinonol D, isolated from Antrodia camphorata, with DNA demethylation and anticancer potential.
Anxiety is associated with higher levels of global DNA methylation and altered expression of epigenetic and interleukin-6 genes.
Application of mRNA regulatory regions to improve tumor specificity of transgene expression.
Array-based approaches for the identification of epigenetic silenced tumor suppressor genes.
Arsenic exposure disrupts epigenetic regulation of SIRT1 in human keratinocytes.
Artesunate Suppresses the Growth of Prostatic Cancer Cells through Inhibiting Androgen Receptor.
Association between serum concentrations of perfluoroalkyl substances (PFAS) and expression of serum microRNAs in a cohort highly exposed to PFAS from drinking water.
Association of DNMT1 gene polymorphisms in exons with sporadic infiltrating ductal breast carcinoma among chinese han women in the Heilongjiang province.
Association of DNMT3B -283 T > C and -579 G > T polymorphisms with decreased cancer risk: evidence from a meta-analysis.
Association of five genetic variations in DNMT1 and DNMT3A with gastric cancer in a Chinese population.
Association of genetic polymorphisms in DNMT3A with the progression of gastric mucosal atrophy and susceptibility to gastric cancer in Japan.
Association of Polymorphisms in Genes Involved in One-Carbon Metabolism with MTHFR Methylation Levels.
ASXL1 and DNMT3A mutation in a cytogenetically normal B3 thymoma.
ATDC/TRIM29 Drives Invasive Bladder Cancer Formation through miRNA-Mediated and Epigenetic Mechanisms.
Aza-deoxycytidine induces apoptosis or differentiation via DNMT3B and targets embryonal carcinoma cells but not their differentiated derivatives.
Azacitidine induces demethylation of the Epstein-Barr virus genome in tumors.
Azacytidine and decitabine induce gene-specific and non-random DNA demethylation in human cancer cell lines.
Azacytidine induces necrosis of multiple myeloma cells through oxidative stress.
Azacytidine Inhibits RNA Methylation at DNMT2 Target Sites in Human Cancer Cell Lines.
Beyond regulations at DNA levels: A review of epigenetic therapeutics targeting cancer stem cells.
Bile Acid Tethered Docetaxel-Based Nanomicelles Mitigate Tumor Progression through Epigenetic Changes.
Biodegradable system for drug delivery of hydrolytically labile azanucleoside drugs.
Biodistribution, tumor detection and radiation dosimetry of F-18 5-Fluoro-2'-Deoxycytidine (18F-FdCyd) with Tetrahydrouridine in solid tumors.
Bioinformatics Analysis Identifies Key Genes and Pathways in Acute Myeloid Leukemia Associated with DNMT3A Mutation.
Bioinformatics analysis of DNMT1 expression and its role in head and neck squamous cell carcinoma prognosis.
Biological and clinical influences of NPM1 in acute myeloid leukemia patients with DNMT3A mutations.
Biological functions of DNA methyltransferase 1 require its methyltransferase activity.
Biological rationale for the use of DNA methyltransferase inhibitors as new strategy for modulation of tumor response to chemotherapy and radiation.
Black raspberry-derived anthocyanins demethylate tumor suppressor genes through the inhibition of DNMT1 and DNMT3B in colon cancer cells.
Blastic plasmacytoid dendritic cell neoplasm with unusual morphology, MYC rearrangement and TET2 and DNMT3A mutations.
Bortezomib induces DNA hypomethylation and silenced gene transcription by interfering with Sp1/NF-kappaB-dependent DNA methyltransferase activity in acute myeloid leukemia.
BRD4 associates with p53 in DNMT3A-mutated leukemia cells and is implicated in apoptosis by the bromodomain inhibitor JQ1.
Cancer cells escape p53's tumor suppression through ablation of ZDHHC1-mediated p53 palmitoylation.
Cancer cells express aberrant DNMT3B transcripts encoding truncated proteins.
Cancer-Associated DNMT3A Is Recruited by H3K36me2 to Methylate DNA.
Carcinogen-induced gene promoter hypermethylation is mediated by DNMT1 and causal for transformation of immortalized bronchial epithelial cells.
CBFB-MYH11 Fusion Sequesters RUNX1 in Cytoplasm to Prevent DNMT3A Recruitment to Target Genes in AML.
CDK4/6 inhibition triggers anti-tumour immunity.
CDKN2B downregulation and other genetic characteristics in T-acute lymphoblastic leukemia.
Cell Free DNA of Tumor Origin Induces a 'Metastatic' Expression Profile in HT-29 Cancer Cell Line.
Centchroman altered the expressions of tumor-related genes through active chromatin modifications in mammary cancer.
Changes in de novo DNA (cytosine-5-)-methyltransferase activity in oncogenically susceptible rat target tissues induced by N-methyl-N-nitrosourea.
Changes in methyl-sensitive restriction sites of liver DNA from hamsters chronically exposed to hydrazine sulfate.
Characterization of decomposition products and preclinical and low dose clinical pharmacokinetics of decitabine (5-aza-2'-deoxycytidine) by a new liquid chromatography/tandem mass spectrometry quantification method.
Characterization of gene mutations and copy number changes in acute myeloid leukemia using a rapid target enrichment protocol.
Chemoproteomics-Enabled Discovery of a Potent and Selective Inhibitor of the DNA Repair Protein MGMT.
Chicken or Egg: Is Clonal Hematopoiesis Primarily Caused by Genetic or Epigenetic Aberrations?
Chinese herbal medicine Xiaoji decoction inhibited growth of lung cancer cells through AMPK?-mediated inhibition of Sp1 and DNA methyltransferase 1.
Chinese Herbal Mixture, Tien-Hsien Liquid, Induces G2/M Cycle Arrest and Radiosensitivity in MCF-7 Human Breast Cancer Cells through Mechanisms Involving DNMT1 and Rad51 Downregulation.
Chlorogenic Acid Decreases Malignant Characteristics of Hepatocellular Carcinoma Cells by Inhibiting DNMT1 Expression.
Chloroquine eliminates cancer stem cells through deregulation of Jak2 and DNMT1.
Chromatin modifying agents - the cutting edge of anticancer therapy.
Chromatin remodeling agents for cancer therapy.
circ0093740 Promotes Tumor Growth and Metastasis by Sponging miR-136/145 and Upregulating DNMT3A in Wilms Tumor.
Circular RNA CpG island hypermethylation-associated silencing in human cancer.
Clinical and biological implications of IDH1/2 in acute myeloid leukemia with DNMT3Amut.
Clinical and prognosis value of the CIMP status combined with MLH1 or p16 (INK4a) methylation in colorectal cancer.
Clinical Effect of Combined Mutations in DNMT3A, FLT3-ITD, and NPM1 Among Egyptian Acute Myeloid Leukemia Patients.
Clinical molecular testing for ASXL1 c.1934dupG p.Gly646fs mutation in hematologic neoplasms in the NGS era.
Clinical significance of somatic mutation in unexplained blood cytopenia.
Clinical significance of the expression of DNA methyltransferase proteins in gastric cancer.
Clinicopathologic significance of DNA methyltransferase 1, 3a, and 3b overexpression in Tunisian breast cancers.
Clinicopathological significance and prognostic value of DNA methyltransferase 1, 3a, and 3b expressions in sporadic epithelial ovarian cancer.
Clofarabine, a novel adenosine analogue, reactivates DNA methylation-silenced tumour suppressor genes and inhibits cell growth in breast cancer cells.
Clonal Hematopoiesis and Premalignant Diseases.
Clonal hematopoiesis associated with epigenetic aging and clinical outcomes.
Clonal hematopoiesis in acquired aplastic anemia.
Clonal hematopoiesis in angioimmunoblastic T-cell lymphoma with divergent evolution to myeloid neoplasms.
Clonal hematopoiesis of indeterminate potential-associated mutations and risk of comorbidities in patients with myelodysplastic syndrome.
Clonal Hematopoiesis of Indeterminate Potential: A Multidisciplinary Challenge in Personalized Hematology.
Clonal myelopoiesis promotes adverse outcomes in chronic kidney disease.
Cloning, expression and chromosome locations of the human DNMT3 gene family.
CNS-PNETs with C19MC amplification and/or LIN28 expression comprise a distinct histogenetic diagnostic and therapeutic entity.
Colon cancer cells maintain low levels of pyruvate to avoid cell death caused by inhibition of HDAC1/HDAC3.
Colon cancer stemness as a reversible epigenetic state: Implications for anticancer therapies.
Combination of a hypomethylating agent and inhibitors of PARP and HDAC traps PARP1 and DNMT1 to chromatin, acetylates DNA repair proteins, down-regulates NuRD and induces apoptosis in human leukemia and lymphoma cells.
Combination of selenium and green tea improves the efficacy of chemoprevention in a rat colorectal cancer model by modulating genetic and epigenetic biomarkers.
Combination therapy with epigenetic-targeted and chemotherapeutic drugs delivered by nanoparticles to enhance the chemotherapy response and overcome resistance by breast cancer stem cells.
Combination treatment with doxorubicin and microRNA-21 inhibitor synergistically augments anticancer activity through upregulation of tumor suppressing genes.
Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms.
Combined inhibition of JAK1/2 and DNMT1 by newly identified small-molecule compounds synergistically suppresses the survival and proliferation of cervical cancer cells.
Combining DNMT and HDAC6 inhibitors increases anti-tumor immune signaling and decreases tumor burden in ovarian cancer.
Combining epigenetic and immune therapy to overcome cancer resistance.
Combining Epigenetic and Immunotherapy to Combat Cancer.
Commercial glucometer as signal transducer for simple evaluation of DNA methyltransferase activity and inhibitors screening.
Comparison of O-6-methylguanine DNA methyltransferase (MGMT) mRNA levels in Mer+ and Mer- human tumor cell lines containing the MGMT gene by the polymerase chain reaction technique.
Comparison of p16(INK4a) expression with p53 alterations in head and neck cancer by tissue microarray analysis.
Comparison of the effects of olsalazine and decitabine on the expression of CDH1 and uPA genes and cytotoxicity in MDA-MB-231 breast cancer cells.
Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells.
Computational fishing of new DNA methyltransferase inhibitors from natural products.
Concurrent mutations in other epigenetic modulators portend better prognosis in BCOR-mutated myelodysplastic syndrome.
Conformational Selection in Ligand Recognition by the First Tudor Domain of PHF20L1.
Consequences of combining siRNA-mediated DNA methyltransferase 1 depletion with 5-aza-2'-deoxycytidine in human leukemic KG1 cells.
Control of epigenetic states by WT1 via regulation of de novo DNA methyltransferase 3A.
Cooperation between EZH2, NSPc1-mediated histone H2A ubiquitination and Dnmt1 in HOX gene silencing.
Cooperative DNA binding and protein/DNA fiber formation increases the activity of the Dnmt3a DNA methyltransferase.
Coordinate regulation of microenvironmental stimuli and role of methylation in bone metastasis from breast carcinoma.
Correction to: DNMT3A reads and connects histone H3K36me2 to DNA methylation.
Correlations among PPAR?, DNMT1, and DNMT3B Expression Levels and Pancreatic Cancer.
Correlative Analysis of DNA Methyltransferase Expression and Promoter Hypermethylation of Tumor Suppressor Genes in Hepatocellular Carcinoma.
Coupling hybridization chain reaction with DNAzyme recycling for enzyme-free and dual amplified sensitive fluorescent detection of methyltransferase activity.
CpG island hypermethylation in human colorectal tumors is not associated with DNA methyltransferase overexpression.
CpG island hypermethylation of the DNA repair enzyme methyltransferase predicts response to temozolomide in primary gliomas.
CpG island methylation of DNA damage response genes in advanced ovarian cancer.
CpG methylation is maintained in human cancer cells lacking DNMT1.
Critical role of deltaDNMT3B4/2 in regulating RASSF1A promoter-specific DNA methylation in non-small cell lung cancer.
Critical threshold levels of DNA methyltransferase 1 are required to maintain DNA methylation across the genome in human cancer cells.
Cucurbitacin B Alters the Expression of Tumor-Related Genes by Epigenetic Modifications in NSCLC and Inhibits NNK-Induced Lung Tumorigenesis.
Curcumin down-regulates DNA methyltransferase 1 and plays an anti-leukemic role in acute myeloid leukemia.
Current Aspects of Clonal Hematopoiesis: Implications for Clinical Diagnosis.
Current paradigms in epigenetic anticancer therapeutics and future challenges.
CXXC domain of human DNMT1 is essential for enzymatic activity.
Cytosine-5 methylation-directed construction of a Au nanoparticle-based nanosensor for simultaneous detection of multiple DNA methyltransferases at the single-molecule level.
dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes.
De novo CpG island methylation in human cancer cells.
De novo DNA methyltransferase DNMT3A: Regulation of oligomeric state and mechanism of action in response to pH changes.
De novo DNA methyltransferases Dnmt3a and Dnmt3b primarily mediate the cytotoxic effect of 5-aza-2'-deoxycytidine.
De novo methylation of CpG island sequences in human fibroblasts overexpressing DNA (cytosine-5-)-methyltransferase.
De novo methyltransferases: Potential players in diseases and new directions for targeted therapy.
De-novo DNA methyltransferase DNMT3b interacts with NEDD8 modified proteins.
Decitabine and its role in the treatment of hematopoietic malignancies.
Decitabine and suberoylanilide hydroxamic acid (SAHA) inhibit growth of ovarian cancer cell lines and xenografts while inducing expression of imprinted tumor suppressor genes, apoptosis, G2/M arrest, and autophagy.
Decitabine Augments Chemotherapy-Induced PD-L1 Upregulation for PD-L1 Blockade in Colorectal Cancer.
Decitabine effect on tumor global DNA methylation and other parameters in a phase I trial in refractory solid tumors and lymphomas.
Decitabine inhibits the cell growth of cholangiocarcinoma in cultured cell lines and mouse xenografts.
Decitabine, a DNA methyltransferase inhibitor, induces apoptosis in human leukemia cells through intracellular reactive oxygen species generation.
Decitabine, differently from DNMT1 silencing, exerts its antiproliferative activity through p21 upregulation in malignant pleural mesothelioma (MPM) cells.
Decitabine. MGI Pharma Inc/SuperGen Inc.
Decrease of DNA methyltransferase 1 expression relative to cell proliferation in transitional cell carcinoma.
Decreased DNA methylation in acute myeloid leukemia patients with DNMT3A mutations and prognostic implications of DNA methylation.
Decreases in different Dnmt3b activities drive distinct development of hematologic malignancies in mice.
Deep proteomic analysis of Dnmt1 mutant/hypomorphic colorectal cancer cells reveals dysregulation of epithelial-mesenchymal transition and subcellular re-localization of Beta-Catenin.
Deletion of the de novo DNA methyltransferase Dnmt3a promotes lung tumor progression.
Delivery of 5-Azacytidine to Human Cancer Cells by Elaidic Acid Esterification Increases Therapeutic Drug Efficacy.
Demethylation of a LINE-1 antisense promoter in the cMet locus impairs Met signalling through induction of illegitimate transcription.
Deoxyribonucleic acid methyltransferase 3B promotes epigenetic silencing through histone 3 chromatin modifications in pituitary cells.
Depleting long noncoding RNA HOTAIR attenuates chronic myelocytic leukemia progression by binding to DNA methyltransferase 1 and inhibiting PTEN gene promoter methylation.
Depletion of DNA methyltransferase 1 and/or DNA methyltransferase 3b mediates growth arrest and apoptosis in lung and esophageal cancer and malignant pleural mesothelioma cells.
Depletion of DNMT1 in differentiated human cells highlights key classes of sensitive genes and an interplay with polycomb repression.
Depletion of ZBTB38 potentiates the effects of DNA demethylating agents in cancer cells via CDKN1C mRNA up-regulation.
Deregulation of DNMT1, DNMT3B and miR29s in Burkitt lymphoma suggests novel contribution for disease pathogenesis.
Detection of DNA methyltransferase activity using allosteric molecular beacons.
Detection of the circulating tumor DNAs in angioimmunoblastic T- cell lymphoma.
Detection of the level of DNMT1 based on self-assembled probe signal amplification technique in plasma.
Development of fluorescent methods for DNA methyltransferase assay.
Developmental DNA methyltransferase inhibitors in the treatment of gynecologic cancers.
Dietary methyl donors, methyl metabolizing enzymes, and epigenetic regulators: diet-gene interactions and promoter CpG island hypermethylation in colorectal cancer.
Dietary selenite and azadeoxycytidine treatments affect dimethylhydrazine-induced aberrant crypt formation in rat colon and DNA methylation in HT-29 cells.
Different susceptibility of increased DNMT1 expression by exposure to tobacco smoke according to histology in primary non-small cell lung cancer.
Differential expression of DNA-methyltransferases in drug resistant murine neuroblastoma cells.
Differential expression of the epigenetic methylation-related protein DNMT1 by breast cancer molecular subtype and stromal histology.
Differential Induction of Apoptosis and Senescence by the DNA Methyltransferase Inhibitors 5-Azacytidine and 5-Aza-2'-Deoxycytidine in Solid Tumor Cells.
Differential mRNA expression of the human DNA methyltransferases (DNMTs) 1, 3a and 3b during the G(0)/G(1) to S phase transition in normal and tumor cells.
Differential requirement for DNA methyltransferase 1 in maintaining human cancer cell gene promoter hypermethylation.
Direct monitoring of breast and endometrial cancer cell epigenetic response to DNA methyltransferase and histone deacetylase inhibitors.
Discovery of two novel, small-molecule inhibitors of DNA methylation.
Disruption of DNA methylation via S-adenosylhomocysteine is a key process in high incidence liver carcinogenesis in fish.
Distinct clinical and biological implications of various DNMT3A mutations in myeloid neoplasms.
Distinct demographic profile and molecular markers of primary CNS tumor in 1873 adolescent and young adult patient population.
DLEC1 is a functional 3p22.3 tumour suppressor silenced by promoter CpG methylation in colon and gastric cancers.
DNA damage response as a prognostic indicator in metastatic breast cancer via mutational analysis.
DNA demethylating agents and histone deacetylase inhibitors in hematologic malignancies.
DNA demethylation and histone deacetylation inhibition co-operate to re-express estrogen receptor beta and induce apoptosis in prostate cancer cell-lines.
DNA Electrochemistry Shows DNMT1 Methyltransferase Hyperactivity in Colorectal Tumors.
DNA hypermethylation contributes to incomplete synthesis of carbohydrate determinants in gastrointestinal cancer.
DNA Hypermethylation Involves in the Down-Regulation of Chloride Intracellular Channel 4 (CLIC4) Induced by Photodynamic Therapy.
DNA hypermethylation of myeloid cells, a novel therapeutic target in MDS and AML.
DNA Methyl Transferase 1 Reduces Expression of SRD5A2 in the Aging Adult Prostate.
DNA methyl transferase 1: regulatory mechanisms and implications in health and disease.
DNA methylation and cancer therapy.
DNA methylation and cancer.
DNA methylation and chromosome instability in breast cancer cell lines.
DNA methylation and methylase levels in normal and malignant mouse hepatic tissues.
DNA methylation and not H3K4 trimethylation dictates the expression status of miR-152 gene which inhibits migration of breast cancer cells via DNMT1/CDH1 loop.
DNA methylation and targeted sequencing of methyltransferases family genes in canine acute myeloid leukaemia, modelling human myeloid leukaemia.
DNA Methylation and the Potential Role of Methyl-Containing Nutrients in Cardiovascular Diseases.
DNA methylation by DNMT1 and DNMT3b methyltransferases is driven by the MUC1-C oncoprotein in human carcinoma cells.
DNA methylation changes following 5-azacitidine treatment in patients with myelodysplastic syndrome.
DNA methylation changes in leukaemia.
DNA methylation in ovarian cancer. II. Expression of DNA methyltransferases in ovarian cancer cell lines and normal ovarian epithelial cells.
DNA methylation inhibitor 5-Aza-2'-deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3B.
DNA methylation pathway alterations in an autochthonous murine model of prostate cancer.
DNA Methylation Profile at the DNMT3L Promoter: A Potential Biomarker for Cervical Cancer.
DNA methylation profiling reveals novel biomarkers and important roles for DNA methyltransferases in prostate cancer.
DNA methylation properties: consequences for pharmacology.
DNA methylation represses IFN-gamma-induced and signal transducer and activator of transcription 1-mediated IFN regulatory factor 8 activation in colon carcinoma cells.
DNA methylation status of hMLH1, p16(INK4a), and CDH1 is not associated with mRNA expression levels of DNA methyltransferase and DNA demethylase in gastric carcinomas.
DNA methylation, nuclear structure, gene expression and cancer.
DNA Methylation-Targeted Drugs.
Dna methyltransferase 1 (DNMT1) gene activity in human lymphomas correlates with aberrant p53 gene expression.
DNA methyltransferase 1 inhibits O6-methylguanine-DNAmethyl-transferase-mediated cell growth and metastasis of hypopharyngeal squamous carcinoma.
DNA methyltransferase 1 is essential for initiation of the colon cancers.
DNA methyltransferase 1 knock down induces gene expression by a mechanism independent of DNA methylation and histone deacetylation.
DNA methyltransferase 1, cytosine methylation, and cytosine hydroxymethylation in mammalian mitochondria.
DNA methyltransferase 1/3a overexpression in sporadic breast cancer is associated with reduced expression of estrogen receptor-alpha/breast cancer susceptibility gene 1 and poor prognosis.
DNA Methyltransferase 1: A Potential Gene Therapy Target for Hepatocellular Carcinoma?
DNA methyltransferase 3-like affects promoter methylation of thymine DNA glycosylase independently of DNMT1 and DNMT3B in cancer cells.
DNA methyltransferase 3A isoform b contributes to repressing E-cadherin through cooperation of DNA methylation and H3K27/H3K9 methylation in EMT-related metastasis of gastric cancer.
DNA methyltransferase 3a rs1550117 genetic polymorphism predicts poor survival in gastric cancer patients.
DNA methyltransferase 3b (DNMT3b), tumor tissue DNA methylation, Gleason score, and prostate cancer mortality: investigating causal relationships.
DNA methyltransferase 3B -149C/T polymorphism and the risk of laryngeal squamous cell carcinoma: a case-control study.
DNA methyltransferase 3b contributes to oncogenic transformation induced by SV40T antigen and activated Ras.
DNA methyltransferase 3B expression is associated with poor outcome of stage I testicular seminoma.
DNA methyltransferase 3B plays a protective role against hepatocarcinogenesis caused by chronic inflammation via maintaining mitochondrial homeostasis.
DNA methyltransferase 3b silencing affects locus-specific DNA methylation and inhibits proliferation, migration and invasion in human hepatocellular carcinoma SMMC-7721 and BEL-7402 cells.
DNA Methyltransferase Activity Assays: Advances and Challenges.
DNA methyltransferase and demethylase in human prostate cancer.
DNA methyltransferase deficiency modifies cancer susceptibility in mice lacking DNA mismatch repair.
DNA methyltransferase detection based on digestion triggering the combination of poly adenine DNA with gold nanoparticles.
DNA methyltransferase DNMT3b protein overexpression as a prognostic factor in patients with diffuse large B-cell lymphomas.
DNA methyltransferase expression and DNA methylation in human hepatocellular carcinoma and their clinicopathological correlation.
DNA methyltransferase expression in odontogenic cysts and tumours.
DNA methyltransferase expression in triple-negative breast cancer predicts sensitivity to decitabine.
DNA methyltransferase expression is associated with cell proliferation in salivary mucoepidermoid carcinoma.
DNA methyltransferase I is a mediator of doxorubicin-induced genotoxicity in human cancer cells.
DNA methyltransferase inhibition accelerates the immunomodulation and migration of human mesenchymal stem cells.
DNA methyltransferase inhibition increases efficacy of adoptive cellular immunotherapy of murine breast cancer.
DNA methyltransferase inhibition induces the transcription of the tumor suppressor p21(WAF1/CIP1/sdi1).
DNA methyltransferase inhibition may limit cancer cell growth by disrupting ribosome biogenesis.
DNA methyltransferase inhibitor, zebularine, delays tumor growth and induces apoptosis in a genetically engineered mouse model of breast cancer.
DNA methyltransferase inhibitors and the development of epigenetic cancer therapies.
DNA methyltransferase inhibitors and their emerging role in epigenetic therapy of cancer.
DNA Methyltransferase Inhibitors and their Therapeutic Potential.
DNA methyltransferase inhibitors as epigenetic therapy for cancer.
DNA methyltransferase inhibitors combination therapy for the treatment of solid tumor: mechanism and clinical application.
DNA methyltransferase inhibitors for cancer therapy.
DNA Methyltransferase Inhibitors Improve the Effect of Chemotherapeutic Agents in SW48 and HT-29 Colorectal Cancer Cells.
DNA methyltransferase inhibitors in cancer: a chemical and therapeutic patent overview and selected clinical studies.
DNA methyltransferase inhibitors in cancer: From pharmacology to translational studies.
DNA Methyltransferase Inhibitors in Myeloid Cancer: Clonal Eradication or Clonal Differentiation?
DNA methyltransferase inhibitors induce a BRCAness phenotype that sensitizes NSCLC to PARP inhibitor and ionizing radiation.
DNA Methyltransferase Inhibitors: Catalysts For Antitumour Immune Responses.
DNA methyltransferase inhibitors: old and new drugs for an epigenetic cancer therapy.
DNA methyltransferase mediates the hypermethylation of the microRNA 34a promoter and enhances the resistance of patient-derived pancreatic cancer cells to molecular targeting agents.
DNA methyltransferase-3 like protein expression in various histological types of testicular germ cell tumor.
DNA Methyltransferase-3a Interacts with p53 and Represses p53-Mediated Gene Expression.
DNA methyltransferases 1, 3a, and 3b overexpression and clinical significance in gastroenteropancreatic neuroendocrine tumors.
