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EC Tree
The taxonomic range for the selected organisms is: Rattus norvegicus The enzyme appears in selected viruses and cellular organisms
Synonyms
dnmt1, dnmt3a, dna methyltransferase, dnmt3b, dna methyltransferase 1, dnmt2, dna mtase, nsun2, dna methylase, dna methyltransferase 3a,
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cytosine 5-methyltransferase
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cytosine DNA methylase
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cytosine DNA methyltransferase
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cytosine-specific DNA methyltransferase
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deoxyribonucleate methylase
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deoxyribonucleate methyltransferase
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deoxyribonucleic (cytosine-5-)-methyltransferase
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deoxyribonucleic acid (cytosine-5-)-methyltransferase
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deoxyribonucleic acid methylase
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deoxyribonucleic acid methyltransferase
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deoxyribonucleic acid modification methylase
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deoxyribonucleic methylase
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DNA 5-cytosine methylase
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DNA cytosine c5 methylase
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DNA cytosine methylase
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DNA methyltransferase
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DNA transmethylase
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DNA-cytosine 5-methylase
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DNA-cytosine methyltransferase
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methylphosphotriester-DNA methyltransferase
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methyltransferase, deoxyribonucleate
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type II DNA methylase
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methyl group transfer
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S-adenosyl-L-methionine:DNA (cytosine-5-)-methyltransferase
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S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
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DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
additional information
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DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
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DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
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DNMT1 is crucial for cell survival
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S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
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S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
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S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
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S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
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S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
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native and heat-denatured DNA from ethionine-treated synchronized Novikoff cells. The native DNA sample is about 3.5 fold better as a methyl acceptor than the heat-denatured sample
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S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
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the enzyme is able to methylate single stranded and double stranded DNA. Previously unmethylated double-stranded DNA from prokaryotes, Micrococcus luteus, as well as from eukaryotes, Ascaris suis, can serve as substrates. The synthetic copolymers (dG-dC)n*(dC-dG)n and (dG,dC)n are also methylated. SV40 DNA is almost not methylated. PM2 DNA is a good substrate even in the supercoiled form. The enzyme methylates 1 in 17 bases in heterologous Micrococcus luteus DNA, but only 1 in 590 in homologous rat liver DNA
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additional information
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methylation of genomic DNA is involved in the basic mechanism of gene inactivation, chromatin organization, X-chromosome inactivation, and genomic imprinting
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additional information
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the enzyme catalyzes the methylation of DNA during replication, in NGF-induced PC12 cell. The enzyme activity is sharply reduced 4 days after induction of differentiation
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DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
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DNMT1 is crucial for cell survival
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additional information
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additional information
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methylation of genomic DNA is involved in the basic mechanism of gene inactivation, chromatin organization, X-chromosome inactivation, and genomic imprinting
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additional information
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the enzyme catalyzes the methylation of DNA during replication, in NGF-induced PC12 cell. The enzyme activity is sharply reduced 4 days after induction of differentiation
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S-adenosyl-L-methionine
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putrescine
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1 mM, 42% inhibition
S-adenosyl-L-homocysteine
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potent competitive inhibitor
spermidine
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1 mM, 59% inhibition
spermine
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1 mM, 97% inhibition
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0.00025
S-adenosyl-L-methionine
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in presence of Micrococcus luteus DNA
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0.00033
S-adenosyl-L-homocysteine
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Uniprot
brenda
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the enzyme is highly expressed in placenta during mid-to late-pregnancy
brenda
the enzyme is regulated at the posttranscriptional level in terminally differentiating Rcho-1 cell
brenda
giant cell
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different levels of global methylation in the adult rat dentate gyrus and CA1 region in comparison with the CA2 and CA3 regions. mRNA levels of DNA methyltransferases exhibit similar regional specificity and are correlated with global DNA methylation levels
brenda
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brenda
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brenda
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brenda
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malfunction
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DNMT1 is crucial for cell survival, as in its absence cells undergo arrest in G1/S, a DNA damage response is triggered, and the cells undergo mitotic catastrophe
physiological function
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DNA methylation may play a dynamic physiological role in the adult brain, possibly, the DNA methylation pattern is undergoing constant remodeling and requires the presence of DNA methyltransferases to allow adaptation at the level of the DNA methylation pattern in response to environmental cues
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DNMT1_RAT
1622
0
182774
Swiss-Prot
Mitochondrion (Reliability: 3 )
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115000
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glycerol gradient centrifugation
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-70°C, the purified enzyme preparation is stable for at least 6 months
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4°C, the purified enzyme preparation is rather unstable
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Sneider, T.W.; Teague, W.M.; Rogachevsky, L.M.
S-Adenosylmethionine: DNA-cytosine 5-methyltransferase from a Novikoff rat hepatoma cell line
Nucleic Acids Res.
2
1685-1700
1975
Rattus norvegicus
brenda
Simon, D.; Grunert, F.; v.Acken, U.; Dring, H.P.; Krger, H.
DNA-methylase from regenerating rat liver: purification and characterisation
Nucleic Acids Res.
5
2153-2167
1978
Rattus norvegicus
brenda
Cox, R.
Polyamines inhibit DNA methylation in vitro
Biochem. Biophys. Res. Commun.
86
594-598
1979
Rattus norvegicus
brenda
Deng, J.; Szyf, M.
Downregulation of DNA (cytosine-5-)methyltransferase is a late event in NGF-induced PC12 cell differentiation
Mol. Brain Res.
71
23-31
1999
Rattus norvegicus
brenda
Kimura, H.; Takeda, T.; Tanaka, S.; Ogawa, T.; Shiota, K.
Expression of rat DNA (cytosine-5) methyltransferase (DNA MTase) in rodent trophoblast giant cells: molecular cloning and characterization of rat DNA MTase
Biochem. Biophys. Res. Commun.
253
495-501
1998
Rattus norvegicus (Q9Z330)
brenda
Brown, S.E.; Weaver, I.C.; Meaney, M.J.; Szyf, M.
Regional-specific global cytosine methylation and DNA methyltransferase expression in the adult rat hippocampus
Neurosci. Lett.
440
49-53
2008
Rattus norvegicus
brenda