DNA methyltransferases 3a and 3b are differentially expressed in the early stages of a rat liver carcinogenesis model.
DNA methyltransferases as targets for cancer therapy.
DNA methyltransferases expression in normal tissues and various human cancer cell lines, xenografts and tumors.
DNA methyltransferases messenger RNA expression and aberrant methylation of CpG islands in non-small-cell lung cancer: association and prognostic value.
DNA methyltransferases: a novel target for prevention and therapy.
DNA-methyltransferase 3B 39179 G > T polymorphism and risk of sporadic colorectal cancer in a subset of Iranian population.
DNMT cooperativity--the developing links between methylation, chromatin structure and cancer.
DNMT Inhibitors Increase Methylation in the Cancer Genome.
DNMT1 and Cancer: An Electrifying Link.
DNMT1 and DNMT3b cooperate to silence genes in human cancer cells.
DNMT1 and DNMT3B modulate distinct polycomb-mediated histone modifications in colon cancer.
DNMT1 and DNMT3B regulate tumorigenicity of human prostate cancer cells by controlling RAD9 expression through targeted methylation.
DNMT1 and DNMT3b silencing sensitizes human hepatoma cells to TRAIL-mediated apoptosis via up-regulation of TRAIL-R2/DR5 and caspase-8.
DNMT1 and EZH2 mediated methylation silences the microRNA-200b/a/429 gene and promotes tumor progression.
DNMT1 as a molecular target in a multimodality-resistant phenotype in tumor cells.
DNMT1 as a therapeutic target in pancreatic cancer: mechanisms and clinical implications.
DNMT1 but not its interaction with the replication machinery is required for maintenance of DNA methylation in human cells.
DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters.
DNMT1 is associated with cell cycle and DNA replication gene sets in diffuse large B-cell lymphoma.
DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis.
DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells.
Dnmt1 links BCR-ABLp210 to epigenetic tumor stem cell priming in myeloid leukemia.
DNMT1 maintains the methylation of miR-152-3p to regulate TMSB10 expression, thereby affecting the biological characteristics of colorectal cancer cells.
DNMT1 mediates metabolic reprogramming induced by Epstein-Barr virus latent membrane protein 1 and reversed by grifolin in nasopharyngeal carcinoma.
DNMT1 promotes cell proliferation via methylating hMLH1 and hMSH2 promoters in EGFR-mutated non-small cell lung cancer.
DNMT1 recruited by EZH2-mediated silencing of miR-484 contributes to the malignancy of cervical cancer cells through MMP14 and HNF1A.
DNMT1 Regulates Epithelial-Mesenchymal Transition and Cancer Stem Cells, Which Promotes Prostate Cancer Metastasis.
DNMT1, DNMT3A and DNMT3B Polymorphisms Associated With Gastric Cancer Risk: A Systematic Review and Meta-analysis.
DNMT1: A key drug target in triple-negative breast cancer.
Dnmt1N/+ reduces the net growth rate and multiplicity of intestinal adenomas in C57BL/6-multiple intestinal neoplasia (Min)/+ mice independently of p53 but demonstrates strong synergy with the modifier of Min 1(AKR) resistance allele.
DNMT3A -448A>G polymorphism and cancer risk: a meta-analysis.
DNMT3A -448A>G polymorphism and the risk for hepatocellular carcinoma.
DNMT3A alterations associated with myeloid malignancies dictate differential responses to hypomethylating agents.
DNMT3A and IDH mutations in acute myeloid leukemia and other myeloid malignancies: associations with prognosis and potential treatment strategies.
DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells.
DNMT3A and TET2 in the Pre-Leukemic Phase of Hematopoietic Disorders.
DNMT3a contributes to the development and maintenance of bone cancer pain by silencing Kv1.2 expression in spinal cord dorsal horn.
Dnmt3a deficiency in the skin causes focal, canonical DNA hypomethylation and a cellular proliferation phenotype.
DNMT3a epigenetic program regulates the HIF-2? oxygen-sensing pathway and the cellular response to hypoxia.
DNMT3a expression pattern and its prognostic value in lung adenocarcinoma.
Dnmt3a haploinsufficiency cooperates with oncogenic Kras to promote an early-onset T-cell acute lymphoblastic leukemia.
DNMT3A in haematological malignancies.
DNMT3A in Leukemia.
DNMT3A intragenic hypomethylation is associated with adverse prognosis in acute myeloid leukemia.
Dnmt3a Is a Haploinsufficient Tumor Suppressor in CD8+ Peripheral T Cell Lymphoma.
Dnmt3a is required for the tumor stemness of B16 melanoma cells.
DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias.
Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation.
DNMT3A mutants provide proliferating advantage with augmentation of self-renewal activity in the pathogenesis of AML in KMT2A-PTD-positive leukemic cells.
DNMT3A mutational analysis in primary myelofibrosis, chronic myelomonocytic leukemia and advanced phases of myeloproliferative neoplasms.
DNMT3A mutations in myeloproliferative neoplasms.
DNMT3A mutations occur early or late in patients with myeloproliferative neoplasms and mutation order influences phenotype.
DNMT3A overexpression is associated with aggressive behavior and enteroblastic differentiation of gastric adenocarcinoma.
Dnmt3a protects active chromosome domains against cancer-associated hypomethylation.
Dnmt3a regulates myeloproliferation and liver-specific expansion of hematopoietic stem and progenitor cells.
Dnmt3a regulates T-cell development and suppresses T-ALL transformation.
DNMT3A rs36012910 A>G polymorphism and gastric cancer susceptibility in a Chinese population.
DNMT3B -149 C>T and -579 G>T Polymorphisms and Risk of Gastric and Colorectal Cancer: a Meta-analysis.
DNMT3b -149C/T promoter variants and methylation of colorectal cancer-associated genes.
DNMT3B -579 G>T promoter polymorphism and risk of gallbladder carcinoma in North Indian population.
DNMT3B -579 G>T Promoter Polymorphism and the Risk of Gastric Cancer in the West of Iran.
DNMT3B C46359T and SHMT1 C1420T polymorphisms in the folate pathway in carcinogenesis of head and neck.
Dnmt3b catalytic activity is critical for its tumour suppressor function in lymphomagenesis and is associated with c-Met oncogenic signalling.
DNMT3B Expression Might Contribute to Abnormal Methylation of RASSF1A in Lager Colorectal Adenomatous Polyps.
DNMT3B expression might contribute to CpG island methylator phenotype in colorectal cancer.
DNMT3B Functions: Novel Insights From Human Disease.
DNMT3B gene amplification predicts resistance to DNA demethylating drugs.
DNMT3B in vitro knocking-down is able to reverse embryonal rhabdomyosarcoma cell phenotype through inhibition of proliferation and induction of myogenic differentiation.
Dnmt3b is a haploinsufficient tumor suppressor gene in Myc-induced lymphomagenesis.
DNMT3b Modulates Melanoma Growth by Controlling Levels of mTORC2 Component RICTOR.
DNMT3B modulates the expression of cancer-related genes and downregulates the expression of the gene VAV3 via methylation.
DNMT3B Oncogenic Activity in Human Intestinal Cancer Is Not Linked to CIMP or BRAFV600E Mutation.
DNMT3B overexpression by deregulation of FOXO3a-mediated transcription repression and MDM2 overexpression in lung cancer.
DNMT3b overexpression contributes to a hypermethylator phenotype in human breast cancer cell lines.
DNMT3B overexpression contributes to aberrant DNA methylation and MYC-driven tumor maintenance in T-ALL and Burkitt's lymphoma.
DNMT3B polymorphisms and cancer risk: a meta analysis of 24 case-control studies.
Dnmt3b Prefers Germ Line Genes and Centromeric Regions: Lessons from the ICF Syndrome and Cancer and Implications for Diseases.
DNMT3B promoter polymorphisms and maternal risk of birth of a child with Down syndrome.
DNMT3B7 expression promotes tumor progression to a more aggressive phenotype in breast cancer cells.
DNMT3B7, a truncated DNMT3B isoform expressed in human tumors, disrupts embryonic development and accelerates lymphomagenesis.
DNMT3L enables accumulation and inheritance of epimutations in transgenic Drosophila.
DNMTs inhibitor SGI-1027 induces apoptosis in Huh7 human hepatocellular carcinoma cells.
Docking of a novel DNA methyltransferase inhibitor identified from high-throughput screening: insights to unveil inhibitors in chemical databases.
Does Wnt/?-catenin pathway contribute to the stability of DNMT1 expression in urological cancer cell lines?
Dose response evaluation of gene expression profiles in the skin of K6/ODC mice exposed to sodium arsenite.
Down expression of lnc-BMP1-1 decreases that of Caveolin-1 is associated with the lung cancer susceptibility and cigarette smoking history.
Down-regulated lncRNA DLX6-AS1 inhibits tumorigenesis through STAT3 signaling pathway by suppressing CADM1 promoter methylation in liver cancer stem cells.
Down-regulation of UHRF1, associated with re-expression of tumor suppressor genes, is a common feature of natural compounds exhibiting anti-cancer properties.
Downregulation of miR-152 contributes to DNMT1-mediated silencing of SOCS3/SHP-1 in non-Hodgkin lymphoma.
Downregulation of miR-217 correlates with resistance of ph(+) leukemia cells to ABL tyrosine kinase inhibitors.
Doxorubicin inhibits DNMT1, resulting in conditional apoptosis.
Drug-resistance gene expression and progression of astrocytic tumors.
Dual-signal ratiometric electrochemiluminescence assay for detecting the activity of human methyltransferase.
Dynamic silencing of somatic L1 retrotransposon insertions reflects the developmental and cellular contexts of their genomic integration.
Dysregulation of microRNA expression drives aberrant DNA hypermethylation in basal-like breast cancer.
Dysregulation of p53/Sp1 control leads to DNA methyltransferase-1 overexpression in lung cancer.
Dysregulation of the epigenome in human breast cancer: contributions of gene-specific DNA hypermethylation to breast cancer pathobiology and targeting the breast cancer methylome for improved therapy.
E-Cadherin, NFATC3, and PLP2 Are Differentially Methylated in Multiple Cancers.
E6 and E7 gene silencing results in decreased methylation of tumor suppressor genes and induces phenotype transformation of human cervical carcinoma cell lines.
Early-onset colorectal cancer: A distinct entity with unique genetic features.
Ectopic expression of activation-induced cytidine deaminase caused by epigenetics modification.
Effect of age on the association between p16CDKN2A methylation and DNMT3B polymorphism in head and neck carcinoma and patient survival.
Effect of antisense DNMT3b gene eukaryotic expression plasmid on expression of the DNMT3b gene in human biliary tract carcinoma cells.
Effect of BIX-01294 on proliferation, apoptosis and histone methylation of acute T lymphoblastic leukemia cells.
Effect of DNA Methylation in Various Diseases and the Probable Protective Role of Nutrition: A Mini-Review.
Effect of DNA-binding drugs on the activity of DNA methylase from Ehrlich's ascites tumour cells.
Effect of in ovo feeding of vitamin C on antioxidation and immune function of broiler chickens.
Effect of maternal and postweaning folic acid supplementation on mammary tumor risk in the offspring.
Effect of methylation on expression of microinjected genes.
Effect of mitogenic stimulation and DNA methylation on human T cell DNA methyltransferase expression and activity.
Effects of 5-aza-2'deoxycytidine on RECK gene expression and tumor invasion in salivary adenoid cystic carcinoma.
Effects of 5-Aza-CdR on the proliferation of human breast cancer cell line MCF-7 and on the expression of Apaf-1 gene.
Effects of cadmium on DNA-(Cytosine-5) methyltransferase activity and DNA methylation status during cadmium-induced cellular transformation.
Effects of DNA Methylation on Leukemia Cell Proliferation.
Effects of DNA methyltransferase 1 inhibition on esophageal squamous cell carcinoma.
Effects of DNMT1 silencing on malignant phenotype and methylated gene expression in cervical cancer cells.
Effects of Propolis and Phenolic Acids on Triple-Negative Breast Cancer Cell Lines: Potential Involvement of Epigenetic Mechanisms.
Effects of Zebularine on Invasion Activity and Intracellular Expression Level of let-7b in Colorectal Cancer Cells.
Effects on biological behavior of bladder carcinoma T24 cells via silencing DNMT1 and/or DNMT3b with shRNA In Vitro.
Efficacy and tolerability of temozolomide in an alternating weekly regimen in patients with recurrent glioma.
Efficacy of decitabine-loaded nanogels in overcoming cancer drug resistance is mediated via sustained DNA methyltransferase 1 (DNMT1) depletion.
Elevated expression and altered pattern of activity of DNA methyltransferase in liver tumors of rats fed methyl-deficient diets.
Eliminating epigenetic barriers induces transient hormone-regulated gene expression in estrogen receptor negative breast cancer cells.
Emergent issues in the genetics of intestinal neoplasia.
Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1.
Enhanced anticancer effects of a methylation inhibitor by inhibiting a novel DNMT1 target, CEP 131, in cervical cancer.
Enhanced growth inhibition by combined DNA methylation/HDAC inhibitors in lung tumor cells with silenced CDKN2A.
Enhancement of chemotherapeutic efficacy in hypermethylator breast cancer cells through targeted and pharmacologic inhibition of DNMT3b.
Enhancing the cytotoxicity of chemoradiation with radiation-guided delivery of anti-MGMT morpholino oligonucleotides in non-methylated solid tumors.
Enigmatic Ladies of the Rings: How Cohesin Dysfunction Affects Myeloid Neoplasms Insurgence.
Epidrug Modulated Expression of MiR--152 and MiR-148a Reverse Cisplatin Resistance in Ovarian Cancer Cells: An Experimental In-vitro Study.
Epigallocatechin gallate inhibits HeLa cells by modulation of epigenetics and signaling pathways.
Epigallocatechin gallate inhibits the growth and promotes the apoptosis of bladder cancer cells.
Epigallocatechin-3-gallate inhibits homocysteine-induced apoptosis of endothelial cells by demethylation of the DDAH2 gene.
Epigallocatechin-3-gallate up-regulates tumor suppressor gene expression via a reactive oxygen species-dependent down-regulation of UHRF1.
Epigenetic aberrations in myeloid malignancies (Review).
Epigenetic alterations in hematopoietic malignancies.
Epigenetic approach for angiostatic therapy: promising combinations for cancer treatment.
Epigenetic approaches for chemosensitization of refractory diffuse large B-cell lymphomas.
Epigenetic Aspects on Therapy Development for Gastroenteropancreatic Neuroendocrine Tumors.
Epigenetic cancer therapies: DNA methyltransferase inhibitors.
Epigenetic changes by zebularine leading to enhanced differentiation of human promyelocytic leukemia NB4 and KG1 cells.
Epigenetic control of Foxp3 in intratumoral T-cells regulates growth of hepatocellular carcinoma.
Epigenetic control of tumor angiogenesis.
Epigenetic DNA methylation in radiation biology: on the field or on the sidelines?
Epigenetic dysregulation of hematopoietic stem cells and preleukemic state.
Epigenetic Guardian: A Review of the DNA Methyltransferase DNMT3A in Acute Myeloid Leukaemia and Clonal Haematopoiesis.
Epigenetic inactivation of BRCA1 is associated with aberrant expression of CTCF and DNA methyltransferase (DNMT3B) in some sporadic breast tumours.
Epigenetic inactivation of tumor suppressor genes in serum of patients with cutaneous melanoma.
Epigenetic inhibition of the tumor suppressor ARHI by light at night-induced circadian melatonin disruption mediates STAT3-driven paclitaxel resistance in breast cancer.
Epigenetic mechanisms in cancer: push and pull between kneaded erasers and fate writers.
Epigenetic mechanisms underlying prostate cancer radioresistance.
Epigenetic modification augments the immunogenicity of human leukocyte antigen G serving as a tumor antigen for T cell-based immunotherapy.
Epigenetic modifiers DNMT3A and BCOR are recurrently mutated in CYLD cutaneous syndrome.
Epigenetic modifiers enhance the synergistic cytotoxicity of combined nucleoside analog-DNA alkylating agents in lymphoma cell lines.
Epigenetic modulating agents as a new therapeutic approach in multiple myeloma.
Epigenetic modulation combined with PD-1/PD-L1 blockade enhances immunotherapy based on MAGE-A11 antigen-specific CD8+T cells against esophageal carcinoma.
Epigenetic modulation of endogenous tumor suppressor expression in lung cancer xenografts suppresses tumorigenicity.
Epigenetic modulation of immune synaptic-cytoskeletal networks potentiates ?? T cell-mediated cytotoxicity in lung cancer.
Epigenetic modulation of immunotherapy and implications in head and neck cancer.
Epigenetic Modulators as Potential Multi-targeted Drugs Against Hedgehog Pathway for Treatment of Cancer.
Epigenetic modulators hydralazine and sodium valproate act synergistically in VEGI-mediated anti-angiogenesis and VEGF interference in human osteosarcoma and vascular endothelial cells.
Epigenetic Perturbations by Arg882-Mutated DNMT3A Potentiate Aberrant Stem Cell Gene-Expression Program and Acute Leukemia Development.
Epigenetic regulation by decitabine of melanoma differentiation in vitro and in vivo.
Epigenetic regulation by selected dietary phytochemicals in cancer chemoprevention.
Epigenetic regulation in myelodysplastic syndromes: implications for therapy.
Epigenetic Regulation of CXCL12 Plays a Critical Role in Mediating Tumor Progression and the Immune Response In Osteosarcoma.
Epigenetic regulation of DNA methyltransferases: DNMT1 and DNMT3B in gliomas.
Epigenetic regulation of GATA2 and its impact on normal karyotype acute myeloid leukemia.
Epigenetic regulation of glycosylation and the impact on chemo-resistance in breast and ovarian cancer.
Epigenetic regulation of metallothionein-i gene expression: differential regulation of methylated and unmethylated promoters by DNA methyltransferases and methyl CpG binding proteins.
Epigenetic regulation of thyroid hormone receptor beta in renal cancer.
Epigenetic regulation of X-linked cancer/germline antigen genes by DNMT1 and DNMT3b.
Epigenetic regulation: a new research area for melatonin?
Epigenetic remodeling combined with photodynamic therapy elicits anticancer immune responses.
Epigenetic reprogramming modulates malignant properties of human liver cancer.
Epigenetic reprogramming of cancer cells via targeted DNA methylation.
Epigenetic silencing of miR-342-3p in B cell lymphoma and its impact on autophagy.
Epigenetic silencing of SFRP1 and SFRP5 by Hepatitis B Virus X protein enhances hepatoma cell tumorigenicity through wnt signaling pathway.
Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy.
Epigenetic silencing of the RASSF1A tumor suppressor gene through HOXB3-mediated induction of DNMT3B expression.
Epigenetic targeting DNMT1 of pancreatic ductal adenocarcinoma using interstitial control release biodegrading polymer reduced tumor growth through hedgehog pathway inhibition.
Epigenetic targets in cancer and aging: dietary and therapeutic interventions.
Epigenetic targets in hematopoietic malignancies.
Epigenetic therapies in patients with solid tumors: Focus on monotherapy with deoxyribonucleic acid methyltransferase inhibitors and histone deacetylase inhibitors.
Epigenetic therapy for colorectal cancer.
Epigenetic therapy for solid tumors: from bench science to clinical trials.
Epigenetic Therapy for Solid Tumors: Highlighting the Impact of Tumor Hypoxia.
Epigenetic therapy in cancer: molecular background and clinical development of histone deacetylase and DNA methyltransferase inhibitors.
Epigenetic Up-regulation of Gene Expression in KAS 6/1 Human Multiple Myeloma Cells.
Epigenetic upregulation of Bak by ZBP-89 inhibits the growth of hepatocellular carcinoma.
Epigenetic-based cancer therapeutics: new potential HDAC8 inhibitors.
Epigenetics and blood disorders.
Epigenetics as a Therapeutic Target in Breast Cancer.
Epigenetics of glioblastoma multiforme: From molecular mechanisms to therapeutic approaches.
Epigenomic networking in drug development: from pathogenic mechanisms to pharmacogenomics.
Epigenomic reactivation screening to identify genes silenced by DNA hypermethylation in human cancer.
Epimutations mimic genomic mutations of DNMT3A in acute myeloid leukemia.
Epstein-Barr virus and gastric carcinoma.
Epstein-Barr virus-associated gastric carcinoma.
Erratum to: A Comparative Study on the In Vitro Effects of the DNA Methyltransferase Inhibitor 5-Azacytidine (5-AzaC) in Breast/Mammary Cancer of Different Mammalian Species.
Erratum to: DNMT3B polymorphisms and cancer risk: a meta analysis of 24 case-control studies.
Erratum: Increased DNA methyltransferase expression in rhabdomyosarcomas. Int. J. Cancer, 83, 10-14 (1999).
Essential role of DNA methyltransferase 1-mediated transcription of insulin-like Growth Factor 2 in Resistance to Histone Deacetylase Inhibitors.
Establishment and functional validation of a structural homology model for human DNA methyltransferase 1.
Establishment of conditional vectors for hairpin siRNA knockdowns.
Estrogen-induced hypomethylation and overexpression of YAP1 facilitate breast cancer cell growth and survival.
ETV6 mutations in early immature human T cell leukemias.
Evaluation of MUC1-Aptamer Functionalized Hybrid Nanoparticles for Targeted Delivery of miRNA-29b to Nonsmall Cell Lung Cancer.
Evaluation of noncytotoxic DNMT1-depleting therapy in patients with myelodysplastic syndromes.
Evidence that tumor necrosis factor-related apoptosis-inducing ligand induction by 5-Aza-2'-deoxycytidine sensitizes human breast cancer cells to adriamycin.
Evodiamine, a Novel NOTCH3 Methylation Stimulator, Significantly Suppresses Lung Carcinogenesis in Vitro and in Vivo.
Evolution of a contagious cancer: epigenetic variation in Devil Facial Tumour Disease.
Examination of the DNA substrate selectivity of DNA cytosine methyltransferases using mass tagging.
Exceptionally high protection of photocarcinogenesis by topical application of (--)-epigallocatechin-3-gallate in hydrophilic cream in SKH-1 hairless mouse model: relationship to inhibition of UVB-induced global DNA hypomethylation.
Exome sequencing reveals DNMT3A and ASXL1 variants associate with progression of chronic myeloid leukemia after tyrosine kinase inhibitor therapy.
Exosomal DNMT1 mediates cisplatin resistance in ovarian cancer.
Expression analysis of DNA methyltransferases 1, 3A, and 3B in sporadic breast carcinomas.
Expression and function role of DNA methyltransferase 1 in human bladder cancer.
Expression changes in EZH2, but not in BMI-1, SIRT1, DNMT1 or DNMT3B are associated with DNA methylation changes in prostate cancer.
Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells.
Expression of antisense to DNA methyltransferase mRNA induces DNA demethylation and inhibits tumorigenesis.
Expression of DNA methylation-related proteins in metastatic breast cancer.
Expression of DNA Methyltransferase 1 Is a Hallmark of Melanoma, Correlating with Proliferation and Response to B-Raf and Mitogen-Activated Protein Kinase Inhibition in Melanocytic Tumors.
Expression of DNA methyltransferase in LEC rats during hepatocarcinogenesis.
Expression of Dnmt1, demethylase, MeCP2 and methylation of tumor-related genes in human gastric cancer.
Expression of DNMTs and MBD2 in GIST.
Expression of human DNA methyltransferase 1 in colorectal cancer tissues and their corresponding distant normal tissues.
Expression of methylation-related genes is associated with overall survival in patients with non-small cell lung cancer.
Expression of NOL1/NOP2/sun domain (Nsun) RNA methyltransferase family genes in early mouse embryogenesis.
Expression of O(6) -methylguanine DNA methyltransferase (MGMT) and immunohistochemical analysis of 12 pineal parenchymal tumors.
Expression of O(6)-methylguanine DNA methyltransferase (MGMT) and its clinical significance in gastroenteropancreatic neuroendocrine neoplasm.
Expression of prokaryotic HhaI DNA methyltransferase is transforming and lethal to NIH 3T3 cells.
Expression of RASSF1A, an epigenetically silenced tumor suppressor, overcomes resistance to apoptosis induction by interferons.
Expression of ribonucleotide reductase M2 subunit in gastric cancer and effects of RRM2 inhibition in vitro.
Expression of {Delta}DNMT3B Variants and Its Association with Promoter Methylation of p16 and RASSF1A in Primary Non-Small Cell Lung Cancer.
Expression pattern and clinical significance of DNA methyltransferase 3B variants in gastric carcinoma.
Expression profiles and function of IL6 in polymorphonuclear myeloid-derived suppressor cells.
Extended experience with a non-cytotoxic DNMT1-targeting regimen of decitabine to treat myeloid malignancies.
EZH2 Regulates Protein Stability via Recruiting USP7 to Mediate Neuronal Gene Expression in Cancer Cells.
Factors influencing epigenetic mechanisms and related diseases.
Feature-based classification of amino acid substitutions outside conserved functional protein domains.
Feedback regulation of DNA methyltransferase gene expression by methylation.
Fenofibrate Exerts Antitumor Effects in Colon Cancer via Regulation of DNMT1 and CDKN2A.
Flavonoids as Epigenetic Modulators for Prostate Cancer Prevention.
Fluorescence-based Polymerase Amplification for the Sensitive Detection of DNA Methyltransferase Activity.
Focus on deacetylation for therapeutic benefit.
FOXM1 induces a global methylation signature that mimics the cancer epigenome in head and neck squamous cell carcinoma.
Frequent Increased Gene Copy Number and High Protein Expression of tRNA (Cytosine-5-)-Methyltransferase (NSUN2) in Human Cancers.
FRET-Based Method for Direct, Real-Time Measurement of DNA Methyltransferase Activity.
From Natural Products to Drugs for Epimutation Computer-Aided Drug Design.
Function of DNA methyltransferase 3a in lead (Pb(2+) )-Induced Cyclooxygenase-2 gene.
Function of microRNA-143 in different signal pathways in cancer: New insights into cancer therapy.
Functional and genomic characterization of patient-derived xenograft model to study the adaptation to mTORC1 inhibitor in clear cell renal cell carcinoma.
Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines.
Further delineation of neuropsychiatric findings in Tatton-Brown-Rahman syndrome due to disease-causing variants in DNMT3A: seven new patients.
FXR silencing in human colon cancer by DNA methylation and KRAS signaling.
GAD1 Upregulation Programs Aggressive Features of Cancer Cell Metabolism in the Brain Metastatic Microenvironment.
Gain-of-function mutations in DNMT3A in patients with paraganglioma.
Gene expression and promoter polymorphisms of DNA methyltransferase 3B in nasopharyngeal carcinomas in Taiwanese people: a case-control study.
Gene expression profiling of the DNMT3A R882 mutation in acute leukemia.
Gene Silencing Associated with SWI/SNF Complex Loss during NSCLC Development.
Gene-Specific Methylation Analysis in Thymomas of Patients with Myasthenia Gravis.
Generation of antigen-presenting cells from tumor-infiltrated CD11b myeloid cells with DNA demethylating agent 5-aza-2'-deoxycytidine.
Genes methylated by DNA methyltransferase 3b are similar in mouse intestine and human colon cancer.
Genetic and Epigenetic Perturbations by DNMT3A-R882 Mutants Impaired Apoptosis through Augmentation of PRDX2 in Myeloid Leukemia Cells.
Genetic and epigenetic variation in the DNMT3B and MTHFR genes and colorectal adenoma risk.
Genetic disruption of cytosine DNA methyltransferase enzymes induces chromosomal instability in human cancer cells.
Genetic Polymorphism of DNA Methyltransferase 3A rs1550117 A>G and Risk of Cancer: A Meta-analysis.
Genetic unmasking of an epigenetically silenced microRNA in human cancer cells.
Genetic variation in healthy oldest-old.
Genetic variations in epigenetic genes are predictors of recurrence in stage I or II non-small cell lung cancer patients.
Genome-wide analysis in a murine dnmt1 knockdown model identifies epigenetically silenced genes in primary human pituitary tumors.
Genome-wide hypomethylation in cancer may be a passive consequence of transformation.
Genomic markers of midostaurin drug sensitivity in FLT3 mutated and FLT3 wild-type acute myeloid leukemia patients.
Genomic profiling of well-differentiated hepatocellular neoplasms with diffuse glutamine synthetase staining reveals similar genetics across the adenoma to carcinoma spectrum.
Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in human breast cancer.
Germline DNMT3A mutation in familial acute myeloid leukaemia.
GLAD-PCR Assay of R(5mC)GY Sites in the Regulatory Region of Tumor-Suppressor Genes Associated with Gastric Cancer.
Global identification of genes targeted by DNMT3b for epigenetic silencing in lung cancer.
Grifolin directly targets ERK1/2 to epigenetically suppress cancer cell metastasis.
Growth disrupting mutations in epigenetic regulatory molecules are associated with abnormalities of epigenetic aging.
Hammerhead ribozyme-mediated sensitization of human tumor cells after treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea.
Haploinsufficiency for DNA methyltransferase 3A predisposes hematopoietic cells to myeloid malignancies.
Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains.
HBP1-mediated transcriptional regulation of DNA methyltransferase 1 and its impact on cell senescence.
HDL-AuNPs-BMS Nanoparticle Conjugates as Molecularly Targeted Therapy for Leukemia.
Helicobacter pylori CagA induces tumor suppressor gene hypermethylation by upregulating DNMT1 via AKT-NF?B pathway in gastric cancer development.
Hematopoietic expression of O(6)-methylguanine DNA methyltransferase-P140K allows intensive treatment of human glioma xenografts with combination O(6)-benzylguanine and 1,3-bis-(2-chloroethyl)-1-nitrosourea.
Hepatitis C virus core protein epigenetically silences SFRP1 and enhances HCC aggressiveness by inducing epithelial-mesenchymal transition.
Heterogeneity of chromatin modifications in testicular spermatocytic seminoma point toward an epigenetically unstable phenotype.
HIGD1A Regulates Oxygen Consumption, ROS Production, and AMPK Activity during Glucose Deprivation to Modulate Cell Survival and Tumor Growth.
High DNA methyltransferase 3B expression mediates 5-aza-deoxycytidine hypersensitivity in testicular germ cell tumors.
High DNMT1 Is Associated With Worse Local Control in Early-Stage Laryngeal Squamous Cell Carcinoma.
High expression of DNA methyltransferase 1 in Kazakh esophageal epithelial cells may promote malignant transformation induced by N-methyl-N'-nitro-N-nitrosoguanidine.
High expression of the DNA methyltransferase gene characterizes human neoplastic cells and progression stages of colon cancer.
Higher methylation intensity induced by EBV LMP1 via NF-?B/ DNMT3b signaling contributes to silencing of PTEN gene.
Highly sensitive photoelectrochemical assay for DNA methyltransferase activity and inhibitor screening by exciton energy transfer coupled with enzyme cleavage biosensing strategy.
Histone Deacetylase Inhibitors Reverse CpG Methylation by Regulating DNMT1 through ERK Signaling.
Histone deacetylases and epigenetic therapies of hematological malignancies.
hNaa10p contributes to tumorigenesis by facilitating DNMT1-mediated tumor suppressor gene silencing.
Homology modeling, docking and structure-based pharmacophore of inhibitors of DNA methyltransferase.
Hormonal therapy promotes hormone-resistant phenotype by increasing DNMT activity and expression in prostate cancer models.
HOTAIR Induces Methylation of PCDH10, a Tumor Suppressor Gene, by Regulating DNMT1 and Sponging with miR-148b in Gastric Adenocarcinoma.
HOTAIR-mediated reciprocal regulation of EZH2 and DNMT1 contribute to polyphyllin I-inhibited growth of castration-resistant prostate cancer cells in vitro and in vivo.
How does DNA methyltransferase cause oncogenic transformation?
HOXB13, a target of DNMT3B, is methylated at an upstream CpG island, and functions as a tumor suppressor in primary colorectal tumors.
HPV-16 E6 upregulation of DNMT1 through repression of tumor suppressor p53.
Human concentrative nucleoside transporter 1-mediated uptake of 5-azacytidine enhances DNA demethylation.
Human DNA methyltransferase 1 is required for maintenance of the histone H3 modification pattern.
Human hepatic cancer stem cells are characterized by common stemness traits and diverse oncogenic pathways.
Human papillomavirus type 16 E6 suppresses microRNA-23b expression in human cervical cancer cells through DNA methylation of the host gene C9orf3.
Human papillomavirus type 16 E7 oncoprotein mediates CCNA1 promoter methylation.
Human polyomavirus BKV transcriptionally activates DNA methyltransferase 1 through the pRb/E2F pathway.
Hyaluronan-CD44v3 interaction with Oct4/Sox2/Nanog promotes miR-302 expression leading to self-renewal, clonal formation and cisplatin resistance in cancer stem cells from head and neck squamous cell carcinoma.
Hydrogen gas alleviates sepsis-induced neuroinflammation and cognitive impairment through regulation of DNMT1 and DNMT3a-mediated BDNF promoter IV methylation in mice.
Hypermethylation of RAS effector related genes and DNA methyltransferase 1 expression in endometrial carcinogenesis.
Hypermethylation of the DNA repair gene O(6)-methylguanine DNA methyltransferase and survival of patients with diffuse large B-cell lymphoma.
Hypermethylation of the progesterone receptor A in constitutive antiprogestin-resistant mouse mammary carcinomas.
Hypermethylation patterns in the Fhit regulatory region are tissue specific.
Hypomethylation and overexpression of c-jun and c-myc protooncogenes and increased DNA methyltransferase activity in dichloroacetic and trichloroacetic acid-promoted mouse liver tumors.
Hypomethylation of cytosine 5-methyltransferase in human neoplasms.
Hypomethylation of the DNMT3L promoter in ocular surface squamous neoplasia.
Hypoxia-inducible factor-2 alpha up-regulates CD70 under hypoxia and enhances anchorage-independent growth and aggressiveness in cancer cells.
Ibandronate increases the expression of the pro-apoptotic gene FAS by epigenetic mechanisms in tumor cells.
Identification and validation of mRNA 3'untranslated regions of DNMT3B and TET3 as novel competing endogenous RNAs of the tumor suppressor PTEN.
Identification of a novel leukemic-specific splice variant of DNMT3B and its stability.
Identification of clinical molecular targets for childhood Burkitt lymphoma.
Identification of clinical trait-related lncRNA and mRNA biomarkers with weighted gene co-expression network analysis as useful tool for personalized medicine in ovarian cancer.
Identification of DBCCR1 as a suppressor in the development of lung cancer that is associated with increased DNA methyltransferase 1.
Identification of DNMT1 (DNA methyltransferase 1) hypomorphs in somatic knockouts suggests an essential role for DNMT1 in cell survival.
Identification of DNMT1 selective antagonists using a novel scintillation proximity assay.
Identification of epigenetically silenced genes in tumor endothelial cells.
Identification of HRK as a target of epigenetic inactivation in colorectal and gastric cancer.
Identification of key genes by integrating DNA methylation and next-generation transcriptome sequencing for esophageal squamous cell carcinoma.
Identification of novel DNA methylation inhibitors via a two-component reporter gene system.
Identification of potent inhibitors of DNA methyltransferase 1 (DNMT1) through a pharmacophore-based virtual screening approach.
Identification of putative targets of DNA (cytosine-5) methylation-mediated transcriptional silencing using a novel conditionally active form of DNA methyltransferase 3a.
Identifying novel selective non-nucleoside DNA methyltransferase 1 inhibitors through docking-based virtual screening.
IFN-? potentiates the direct and immune-mediated antitumor effects of epigenetic drugs on both metastatic and stem cells of colorectal cancer.
IL-6 enriched lung cancer stem-like cell population by inhibition of cell cycle regulators via DNMT1 upregulation.
Immune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers.
Immunocytochemical staining of different cell types in vaginal smears by monoclonal anti-DNA methylase antibodies.
Immunohistochemical analysis of polycomb group protein expression in advanced gastric cancer.
Immunohistochemical analysis of the DNA methyltransferase 3b expression is associated with significant improvements in the discrimination of ulcerative colitis-associated neoplastic lesions.
Immunohistochemical evaluation of Klotho and DNA methyltransferase 3a in oral squamous cell carcinomas.
Immunohistochemical evaluation of O(6) -methylguanine DNA methyltransferase (MGMT) expression in 117 cases of glioblastoma.
Immunohistochemical expression of DNA methyltransferases 1, 3a and 3b in oral leukoplakias and squamous cell carcinomas.
Immunolocalization of DNMT1 and DNMT3a in salivary gland neoplasms.
Immunotherapy augments the effect of 5-azacytidine on HPV16-associated tumours with different MHC class I-expression status.
Impact of Dnmt1 deficiency, with and without low folate diets, on tumor numbers and DNA methylation in Min mice.
Impact on DNA Methylation in Cancer Prevention and Therapy by Bioactive Dietary Components.
Improving cancer immunotherapy with DNA methyltransferase inhibitors.
In silico docking of methyl isocyanate (MIC) and its hydrolytic product (1, 3-dimethylurea) shows significant interaction with DNA Methyltransferase 1 suggests cancer risk in Bhopal-Gas- Tragedy survivors.
Incorporating DNA Methyltransferase Inhibitors (DNMTis) in the Treatment of Genitourinary Malignancies: A Systematic Review.
Incorporation of mutations in five genes in the revised International Prognostic Scoring System can improve risk stratification in the patients with myelodysplastic syndrome.
Increased cytosine DNA-methyltransferase activity is target-cell-specific and an early event in lung cancer.
Increased DNA methyltransferase 1 (DNMT1) protein expression correlates significantly with poorer tumor differentiation and frequent DNA hypermethylation of multiple CpG islands in gastric cancers.
Increased DNA methyltransferase 1 (DNMT1) protein expression in precancerous conditions and ductal carcinomas of the pancreas.
Increased DNA methyltransferase 1 protein expression in human transitional cell carcinoma of the bladder.
Increased DNA methyltransferase expression in rhabdomyosarcomas.
Increased expression of deoxyribonucleic acid methyltransferase gene in human astrocytic tumors.
Increased expression of DNA methyltransferase 1 (DNMT1) protein in uterine cervix squamous cell carcinoma and its precursor lesion.
Increased Expression of DNA Methyltransferase 3a in Obese Adipose Tissue: Studies With Transgenic Mice.
Increased expression of DNA methyltransferase-1 in non-neoplastic epithelium helps predict colorectal neoplasia risk in ulcerative colitis.
Increased expression of hepatic DNA methyltransferase in smokers.
Increased protein expression of DNA methyltransferase (DNMT) 1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular carcinomas.
Increased protein stability causes DNA methyltransferase 1 dysregulation in breast cancer.
Indirubin regulates MPL and TNF expression in peripheral blood mononuclear cells from patients with primary immune thrombocytopenia.
Induced DNA demethylation can reshape chromatin topology at the IGF2-H19 locus.
Induction of active demethylation and 5hmC formation by 5-azacytidine is TET2 dependent and suggests new treatment strategies against hepatocellular carcinoma.
Induction of DNMT3B by PGE2 and IL6 at Distant Metastatic Sites Promotes Epigenetic Modification and Breast Cancer Colonization.
Influence of Histone Deacetylase Inhibitors and DNA-Methyltransferase Inhibitors on the NK Cell-Mediated Lysis of Pediatric B-Lineage Leukemia.
Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses.
Inhibition of de novo Methyltransferase 3B is a Potential Therapy for Hepatocellular Carcinoma.
Inhibition of DNA methylation and histone deacetylation prevents murine lung cancer.
Inhibition of DNA methylation by antisense oligonucleotide MG98 as cancer therapy.
Inhibition of DNA Methylation Suppresses Intestinal Tumor Organoids by Inducing an Anti-Viral Response.
Inhibition of DNA methyltransferase 1 by RNA interference reverses epithelial-mesenchymal transition in highly metastatic 95D lung cancer cells by inhibiting the Wnt signaling pathway.
Inhibition of DNA methyltransferase activates tumor necrosis factor alpha-induced monocytic differentiation in acute myeloid leukemia cells.
Inhibition of DNA methyltransferase activity prevents tumorigenesis in a mouse model of prostate cancer.
Inhibition of DNA methyltransferase as a novel therapeutic strategy to overcome acquired resistance to dual PI3K/mTOR inhibitors.
Inhibition of DNA methyltransferase induces G2 cell cycle arrest and apoptosis in human colorectal cancer cells via inhibition of JAK2/STAT3/STAT5 signaling.
Inhibition of DNA methyltransferase induces G2 cell cycle arrest and apoptosis in human colorectal cancer cells via inhibition of JAK2/STAT3/STAT5 signalling.
Inhibition of DNA methyltransferase stimulates the expression of signal transducer and activator of transcription 1, 2, and 3 genes in colon tumor cells.
Inhibition of EZH2 via activation of SAPK/JNK and reduction of p65 and DNMT1 as a novel mechanism in inhibition of human lung cancer cells by polyphyllin I.
Inhibition of histone deacetylation does not block resilencing of p16 after 5-aza-2'-deoxycytidine treatment.
Inhibition of intestinal tumor formation by deletion of the DNA methyltransferase 3a.
Inhibition of p53 represses E-cadherin expression by increasing DNA methyltransferase-1 and promoter methylation in serous borderline ovarian tumor cells.
Inhibition of the mevalonate pathway affects epigenetic regulation in cancer cells.
Insight into the molecular pathophysiology of myelodysplastic syndromes: targets for novel therapy.
Insulin-like growth factor binding protein-3 (IGFBP-3) plays a role in the anti-tumorigenic effects of 5-Aza-2'-deoxycytidine (AZA) in breast cancer cells.
Integrative Analysis Reveals Comprehensive Altered Metabolic Genes Linking with Tumor Epigenetics Modification in Pan-Cancer.
Interplay between DNA Methyltransferase 1 and microRNAs During Tumorigenesis.
Interplay of DNA methyltransferase 1 and EZH2 through inactivation of Stat3 contributes to ?-elemene-inhibited growth of nasopharyngeal carcinoma cells.
Intestinal PPAR? Protects Against Colon Carcinogenesis via Regulation of Methyltransferases DNMT1 and PRMT6.
Intragenic DNA methylation prevents spurious transcription initiation.
Intravenous 5-fluoro-2'-deoxycytidine administered with tetrahydrouridine increases the proportion of p16-expressing circulating tumor cells in patients with advanced solid tumors.
Invasive and Noninvasive Nonfunctioning Gonadotroph Pituitary Tumors Differ in DNA Methylation Level of LINE-1 Repetitive Elements.
Investigation of GSTP1 and epigenetic regulators expression pattern in a population of Iranian patient with prostate cancer.
Investigation of the expression patterns and correlation of DNA methyltransferases and class I histone deacetylases in ovarian cancer tissues.
Involvement of epigenetics and microRNA-29b in the urethane induced inception and establishment of mouse lung tumors.
Is the Proteome of Bronchoalveolar Lavage Extracellular Vesicles a Marker of Advanced Lung Cancer?
Ischemia dysregulates DNA methyltransferases and p16(INK4a) methylation in human colorectal cancer cells.
Isocitrate dehydrogenase 1 Gene Mutation Is Associated with Prognosis in Clinical Low-Grade Gliomas.
Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery.
Isovitexin Suppresses Cancer Stemness Property And Induces Apoptosis Of Osteosarcoma Cells By Disruption Of The DNMT1/miR-34a/Bcl-2 Axis.
JAK2 regulates mismatch repair protein-mediated epigenetic alterations in response to oxidative damage.
Kindlin-2 interacts with and stabilizes DNMT1 to promote breast cancer development.
Knockdown of DNA methyltransferase-1 inhibits proliferation and derepresses tumor suppressor genes in myeloma cells.
KRAB-Induced Heterochromatin Effectively Silences PLOD2 Gene Expression in Somatic Cells and is Resilient to TGF?1 Activation.
Kruppel-Like Factor 9 Loss-of-Expression in Human Endometrial Carcinoma Links Altered Expression of Growth-Regulatory Genes with Aberrant Proliferative Response to Estrogen.
Label-free electrochemical detection of human methyltransferase from tumors.
Label-free fluorescence detection of DNA methylation and methyltransferase activity based on restriction endonuclease HpaII and exonuclease III.
Label-free fluorescence strategy for methyltransferase activity assay based on poly-thymine copper nanoclusters engineered by terminal deoxynucleotidyl transferase.
Laccaic Acid A Is a Direct, DNA-competitive Inhibitor of DNA Methyltransferase 1.
Lack of ADAM2, CALR3 and SAGE1 Cancer/Testis Antigen Expression in Lung and Breast Cancer.
Lactate-fueled oxidative metabolism drives DNA methyltransferase 1-mediated transcriptional co-activator with PDZ binding domain protein activation.
Limited gene activation in tumor and normal epithelial cells treated with the DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine.
Limoniastrum guyonianum aqueous gall extract induces apoptosis in human cervical cancer cells involving p16 INK4A re-expression related to UHRF1 and DNMT1 down-regulation.
LINC00337 promotes tumor angiogenesis in colorectal cancer by recruiting DNMT1, which suppresses the expression of CNN1.
LncRNA NEAT1 Interacted With DNMT1 to Regulate Malignant Phenotype of Cancer Cell and Cytotoxic T Cell Infiltration via Epigenetic Inhibition of p53, cGAS, and STING in Lung Cancer.
LncRNATCF7 up-regulates DNMT1 mediated by HPV-18 E6 and regulates biological behavior of cervical cancer cells by inhibiting miR-155.
Long non-coding RNA DBCCR1-003 regulate the expression of DBCCR1 via DNMT1 in bladder cancer.
Long noncoding RNA NEAT1 promotes progression of glioma as a ceRNA by sponging miR-185-5p to stimulate DNMT1/mTOR signaling.
Long term transcriptional reactivation of epigenetically silenced genes in colorectal cancer cells requires DNA hypomethylation and histone acetylation.
Long-term cadmium exposure leads to the enhancement of lymphocyte proliferation via down-regulating p16 by DNA hypermethylation.
Long-term stability of demethylation after transient exposure to 5-aza-2'-deoxycytidine correlates with sustained RNA polymerase II occupancy.
Loss of 5-hydroxymethylcytosine is accompanied with malignant cellular transformation.
Loss of Dnmt3a and Dnmt3b does not affect epidermal homeostasis but promotes squamous transformation through PPAR-?.
Loss of Dnmt3a and endogenous Kras(G12D/+) cooperate to regulate hematopoietic stem and progenitor cell functions in leukemogenesis.
Loss of Dnmt3a Immortalizes Hematopoietic Stem Cells In Vivo.
Loss of Dnmt3b accelerates MLL-AF9 leukemia progression.
Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis.
Loss of exosomal miR-148b from cancer-associated fibroblasts promotes endometrial cancer cell invasion and cancer metastasis.
Loss of pericentromeric DNA methylation pattern in human glioblastoma is associated with altered DNA methyltransferases expression and involves the stem cell compartment.
Loss of post-transcriptional regulation of DNMT3b by microRNAs: a possible molecular mechanism for the hypermethylation defect observed in a subset of breast cancer cell lines.
Loss of RB compromises specific heterochromatin modifications and modulates HP1alpha dynamics.
Low expression of PRKCDBP promoted cisplatin resistance in lung adenocarcinoma by DNMT1 and TNF??.
Lower expression of p14ARF and p16INK4a correlates with higher DNMT3B expression in human oesophageal squamous cell carcinomas.
LSD1 dual function in mediating epigenetic corruption of the vitamin D signaling in prostate cancer.
m5C RNA Methylation Primarily Affects the ErbB and PI3K-Akt Signaling Pathways in Gastrointestinal Cancer.
Magnetic bead-liposome hybrids enable sensitive and portable detection of DNA methyltransferase activity using personal glucose meter.
Magnetic immunoassay using CdSe/ZnS quantum dots as fluorescent probes to detect the level of DNA methyltransferase 1 in human serum sample.
Maintenance of DNA methylation: Dnmt3b joins the dance.
Maintenance Therapy with Decitabine after Allogeneic Stem Cell Transplantation for Acute Myelogenous Leukemia and Myelodysplastic Syndrome.
Mammalian DNA methyltransferase 1: inspiration for new directions.
Mapping and significance of the mRNA methylome.
Marginal Time-Dependent Causal Effects in Mediation Analysis With Survival Data.
Maternal nicotinamide supplementation causes global DNA hypomethylation, uracil hypo-incorporation and gene expression changes in fetal rats.
MDGA2 is a novel tumour suppressor cooperating with DMAP1 in gastric cancer and is associated with disease outcome.
Mechanism-Based Inhibitor of DNA Cytosine-5 Methyltransferase by a S
Mechanisms of DNA damage, DNA hypomethylation, and tumor progression in the folate/methyl-deficient rat model of hepatocarcinogenesis.
Messenger RNA expression and methylation of candidate tumor-suppressor genes and risk of ovarian cancer-a case-control analysis.
Meta-analysis Reveals No Association of DNMT3B -149 C>T Gene Polymorphism With Overall Cancer Risk.
Metastasis-associated protein 1 is an upstream regulator of DNMT3a and stimulator of insulin-growth factor binding protein-3 in breast cancer.
Metformin selectively inhibits metastatic colorectal cancer with the KRAS mutation by intracellular accumulation through silencing MATE1.
Methods for cancer epigenome analysis.
Methylation and miRNA effects of resveratrol on mammary tumors vs. normal tissue.
Methylation of MGMT in malignant pleural mesothelioma occurs in a subset of patients and is associated with the T allele of the rs16906252 MGMT promoter SNP.
Methylation of miR-124a-1, miR-124a-2, and miR-124a-3 genes correlates with aggressive and advanced breast cancer disease.
Methylation of RASSF1A gene promoter and the correlation with DNMT1 expression that may contribute to esophageal squamous cell carcinoma.
Methylation of the miR?29b?3p promoter contributes to angiogenesis, invasion, and migration in pancreatic cancer.
Methylation of Wnt7a Is Modulated by DNMT1 and Cigarette Smoke Condensate in Non-Small Cell Lung Cancer.
Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis.
Methylation profiling of CpG islands in human breast cancer cells.
Methylation-independent repression of Dnmt3b contributes to oncogenic activity of Dnmt3a in mouse MYC-induced T-cell lymphomagenesis.
Methylator phenotype of malignant germ cell tumours in children identifies strong candidates for chemotherapy resistance.
Methylomic Signatures of High Grade Serous Ovarian Cancer.
Methyltransferase expression and tumor suppressor gene methylation in sporadic and familial colorectal cancer.
Mgmt deficiency alters the in vivo mutational spectrum of tissues exposed to the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).
MGMT promoter methylation is associated with temozolomide response and prolonged progression-free survival in disseminated cutaneous melanoma.
Micro RNAs and DNA methylation are regulatory players in human cells with altered X chromosome to autosome balance.
Microenvironment-induced downregulation of miR-193b drives ovarian cancer metastasis.
MicroRNA -29b induces global DNA hypomethylation and tumor suppressor gene re-expression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1.
MicroRNA-129-5p inhibits human glioma cell proliferation and induces cell cycle arrest by directly targeting DNMT3A.
MicroRNA-143 targets DNA methyltransferases 3A in colorectal cancer.
MicroRNA-148a is silenced by hypermethylation and interacts with DNA methyltransferase 1 in gastric cancer.
MicroRNA-148a overexpression improves the early development of porcine somatic cell nuclear transfer embryos.
MicroRNA-148a: A potential therapeutic target for cancer.
MicroRNA-148b and microRNA-152 reactivate tumor suppressor genes through suppression of DNA methyltransferase-1 gene in pancreatic cancer cell lines.
MicroRNA-26a inhibits proliferation and metastasis of human hepatocellular carcinoma by regulating DNMT3B-MEG3 axis.
MicroRNA-342 inhibits colorectal cancer cell proliferation and invasion by directly targeting DNA methyltransferase 1.
MicroRNA-dependent regulation of DNA methyltransferase-1 and tumor suppressor gene expression by interleukin-6 in human malignant cholangiocytes.
MiR-137 Suppresses Triple-Negative Breast Cancer Stemness and Tumorigenesis by Perturbing BCL11A-DNMT1 Interaction.
MiR-139-5p suppresses osteosarcoma cell growth and invasion through regulating DNMT1.
MiR-142-3p is downregulated in aggressive p53 mutant mouse models of pancreatic ductal adenocarcinoma by hypermethylation of its locus.
miR-148-3p Inhibits Growth of Glioblastoma Targeting DNA Methyltransferase-1 (DNMT1).
miR-148a-3p represses proliferation and EMT by establishing regulatory circuits between ERBB3/AKT2/c-myc and DNMT1 in bladder cancer.
miR-148b reverses cisplatin-resistance in non-small cell cancer cells via negatively regulating DNA (cytosine-5)-methyltransferase 1(DNMT1) expression.
MiR-152 functioning as a tumor suppressor that interacts with DNMT1 in nasopharyngeal carcinoma.
miR-155 increases stemness and decitabine resistance in triple-negative breast cancer cells by inhibiting TSPAN5.
miR-185 inhibits hepatocellular carcinoma growth by targeting the DNMT1/PTEN/Akt pathway.
miR-185 suppresses tumor proliferation by directly targeting E2F6 and DNMT1 and indirectly upregulating BRCA1 in triple-negative breast cancer.
MiR-211 is epigenetically regulated by DNMT1 mediated methylation and inhibits EMT of melanoma cells by targeting RAB22A.
miR-29c plays a suppressive role in breast cancer by targeting the TIMP3/STAT1/FOXO1 pathway.
miR-29c-3p regulates DNMT3B and LATS1 methylation to inhibit tumor progression in hepatocellular carcinoma.
miR-29s inhibit the malignant behavior of U87MG glioblastoma cell line by targeting DNMT3A and 3B.
MiR-339 and especially miR-766 reactivate the expression of tumor suppressor genes in colorectal cancer cell lines through DNA methyltransferase 3B gene inhibition.
miR-373 Negatively Regulates Methyl-CpG-Binding Domain Protein 2 (MBD2) in Hilar Cholangiocarcinoma.
MiR-377 reverses cancerous phenotypes of pancreatic cells via suppressing DNMT1 and demethylating tumor suppressor genes.
MiR-410 is overexpressed in liver and colorectal tumors and enhances tumor cell growth by silencing FHL1 via a direct/indirect mechanism.
MiRNA-140 acts as a liver tumor suppressor by controlling NF-?B activity via directly targeting Dnmt1 expression.
Mismatch repair genes identified using genetic screens in Blm-deficient embryonic stem cells.
Missing in metastasis B, regulated by DNMT1, functions as a putative cancer suppressor in human lung giant-cell carcinoma.
MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-Enhancers at Tumor Suppressor Genes.
Moderate DNA hypomethylation suppresses intestinal tumorigenesis by promoting caspase-3 expression and apoptosis.
Modes of action of the DNA methyltransferase inhibitors azacytidine and decitabine.
Modulation by bexarotene of mRNA expression of genes in mouse lung tumors.
Modulation of miR-203 and its regulators as a function of time during the development of 7, 12 dimethylbenz [a] anthracene induced mouse skin tumors in presence or absence of the antitumor agents.
Molecular alterations in retinoblastoma beyond RB1.
Molecular Characterization of a Rare Case of Bilateral Vitreoretinal T Cell Lymphoma through Vitreous Liquid Biopsy.
Molecular Mechanism of SLC5A8 Inactivation in Breast Cancer.
Molecular pathogenesis of breast cancer: impact of miR-99a-5p and miR-99a-3p regulation on oncogenic genes.
Mouse ascites DNA methylase: characterisation of size, proteolytic breakdown and nucleotide recognition.
MTSS1, a novel target of DNA methyltransferase 3B, functions as a tumor suppressor in hepatocellular carcinoma.
MUC1-C induces DNA methyltransferase 1 and represses tumor suppressor genes in acute myeloid leukemia.
Multi-gene epigenetic silencing of tumor suppressor genes in T-cell lymphoma cells; delayed expression of the p16 protein upon reversal of the silencing.
Multifunctional Gold Nanoparticles Overcome MicroRNA Regulatory Network Mediated-Multidrug Resistant Leukemia.
Multigene methylation analysis of gastrointestinal tumors: TPEF emerges as a frequent tumor-specific aberrantly methylated marker that can be detected in peripheral blood.
Multiple sealed primers-mediated rolling circle amplification strategy for sensitive and specific detection of DNA methyltransferase activity.
Multiproteomic and Transcriptomic Analysis of Oncogenic ?-Catenin Molecular Networks.
Mutation analysis of ASXL1, CBL, DNMT3A, IDH1, IDH2, JAK2, MPL, NF1, SF3B1, SUZ12, and TET2 in myeloproliferative neoplasms.
Mutation analysis of JAK2V617F, FLT3-ITD, NPM1, and DNMT3A in Chinese patients with myeloproliferative neoplasms.
Mutational analysis of DNMT3A gene in acute leukemias and common solid cancers.
Mutations found in cell-free DNAs of patients with malignant lymphoma at remission can derive from clonal hematopoiesis.
Mutations in DNMT3A and loss of RKIP are independent events in acute monocytic leukemia.
Mutations of myelodysplastic syndromes (MDS): An update.
Mutations of R882 change flanking sequence preferences of the DNA methyltransferase DNMT3A and cellular methylation patterns.
Mutually Exclusive Promoter Hypermethylation Patterns of hMLH1 and O6-Methylguanine DNA Methyltransferase in Colorectal Cancer.
Myc sensitizes p53-deficient cancer cells to the DNA-damaging effects of the DNA methyltransferase inhibitor decitabine.
MYC suppresses STING-dependent innate immunity by transcriptionally upregulating DNMT1 in triple-negative breast cancer.
Myeloid malignancies with isolated 7q deletion can be further characterized by their accompanying molecular mutations.
Myeloid malignancies: mutations, models and management.
Myeloproliferative neoplasms: Current molecular biology and genetics.
Nanaomycin A Selectively Inhibits DNMT3B and Reactivates Silenced Tumor Suppressor Genes in Human Cancer Cells.
Nanomaterial-based biosensors for DNA methyltransferase assay.
Negative regulation of DNMT3A de novo DNA methylation by frequently overexpressed UHRF family proteins as a mechanism for widespread DNA hypomethylation in cancer.
Neoantigen-based EpiGVAX vaccine initiates antitumor immunity in colorectal cancer.
New 5' regions of the murine and human genes for DNA (cytosine-5)-methyltransferase.
New insights into estrogenic regulation of O(6)-methylguanine DNA-methyltransferase (MGMT) in human breast cancer cells: Co-degradation of ER-? and MGMT proteins by fulvestrant or O(6)-benzylguanine indicates fresh avenues for therapy.
Next-generation sequencing of acute myeloid leukemia identifies the significance of TP53, U2AF1, ASXL1, and TET2 mutations.
Nicotinamide supplementation induces detrimental metabolic and epigenetic changes in developing rats.
NNK-induced DNA methyltransferase 1 in lung tumorigenesis in A/J mice and inhibitory effects of (-)-epigallocatechin-3-gallate.
Non-epigenetic induction of HEXIM1 by DNMT1 inhibitors and functional relevance.
Notch1 binds and induces degradation of Snail in hepatocellular carcinoma.
Novel and selective DNA methyltransferase inhibitors: Docking-based virtual screening and experimental evaluation.
Novel Curcumin Liposome Modified with Hyaluronan Targeting CD44 Plays an Anti-Leukemic Role in Acute Myeloid Leukemia in Vitro and in Vivo.
Novel DNA methyltransferase-1 (DNMT1) depleting anticancer nucleosides, 4'-thio-2'-deoxycytidine and 5-aza-4'-thio-2'-deoxycytidine.
Novel long noncoding RNA NMR promotes tumor progression via NSUN2 and BPTF in esophageal squamous cell carcinoma.
Novel oligoamine analogues inhibit lysine-specific demethylase 1 and induce reexpression of epigenetically silenced genes.
Novel Quinoline Compounds Active in Cancer Cells through Coupled DNA Methyltransferase Inhibition and Degradation.
Novel therapeutic targets for multiple myeloma.
NSun2 Deficiency Protects Endothelium From Inflammation via mRNA Methylation of ICAM-1.
NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation.
NSUN2-mediated RNA 5-methylcytosine promotes esophageal squamous cell carcinoma progression via LIN28B-dependent GRB2 mRNA stabilization.
NT1721, a novel epidithiodiketopiperazine, exhibits potent in vitro and in vivo efficacy against acute myeloid leukemia.
NUC041, a Prodrug of the DNA Methytransferase Inhibitor 5-aza-2',2'-Difluorodeoxycytidine (NUC013), Leads to Tumor Regression in a Model of Non-Small Cell Lung Cancer.
O(6)-Methylguanine DNA methyltransferase expression in tumor cells predicts outcome of radiotherapy plus concomitant and adjuvant temozolomide therapy in patients with primary glioblastoma.
O(6)-methylguanine DNA methyltransferase immunoexpression in nonfunctioning pituitary adenomas: are progressive tumors potential candidates for temozolomide treatment?
O6-methylguanine DNA methyltransferase deficiency and response to temozolomide-based therapy in patients with neuroendocrine tumors.
O6-Methylguanine DNA Methyltransferase Status Does Not Predict Response or Resistance to Alkylating Agents in Well-Differentiated Pancreatic Neuroendocrine Tumors.
OAS-RNase L innate immune pathway mediates the cytotoxicity of a DNA-demethylating drug.
On your histone mark, SET, methylate!
Oncogenic human papillomavirus imposes an instructive pattern of DNA methylation changes which parallel the natural history of cervical HPV infection in young women.
Oncogenic nature of a novel mutant AATF and its interactome existing within human cancer cells.
Oncogenic Roles and Inhibitors of DNMT1, DNMT3A, and DNMT3B in Acute Myeloid Leukaemia.
Oncolytic adenovirus-expressed RNA interference of O(6)-methylguanine DNA methyltransferase activity may enhance the antitumor effects of temozolomide.
Opposing roles of Dnmt1 in early- and late-stage murine prostate cancer.
Opposite alterations of DNA methyltransferase gene expression in endometrioid and serous endometrial cancers.
Oral vitamin C supplementation to patients with myeloid cancer on azacitidine treatment: Normalization of plasma vitamin C induces epigenetic changes.
Osteopontin alters DNA methylation through up-regulating DNMT1 and sensitizes CD133+/CD44+ cancer stem cells to 5 azacytidine in hepatocellular carcinoma.
Over-expression of DNMT3A predicts the risk of recurrent vulvar squamous cell carcinomas.
Overcoming resistance to interferon-induced apoptosis of renal carcinoma and melanoma cells by DNA demethylation.
Overexpression of DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) And DNA (Cytosine-5)-Methyltransferase 3A (DNMT3A) Is Associated with Aggressive Behavior and Hypermethylation of Tumor Suppressor Genes in Human Pituitary Adenomas.
Overexpression of DNA methyltransferase 1 (DNMT1) protein in astrocytic tumour and its correlation with O6-methylguanine-DNA methyltransferase (MGMT) expression.
Overexpression of DNA methyltransferase 1 and its biological significance in primary hepatocellular carcinoma.
Overexpression of NSUN2 by DNA hypomethylation is associated with metastatic progression in human breast cancer.
Overexpression of transposable elements is associated with immune evasion and poor outcome in colorectal cancer.
P16 methylation increases the sensitivity of cancer cells to the CDK4/6 inhibitor palbociclib.
Paederia foetida induces anticancer activity by modulating chromatin modification enzymes and altering pro-inflammatory cytokine gene expression in human prostate cancer cells.
Pan-cancer analysis of RNA methyltransferases identifies FTSJ3 as a potential regulator of breast cancer progression.
Pancreatic cancer DNMT1 expression and sensitivity to DNMT1 inhibitors.
Paradoxical association of TET loss of function with genome-wide DNA hypomethylation.
PART-1 functions as a competitive endogenous RNA for promoting tumor progression by sponging miR-143 in colorectal cancer.
PARTICLE - The RNA podium for genomic silencers.
Pathological classification of brain tumors.
Peperomin E reactivates silenced tumor suppressor genes in lung cancer cells via inhibition of DNA methyltransferase.
Perturbed hematopoiesis in individuals with germline DNMT3A overgrowth Tatton-Brown-Rahman syndrome.
Pharmaco-epigenomics: discovering therapeutic approaches and biomarkers for cancer therapy.
Pharmacologic induction of innate immune signaling directly drives homologous recombination deficiency.
Phase I and pharmacodynamic trial of the DNA methyltransferase inhibitor decitabine and carboplatin in solid tumors.
Phase I study of MG98, an oligonucleotide antisense inhibitor of human DNA methyltransferase 1, given as a 7-day infusion in patients with advanced solid tumors.
Phase I Trial of DNA Methyltransferase Inhibitor Guadecitabine Combined with Cisplatin and Gemcitabine for Solid Malignancies Including Urothelial Carcinoma (SPIRE).
Phase II trial of DNA methyltransferase 1 inhibition with the antisense oligonucleotide MG98 in patients with metastatic renal carcinoma: a National Cancer Institute of Canada Clinical Trials Group investigational new drug study.
Phosphatidylinositol 3-kinase/protein kinase B pathway stabilizes DNA methyltransferase I protein and maintains DNA methylation.
Phosphorylation of human DNMT1: implication of cyclin-dependent kinases.
Physcion 8-O-?-glucopyranoside induces apoptosis, suppresses invasion and inhibits epithelial to mesenchymal transition of hepatocellular carcinoma HepG2 cells.
piR-823 demonstrates tumor oncogenic activity in esophageal squamous cell carcinoma through DNA methylation induction via DNA methyltransferase 3B.
piRNA-823 contributes to tumorigenesis by regulating de novo DNA methylation and angiogenesis in multiple myeloma.
piRNA-823 Is Involved in Cancer Stem Cell Regulation Through Altering DNA Methylation in Association With Luminal Breast Cancer.
Plasma and cerebrospinal fluid pharmacokinetics of the DNA methyltransferase inhibitor, 5-azacytidine, alone and with inulin, in nonhuman primate models.
Polycomb and DNA methyltransferase complexes participate in global and focal epigenetic alteration in cancer cells.
Polycomb group genes are targets of aberrant DNA methylation in renal cell carcinoma.
Polymorphism of DNA methyltransferase 3B -149C/T and cancer risk: a meta-analysis.
Polymorphism of DNA Methyltransferase 3b and Association with Development and Prognosis in Gastric Cancer.
Polymorphisms of the DNMT3B gene and risk of squamous cell carcinoma of the head and neck: a case-control study.
Polyphenols in brewed green tea inhibit prostate tumor xenograft growth by localizing to the tumor and decreasing oxidative stress and angiogenesis.
Potential advantages of DNA methyltransferase 1 (DNMT1)-targeted inhibition for cancer therapy.
Potential Epigenetic-Based Therapeutic Targets for Glioma.
PPAR-Responsive Elements Enriched with Alu Repeats May Contribute to Distinctive PPAR?-DNMT1 Interactions in the Genome.
Predictive factors for the sensitivity of radiotherapy and prognosis of esophageal squamous cell carcinoma.
Predictive value of m5C regulatory gene expression in pancreatic adenocarcinoma.
Preferential response of cancer cells to zebularine.
Presence of a consensus DNA motif at nearby DNA sequence of the mutation susceptible CG nucleotides.
Prevalence, predictors, and outcomes of clonal hematopoiesis in individuals aged ?80 years.
Primary CNS T-cell Lymphomas: A Clinical, Morphologic, Immunophenotypic, and Molecular Analysis.
Procainamide is a specific inhibitor of DNA methyltransferase 1.
Progesterone receptor gene inactivation and CpG island hypermethylation in human leukemia cancer cells.
Prolonged inhibition of O(6)-methylguanine DNA methyltransferase in human tumor cells by O(6)-benzylguanine in vitro and in vivo.
Promoter hypermethylation of the O(6)-methylguanine DNA methyltransferase gene and microsatellite instability in metastatic melanoma.
Promoter Hypomethylation and Expression Is Conserved in Mouse Chronic Lymphocytic Leukemia Induced by Decreased or Inactivated Dnmt3a.
Promoter methylation status of tumor suppressor genes and inhibition of expression of DNA methyltransferase 1 in non-small cell lung cancer.
Promoter methylation, mRNA expression of goat tumor?associated genes and mRNA expression of DNA methyltransferase in enzootic nasal tumors.
Promoter polymorphisms of DNA methyltransferase 3B and risk of hepatocellular carcinoma.
Promoter polymorphisms of DNMT3B and the risk of colorectal cancer in Chinese: a case-control study.
Promoter polymorphisms of DNMT3B and the risk of head and neck squamous cell carcinoma in Taiwan: a case-control study.
Prostaglandin E2 induces DNA hypermethylation in gastric cancer in vitro and in vivo.
Protein arginine methyltransferase 5-mediated epigenetic silencing of IRX1 contributes to tumorigenicity and metastasis of gastric cancer.
Protein expression trends of DNMT1 in gastrointestinal diseases: From benign to precancerous lesions to cancer.
Protein expression, mRNA expression and gene amplification of DNA methyltransferase 1 in endometrial tumor tissues.
Quantitative analysis of associations between DNA hypermethylation, hypomethylation, and DNMT RNA levels in ovarian tumors.
Quantitative analysis of mRNA expression levels and DNA methylation profiles of three neighboring genes: FUS1, NPRL2/G21 and RASSF1A in non-small cell lung cancer patients.
Quantitative analysis of promoter hypermethylation in multiple genes in osteosarcoma.
Quantitative O(6)-methylguanine DNA methyltransferase methylation analysis in curatively resected non-small cell lung cancer: associations with clinical outcome.
Radiation-induced hypomethylation triggers urokinase plasminogen activator transcription in meningioma cells.
Randomized trial of the combination of lomeguatrib and temozolomide compared with temozolomide alone in chemotherapy naive patients with metastatic cutaneous melanoma.
Rapid restriction enzyme free detection of DNA methyltransferase activity based on DNA-templated silver nanoclusters.
Rare mutations in DNMT3A in myeloproliferative neoplasms and myelodysplastic syndromes.
RCC2 promotes proliferation and radio-resistance in glioblastoma via activating transcription of DNMT1.
Re-expression of RASSF1A by 5-Aza-CdR induced demethylation of the promoter region in human biliary tract carcinoma cells.
Reactivating the expression of methylation silenced genes in human cancer.
Reactivation of Atp4a concomitant with intragenic DNA demethylation for cancer inhibition in a gastric cancer model.
Reactivation of epigenetically silenced genes by DNA methyltransferase inhibitors: basic concepts and clinical applications.
Real-time PCR analysis of genes encoding tumor antigens in esophageal tumors and a cancer vaccine.
Recessive cancer genes engage in negative genetic interactions with their functional paralogs.
Recurrent DNMT3A R882 mutations in Chinese patients with acute myeloid leukemia and myelodysplastic syndrome.
Reduced levels of methyltransferase DNMT2 sensitize human fibroblasts to oxidative stress and DNA damage that is accompanied by changes in proliferation-related miRNA expression.
Reduction of pancreatic acinar cell tumor multiplicity in Dnmt1 hypomorphic mice.
Reduction of pancreatic cancer cell viability and induction of apoptosis mediated by siRNA targeting DNMT1 through suppression of total DNA methyltransferase activity.
Reduction of two histone marks, H3k9me3 and H3k27me3 by epidrug induces neuroendocrine differentiation in prostate cancer.
Reexpression of epigenetically silenced AML tumor suppressor genes by SUV39H1 inhibition.
Regional DNA hypermethylation and DNA methyltransferase (DNMT) 1 protein overexpression in both renal tumors and corresponding nontumorous renal tissues.
Regulation of carcinogenesis and modulation through Wnt/?-catenin signaling by curcumin in an ovarian cancer cell line.
Regulation of DNA methylation and tumor suppression gene expression by miR-29b in leukemia patients and related mechanisms.
Regulation of the DNA methylation machinery and its role in cellular transformation.
Reprogramming of HeLa cells upon DNMT3L overexpression mimics carcinogenesis.
Restoration of miR-101 suppresses lung tumorigenesis through inhibition of DNMT3a-dependent DNA methylation.
Restoration of the methylation status of hypermethylated gene promoters by microRNA-29b in human breast cancer: A novel epigenetic therapeutic approach.
Resveratrol promotes oxidative stress to drive DLC1 mediated cellular senescence in cancer cells.
Resveratrol-salicylate derivatives as selective DNMT3 inhibitors and anticancer agents.
Retinoblastoma pathway dysregulation causes DNA methyltransferase 1 overexpression in cancer via MAD2-mediated inhibition of the anaphase-promoting complex.
Retinoids, retinoic acid receptors, and cancer.
Reversal of hypermethylation and reactivation of p16INK4a, RARbeta, and MGMT genes by genistein and other isoflavones from soy.
Reversal of increased mammary tumorigenesis by valproic acid and hydralazine in offspring of dams fed high fat diet during pregnancy.
Reversal of loss of imprinting in tumor cells by 5-aza-2'-deoxycytidine.
Rewriting the epigenetic code for tumor resensitization: a review.
RFTS-deleted DNMT1 enhances tumorigenicity with focal hypermethylation and global hypomethylation.
RGS6 as a Novel Therapeutic Target in CNS Diseases and Cancer.
RGS6 is an essential tumor suppressor that prevents bladder carcinogenesis by promoting p53 activation and DNMT1 downregulation.
RGS6 suppresses Ras-induced cellular transformation by facilitating Tip60-mediated Dnmt1 degradation and promoting apoptosis.
RNA interference-mediated knockdown of DNA methyltransferase 1 leads to promoter demethylation and gene re-expression in human lung and breast cancer cells.
RNA methyltransferase NSUN2 promotes gastric cancer cell proliferation by repressing p57Kip2 by an m5C-dependent manner.
RNA methyltransferase NSUN2 promotes growth of hepatocellular carcinoma cells by regulating fizzy-related-1 in vitro and in vivo.
RNA methyltransferase NSUN2 promotes hypopharyngeal squamous cell carcinoma proliferation and migration by enhancing TEAD1 expression in an m5C-dependent manner.
RNAPol-ChIP analysis of transcription from FSHD-linked tandem repeats and satellite DNA.
Role of antimetabolites of purine and pyrimidine nucleotide metabolism in tumor cell differentiation.
Role of de novo DNA methyltransferases and methyl CpG-binding proteins in gene silencing in a rat hepatoma.
Role of DNA methylation on human CTSG in dermatomyositic myoideum.
Role of DNA methyltransferase 1 in hormone-resistant prostate cancer.
Role of DNA methyltransferase 1 in pharyngeal cancer related to treatment resistance.
Role of estrogen receptor gene demethylation and DNA methyltransferase.DNA adduct formation in 5-aza-2'deoxycytidine-induced cytotoxicity in human breast cancer cells.
Role of NADPH Oxidase NOX5-S, NF-kB and DNMT1 in Acid-Induced P16 Hypermethylation in Barrett's cells.
Role of the cytosine DNA-methyltransferase and p16INK4a genes in the development of mouse lung tumors.
Role of the DNA methyltransferase variant DNMT3b3 in DNA methylation.
RX-3117 (fluorocyclopentenyl cytosine): a novel specific antimetabolite for selective cancer treatment.
S-allylcysteine suppresses ovarian cancer cell proliferation by DNA methylation through DNMT1.
SALL3 interacts with DNMT3A and shows the ability to inhibit CpG island methylation in hepatocellular carcinoma.
Selective inhibition of DNA methyltransferase enzymes as a novel strategy for cancer treatment.
Selective inhibition of esophageal cancer cells by combination of HDAC inhibitors and Azacytidine.
Selenium and Epigenetics in Cancer: Focus on DNA Methylation.
Self-Powered Biosensing Platform Based on "Signal-On" Enzymatic Biofuel Cell for DNA Methyltransferase Activity Analysis and Inhibitor Screening.
Sensitive Electrochemical Detection of Human Methyltransferase Based on a Dual Signal Amplification Strategy Coupling Gold Nanoparticle-DNA Complexes with Ru(III) Redox Recycling.
Sensitive fluorescent detection of DNA methyltransferase using nicking endonuclease-mediated multiple primers-like rolling circle amplification.
Sensitive fluorescent detection of methyltransferase based on thermosensitive poly(N-isopropylacrylamide).
Sensitive surface plasmon resonance detection of methyltransferase activity and screening of its inhibitors amplified by p53 protein bound to methylation-specific ds-DNA consensus sites.
Serological identification and bioinformatics analysis of immunogenic antigens in multiple myeloma.
si-DNMT1 restore tumor suppressor genes expression through the reversal of DNA hypermethylation in cholangiocarcinoma.
Significance of DNA methyltransferase-1 and histone deacetylase-1 in pancreatic cancer.
Significance of DNMT3b in Oral Cancer.
Silencing DNA methyltransferase 1 (DNMT1) inhibits proliferation, metastasis and invasion in ESCC by suppressing methylation of RASSF1A and DAPK.
Silencing DNA methyltransferase 1 leads to the activation of the esophageal suppressor gene p16 in vitro and in vivo.
Silencing of miR-152 contributes to DNMT1-mediated CpG methylation of the PTEN promoter in bladder cancer.
Similarity in gene-regulatory networks suggests that cancer cells share characteristics of embryonic neural cells.
Single nucleotide polymorphism in DNMT3B promoter and its association with hepatocellular carcinoma in a Moroccan population.
Single-nucleotide polymorphisms in DNMT3B gene and DNMT3B mRNA expression in association with prostate cancer mortality.
Single-ribonucleotide repair-mediated ligation-dependent cycling signal amplification for sensitive and specific detection of DNA methyltransferase.
SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities.
Somatic cancer mutations in the DNMT2 tRNA methyltransferase alter its catalytic properties.
Somatic mutations identify a subgroup of aplastic anemia patients who progress to myelodysplastic syndrome.
Specific inhibition of one DNMT1-including complex influences tumor initiation and progression.
Specific Protein 1 and p53 Interplay Modulates the Expression of the KCTD-Containing Cullin3 Adaptor Suppressor of Hedgehog 2.
SPIRE - combining SGI-110 with cisplatin and gemcitabine chemotherapy for solid malignancies including bladder cancer: study protocol for a phase Ib/randomised IIa open label clinical trial.
Splice variants DNMT3B4 and DNMT3B7 overexpression inhibit cell proliferation in 293A cell line.
Stage-specific alterations of DNA methyltransferase expression, DNA hypermethylation, and DNA hypomethylation during prostate cancer progression in the transgenic adenocarcinoma of mouse prostate model.
STAT3 induces transcription of the DNA methyltransferase 1 gene (DNMT1) in malignant T lymphocytes.
STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes.
STAT5A regulates DNMT3A in CD34(+)/CD38(-) AML cells.
STK11/LKB1 Loss of Function Is Associated with Global DNA Hypomethylation and S-Adenosyl-Methionine Depletion in Human Lung Adenocarcinoma.
Stratification and Prognostic Relevance of Jass's Molecular Classification of Colorectal Cancer.
Structural basis for specific binding of human MPP8 chromodomain to histone H3 methylated at lysine 9.
Structural optimization of non-nucleoside DNA methyltransferase inhibitor as anti-cancer agent.
Structurally designed trans-2-phenylcyclopropylamine derivatives potently inhibit histone demethylase LSD1/KDM1 .
Substituted anthraquinones represent a potential scaffold for DNA methyltransferase 1-specific inhibitors.
Sulforaphane Alone and in Combination with Clofarabine Epigenetically Regulates the Expression of DNA Methylation-Silenced Tumour Suppressor Genes in Human Breast Cancer Cells.
Sulforaphane Reverses the Expression of Various Tumor Suppressor Genes by Targeting DNMT3B and HDAC1 in Human Cervical Cancer Cells.
Suppressing effects of down-regulating DNMT1 and DNMT3b expression on the growth of human cholangiocarcinoma cell line.
Suppression of DNA methyltransferase 1 levels in head and neck squamous carcinoma cells using small interfering RNA results in growth inhibition and increase in Cdk inhibitor p21.
Suppression of intestinal neoplasia by deletion of Dnmt3b.
Suppression of intestinal neoplasia by DNA hypomethylation.
Suppression of Wnt signaling by the miR-29 family is mediated by demethylation of WIF-1 in non-small-cell lung cancer.
Suppression of Wnt1-induced mammary tumor growth and lower serum insulin in offspring exposed to maternal blueberry diet suggest early dietary influence on developmental programming.
Synergetic effects of DNA demethylation and histone deacetylase inhibition in primary rat hepatocytes.
Synergistic Effect of Epigenetic Inhibitors Decitabine and Suberoylanilide Hydroxamic Acid on Colorectal Cancer in vitro.
Synergistic effect of trichostatin A and 5-aza-2'-deoxycytidine on growth inhibition of pancreatic endocrine tumour cell lines: a proteomic study.
Synthesis of novel 3-halo-3-nitroflavanones and their activities as DNA methyltransferase inhibitors in cancer cells.
Systematic evaluation of cancer risk associated with DNMT3B polymorphisms.
Systematic profiling of DNMT3A variants reveals protein instability mediated by the DCAF8 E3 ubiquitin ligase adaptor.
T Cell Exhaustion: An Epigenetically Imprinted Phenotypic and Functional Makeover.
Tamoxifen accelerates proteasomal degradation of O(6)-methylguanine DNA methyltransferase in human cancer cells.
Targeting cancer epigenetic pathways with small-molecule compounds: Therapeutic efficacy and combination therapies.
Targeting cellular memory to reprogram the epigenome, restore potential, and improve somatic cell nuclear transfer.
Targeting DNA methylation for treating triple-negative breast cancer.
Targeting DNA methyltransferase in cancer.
Targeting epigenetic machinery: Emerging novel allosteric inhibitors.
Targeting epigenetic networks with polypharmacology: a new avenue to tackle cancer.
Targeting epigenetic pathway with gold nanoparticles for acute myeloid leukemia therapy.
Targeting epigenetics for the treatment of prostate cancer: recent progress and future directions.
Targeting the cancer epigenome: synergistic therapy with bromodomain inhibitors.
Targets and genomic constraints of ectopic Dnmt3b expression.
TCF3 is epigenetically silenced by EZH2 and DNMT3B and functions as a tumor suppressor in endometrial cancer.
Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines.
Technology evaluation: MG-98, MethylGene.
Telomerase reverse transcriptase regulates DNMT3B expression/aberrant DNA methylation phenotype and AKT activation in hepatocellular carcinoma.
Temozolomide as monotherapy is effective in treatment of advanced malignant neuroendocrine tumors.
Temozolomide in advanced and recurrent uterine leiomyosarcoma and correlation with o6-methylguanine DNA methyltransferase expression: a case series.
TET proteins and the control of cytosine demethylation in cancer.
TET2 and DNMT3A mutations and exceptional response to 4'-thio-2'-deoxycytidine in human solid tumor models.
TGF-? regulates DNA methyltransferase expression in prostate cancer, correlates with aggressive capabilities, and predicts disease recurrence.
TGF-?-mediated repression of MST1 by DNMT1 promotes glioma malignancy.
The application of epigenetic modifiers on the treatment of prostate and bladder cancer.
The association of DNA methyltransferase 1 gene polymorphisms with susceptibility to childhood acute lymphoblastic leukemia.
The BRAF oncoprotein functions through the transcriptional repressor MAFG to mediate the CpG Island Methylator phenotype.
The Brain Microenvironment Induces DNMT1 Suppression and Indolence of Metastatic Cancer Cells.
The Cancer/Testis Antigen Gene VCX2 Is Rarely Expressed in Malignancies but Can Be Epigenetically Activated Using DNA Methyltransferase and Histone Deacetylase Inhibitors.
The combination of dimethoxycurcumin with DNA methylation inhibitor enhances gene re-expression of promoter-methylated genes and antagonizes their cytotoxic effect.
The complete DNA sequence of lymphocystis disease virus.
The de novo DNA methyltransferase DNMT3A in development and cancer.
The DNA methylation inhibitor induces telomere dysfunction and apoptosis of leukemia cells that is attenuated by telomerase over-expression.
The DNA methylation landscape of advanced prostate cancer.
The DNA Methyltransferase 3B -149 Genetic Polymorphism Modulates Lung Cancer Risk from Smoking
The DNA Methyltransferase DNMT1 and Tyrosine-Protein Kinase KIT Cooperatively Promote Resistance to 5-Aza-2'-deoxycytidine (Decitabine) and Midostaurin (PKC412) in Lung Cancer Cells.
The DNA methyltransferase inhibitor zebularine induces mitochondria-mediated apoptosis in gastric cancer cells in vitro and in vivo.
The DNA methyltransferase inhibitor, guadecitabine, targets tumor-induced myelopoiesis and recovers T cell activity to slow tumor growth in combination with adoptive immunotherapy in a mouse model of breast cancer.
The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells.
The DNA-methyltransferase inhibitors zebularine and decitabine induce mitochondria-mediated apoptosis and DNA damage in p53 mutant leukemic T cells.
The DNMT1/miR-34a Axis Is Involved in the Stemness of Human Osteosarcoma Cells and Derived Stem-Like Cells.
The DNMT3A R882H mutant displays altered flanking sequence preferences.
The DNMT3B C-->T promoter polymorphism and risk of breast cancer in a British population: a case-control study.
The effect of acute dichlorodiphenyltrichloroethane exposure on hypermethylation status and down-regulation of p53 and p16(INK4a) genes in rat liver.
The effect of azacitidine on interleukin-6 signaling and nuclear factor-kappaB activation and its in vitro and in vivo activity against multiple myeloma.
The effect of decitabine on the expression and methylation of the PPP1CA, BTG2, and PTEN in association with changes in miR-125b, miR-17, and miR-181b in NALM6 cell line.
The effect of folate-related SNPs on clinicopathological features, response to neoadjuvant treatment and survival in pre- and postmenopausal breast cancer patients.
The Effect of Hormone Therapy on the Expression of Prostate Cancer and Multi-Epigenetic Marker Genes in a Population of Iranian Patients.
The epigenetic agents suberoylanilide hydroxamic acid and 5?AZA?2' deoxycytidine decrease cell proliferation, induce cell death and delay the growth of MiaPaCa2 pancreatic cancer cells in vivo.
The expression and clinical significance of DNA methyltransferase proteins in human gastric cancer.
The Histone Deacetylase Inhibitor JAHA Down-Regulates pERK and Global DNA Methylation in MDA-MB231 Breast Cancer Cells.
The histone methyltransferase SETDB1 and the DNA methyltransferase DNMT3A interact directly and localize to promoters silenced in cancer cells.
The human DNA methyltransferases (DNMTs) 1, 3a and 3b: coordinate mRNA expression in normal tissues and overexpression in tumors.
The Importance of Mutational Drivers in GBM.
The interaction between miR?148a and DNMT1 suppresses cell migration and invasion by reactivating tumor suppressor genes in pancreatic cancer.
The interaction of histone deacetylase inhibitors and DNA methyltransferase inhibitors in the treatment of human cancer cells.
The Interplay Between miR-148a and DNMT1 Might be Exploited for Pancreatic Cancer Therapy.
The interplay between the lysine demethylase KDM1A and DNA methyltransferases in cancer cells is cell cycle dependent.
The involvement of promoter methylation and DNA methyltransferase-1 in the regulation of EpCAM expression in oral squamous cell carcinoma.
The long noncoding RNA LUCAT1 promotes tumorigenesis by controlling ubiquitination and stability of DNA methyltransferase 1 in esophageal squamous cell carcinoma.
The loss-of-function of DNA methyltransferase 1 by siRNA impairs the growth of non-small cell lung cancer with alleviated side effects via reactivation of RASSF1A and APC in vitro and vivo.
The mechanism involved in the loss of PTEN expression in NSCLC tumor cells.
The methyl donor S-Adenosylmethionine inhibits active demethylation of DNA: a candidate novel mechanism for the pharmacological effects of S-Adenosylmethionine.
The mutational landscape of cutaneous T cell lymphoma and Sézary syndrome.
The negative feedback between miR-143 and DNMT3A regulates cisplatin resistance in ovarian cancer.
The pivotal role of DNA methylation in the radio-sensitivity of tumor radiotherapy.
The possible role of EZH2 and DNMT1 polymorphisms in sporadic triple-negative breast carcinoma in southern Chinese females.
The R882H DNMT3A hot spot mutation stabilizes the formation of large DNMT3A oligomers with low DNA methyltransferase activity.
The R882H substitution in the human de novo DNA methyltransferase DNMT3A disrupts allosteric regulation by the tumor supressor p53.
The RNA Methyltransferase NSUN2 and Its Potential Roles in Cancer.
The role of a ginseng saponin metabolite as a DNA methyltransferase inhibitor in colorectal cancer cells.
The role of autophagy in targeted therapy for acute myeloid leukemia.
The role of BLIMP1 and its putative downstream target TFAP2C in germ cell development and germ cell tumours.
The Role of Dietary Extra Virgin Olive Oil and Corn Oil on the Alteration of Epigenetic Patterns in the Rat DMBA-Induced Breast Cancer Model.
The role of DNA damage and repair in decitabine-mediated apoptosis in multiple myeloma.
The role of DNA methylation in cancer development.
The role of DNA methyltransferase 1 in growth control.
The role of DNA methyltransferase 3b in esophageal squamous cell carcinoma.
The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation and tumor suppressor gene hypermethylation in mice and lung cancer patients.
The tobacco-specific carcinogen NNK induces DNA methyltransferase 1 accumulation in Laryngeal carcinoma.
The Ubiquitin-Proteasome Pathway and Epigenetic Modifications in Cancer.
Theaflavin-Containing Black Tea Extract: A Potential DNA Methyltransferase Inhibitor in Human Colon Cancer Cells and Ehrlich Ascites Carcinoma-Induced Solid Tumors in Mice.
Therapeutic Delivery of MicroRNA-29b by Cationic Lipoplexes for Lung Cancer.
Therapeutic potential of DNA methyltransferase inhibitors with immune checkpoint inhibitor therapy in breast cancer.
Therapy-related acute lymphoblastic leukemia is a distinct entity with adverse genetic features and clinical outcomes.
Thymoquinone exerts potent growth-suppressive activity on leukemia through DNA hypermethylation reversal in leukemia cells.
Thymoquinone-Induced Reactivation of Tumor Suppressor Genes in Cancer Cells Involves Epigenetic Mechanisms.
Tissue-Biased Expansion of DNMT3A-Mutant Clones in a Mosaic Individual Is Associated with Conserved Epigenetic Erosion.
Tissue-specific induced DNA methyltransferase 1 (Dnmt1) in endocrine pancreas by RCAS-TVA-based somatic gene transfer system promotes ?-cell proliferation.
Tobacco carcinogens and the methionine metabolism in human bladder cancer.
Towards a pharmacology of DNA methylation.
Toxicity of 5-aza-2'-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation.
Transcriptional alterations of genes related to fertility decline in male rats induced by chronic sleep restriction.
Transcriptional analysis of CXCR4, DNMT3A, DNMT3B and DNMT1 gene expression in primary advanced uterine cervical carcinoma.
Transcriptional control of the DNA methyltransferases is altered in aging and neoplastically-transformed human fibroblasts.
Transcriptional regulation of urokinase (uPA) gene expression in breast cancer cells: role of DNA methylation.
Transcriptomic profiling of Aspergillus flavus in response to 5-azacytidine.
Treatment with a DNA methyltransferase inhibitor feminizes zebrafish and induces long-term expression changes in the gonads.
Trimethylaurintricarboxylic acid inhibits human DNA methyltransferase 1: insights from enzymatic and molecular modeling studies.
tRNA modifying enzymes, NSUN2 and METTL1, determine sensitivity to 5-fluorouracil in HeLa cells.
Truncated DNMT3B Isoform DNMT3B7 Suppresses Growth, Induces Differentiation, and Alters DNA Methylation in Human Neuroblastoma.
Tumor suppressor functions of Dnmt3a and Dnmt3b in the prevention of malignant mouse lymphopoiesis.
Tumor suppressor gene inactivation during cadmium-induced malignant transformation of human prostate cells correlates with overexpression of de novo DNA methyltransferase.
Tumor-Associated Macrophages Promote Epigenetic Silencing of Gelsolin through DNA Methyltransferase 1 in Gastric Cancer Cells.
Two Case Reports of Resensitization to Previous Chemotherapy with the Novel Hypoxia-Activated Hypomethylating Anticancer Agent RRx-001 in Metastatic Colorectal Cancer Patients.
Two competing mechanisms of DNMT3A recruitment regulate the dynamics of de novo DNA methylation at PRC1-targeted CpG islands.
Two siblings with immunodeficiency, facial abnormalities and chromosomal instability without mutation in DNMT3B gene but liability towards malignancy; a new chromatin disorder delineation?
UHRF1 Induces Methylation of the TXNIP Promoter and Down-Regulates Gene Expression in Cervical Cancer.
Ultrasensitive and Accurate Assay of Human Methyltransferase Activity at the Single-Cell Level Based on a Single Integrated Magnetic Microprobe.
Unanswered questions about the role of promoter methylation in carcinogenesis.
Up-regulation of DNA methyltransferase 3B expression in endometrial cancers.
Up-regulation of DNA-methyltransferase 3A expression is associated with hypomethylation of intron 25 in human testicular germ cell tumors.
Upregulation of DNA methyltransferase-mediated gene silencing, anchorage-independent growth, and migration of colon cancer cells by interleukin-6.
Upregulation of miR-137 Expression Suppresses Tumor Growth and Progression via Interacting with DNMT3a Through Inhibiting the PTEN/Akt Signaling in HCC.
Upregulation of SPP1 Is a Marker for Poor Lung Cancer Prognosis and Contributes to Cancer Progression and Cisplatin Resistance.
USP24 induces IL-6 in tumor-associated microenvironment by stabilizing p300 and ?-TrCP and promotes cancer malignancy.
Utilization of antisense oligonucleotides to study the role of 5-cytosine DNA methyltransferase in cellular transformation and oncogenesis.
Valproic acid, in combination with all-trans retinoic acid and 5-aza-2'-deoxycytidine, restores expression of silenced RARbeta2 in breast cancer cells.
Variants of DNMT3A cause transcript-specific DNA methylation patterns and affect hematopoiesis.
VEGFA activates an epigenetic pathway upregulating ovarian cancer-initiating cells.
Vitamin C increases viral mimicry induced by 5-aza-2'-deoxycytidine.
Whole exome sequencing reveals mutations in FAT1 tumor suppressor gene clinically impacting on peripheral T-cell lymphoma not otherwise specified.
YY1-mediated long non-coding RNA Kcnq1ot1 promotes the tumor progression by regulating PTEN via DNMT1 in triple negative breast cancer.
Zebularine elevates STING expression and enhances cGAMP cancer immunotherapy in mice.
Zebularine exerts its antiproliferative activity through S phase delay and cell death in human malignant mesothelioma cells.
Zebularine induces chemosensitization to methotrexate and efficiently decreases AhR gene methylation in childhood acute lymphoblastic leukemia cells.
Zinc-induced Dnmt1 expression involves antagonism between MTF-1 and nuclear receptor SHP.
[Analysis of DNMT3a mutation in childhood acute myeloid leukemia].
[Antisense DNMT1 gene fragment in the sensitivity change of SMMC-7721 cells to tumor necrosis factor related apoptosis inducing ligand and its mechanism]
[Arsenic Trioxide Reverses Hypermethylation of p16 and Activates Its Transcription in Malignant Lymphoma Cell Line CA46.]
[Characteristic and clinical significance of DNA methyltransferase 3B overexpression in endometrial carcinoma].
[Decitabine treatment in myelodysplastic syndromes--results of a compassionate patient program in Israel].
[DNA methyltransferases: the role in regulation of gene expression and biological processes]
[Effect of phenelzine on the proliferation, apoptosis and histone methylation and acetylation of Molt-4 cells].
[Effect of stable DNA methyltransferase 3bknockdown on proliferation and apoptosis in bladder cancer cells in vitro].
[Effects of dnmt1 Gene Silencing on Cell Cycle, Proliferation, and Apoptosis of Gastric Cancer Cell Line AGS.]
[Expression of DNA methyltransferase 1, 3A and 3B mRNA in the epithelial ovarian carcinoma]
[Expression of DNA methyltransferases in salivary adenoid cystic carcinoma and its association with the CpG islands methylation of tumor suppressor genes]
[Expression of DNMT3b in human bladder cancer tissue and its correlation with clinical prognosis].
[Expression of ER alpha in chemically induced MDA-MB-435 cells and its responsiveness to endocrine]
[Gene expressions of DNA methyltransferase 1 and human leukocyte antigen-DRalpha in hepatocelluar carcinoma and their clinical significance.]
[Genetic abnormalities in AML].
[High expression of DNMT1 was correlated with beta-catenin accumulation and malignant phynotype of lung squamous cell carcinoma and adenocarcinoma]
[High expression of DNMT3B promotes proliferation and invasion of hepatocellular carcinoma cells via Hippo signaling pathway].
[Inhibitory effect of 5-Aza-2'-deoxycytidine on human nasopharyngeal carcinoma xenograft in nude mice]
[Methylation and demethylation of SOX2 gene promoter in BGC-823 gastric cancer cells].
[Molecular mechanisms involved in epigenetic alterations in cancer].
[Myeloproliferative neoplasms: pathophysiology and therapeutic strategy].
[Regulation of Gene Expression of Cancer/Testis Antigens in Colorectal Cancer Patients].
[Research on molecular markers for epigenetic changes in myeloid malignancies].
[Studies on DNA methylation in transformed mouse liver cells]
[The Relationship of Clinicopathology of p16 in Non-small Cell Lung Cancer and 5-nitrogen impurity-2'-deoxycytidine-nitrogen Impurity on the Influence of p16 Expression in Lung Cancer A549 Cells].
Neoplasms, Germ Cell and Embryonal
A miR-199a/miR-214 self-regulatory network via PSMD10, TP53 and DNMT1 in testicular germ cell tumor.
A novel somatic MAPK1 mutation in primary ovarian mixed germ cell tumors.
DNA methyltransferase-3 like protein expression in various histological types of testicular germ cell tumor.
High DNA methyltransferase 3B expression mediates 5-aza-deoxycytidine hypersensitivity in testicular germ cell tumors.
The role of BLIMP1 and its putative downstream target TFAP2C in germ cell development and germ cell tumours.
Up-regulation of DNA-methyltransferase 3A expression is associated with hypomethylation of intron 25 in human testicular germ cell tumors.
Nephritis
Expanding the phenotype of biallelic loss-of-function variants in the NSUN2 gene: Description of four individuals with juvenile cataract, chronic nephritis, or brain anomaly as novel complications.
Nervous System Diseases
Abnormalities of the DNA methylation mark and its machinery: an emerging cause of neurologic dysfunction.
Defects of mutant DNMT1 are linked to a spectrum of neurological disorders.
Neural Tube Defects
Genetic modifiers of folate, vitamin B-12, and homocysteine status in a cross-sectional study of the Canadian population.
Neuralgia
Author Correction: DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons.
Change in microRNAs associated with neuronal adaptive responses in the nucleus accumbens under neuropathic pain.
Contribution of DNMT1 to Neuropathic Pain Genesis Partially through Epigenetically Repressing Kcna2 in Primary Afferent Neurons.
Contribution of dorsal root ganglion octamer transcription factor 1 to neuropathic pain after peripheral nerve injury.
CREB Participates in Paclitaxel-Induced Neuropathic Pain Genesis Through Transcriptional Activation of Dnmt3a in Primary Sensory Neurons.
Demethylation of G-Protein-Coupled Receptor 151 Promoter Facilitates the Binding of Krüppel-Like Factor 5 and Enhances Neuropathic Pain after Nerve Injury in Mice.
DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons.
DNMT3a methylation in neuropathic pain.
DNMT3b SUMOylation Mediated MMP-2 Upregulation Contribute to Paclitaxel Induced Neuropathic Pain.
Intrathecal 5-azacytidine inhibits global DNA methylation and methyl- CpG-binding protein 2 expression and alleviates neuropathic pain in rats following chronic constriction injury.
Nerve Injury-Induced Epigenetic Silencing Of Opioid Receptors Controlled By Dnmt3a In Primary Afferent Neurons.
Neuroblastoma
A rapid screening system evaluates novel inhibitors of DNA methylation and suggests F-box proteins as potential therapeutic targets for high-risk neuroblastoma.
Differential expression of DNA-methyltransferases in drug resistant murine neuroblastoma cells.
Inhibition of DNA methyltransferase reverses cisplatin induced drug resistance in murine neuroblastoma cells.
Liganded Thyroid Hormone Receptors Transactivate the DNA Methyltransferase 3a Gene in Mouse Neuronal Cells.
RGS6 interacts with DMAP1 and DNMT1 and inhibits DMAP1 transcriptional repressor activity.
Stable DNMT3L overexpression in SH-SY5Y neurons recreates a facet of the genome-wide Down syndrome DNA methylation signature.
Truncated DNMT3B Isoform DNMT3B7 Suppresses Growth, Induces Differentiation, and Alters DNA Methylation in Human Neuroblastoma.
Neurodegenerative Diseases
Comparison of the Effects of Curcumin and RG108 on NGF-Induced PC-12?Adh Cell Differentiation and Neurite Outgrowth.
Disease-Associated Mutations G589A and V590F Relieve Replication Focus Targeting Sequence-Mediated Autoinhibition of DNA Methyltransferase 1.
Epigenomic networking in drug development: from pathogenic mechanisms to pharmacogenomics.
Lack of association between DNMT1 gene polymorphisms and noise-induced hearing loss in a Chinese population.
Mutation-induced DNMT1 cleavage drives neurodegenerative disease.
Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss.
PDmethDB: A curated Parkinson's disease associated methylation information database.
The replication foci targeting sequence (RFTS) of DNMT1 functions as a potent histone H3 binding domain regulated by autoinhibition.
Neuroectodermal Tumors, Primitive
CNS-PNETs with C19MC amplification and/or LIN28 expression comprise a distinct histogenetic diagnostic and therapeutic entity.
Neuroendocrine Tumors
DNA methyltransferases 1, 3a, and 3b overexpression and clinical significance in gastroenteropancreatic neuroendocrine tumors.
Tissue-specific induced DNA methyltransferase 1 (Dnmt1) in endocrine pancreas by RCAS-TVA-based somatic gene transfer system promotes ?-cell proliferation.
Neuroinflammatory Diseases
Hydrogen gas alleviates sepsis-induced neuroinflammation and cognitive impairment through regulation of DNMT1 and DNMT3a-mediated BDNF promoter IV methylation in mice.
Neuronal Ceroid-Lipofuscinoses
Genetic and phenotypic characterization of complex hereditary spastic paraplegia.
Nevus
Expression of DNA Methyltransferase 1 Is a Hallmark of Melanoma, Correlating with Proliferation and Response to B-Raf and Mitogen-Activated Protein Kinase Inhibition in Melanocytic Tumors.
Non-alcoholic Fatty Liver Disease
Intestinal FGF15/19 physiologically repress hepatic lipogenesis in the late fed-state by activating SHP and DNMT3A.
Obesity
Comparative transcriptome analysis identifies CARM1 and DNMT3A as genes associated with osteoporosis.
DNMT1 maintains metabolic fitness of adipocytes through acting as an epigenetic safeguard of mitochondrial dynamics.
Dnmt3b Deficiency in Myf5+-Brown Fat Precursor Cells Promotes Obesity in Female Mice.
Epigenetic regulation of macrophage polarization by DNA methyltransferase 3b.
Fatty acid-binding protein FABP4 mechanistically links obesity with aggressive AML by enhancing aberrant DNA methylation in AML cells.
Functional and epigenetic phenotypes of humans and mice with DNMT3A Overgrowth Syndrome.
Maternal obesity alters the expression of embryonic regulatory transcripts in the preimplantation ovine conceptus.
Neuronal Dnmt1 Deficiency Attenuates Diet-Induced Obesity in Mice.
Obesity alters the ovarian proteomic response to zearalenone exposure†.
Obesity Associated Modulation of miRNA and Co-Regulated Target Transcripts in Human Adipose Tissue of Non-Diabetic Subjects.
Obesity promotes the global hypomethylation of CD4+ T cells in patients with systemic lupus erythematosus via downregulating DNMT1.
The Impact of Maternal Pre-Pregnancy Body Weight and Gestational Diabetes on Markers of Folate Metabolism in the Placenta.
The Level of Feed Intake Affects Embryo Survival and Gene Expression During Early Pregnancy in Gilts.
Obesity, Maternal
Maternal obesity alters the expression of embryonic regulatory transcripts in the preimplantation ovine conceptus.
Odontogenic Cysts
DNA methyltransferase expression in odontogenic cysts and tumours.
Odontogenic Tumors
DNA methyltransferase immunohistochemical expression in odontogenic tumours.
Oligodendroglioma
Frequent promoter hypermethylation and low expression of the MGMT gene in oligodendroglial tumors.
Oligospermia
Decreased expression of DNA methyltransferases in the testes of patients with non-obstructive azoospermia leads to changes in global DNA methylation levels.
Polymorphism in DNMT1 may modify the susceptibility to oligospermia.
Osteoarthritis
CircRNA circ_SEC24A upregulates DNMT3A expression by sponging miR-26b-5p to aggravate osteoarthritis progression.
DNA hypomethylation in rheumatoid arthritis synovial fibroblasts.
Downregulation of microRNA-29b by DNMT3B decelerates chondrocyte apoptosis and the progression of osteoarthritis via PTHLH/CDK4/RUNX2 axis.
Effect of the interaction between MiR-200b-3p and DNMT3A on cartilage cells of osteoarthritis patients.
Epigenetic and therapeutic implications of dnmt3b in temporomandibular joint osteoarthritis.
Exhausting circ_0136474 and Restoring miR-766-3p Attenuate Chondrocyte Oxidative Injury in IL-1?-Induced Osteoarthritis Progression Through Regulating DNMT3A.
Inhibition of 4-aminobutyrate aminotransferase protects against injury-induced osteoarthritis in mice.
MiR-33b-3p promotes chondrocyte proliferation and inhibits chondrocyte apoptosis and cartilage ECM degradation by targeting DNMT3A in osteoarthritis.
Osteoarthritis, Hip
Evaluation of relationship between DNA methyltransferase 3 ? gene and the risk of hip osteoarthritis: A case-control study based on a Han Chinese population.
Osteoarthritis, Knee
DNA methyltransferase genes polymorphisms are associated with primary knee osteoarthritis: a matched case-control study.
Does DNMT3B gene contribute the shared susceptibility to knee osteoarthritis and hip osteoarthritis?
MicroRNA-199-3p up-regulation enhances chondrocyte proliferation and inhibits apoptosis in knee osteoarthritis via DNMT3A repression.
Osteolysis
Epigenetic regulation of HGF/Met receptor axis is critical for the outgrowth of bone metastasis from breast carcinoma.
Osteoporosis
Comparative transcriptome analysis identifies CARM1 and DNMT3A as genes associated with osteoporosis.
Overexpression of DNMT1 leads to hypermethylation of H19 promoter and inhibition of Erk signaling pathway in disuse osteoporosis.
Oxidative Stress-Induced Hypermethylation of KLF5 Promoter Mediated by DNMT3B Impairs Osteogenesis by Diminishing the Interaction with ?-Catenin.
Osteosarcoma
A Quinoline-Based DNA Methyltransferase Inhibitor as a Possible Adjuvant in Osteosarcoma Therapy.
DNA methylation-mediated downregulation of PTPN3 attenuates to boost TGF-? signaling in osteosarcoma cells.
Epigenetic Regulation of CXCL12 Plays a Critical Role in Mediating Tumor Progression and the Immune Response In Osteosarcoma.
Epigenetic regulation of the pro-apoptosis gene TSSC3 in human osteosarcoma cells.
Expression profiling of DNA methyl transferase I (DNMT1) and efficacy of a DNA-hypomethylating agent (decitabine) in combination with chemotherapy in osteosarcoma.
Isovitexin Suppresses Cancer Stemness Property And Induces Apoptosis Of Osteosarcoma Cells By Disruption Of The DNMT1/miR-34a/Bcl-2 Axis.
Kruppel-Like Factor 9 Loss-of-Expression in Human Endometrial Carcinoma Links Altered Expression of Growth-Regulatory Genes with Aberrant Proliferative Response to Estrogen.
LncRNA SNHG7 participates in osteosarcoma progression by down-regulating p53 via binding to DNMT1.
MicroRNA-29a suppresses the invasion and migration of osteosarcoma cells by regulating the SOCS1/NF-?B signalling pathway through negatively targeting DNMT3B.
MiR-139-5p suppresses osteosarcoma cell growth and invasion through regulating DNMT1.
Separate and combined effects of DNMT and HDAC inhibitors in treating human multi-drug resistant osteosarcoma HosDXR150 cell line.
Sustained Low-Dose Treatment with the Histone Deacetylase Inhibitor LBH589 Induces Terminal Differentiation of Osteosarcoma Cells.
Zebularine enhances apoptosis of human osteosarcoma cells by suppressing methylation of ARHI.
Otitis Media
ModM DNA methyltransferase methylome analysis reveals a potential role for Moraxella catarrhalis phasevarions in otitis media.
The Moraxella catarrhalis phase-variable DNA methyltransferase ModM3 is an epigenetic regulator that affects bacterial survival in an in vivo model of otitis media.
Ovarian Neoplasms
A Feedback Loop Between miR-30a/c-5p and DNMT1 Mediates Cisplatin Resistance in Ovarian Cancer Cells.
ALDH1A2 Is a Candidate Tumor Suppressor Gene in Ovarian Cancer.
An Effective Epigenetic-PARP inhibitor Combination Therapy for Breast and Ovarian Cancers Independent of BRCA-mutations.
Association of tRNA methyltransferase NSUN2/IGF-II molecular signature with ovarian cancer survival.
Clinicopathological significance and prognostic value of DNA methyltransferase 1, 3a, and 3b expressions in sporadic epithelial ovarian cancer.
Combination of AT-101/cisplatin overcomes chemoresistance by inducing apoptosis and modulating epigenetics in human ovarian cancer cells.
DNA methylation in ovarian cancer. II. Expression of DNA methyltransferases in ovarian cancer cell lines and normal ovarian epithelial cells.
DNA methyltransferase inhibitors induce a BRCAness phenotype that sensitizes NSCLC to PARP inhibitor and ionizing radiation.
DNMT1, DNMT3A and DNMT3B gene variants in relation to ovarian cancer risk in the Polish population.
Double RNA interference of DNMT3b and DNMT1 enhances DNA demethylation and gene reactivation.
Double-negative feedback interaction between DNA methyltransferase 3A and microRNA-145 in the Warburg effect of ovarian cancer cells.
Downregulation of DNMT3a expression increases miR-182-induced apoptosis of ovarian cancer through caspase-3 and caspase-9-mediated apoptosis and DNA damage response.
Effect of the HDAC Inhibitor on Histone Acetylation and Methyltransferases in A2780 Ovarian Cancer Cells.
Epigenetic activation of MGAT3 and corresponding bisecting GlcNAc shortens the survival of cancer patients.
Epigenetic modifications of the Estrogen receptor beta gene in epithelial ovarian cancer cells.
Epigenetic modifiers upregulate MHC II and impede ovarian cancer tumor growth.
Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells.
Epigenetic regulation of RGS2 (Regulator of G-protein signaling 2) in chemoresistant ovarian cancer cells.
Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy.
Epigenetic suppression of the TGF-beta pathway revealed by transcriptome profiling in ovarian cancer.
Epigenetic-mediated immune suppression of positive co-stimulatory molecules in chemoresistant ovarian cancer cells.
Exosomal DNMT1 mediates cisplatin resistance in ovarian cancer.
Genomic and Epigenomic Signatures in Ovarian Cancer Associated with Resensitization to Platinum Drugs.
In Vivo Ovarian Cancer Gene Therapy Using CRISPR-Cas9.
Increased DNA methyltransferase activity and DNA methylation following Epidermal Growth Factor stimulation in ovarian cancer cells.
Inhibition of HDAC1 and DNMT1 modulate RGS10 expression and decrease ovarian cancer chemoresistance.
Investigation of the expression patterns and correlation of DNA methyltransferases and class I histone deacetylases in ovarian cancer tissues.
KRAS Genomic Status Predicts the Sensitivity of Ovarian Cancer Cells to Decitabine.
Live-attenuated measles virus vaccine confers cell contact loss and apoptosis of ovarian cancer cells via ROS-induced silencing of E-cadherin by methylation.
Messenger RNA expression and methylation of candidate tumor-suppressor genes and risk of ovarian cancer-a case-control analysis.
miR-145 promotes miR-133b expression through c-myc and DNMT3A-mediated methylation in ovarian cancer cells.
MiR-152 and miR-185 co-contribute to ovarian cancer cells cisplatin sensitivity by targeting DNMT1 directly: a novel epigenetic therapy independent of decitabine.
Nicotinamide adenine dinucleotide (NAD) may affect DNA methyltransferase 1 through regulation of BRCA1 in ovarian cancer.
Overcoming immune suppression with epigenetic modification in ovarian cancer.
Prostaglandin E2 Leads to the Acquisition of DNMT3A-Dependent Tolerogenic Functions in Human Myeloid-Derived Suppressor Cells.
Reactive oxygen species regulate ERBB2 and ERBB3 expression via miR-199a/125b and DNA methylation.
S-allylcysteine suppresses ovarian cancer cell proliferation by DNA methylation through DNMT1.
Suppressing miR-199a-3p by promoter methylation contributes to tumor aggressiveness and cisplatin resistance of ovarian cancer through promoting DDR1 expression.
The negative feedback between miR-143 and DNMT3A regulates cisplatin resistance in ovarian cancer.
Transcriptional analysis of multiple ovarian cancer cohorts reveals prognostic and immunomodulatory consequences of ERV expression.
WNT7A Regulation by miR-15b in Ovarian Cancer.
[Expression of DNA methyltransferase 1, 3A and 3B mRNA in the epithelial ovarian carcinoma]
[Ginsenoside 20(S)-Rg3 upregulates tumor suppressor VHL gene expression by suppressing DNMT3A-mediated promoter methylation in ovarian cancer cells].
Pancreatic Neoplasms
A pilot clinical trial of the cytidine deaminase inhibitor tetrahydrouridine combined with decitabine to target DNMT1 in advanced, chemorefractory pancreatic cancer.
Apoptosis, proliferation and differentiation patterns are influenced by Zebularine and SAHA in pancreatic cancer models.
Correlations among PPAR?, DNMT1, and DNMT3B Expression Levels and Pancreatic Cancer.
DNA methyltransferase 3a modulates chemosensitivity to gemcitabine and oxaliplatin via CHK1 and AKT in p53?deficient pancreatic cancer cells.
DNA methyltransferase mediates the hypermethylation of the microRNA 34a promoter and enhances the resistance of patient-derived pancreatic cancer cells to molecular targeting agents.
DNA-Methyltransferase 1 Induces Dedifferentiation of Pancreatic Cancer Cells through Silencing of Krüppel-Like Factor 4 Expression.
DNMT1 as a therapeutic target in pancreatic cancer: mechanisms and clinical implications.
DNMT1 Inhibition Reprograms Pancreatic Cancer Stem Cells via Upregulation of the miR-17-92 Cluster.
DNMT3a promotes proliferation by activating the STAT3 signaling pathway and depressing apoptosis in pancreatic cancer.
Downregulation of miR?29b targets DNMT3b to suppress cellular apoptosis and enhance proliferation in pancreatic cancer.
Effect of Zebularine on p16INK4a, p14ARF, p15INK4b, and DNA Methyltransferase 1 Gene Expression, Cell Growth Inhibition, and Apoptosis Induction in Human Hepatocellular Carcinoma PLC/PRF5 and Pancreatic Cancer PA-TU-8902 Cell Lines.
Epigenetic Regulation Affects N-myc Downstream-Regulated Gene 1 Expression Indirectly in Pancreatic Cancer Cells.
Epigenetic regulation and molecular characterization of C/EBPalpha in pancreatic cancer cells.
Epigenetic silencing of EYA2 in pancreatic adenocarcinomas promotes tumor growth.
Expression of DNMT1 and DNMT3a are regulated by GLI1 in human pancreatic cancer.
Identification of maspin and S100P as novel hypomethylation targets in pancreatic cancer using global gene expression profiling.
Increased CXCR4 expression in AsPC1 pancreatic carcinoma cells with RNA interference-mediated knockdown of DNMT1 and DNMT3B.
Interplay between menin and Dnmt1 reversibly regulates pancreatic cancer cell growth downstream of the Hedgehog signaling pathway.
Krüppel-like factor 10 expression as a prognostic indicator for pancreatic adenocarcinoma.
MeCP2 suppresses LIN28A expression via binding to its methylated-CpG islands in pancreatic cancer cells.
Methylation of the miR?29b?3p promoter contributes to angiogenesis, invasion, and migration in pancreatic cancer.
MicroRNA-148b and microRNA-152 reactivate tumor suppressor genes through suppression of DNA methyltransferase-1 gene in pancreatic cancer cell lines.
MiR-29b suppresses proliferation and mobility by targeting SOX12 and DNMT3b in pancreatic cancer.
MiR-377 reverses cancerous phenotypes of pancreatic cells via suppressing DNMT1 and demethylating tumor suppressor genes.
MUC2 expression is regulated by histone H3 modification and DNA methylation in pancreatic cancer.
Neuronal pentraxin II (NPTX2) Is Frequently Down-Regulated by Promoter Hypermethylation in Pancreatic Cancers.
Pancreatic cancer DNMT1 expression and sensitivity to DNMT1 inhibitors.
Reduction of pancreatic acinar cell tumor multiplicity in Dnmt1 hypomorphic mice.
Reduction of pancreatic cancer cell viability and induction of apoptosis mediated by siRNA targeting DNMT1 through suppression of total DNA methyltransferase activity.
Significance of DNA methyltransferase-1 and histone deacetylase-1 in pancreatic cancer.
The interaction between miR?148a and DNMT1 suppresses cell migration and invasion by reactivating tumor suppressor genes in pancreatic cancer.
The Interplay Between miR-148a and DNMT1 Might be Exploited for Pancreatic Cancer Therapy.
Time-Qualified Patterns of Variation of PPAR?, DNMT1, and DNMT3B Expression in Pancreatic Cancer Cell Lines.
Transcriptional activity of DNMT3B in pancreatic cancer cells: Effects of -149 (C?T) promoter polymorphism.
Transcriptional repression of SOCS3 mediated by IL-6/STAT3 signaling via DNMT1 promotes pancreatic cancer growth and metastasis.
Panniculitis
Lobular neutrophilic panniculitis associated with DNA methyltransferase inhibitors in the treatment of myeloid disease.
Papilloma
Black raspberries demethylate Sfrp4, a WNT pathway antagonist, in rat esophageal squamous cell papilloma.
Papillomavirus Infections
An association of DNMT3b protein expression with P16INK4a promoter hypermethylation in non-smoking female lung cancer with human papillomavirus infection.
Differential Wnt-?- catenin pathway activation in HPV positive and negative oral epithelium is transmitted during head and neck tumorigenesis: clinical implications.
Paraganglioma
Gain-of-function mutations in DNMT3A in patients with paraganglioma.
Novel DNMT3A Germline Variant in a Patient with Multiple Paragangliomas and Papillary Thyroid Carcinoma.
Paralysis
Opposing roles of STAT4 and Dnmt3a in Th1 gene regulation.
Paraplegia
Genetic and phenotypic characterization of complex hereditary spastic paraplegia.
Paraproteinemias
DNA-methylation analysis identifies the E-cadherin gene as a potential marker of disease progression in patients with monoclonal gammopathies.
Genome-wide transcriptional response to 5-aza-2'-deoxycytidine and trichostatin a in multiple myeloma cells.
Paratuberculosis
Rapid and sensitive method to identify Mycobacterium avium subsp. paratuberculosis in cow's milk by DNA methylase genotyping.
Parkinson Disease
Association between DNA methyltransferase gene polymorphism and Parkinson's disease.
Association of DNMT3b gene variants with sporadic Parkinson's disease in a Chinese Han population.
DNA Methyltransferase 1 Is Dysregulated in Parkinson's Disease via Mediation of miR-17.
Lack of Association Between DNMT3B Polymorphisms and Sporadic Parkinson's Disease in a Han Chinese Population.
Lead neurotoxicity: exploring the potential impact of lead substitution in zinc-finger proteins on mental health.
PDmethDB: A curated Parkinson's disease associated methylation information database.
Protective effect of plastrum testudinis extract on dopaminergic neurons in a Parkinson's disease model through DNMT1 nuclear translocation and SNCA's methylation.
Penile Neoplasms
Multidimensional integrative analysis uncovers driver candidates and biomarkers in penile carcinoma.
Peptic Ulcer
The Helicobacter pylori genome is modified at CATG by the product of hpyIM.
Periodontitis
Decitabine Inhibits Bone Resorption in Periodontitis by Upregulating Anti-Inflammatory Cytokines and Suppressing Osteoclastogenesis.
miR-9-1 gene methylation and DNMT3B (rs2424913) polymorphism may contribute to periodontitis.
Porphyromonas gingivalis lipopolysaccharide stimulation in human periodontal ligament stem cells: role of epigenetic modifications to the inflammation.
Porphyromonas gingivalis LPS stimulation downregulates DNMT1, DNMT3a, and JMJD3 gene expression levels in human HaCaT keratinocytes.
Peripheral Nerve Injuries
Contribution of DNMT1 to Neuropathic Pain Genesis Partially through Epigenetically Repressing Kcna2 in Primary Afferent Neurons.
DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons.
Role of MicroRNA-143 in Nerve Injury-Induced Upregulation of Dnmt3a Expression in Primary Sensory Neurons.
Peripheral Nervous System Diseases
DNMT1, a Novel Regulator Mediating mTORC1/mTORC2 Pathway-Induced NGF Expression in Schwann Cells.
The Akt/mTOR cascade mediates high glucose-induced reductions in BDNF via DNMT1 in Schwann cells in diabetic peripheral neuropathy.
TXNIP, a novel key factor to cause Schwann cell dysfunction in diabetic peripheral neuropathy, under the regulation of PI3K/Akt pathway inhibition-induced DNMT1 and DNMT3a overexpression.
Pharyngeal Neoplasms
Role of DNA methyltransferase 1 in pharyngeal cancer related to treatment resistance.
Pheochromocytoma
Gain-of-function mutations in DNMT3A in patients with paraganglioma.
Pinealoma
Expression of O(6) -methylguanine DNA methyltransferase (MGMT) and immunohistochemical analysis of 12 pineal parenchymal tumors.
Pituitary ACTH Hypersecretion
High incidence of low O(6)-methylguanine DNA methyltransferase expression in invasive macroadenomas of Cushing's disease.
Pituitary Neoplasms
Genome-wide analysis in a murine dnmt1 knockdown model identifies epigenetically silenced genes in primary human pituitary tumors.
O(6)-methylguanine DNA methyltransferase immunoexpression in nonfunctioning pituitary adenomas: are progressive tumors potential candidates for temozolomide treatment?
Overexpression of DNA (Cytosine-5)-Methyltransferase 1 (DNMT1) And DNA (Cytosine-5)-Methyltransferase 3A (DNMT3A) Is Associated with Aggressive Behavior and Hypermethylation of Tumor Suppressor Genes in Human Pituitary Adenomas.
Recent clinical and pathophysiological advances in non-functioning pituitary adenomas.
The Epigenomics of Pituitary Adenoma.
Plague
[Comparison of specific recognition sites of adenine and cytosine DNA-methylase of Yersinia Pestis EV 76 C dam and dcm by Escherichia coli methylases]
[DNA-methyltransferase of the plague microbe]
Plasmacytoma
De novo and maintenance DNA methylation by a mouse plasmacytoma cell DNA methyltransferase.
Pneumonia
Bronchial epithelial DNA methyltransferase 3b dampens pulmonary immune responses during Pseudomonas aeruginosa infection.
DNA methyltransferase inhibitor alleviates bleomycin-induced pulmonary inflammation.
Regulatory T Cell DNA Methyltransferase Inhibition Accelerates Resolution of Lung Inflammation.
Polycythemia Vera
Clonal and lineage analysis of somatic DNMT3A and JAK2 mutations in a chronic phase polycythemia vera patient.
DNMT3A, TET2, and JAK2 mutations in polycythemia vera following long-term remission of secondary acute myeloid leukemia.
Jak2V617F and Dnmt3a loss cooperate to induce myelofibrosis through activated enhancer-driven inflammation.
Polyneuropathies
A Patient With DNMT1 Gene Mutation Presenting With Polyneuropathy, Hearing Loss, and Personality Changes.
Post-Concussion Syndrome
Reducing the time interval between concussion and voluntary exercise restores motor impairment, short-term memory, and alterations to gene expression.
Pre-Eclampsia
Dysregulated DNA Methyltransferase 3A Upregulates IGFBP5 to Suppress Trophoblast Cell Migration and Invasion in Preeclampsia.
Induction of TGF-? receptor I expression in a DNA methylation-independent manner mediated by DNMT3A downregulation is involved in early-onset severe preeclampsia.
Modulation of FABP4 hypomethylation by DNMT1 and its inverse interaction with miR-148a/152 in the placenta of preeclamptic rats and HTR-8 cells.
Preeclampsia is associated with hypermethylation of IGF-1 promoter mediated by DNMT1.
Precancerous Conditions
Alterations in gene expression associated with the overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, during human hepatocarcinogenesis.
Increased DNA methyltransferase 1 (DNMT1) protein expression in precancerous conditions and ductal carcinomas of the pancreas.
Increased DNA methyltransferase expression is associated with an early stage of human hepatocarcinogenesis.
Increased protein expression of DNA methyltransferase (DNMT) 1 is significantly correlated with the malignant potential and poor prognosis of human hepatocellular carcinomas.
Overexpression of a splice variant of DNA methyltransferase 3b, DNMT3b4, associated with DNA hypomethylation on pericentromeric satellite regions during human hepatocarcinogenesis.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
6-Thioguanine reactivates epigenetically silenced genes in acute lymphoblastic leukemia cells by facilitating proteasome-mediated degradation of DNMT1.
?-Arrestin1 promotes the self-renewal of the leukemia-initiating cell-enriched subpopulation in B-lineage acute lymphoblastic leukemia related to DNMT1 activity.
Clinicopathologic Effect of DNMT3A Mutation in Adult T-Cell Acute Lymphoblastic Leukemia.
Cost-effective screening of DNMT3A coding sequence identifies somatic mutation in pediatric T-cell acute lymphoblastic leukemia.
DNA methyltransferase 3a hot-spot locus is not mutated in pediatric patients affected by acute myeloid or T-cell acute lymphoblastic leukemia: an Italian study.
DNA methyltransferase expression differs with proliferation in childhood acute lymphoblastic leukemia.
Dnmt3a haploinsufficiency cooperates with oncogenic Kras to promote an early-onset T-cell acute lymphoblastic leukemia.
Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation.
DNMT3A mutation analysis in adult patients with acute lymphoblastic leukemia.
DNMT3A mutation is associated with increased age and adverse outcome in adult T-acute lymphoblastic leukemia.
DNMT3A mutations and prognostic significance in childhood acute lymphoblastic leukemia.
Downregulation of miR-217 correlates with resistance of ph(+) leukemia cells to ABL tyrosine kinase inhibitors.
Early T-cell precursor acute lymphoblastic leukemia with KRAS and DNMT3A mutations and unexpected monosomy 7.
Epigenetic alterations in hematopoietic malignancies.
Erratum.
Exosomal DNMT1 mRNA transcript is elevated in acute lymphoblastic leukemia which might reprograms leukemia progression.
Gene expression profiling of the DNMT3A R882 mutation in acute leukemia.
Imatinib causes epigenetic alterations of PTEN gene via upregulation of DNA methyltransferases and polycomb group proteins.
Patterns of DNMT1 Promoter Methylation in Patients with Acute Lymphoblastic Leukemia.
Tatton-Brown-Rahman syndrome: Six individuals with novel features.
The association of DNA methyltransferase 1 gene polymorphisms with susceptibility to childhood acute lymphoblastic leukemia.
The effects of clofarabine in ALL inhibition through DNA methylation regulation.
The molecular profile of adult T-cell acute lymphoblastic leukemia: mutations in RUNX1 and DNMT3A are associated with poor prognosis in T-ALL.
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
CDKN2B downregulation and other genetic characteristics in T-acute lymphoblastic leukemia.
Clinicopathologic Effect of DNMT3A Mutation in Adult T-Cell Acute Lymphoblastic Leukemia.
Cost-effective screening of DNMT3A coding sequence identifies somatic mutation in pediatric T-cell acute lymphoblastic leukemia.
Deleterious point mutations in T-cell acute lymphoblastic leukemia: Mechanistic insights into leukemogenesis.
Dnmt3a deletion cooperates with the Flt3/ITD mutation to drive leukemogenesis in a murine model.
Dnmt3a haploinsufficiency cooperates with oncogenic Kras to promote an early-onset T-cell acute lymphoblastic leukemia.
DNMT3A mutation analysis in adult patients with acute lymphoblastic leukemia.
DNMT3A mutation is associated with increased age and adverse outcome in adult T-acute lymphoblastic leukemia.
Dnmt3a regulates T-cell development and suppresses T-ALL transformation.
DNMT3B overexpression contributes to aberrant DNA methylation and MYC-driven tumor maintenance in T-ALL and Burkitt's lymphoma.
Epigenetic analysis of patients with T-ALL identifies poor outcomes and a hypomethylating agent-responsive subgroup.
Erratum.
The molecular profile of adult T-cell acute lymphoblastic leukemia: mutations in RUNX1 and DNMT3A are associated with poor prognosis in T-ALL.
Therapy-related acute lymphoblastic leukemia is a distinct entity with adverse genetic features and clinical outcomes.
Premature Birth
DNMT3B rs1569686 and rs2424913 gene polymorphisms are associated with positive family history of preterm birth and smoking status.
Primary Myelofibrosis
Accelerating myelofibrosis through loss of Dnmt3a.
Array comparative genomic hybridization and sequencing of 23 genes in 80 patients with myelofibrosis at chronic or acute phase.
Bone marrow findings in blast phase of polycythemia vera.
Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation.
DNMT3A mutational analysis in primary myelofibrosis, chronic myelomonocytic leukemia and advanced phases of myeloproliferative neoplasms.
Jak2V617F and Dnmt3a loss cooperate to induce myelofibrosis through activated enhancer-driven inflammation.
Ruxolitinib in combination with DNA methyltransferase inhibitors: clinical responses in patients with symptomatic myelofibrosis with cytopenias and elevated blast(s) counts.
Progeria
Genetic variation in healthy oldest-old.
Prostatic Hyperplasia
Aberrant methylation and deacetylation of deleted in liver cancer-1 gene in prostate cancer: potential clinical applications.
Altered methylation of multiple genes in carcinogenesis of the prostate.
DNA methyltransferase and demethylase in human prostate cancer.
Polymorphisms in the DNA methyltransferase 3b gene and prostate cancer risk.
Prostatic Intraepithelial Neoplasia
Altered methylation of multiple genes in carcinogenesis of the prostate.
Inhibition of DNA methyltransferase activity prevents tumorigenesis in a mouse model of prostate cancer.
Stage-specific alterations of DNA methyltransferase expression, DNA hypermethylation, and DNA hypomethylation during prostate cancer progression in the transgenic adenocarcinoma of mouse prostate model.
Prostatic Neoplasms
5,6 Dihydro-5'-azacytidine (DHAC) restores androgen responsiveness in androgen-insensitive prostate cancer cells.
5-Aza-2'-deoxycytidine stress response and apoptosis in prostate cancer.
A feedback regulation between miR-145 and DNA methyltransferase 3b in prostate cancer cell and their responses to irradiation.
A novel DNA methyltransferase I-derived peptide eluted from soluble HLA-A*0201 induces peptide-specific, tumor-directed cytotoxic T cells.
Aberrant methylation and deacetylation of deleted in liver cancer-1 gene in prostate cancer: potential clinical applications.
Activation of silenced tumor suppressor genes in prostate cancer cells by a novel energy restriction-mimetic agent.
Altered methylation of multiple genes in carcinogenesis of the prostate.
Antagonistic activities of miR-148a and DNMT1: Ectopic expression of miR-148a impairs DNMT1 mRNA and dwindle cell proliferation and survival.
Co-Targeting Plk1 and DNMT3a in Advanced Prostate Cancer.
Correlation between the expression of DNMT1, and GSTP1 and APC, and the methylation status of GSTP1 and APC in association with their clinical significance in prostate cancer.
CRISPR-Mediated Reactivation of DKK3 Expression Attenuates TGF-? Signaling in Prostate Cancer.
Disulfiram is a DNA demethylating agent and inhibits prostate cancer cell growth.
DNA methyltransferase 3b (DNMT3b), tumor tissue DNA methylation, Gleason score, and prostate cancer mortality: investigating causal relationships.
DNA methyltransferase and demethylase in human prostate cancer.
DNMT1 and DNMT3B regulate tumorigenicity of human prostate cancer cells by controlling RAD9 expression through targeted methylation.
DNMT1 Regulates Epithelial-Mesenchymal Transition and Cancer Stem Cells, Which Promotes Prostate Cancer Metastasis.
DNMT1 silencing affects locus specific DNA methylation and increases prostate cancer derived PC3 cell invasiveness.
DNMT3a contributes to the development and maintenance of bone cancer pain by silencing Kv1.2 expression in spinal cord dorsal horn.
Effect of histone deacetylase and DNA methyltransferase inhibitors on the expression of the androgen receptor gene in androgen-independent prostate cancer cell lines.
Effects of sulforaphane and 3,3'-diindolylmethane on genome-wide promoter methylation in normal prostate epithelial cells and prostate cancer cells.
Epigenetic effects of green tea polyphenols in cancer.
Epigenetic regulation of vitamin D 24-hydroxylase/CYP24A1 in human prostate cancer.
Epigenetic therapy in urologic cancers: an update on clinical trials.
Epigenetics and prostate cancer: defining the timing of DNA methyltransferase deregulation during prostate cancer progression.
Expression changes in EZH2, but not in BMI-1, SIRT1, DNMT1 or DNMT3B are associated with DNA methylation changes in prostate cancer.
Expression of UDP Glucuronosyltransferases 2B15 and 2B17 is associated with methylation status in prostate cancer cells.
EZH2 dependent H3K27me3 is involved in epigenetic silencing of ID4 in prostate cancer.
Frequent methylation of estrogen receptor in prostate cancer: correlation with tumor progression.
GSTP1 DNA methylation and expression status is indicative of 5-aza-2'-deoxycytidine efficacy in human prostate cancer cells.
Histone deacetylase and DNA methyltransferase in human prostate cancer.
HOTAIR-mediated reciprocal regulation of EZH2 and DNMT1 contribute to polyphyllin I-inhibited growth of castration-resistant prostate cancer cells in vitro and in vivo.
Inhibition of DNA methyltransferase activity prevents tumorigenesis in a mouse model of prostate cancer.
Long non-coding RNA BLACAT1 inhibits prostate cancer cell proliferation through sponging miR-361.
Mahanine restores RASSF1A expression by down-regulating DNMT1 and DNMT3B in prostate cancer cells.
Mahanine reverses an epigenetically silenced tumor suppressor gene RASSF1A in human prostate cancer cells.
Manipulation of prostate cancer metastasis by locus-specific modification of the CRMP4 promoter region using chimeric TALE DNA methyltransferase and demethylase.
Marginal Time-Dependent Causal Effects in Mediation Analysis With Survival Data.
Micro-ribonucleic acid 29b inhibits cell proliferation and invasion and enhances cell apoptosis and chemotherapy effects of cisplatin via targeting of DNMT3b and AKT3 in prostate cancer.
Milk disrupts p53 and DNMT1, the guardians of the genome: implications for acne vulgaris and prostate cancer.
Modulation of E-cadherin expression by K-Ras; involvement of DNA methyltransferase-3b.
Multi-target siRNA based on DNMT3A/B homologous conserved region influences cell cycle and apoptosis of human prostate cancer cell line TSU-PR1.
Nephrotoxicity of epigenetic inhibitors used for the treatment of cancer.
Opposing roles of Dnmt1 in early- and late-stage murine prostate cancer.
Polymorphisms in the DNA methyltransferase 3b gene and prostate cancer risk.
Promoter demethylation and chromatin remodeling by green tea polyphenols leads to re-expression of GSTP1 in human prostate cancer cells.
Re: A Feedback Regulation between miR-145 and DNA Methyltransferase 3b in Prostate Cancer Cell and Their Responses to Irradiation.
Regulation of miR-200c and miR-141 by Methylation in Prostate Cancer.
REX-1 Represses RASSF1a and Activates the MEK/ERK Pathway to Promote Tumorigenesis in Prostate Cancer.
Role of DNA methyltransferase 1 in hormone-resistant prostate cancer.
SChLAP1 promotes prostate cancer development through interacting with EZH2 to mediate promoter methylation modification of multiple miRNAs of chromosome 5 with a DNMT3a-feedback loop.
Single-nucleotide polymorphisms in DNMT3B gene and DNMT3B mRNA expression in association with prostate cancer mortality.
Specific zinc finger-induced methylation of PD-L1 promoter inhibits its expression.
Stage-specific alterations of DNA methyltransferase expression, DNA hypermethylation, and DNA hypomethylation during prostate cancer progression in the transgenic adenocarcinoma of mouse prostate model.
Targeting epigenetics for the treatment of prostate cancer: recent progress and future directions.
TGF-? regulates DNA methyltransferase expression in prostate cancer, correlates with aggressive capabilities, and predicts disease recurrence.
The DAXX co-repressor is directly recruited to active regulatory elements genome-wide to regulate autophagy programs in a model of human prostate cancer.
The retinoic acid synthesis gene ALDH1a2 is a candidate tumor suppressor in prostate cancer.
Transcriptome analysis of human colon Caco-2 cells exposed to sulforaphane.
Transcriptome-Wide Effects of Sphingosine Kinases Knockdown in Metastatic Prostate and Breast Cancer Cells: Implications for Therapeutic Targeting.
Tumor suppressor gene inactivation during cadmium-induced malignant transformation of human prostate cells correlates with overexpression of de novo DNA methyltransferase.
[Polymorphisms of DNA methyltransferases and the risk of prostate cancer].
Protein Deficiency
Early-onset colorectal cancer: A distinct entity with unique genetic features.
Pseudomonas Infections
Bronchial epithelial DNA methyltransferase 3b dampens pulmonary immune responses during Pseudomonas aeruginosa infection.
Psoriasis
Polymorphisms in GNMT and DNMT3b are associated with methotrexate treatment outcome in plaque psoriasis.
Pulmonary Disease, Chronic Obstructive
Cigarette smoke extract promotes DNA methyltransferase 3a expression in dendritic cells, inducing Th-17/Treg imbalance via the c-Jun/allograft inflammatory factor 1 axis.
Hypomethylation of LINE-1 repeat elements and global loss of DNA hydroxymethylation in vapers and smokers.
Oxidative stress mediates the apoptosis and epigenetic modification of the Bcl-2 promoter via DNMT1 in a cigarette smoke-induced emphysema model.
[Lung cancer and its epigenetics association with chronic obstructive pulmonary disease].
Pulmonary Fibrosis
Dust induces lung fibrosis through dysregulated DNA methylation.
Purpura
Defective activation of the MAPK/ERK pathway, leading to PARP1 and DNMT1 dysregulation, is a common defect in IgA nephropathy and Henoch-Schönlein purpura.
Purpura, Thrombocytopenic, Idiopathic
Association of DNA Methyltransferase 3B Promotor Polymorphism With Childhood Chronic Immune Thrombocytopenia.
Decreased DNA methyltransferase 3A and 3B mRNA expression in peripheral blood mononuclear cells and increased plasma SAH concentration in adult patients with idiopathic thrombocytopenic purpura.
DNA methyltransferase 3B (DNMT3B -579G>T) promotor polymorphism and the susceptibility to pediatric immune thrombocytopenic purpura in Egypt.
DNA methyltransferase 3B gene promoter and interleukin-1 receptor antagonist polymorphisms in childhood immune thrombocytopenia.
DNMT3B 579G>T Promoter Polymorphism and the Risk for Idiopathic Thrombocytopenic Purpura in a Chinese Population.
DNMT3B promoter polymorphism and risk of immune thrombocytopenic purpura in pediatric Egyptians.
Role of DNA methyltransferase 3A mRNA expression in Egyptian patients with idiopathic thrombocytopenic purpura.
Single nucleotide polymorphism in DNMT3B promoter and the risk for idiopathic thrombocytopenic purpura in Chinese population.
Pyoderma Gangrenosum
Lobular neutrophilic panniculitis associated with DNA methyltransferase inhibitors in the treatment of myeloid disease.
Radiation Fibrosis Syndrome
DNA Methyltransferase Gene Polymorphisms for Prediction of Radiation-induced Skin Fibrosis after Treatment of Breast Cancer: a Multifactorial Genetic Approach.
Radicular Cyst
DNA methyltransferase expression in odontogenic cysts and tumours.
Rectal Neoplasms
Candidate pathway polymorphisms in one-carbon metabolism and risk of rectal tumor mutations.
Relapsing Fever
Characterization of a DNA Adenine Methyltransferase Gene of Borrelia hermsii and Its Dispensability for Murine Infection and Persistence.
Renal Insufficiency
Vesicourethral reflux-induced renal failure in a patient with ICF syndrome due to a novel DNMT3B mutation.
Reperfusion Injury
Untargeted DNA-Demethylation Therapy Neither Prevents Nor Attenuates Ischemia-Reperfusion-Induced Renal Fibrosis.
Retinal Degeneration
DNA methylation and differential gene regulation in photoreceptor cell death.
Retinitis Pigmentosa
Simultaneous Reprogramming and Gene Correction of Patient Fibroblasts.
Retinoblastoma
5-Aza-2''-deoxycytidine inhibits retinoblastoma cell by reactivating epigenetically silenced RASSF1A gene.
Allosteric activator domain of maintenance human DNA (cytosine-5) methyltransferase and its role in methylation spreading.
AMPK promotes mitochondrial biogenesis and function by phosphorylating the epigenetic factors DNMT1, RBBP7, and HAT1.
Association between human papillomavirus and Epstein - Barr virus DNA and gene promoter methylation of RB1 and CDH1 in the cervical lesions: a transversal study.
De-regulated expression of the BRG1 chromatin remodeling factor in bone marrow mesenchymal stromal cells induces senescence associated with the silencing of NANOG and changes in the levels of chromatin proteins.
Deoxyribonucleic acid methyltransferase 3B promotes epigenetic silencing through histone 3 chromatin modifications in pituitary cells.
Different susceptibility of increased DNMT1 expression by exposure to tobacco smoke according to histology in primary non-small cell lung cancer.
DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters.
Down-regulation of DNMT3b in PC3 cells effects locus-specific DNA methylation, and represses cellular growth and migration.
Epigenetic control of trefoil factor family (TFF) peptide expression in human retinoblastoma cell lines.
High levels of global genome methylation in patients with retinoblastoma.
Human polyomavirus BKV transcriptionally activates DNA methyltransferase 1 through the pRb/E2F pathway.
Inhibition of DNA methyltransferase activity prevents tumorigenesis in a mouse model of prostate cancer.
Intestinal PPAR? Protects Against Colon Carcinogenesis via Regulation of Methyltransferases DNMT1 and PRMT6.
Loss of RB compromises specific heterochromatin modifications and modulates HP1alpha dynamics.
Molecular alterations in retinoblastoma beyond RB1.
Overexpression of DNA methyltransferases 1, 3a, and 3b significantly correlates with retinoblastoma tumorigenesis.
Retinoblastoma pathway dysregulation causes DNA methyltransferase 1 overexpression in cancer via MAD2-mediated inhibition of the anaphase-promoting complex.
SUV39H1/DNMT3A-dependent methylation of the RB1 promoter stimulates PIN1 expression and melanoma development.
The retinoblastoma gene product interacts with maintenance human DNA (cytosine-5) methyltransferase and modulates its activity.
[DNMT1 protein promotes retinoblastoma proliferation by silencing MEG3 gene].
Rett Syndrome
Cyclin-dependent kinase-like 5 binds and phosphorylates DNA methyltransferase 1.
Lessons from two human chromatin diseases, ICF syndrome and Rett syndrome.
Losing Dnmt3a dependent methylation in inhibitory neurons impairs neural function by a mechanism impacting Rett syndrome.
Rhabdomyolysis
Procainamide Inhibits DNA Methylation and Alleviates Multiple Organ Dysfunction in Rats with Endotoxic Shock.
Therapeutic Effects of Procainamide on Endotoxin-Induced Rhabdomyolysis in Rats.
Rhabdomyosarcoma
Erratum: Increased DNA methyltransferase expression in rhabdomyosarcomas. Int. J. Cancer, 83, 10-14 (1999).
Increased DNA methyltransferase expression in rhabdomyosarcomas.
lncRNA RMST Enhances DNMT3 Expression through Interaction with HuR.
Targeting Hippo-Dependent and Hippo-Independent YAP1 Signaling for the Treatment of Childhood Rhabdomyosarcoma.
Rhabdomyosarcoma, Alveolar
Increased DNA methyltransferase expression in rhabdomyosarcomas.
Molecular mechanisms of Guadecitabine induced FGFR4 down regulation in alveolar rhabdomyosarcomas.
Rhabdomyosarcoma, Embryonal
DNMT3B in vitro knocking-down is able to reverse embryonal rhabdomyosarcoma cell phenotype through inhibition of proliferation and induction of myogenic differentiation.
Rheumatic Heart Disease
Coordination of PRKCA/PRKCA-AS1 interplay facilitates DNA methyltransferase 1 recruitment on DNA methylation to affect protein kinase C alpha transcription in mitral valve of rheumatic heart disease.
Rickets, Hypophosphatemic
Whole exome sequencing unravels disease-causing genes in consanguineous families in Qatar.
Salivary Gland Neoplasms
Immunolocalization of DNMT1 and DNMT3a in salivary gland neoplasms.
Sarcoma
Chromatin structure predicts epigenetic therapy responsiveness in sarcoma.
FXR silencing in human colon cancer by DNA methylation and KRAS signaling.
Sarcoma, Avian
DNA methylase activity associated with Rous sarcoma virus.
Sarcoma, Myeloid
Case report: Rare myeloid sarcoma development following renal transplantation with KRAS and DNMT3A gene mutations.
Scleroderma, Systemic
TGF?-induced epigenetic deregulation of SOCS3 facilitates STAT3-signaling to promote fibrosis.
Seizures
Association of RASgrf1 methylation with epileptic seizures.
Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis.
Methyl-CpG-Binding Domain Protein 3 Promotes Seizures by Recruiting Methyltransferase DNMT1 to Enhance TREM2 Methylation.
Seizures, Febrile
DNA methyltransferase isoforms expression in the temporal lobe of epilepsy patients with a history of febrile seizures.
Seminoma
Differential expression of DNA methyltransferases and demethylases among the various testicular germ cell tumor subtypes.
DNA methyltransferase 3B expression is associated with poor outcome of stage I testicular seminoma.
DNA methyltransferase-3 like protein expression in various histological types of testicular germ cell tumor.
DNMT1 and HDAC1 gene expression in impaired spermatogenesis and testicular cancer.
Gene expression profiling identifies a set of transcripts that are up-regulated inhuman testicular seminoma.
Genome-wide expression profiling reveals new insights into pathogenesis and progression of testicular germ cell tumors.
Meta-Analysis of Gene Expressions in Testicular Germ Cell Tumor Histologies.
Sepsis
Genetic variation of DNA methyltransferase-3A contributes to protection against persistent MRSA bacteremia in patients.
Host gene expression analysis in Sri Lankan melioidosis patients.
Severe Combined Immunodeficiency
DNMT3B deficiency presenting as severe combined immune deficiency: A case report.
Simultaneous Reprogramming and Gene Correction of Patient Fibroblasts.
Shock, Septic
Circulating extracellular vesicle content reveals de novo DNA methyltransferase expression as a molecular method to predict septic shock.
Skin Diseases
Identification of genes important for cutaneous function revealed by a large scale reverse genetic screen in the mouse.
Lobular neutrophilic panniculitis associated with DNA methyltransferase inhibitors in the treatment of myeloid disease.
Skin Neoplasms
New Experimental Models of Skin Homeostasis and Diseases.
Sleep Deprivation
Role of epigenetic regulatory enzymes in animal models of mania induced by amphetamine and paradoxical sleep deprivation.
Transcriptional alterations of genes related to fertility decline in male rats induced by chronic sleep restriction.
Small Cell Lung Carcinoma
Combinations of DNA methyltransferase and histone deacetylase inhibitors induce DNA damage in small cell lung cancer cells: correlation of resistance with IFN-stimulated gene expression.
H3K27me3 induces multidrug resistance in small cell lung cancer by affecting HOXA1 DNA methylation via regulation of the lncRNA HOTAIR.
Prognostic significance of folate metabolism polymorphisms for lung cancer.
Smoldering Multiple Myeloma
DNA-methylation analysis identifies the E-cadherin gene as a potential marker of disease progression in patients with monoclonal gammopathies.
Sotos Syndrome
Co-occurrence of a maternally inherited DNMT3A duplication and a paternally inherited pathogenic variant in EZH2 in a child with growth retardation and severe short stature: atypical Weaver syndrome or evidence of a DNMT3A dosage effect?
SETD2 and DNMT3A screen in the Sotos-like syndrome French cohort.
Spasms, Infantile
Identification of De Novo DNMT3A Mutations That Cause West Syndrome by Using Whole-Exome Sequencing.
Spinocerebellar Ataxias
Dnmt1 deficiency promotes CAG repeat expansion in the mouse germline.
SETX (senataxin), the helicase mutated in AOA2 and ALS4, functions in autophagy regulation.
Spondylitis, Ankylosing
Evaluation of DNMT1 gene expression profile and methylation of its promoter region in patients with ankylosing spondylitis.
Squamous Cell Carcinoma of Head and Neck
A novel C/T polymorphism in the core promoter of human de novo cytosine DNA methyltransferase 3B6 is associated with prognosis in head and neck cancer.
Analysis of Association Between MGMT and p53 Gene Single Nucleotide Polymorphisms and Laryngeal Cancer.
Bioinformatics analysis of DNMT1 expression and its role in head and neck squamous cell carcinoma prognosis.
DNA methylation-mediated Klotho silencing is an independent prognostic biomarker of head and neck squamous carcinoma.
DNA methyltransferase 3B -149C/T polymorphism and the risk of laryngeal squamous cell carcinoma: a case-control study.
DNMT1 Enhances the Radiosensitivity of HPV-Positive Head and Neck Squamous Cell Carcinomas via Downregulating SMG1.
Effect of age on the association between p16CDKN2A methylation and DNMT3B polymorphism in head and neck carcinoma and patient survival.
Epigenetic screen of human DNA repair genes identifies aberrant promoter methylation of NEIL1 in head and neck squamous cell carcinoma.
Epigenetic therapy regulates the expression of ALDH1 and immunologic response: Relevance to the prognosis of oral cancer.
FOXM1 induces a global methylation signature that mimics the cancer epigenome in head and neck squamous cell carcinoma.
Gene Polymorphisms Involved in Folate Metabolism and DNA Methylation with the Risk of Head and Neck Cancer.
Gene signatures of m5C regulators may predict prognoses of patients with head and neck squamous cell carcinoma.
High DNMT1 Is Associated With Worse Local Control in Early-Stage Laryngeal Squamous Cell Carcinoma.
High tRNA Transferase NSUN2 Gene Expression is Associated with Poor Prognosis in Head and Neck Squamous Carcinoma.
Identification of Expression Patterns and Potential Prognostic Significance of m5C-Related Regulators in Head and Neck Squamous Cell Carcinoma.
Immunohistochemical evaluation of Klotho and DNA methyltransferase 3a in oral squamous cell carcinomas.
Immunohistochemical expression of DNA methyltransferases 1, 3a and 3b in oral leukoplakias and squamous cell carcinomas.
Natural Compounds: DNA Methyltransferase Inhibitors in Oral Squamous Cell Carcinoma.
Noninvasive Molecular Detection of Head and Neck Squamous Cell Carcinoma: An Exploratory Analysis.
Over-expression of DNA methyltransferases and CDKN2A gene methylation status in squamous cell carcinoma of the oral cavity.
Overexpression of Sal-like protein 4 in head and neck cancer: epigenetic effects and clinical correlations.
Promoter polymorphisms of DNMT3B and the risk of head and neck squamous cell carcinoma in Taiwan: a case-control study.
RNA methyltransferase NSUN2 promotes hypopharyngeal squamous cell carcinoma proliferation and migration by enhancing TEAD1 expression in an m5C-dependent manner.
The clinical significance of methylation of MAGE-A1 and-A3 promoters and expression of DNA methyltransferase in patients with laryngeal squamous cell carcinoma.
The involvement of promoter methylation and DNA methyltransferase-1 in the regulation of EpCAM expression in oral squamous cell carcinoma.
Transfer RNA methyltransferase gene NSUN2 mRNA expression modifies the effect of T cell activation score on patient survival in head and neck squamous carcinoma.
[The expression of DNMT1 in laryngeal squamous cell carcinoma and its clinical significance].
Starvation
A new nuclear function of the Entamoeba histolytica glycolytic enzyme enolase: the metabolic regulation of cytosine-5 methyltransferase 2 (Dnmt2) activity.
Modulation of DNA methyltransferase profile by methyl donor starvation followed by gamma irradiation.
Stomach Neoplasms
5-Aza-2'-deoxycitydine induces demethylation and up-regulates transcription of p16INK4A gene in human gastric cancer cell lines.
A functional polymorphism in the DNA methyltransferase-3A promoter modifies the susceptibility in gastric cancer but not in esophageal carcinoma.
A Meta-Analysis of the Association between DNMT1 Polymorphisms and Cancer Risk.
Aberrant methylation of integrin alpha4 gene in human gastric cancer cells.
AKAP12/Gravin is inactivated by epigenetic mechanism in human gastric carcinoma and shows growth suppressor activity.
APC gene is modulated by hsa-miR-135b-5p in both diffuse and intestinal gastric cancer subtypes.
Association between human papillomavirus and Epstein - Barr virus DNA and gene promoter methylation of RB1 and CDH1 in the cervical lesions: a transversal study.
Association of DNMT3B -283T>C polymorphism with risk of lung and gastric cancer: a case-control study and a meta-analysis.
Association of five genetic variations in DNMT1 and DNMT3A with gastric cancer in a Chinese population.
Association of genetic polymorphisms in DNMT3A with the progression of gastric mucosal atrophy and susceptibility to gastric cancer in Japan.
Association of NDRG1 Gene Promoter Methylation with Reduced NDRG1 Expression in Gastric Cancer Cells and Tissue Specimens.
Association of the DNMT3A -448A>G polymorphism with genetic susceptibility to colorectal cancer.
Clinical significance of the expression of DNA methyltransferase proteins in gastric cancer.
Decreased miR-30b-5p expression by DNMT1 methylation regulation involved in gastric cancer metastasis.
Deregulation between miR-29b/c and DNMT3A is associated with epigenetic silencing of the CDH1 gene, affecting cell migration and invasion in gastric cancer.
DNA methyltransferase 1 as a predictive biomarker and potential therapeutic target for chemotherapy in gastric cancer.
DNA methyltransferase 3A isoform b contributes to repressing E-cadherin through cooperation of DNA methylation and H3K27/H3K9 methylation in EMT-related metastasis of gastric cancer.
DNA methyltransferase 3A promotes cell proliferation by silencing CDK inhibitor p18INK4C in gastric carcinogenesis.
DNA methyltransferase 3a rs1550117 genetic polymorphism predicts poor survival in gastric cancer patients.
DNA methyltransferase expression and DNA methylation of CPG islands and peri-centromeric satellite regions in human colorectal and stomach cancers.
DNA methyltransferase inhibitor 5-aza-CdR enhances the radiosensitivity of gastric cancer cells.
DNA methyltransferase3a expression is an independent poor prognostic indicator in gastric cancer.
DNMT1 overexpression predicting gastric carcinogenesis, subsequent progression and prognosis: a meta and bioinformatic analysis.
DNMT1 silencing affects locus specific DNA methylation and increases prostate cancer derived PC3 cell invasiveness.
DNMT1, DNMT3A and DNMT3B Polymorphisms Associated With Gastric Cancer Risk: A Systematic Review and Meta-analysis.
DNMT3A -448A>G polymorphism and the risk for hepatocellular carcinoma.
DNMT3a rs1550117 polymorphism association with increased risk of Helicobacter pylori infection.
DNMT3A rs36012910 A>G polymorphism and gastric cancer susceptibility in a Chinese population.
DNMT3A-mediated down-regulation of microRNA-105 promotes gastric cancer cell proliferation.
DNMT3B -149 C>T and -579 G>T Polymorphisms and Risk of Gastric and Colorectal Cancer: a Meta-analysis.
DNMT3B -579 G>T Promoter Polymorphism and the Risk of Gastric Cancer in the West of Iran.
DNMT3B Promoter Polymorphism and Risk of Gastric Cancer.
Downregulation of ID4 by promoter hypermethylation in gastric adenocarcinoma.
E-cadherin gene promoter hypermethylation in H. pylori-induced enlarged fold gastritis.
Effect of DNMT3A polymorphisms on CpG island hypermethylation in gastric mucosa.
Epigenetically deregulated miR-200c is involved in a negative feedback loop with DNMT3a in gastric cancer cells.
Expression of Dnmt1, demethylase, MeCP2 and methylation of tumor-related genes in human gastric cancer.
Expression of human histo-blood group ABO genes is dependent upon DNA methylation of the promoter region.
Expression pattern and clinical significance of DNA methyltransferase 3B variants in gastric carcinoma.
FOXC2-AS1 stabilizes FOXC2 mRNA via association with NSUN2 in gastric cancer cells.
Functional analysis of the NH2-terminal hydrophobic region and BRICHOS domain of GKN1.
Helicobacter pylori CagA induces tumor suppressor gene hypermethylation by upregulating DNMT1 via AKT-NF?B pathway in gastric cancer development.
Hypermethylation downregulates Runx3 gene expression and its restoration suppresses gastric epithelial cell growth by inducing p27 and caspase3 in human gastric cancer.
Immunohistochemical analysis of polycomb group protein expression in advanced gastric cancer.
Increased DNA methyltransferase 1 (DNMT1) protein expression correlates significantly with poorer tumor differentiation and frequent DNA hypermethylation of multiple CpG islands in gastric cancers.
Inhibition of DNA methyltransferase by antisense oligodeoxynucleotide modifies cell characteristics in gastric cancer cell lines.
Interaction between DNMT3B and MYH11 via hypermethylation regulates gastric cancer progression.
Lack of effects of single nucleotide polymorphisms of the DNA methyltransferase 1 gene on gastric cancer in Iranian patients: a case control study.
LINC00240 promotes gastric cancer cell proliferation, migration and EMT via the miR-124-3p / DNMT3B axis.
Linc00441 interacts with DNMT1 to regulate RB1 gene methylation and expression in gastric cancer.
LncRNA HOXA11-AS Promotes Proliferation and Invasion of Gastric Cancer by Scaffolding the Chromatin Modification Factors PRC2, LSD1, and DNMT1.
LncRNA-SNHG1 contributes to gastric cancer cell proliferation by regulating DNMT1.
Long noncoding RNA LINC00673 epigenetically suppresses KLF4 by interacting with EZH2 and DNMT1 in gastric cancer.
Loss of expression of DNA repair enzymes MGMT, hMLH1, and hMSH2 during tumor progression in gastric cancer.
MDGA2 is a novel tumour suppressor cooperating with DMAP1 in gastric cancer and is associated with disease outcome.
Methylation-induced downregulation and tumor suppressive role of microRNA-29b in gastric cancer through targeting LASP1.
MicroRNA-148a can regulate runt-related transcription factor 3 gene expression via modulation of DNA methyltransferase 1 in gastric cancer.
MicroRNA-148a is silenced by hypermethylation and interacts with DNA methyltransferase 1 in gastric cancer.
MiR-143 inhibits cell proliferation and invasion by targeting DNMT3A in gastric cancer.
MiR-148a regulates MEG3 in gastric cancer by targeting DNA methyltransferase 1.
miR-148a suppresses cell invasion and migration in gastric cancer by targeting DNA methyltransferase 1.
miR-492 promotes chemoresistance to CDDP and metastasis by targeting inhibiting DNMT3B and induces stemness in gastric cancer.
Mutation of the DNA methyltransferase (DNMT) 1 gene in human colorectal cancers.
Mutational analysis of DNMT3A gene in acute leukemias and common solid cancers.
Ndrg2 promoter hypermethylation triggered by helicobacter pylori infection correlates with poor patients survival in human gastric carcinoma.
No evidence of correlation between the single nucleotide polymorphism of DNMT3B promoter and gastric cancer risk in a Japanese population.
NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation.
P16 methylation increases the sensitivity of cancer cells to the CDK4/6 inhibitor palbociclib.
Peperomin E Induces Promoter Hypomethylation of Metastatic-Suppressor Genes and Attenuates Metastasis in Poorly Differentiated Gastric Cancer.
Polymorphism of DNA Methyltransferase 3b and Association with Development and Prognosis in Gastric Cancer.
Polymorphisms of the DNA methyltransferase 1 associated with reduced risks of Helicobacter pylori infection and increased risks of gastric atrophy.
Polymorphisms of the DNA Methyltransferase 1 Gene Predict Survival of Gastric Cancer Patients Receiving Tumorectomy.
Potential advantages of DNA methyltransferase 1 (DNMT1)-targeted inhibition for cancer therapy.
Promoter hypermethylation of cyclooxygenase-2 in gastric carcinoma.
Protein expression and promoter methylation of the candidate biomarker TCF21 in gastric cancer.
Protein expression trends of DNMT1 in gastrointestinal diseases: From benign to precancerous lesions to cancer.
Reactivation of Atp4a concomitant with intragenic DNA demethylation for cancer inhibition in a gastric cancer model.
RNA methyltransferase NSUN2 promotes gastric cancer cell proliferation by repressing p57Kip2 by an m5C-dependent manner.
The DNA methyltransferase inhibitor zebularine induces mitochondria-mediated apoptosis in gastric cancer cells in vitro and in vivo.
The DNMT3B -579G>T Polymorphism Is Significantly Associated With the Risk of Gastric Cancer but not Lung Cancer in Chinese Population.
The expression and clinical significance of DNA methyltransferase proteins in human gastric cancer.
Tumor-Associated Macrophages Promote Epigenetic Silencing of Gelsolin through DNA Methyltransferase 1 in Gastric Cancer Cells.
[Effects of dnmt1 Gene Silencing on Cell Cycle, Proliferation, and Apoptosis of Gastric Cancer Cell Line AGS.]
[Effects of pshRNA-DNMT1 on the proliferation and apoptosis of gastric cancer: experiments in vitro and in vivo]
[Relationship between Runx3 gene expression and its DNA methylation in gastric cancer]
Stroke
Atherosclerosis and clonal hematopoyesis: A new risk factor.
Effect of Inhibition of DNA Methylation Combined with Task-Specific Training on Chronic Stroke Recovery.
Emerging role of epigenetics in stroke: part 1: DNA methylation and chromatin modifications.
Genomic Profiling of a Randomized Trial of Interferon-? versus Hydroxyurea in MPN Reveals Mutation-Specific Responses.
Sweet Syndrome
Lobular neutrophilic panniculitis associated with DNA methyltransferase inhibitors in the treatment of myeloid disease.
Teratocarcinoma
Aza-deoxycytidine induces apoptosis or differentiation via DNMT3B and targets embryonal carcinoma cells but not their differentiated derivatives.
Endogenous assays of DNA methyltransferases: Evidence for differential activities of DNMT1, DNMT2, and DNMT3 in mammalian cells in vivo.
Interference with DNA methyltransferase activity and genome methylation during F9 teratocarcinoma stem cell differentiation induced by polyamine depletion.
Teratoma
DNA methyltransferase-3 like protein expression in various histological types of testicular germ cell tumor.
Establishment and maintenance of genomic methylation patterns in mouse embryonic stem cells by Dnmt3a and Dnmt3b.
Testicular Neoplasms
DNMT1 and HDAC1 gene expression in impaired spermatogenesis and testicular cancer.
microRNA-199a-3p, DNMT3A, and aberrant DNA methylation in testicular cancer.
Tetralogy of Fallot
Association between mRNA levels of DNMT1, DNMT3A, DNMT3B, MBD2 and LINE-1 methylation status in infants with tetralogy of Fallot.
Thrombosis
Risk factors of thrombosis in Chinese subjects with acute promyelocytic leukemia.
[Gene expressions of DNA methyltransferase 1 and human leukocyte antigen-DRalpha in hepatocelluar carcinoma and their clinical significance.]
Thymoma
Association of the DNMT3B -579G>T polymorphism with risk of thymomas in patients with myasthenia gravis.
ASXL1 and DNMT3A mutation in a cytogenetically normal B3 thymoma.
Codelivery of Genistein and miRNA-29b to A549 Cells Using Aptamer-Hybrid Nanoparticle Bioconjugates.
Downregulation of DNMT3a expression by RNAi and its effect on NF-?Bs expression of thymic epithelial cells.
Gene-Specific Methylation Analysis in Thymomas of Patients with Myasthenia Gravis.
Thymus Neoplasms
Gene-Specific Methylation Analysis in Thymomas of Patients with Myasthenia Gravis.
Thyroid Cancer, Papillary
LncRNA LINC00673 inhibits p53 expression by interacting with EZH2 and DNMT1 in papillary thyroid carcinoma.
Novel DNMT3A Germline Variant in a Patient with Multiple Paragangliomas and Papillary Thyroid Carcinoma.
Prognostic significance of DNMT3A alterations in Middle Eastern papillary thyroid carcinoma.
Shikonin Inhibites Migration and Invasion of Thyroid Cancer Cells by Downregulating DNMT1.
The Suppression of miR-199a-3p by Promoter Methylation Contributes to Papillary Thyroid Carcinoma Aggressiveness by Targeting RAP2a and DNMT3a.
Thyroid Diseases
Alterations of Global DNA Methylation and DNA Methyltransferase Expression in T and B Lymphocytes from Patients with Newly Diagnosed Autoimmune Thyroid Diseases After Treatment: A Follow-Up Study.
Association of polymorphisms in DNMT1, DNMT3A, DNMT3B, MTHFR and MTRR genes with global DNA methylation levels and prognosis of autoimmune thyroid disease.
Gene-gene and gene-sex epistatic interactions of DNMT1, DNMT3A and DNMT3B in autoimmune thyroid disease.
Thyroid Neoplasms
Liquid Biopsy as a Minimally Invasive Source of Thyroid Cancer Genetic and Epigenetic Alterations.
Mutations of genes including DNMT3A detected by next-generation sequencing in thyroid cancer.
Shikonin Inhibites Migration and Invasion of Thyroid Cancer Cells by Downregulating DNMT1.
Thyroid cancer 1 (C8orf4) shows high expression, no mutation and reduced methylation level in lung cancers, and its expression correlates with ?-catenin and DNMT1 expression and poor prognosis.
Tics
DAXX Suppresses Tumor-Initiating Cells in Estrogen Receptor-positive Breast Cancer following endocrine therapy.
Human ovarian cancer intrinsic mechanisms regulate lymphocyte activation in response to immune checkpoint blockade.
Transposition of Great Vessels
DNA methyltransferase 1 rs16999593 genetic polymorphism decreases risk in patients with transposition of great arteries.
Tremor
Functional Characterization of DNA Methylation in the Oligodendrocyte Lineage.
Triple Negative Breast Neoplasms
5-AZA-dC induces epigenetic changes associated with modified glycosylation of secreted glycoproteins and increased EMT and migration in chemo-sensitive cancer cells.
DNA methyltransferase expression in triple-negative breast cancer predicts sensitivity to decitabine.
DNMT1: A key drug target in triple-negative breast cancer.
Dysregulation of the epigenome in human breast cancer: contributions of gene-specific DNA hypermethylation to breast cancer pathobiology and targeting the breast cancer methylome for improved therapy.
Effects of SAHA and EGCG on Growth Potentiation of Triple-Negative Breast Cancer Cells.
Epigenetic reprogramming of epithelial mesenchymal transition in triple negative breast cancer cells with DNA methyltransferase and histone deacetylase inhibitors.
Inhibition of DNMT1 and ERR? crosstalk suppresses breast cancer via derepression of IRF4.
miR-185 suppresses tumor proliferation by directly targeting E2F6 and DNMT1 and indirectly upregulating BRCA1 in triple-negative breast cancer.
MYC suppresses STING-dependent innate immunity by transcriptionally upregulating DNMT1 in triple-negative breast cancer.
SAHA and EGCG Promote Apoptosis in Triple-negative Breast Cancer Cells, Possibly Through the Modulation of cIAP2.
YY1-mediated long non-coding RNA Kcnq1ot1 promotes the tumor progression by regulating PTEN via DNMT1 in triple negative breast cancer.
Tuberculosis
DNA methylation impacts gene expression and ensures hypoxic survival of Mycobacterium tuberculosis.
Genome-wide non-CpG methylation of the host genome during M. tuberculosis infection.
MamA essentiality in Mycobacterium smegmatis is explained by the presence of an apparent cognate restriction endonuclease.
Urinary Bladder Neoplasms
5-Aza-2'-Deoxycytidine Enhances Maspin Expression and Inhibits Proliferation, Migration, and Invasion of the Bladder Cancer T24 Cell Line.
A novel regulatory circuit of miR?152 and DNMT1 in human bladder cancer.
Angiogenin contributes to bladder cancer tumorigenesis by DNMT3b-mediated MMP2 activation.
Cancer-testis antigen expression in bladder cancer.
CCND1, NOP14 and DNMT3B are involved in miR-502-5p-mediated inhibition of cell migration and proliferation in bladder cancer.
Combination of Decitabine and Entinostat Synergistically Inhibits Urothelial Bladder Cancer Cells via Activation of FoxO1.
Decrease of DNA methyltransferase 1 expression relative to cell proliferation in transitional cell carcinoma.
DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells.
DNMT1-dependent suppression of microRNA424 regulates tumor progression in human bladder cancer.
DNMT1: An emerging target in the treatment of invasive urinary bladder cancer.
DNMT3B silencing suppresses migration and invasion by epigenetically promoting miR-34a in bladder cancer.
Effects on biological behavior of bladder carcinoma T24 cells via silencing DNMT1 and/or DNMT3b with shRNA In Vitro.
Expression and function role of DNA methyltransferase 1 in human bladder cancer.
Gene Expression, DNA Methylation and Prognostic Significance of DNA Repair Genes in Human Bladder Cancer.
Hypermethylation of FOXA1 and allelic loss of PTEN drive squamous differentiation and promote heterogeneity in bladder cancer.
Identification and characterization of DNAzymes targeting DNA methyltransferase I for suppressing bladder cancer proliferation.
Increased DNA methyltransferase 1 protein expression in human transitional cell carcinoma of the bladder.
Inhibition of bladder cancer invasion by Sp1-mediated BTG2 expression via inhibition of DNA methyltransferase 1.
Kaempferol Modulates DNA Methylation and Downregulates DNMT3B in Bladder Cancer.
Long non-coding RNA DBCCR1-003 regulate the expression of DBCCR1 via DNMT1 in bladder cancer.
microRNA-451a promoter methylation regulated by DNMT3B expedites bladder cancer development via the EPHA2/PI3K/AKT axis.
MiR-124-3p suppresses bladder cancer by targeting DNA methyltransferase 3B.
miR-148a dependent apoptosis of bladder cancer cells is mediated in part by the epigenetic modifier DNMT1.
miR-148a-3p represses proliferation and EMT by establishing regulatory circuits between ERBB3/AKT2/c-myc and DNMT1 in bladder cancer.
Phosphatidylinositol 3-kinase/protein kinase B pathway stabilizes DNA methyltransferase I protein and maintains DNA methylation.
Prognostic value of opioid binding protein/cell adhesion molecule-like promoter methylation in bladder carcinoma.
Regulation of SLD5 gene expression by miR-370 during acute growth of cancer cells.
The effect of heat shock protein 90 inhibitors on histone 4 lysine 20 methylation in bladder cancer.
Tobacco-Specific Carcinogens Induce Hypermethylation, DNA Adducts, and DNA Damage in Bladder Cancer.
[Effect of stable DNA methyltransferase 3bknockdown on proliferation and apoptosis in bladder cancer cells in vitro].
[Expression of DNMT3b in human bladder cancer tissue and its correlation with clinical prognosis].
Urogenital Neoplasms
Does Wnt/?-catenin pathway contribute to the stability of DNMT1 expression in urological cancer cell lines?
Urologic Neoplasms
Does Wnt/?-catenin pathway contribute to the stability of DNMT1 expression in urological cancer cell lines?
Manipulating the epigenome for the treatment of urological malignancies.
Uterine Cervical Neoplasms
Aberrant methylation-mediated downregulation of lncRNA CCND2 AS1 promotes cell proliferation in cervical cancer.
Aberrant Promoter Methylation and Expression of UTF1 during Cervical Carcinogenesis.
CDH1 and SNAI1 are regulated by E7 from human papillomavirus types 16 and 18.
Combined inhibition of JAK1/2 and DNMT1 by newly identified small-molecule compounds synergistically suppresses the survival and proliferation of cervical cancer cells.
Crosstalk between histone modification and DNA methylation orchestrates the epigenetic regulation of the costimulatory factors, Tim?3 and galectin?9, in cervical cancer.
Differential expression of Oct4 in HPV-positive and HPV-negative cervical cancer cells is not regulated by DNA methyltransferase 3A.
DNMT1 recruited by EZH2-mediated silencing of miR-484 contributes to the malignancy of cervical cancer cells through MMP14 and HNF1A.
E-cadherin expression is silenced by DNA methylation in cervical cancer cell lines and tumours.
Effects of DNMT1 silencing on malignant phenotype and methylated gene expression in cervical cancer cells.
Enhanced anticancer effects of a methylation inhibitor by inhibiting a novel DNMT1 target, CEP 131, in cervical cancer.
Epigallocatechin gallate inhibits HeLa cells by modulation of epigenetics and signaling pathways.
Epigenetic silencing of PTPRR activates MAPK signaling, promotes metastasis and serves as a biomarker of invasive cervical cancer.
Folate deficiency and aberrant expression of DNA methyltransferase 1 were associated with cervical cancerization.
HDAC1/DNMT3A-Containing Complex Is Associated with Suppression of Oct4 in Cervical Cancer Cells.
Histone deacetylase inhibitor apicidin downregulates DNA methyltransferase 1 expression and induces repressive histone modifications via recruitment of corepressor complex to promoter region in human cervix cancer cells.
Histone deacetylase inhibitors inducing human cervical cancer cell apoptosis by decreasing DNA-methyltransferase 3B.
HPV-16 E6 upregulation of DNMT1 through repression of tumor suppressor p53.
HPV16 activates the promoter of Oct4 gene by sequestering HDAC1 from repressor complex to target it to proteasomal degradation.
Human papillomavirus type 16 E6 suppresses microRNA-23b expression in human cervical cancer cells through DNA methylation of the host gene C9orf3.
Impact of viral and host DNA methylations on HPV16-related cervical cancer pathogenesis.
Limoniastrum guyonianum aqueous gall extract induces apoptosis in human cervical cancer cells involving p16 INK4A re-expression related to UHRF1 and DNMT1 down-regulation.
LINP1 promotes the progression of cervical cancer by scaffolding EZH2, LSD1, and DNMT1 to inhibit the expression of KLF2 and PRSS8.
LncRNATCF7 up-regulates DNMT1 mediated by HPV-18 E6 and regulates biological behavior of cervical cancer cells by inhibiting miR-155.
Methyl Donor Status Influences DNMT Expression and Global DNA Methylation in Cervical Cancer Cells.
MicroRNA-148a-3p inhibits the proliferation of cervical cancer cells by regulating the expression levels of DNMT1 and UTF1.
miR-182 induces cervical cancer cell apoptosis through inhibiting the expression of DNMT3a.
MiR-29a inhibits invasion and metastasis of cervical cancer via modulating methylation of tumor suppressor SOCS1.
MiR-375 Is Epigenetically Downregulated by HPV-16 E6 Mediated DNMT1 Upregulation and Modulates EMT of Cervical Cancer Cells by Suppressing lncRNA MALAT1.
Reprogramming of HeLa cells upon DNMT3L overexpression mimics carcinogenesis.
Retraction: MiR-375 Is Epigenetically Downregulated by HPV-16 E6 Mediated DNMT1 Upregulation and Modulates EMT of Cervical Cancer Cells by Suppressing lncRNA MALAT1.
Sulforaphane Reverses the Expression of Various Tumor Suppressor Genes by Targeting DNMT3B and HDAC1 in Human Cervical Cancer Cells.
SUV39H1-DNMT3A-mediated epigenetic regulation of Tim-3 and galectin-9 in the cervical cancer.
SUV39H1-Mediated DNMT1 is Participated in the Epigenetic Regulation of Smad3 in Cervical Cancer.
The 46359CT polymorphism of DNMT3B is associated with the risk of cervical cancer.
The role of ADCYAP1, adenylate cyclase activating polypeptide 1, as a methylation biomarker for the early detection of cervical cancer.
Trichosanthin inhibits DNA methyltransferase and restores methylation-silenced gene expression in human cervical cancer cells.
[Effect of DNA methyltransferase 1 and methyl-CpG-binding protein 2 abnormal expression on cervical lesions and related interaction].
[Effect of DNA methyltransferase 1 gene silencing on proliferation and apoptosis of HeLa cells]
[Effect of folate in modulating the expression of DNA methyltransferase 1 and methyl-CpG-bingding protein 2 in cervical cancer cell lines].
[Effect of folic acid and DNA methyltransferase 1 on cervical cancer and its precancerous lesion].
Varicocele
Increased de novo DNA Methylation Enzymes in Sperm of Individuals with Varicocele.
Vascular Diseases
Clonal Hematopoiesis of Indeterminate Potential Reshapes Age-Related CVD: JACC Review Topic of the Week.
Virus Diseases
DNA methylation by DNA methyltransferase 1 is critical for effector CD8 T cell expansion.
DNA methyltransferase induced by PBCV-1 virus infection of a Chlorella-like green alga.
Epigenetic changes mediated by microRNA miR29 activate cyclooxygenase 2 and lambda-1 interferon production during viral infection.
Human polyomavirus BKV transcriptionally activates DNA methyltransferase 1 through the pRb/E2F pathway.
IL-32: a host proinflammatory factor against influenza viral replication is upregulated by aberrant epigenetic modifications during influenza A virus infection.
Loss of DNA methylation in zebrafish embryos activates retrotransposons to trigger antiviral signaling.
T Cell Exhaustion: An Epigenetically Imprinted Phenotypic and Functional Makeover.
The DNA methyltranferase Dnmt2 participates in RNA processing during cellular stress.
The Roles of Host 5-Methylcytosine RNA Methyltransferases during Viral Infections.
Up-regulation of microRNA-203 in influenza A virus infection inhibits viral replication by targeting DR1.
von Hippel-Lindau Disease
Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis.
Williams Syndrome
Metastasis-related methyltransferase 1 (Merm1) represses the methyltransferase activity of Dnmt3a and facilitates RNA polymerase I transcriptional elongation.
Wilms Tumor
circ0093740 Promotes Tumor Growth and Metastasis by Sponging miR-136/145 and Upregulating DNMT3A in Wilms Tumor.
Clonal Cytopenia of Undetermined Significance in a Patient with Congenital Wilms' Tumor 1 and Acquired DNMT3A Gene Mutations.
Control of epigenetic states by WT1 via regulation of de novo DNA methyltransferase 3A.
DNMT3A mutations in Chinese childhood acute myeloid leukemia.
Xeroderma Pigmentosum
DNA polymorphism and risk of esophageal squamous cell carcinoma in a population of North Xinjiang, China.
DNA repair gene polymorphisms and risk of second primary neoplasms and mortality in oral cancer patients.