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Information on EC 2.1.1.37 - DNA (cytosine-5-)-methyltransferase and Organism(s) Oryza sativa and UniProt Accession Q7Y1I7
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2.1.1.37 DNA (cytosine-5-)-methyltransferaseSpecify your search results
Word Map
- 2.1.1.37
- histone
- methyltransferases
- cpg
-
hypermethylation
-
demethylation
- chromatin
- leukemia
- myeloid
- deacetylase
-
dnmts
- 5-aza-2'-deoxycytidine
- bisulfite
- tumorigenesis
- carcinogenesis
- 5-azacytidine
-
methylation-specific
-
hematopoietic
-
myelodysplastic
-
imprint
-
unmethylated
- 5-methylcytosine
- mtases
- decitabine
- hdacs
- endonuclease
- hematologic
-
cytogenetic
-
epigenome
-
pluripotent
-
restriction-modification
-
methylome
-
trimethylation
-
trichostatin
- blastocyst
-
re-expression
- heterochromatin
- o6-methylguanine
-
centromeric
-
nanog
- p16ink4a
- cdh1
-
flt3-itd
- adomet
-
polycomb
-
methylation-sensitive
-
leukemogenesis
-
rassf1a
-
h3k9me3
- biotechnology
-
line-1
- hpaii
- drug development
- analysis
The taxonomic range for the selected organisms is: Oryza sativa
The enzyme appears in selected viruses and cellular organisms
The enzyme appears in selected viruses and cellular organisms
Reaction Schemes
Synonyms
dnmt1, dnmt3a, dna methyltransferase, dnmt3b, dna methyltransferase 1, dnmt2, dna mtase, nsun2, dna methylase, dna methyltransferase 3a, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
C5-MTase
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-
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cytosine 5-methyltransferase
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-
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cytosine DNA methylase
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-
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cytosine DNA methyltransferase
cytosine-specific DNA methyltransferase
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-
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DCMT
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-
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deoxyribonucleate methylase
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-
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deoxyribonucleate methyltransferase
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-
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deoxyribonucleic (cytosine-5-)-methyltransferase
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-
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deoxyribonucleic acid (cytosine-5-)-methyltransferase
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-
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deoxyribonucleic acid methylase
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deoxyribonucleic acid methyltransferase
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-
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deoxyribonucleic acid modification methylase
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-
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deoxyribonucleic methylase
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DNA 5-cytosine methylase
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-
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DNA cytosine c5 methylase
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-
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DNA cytosine methylase
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-
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DNA methylase
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-
-
-
DNA methyltransferase
DNA transmethylase
-
-
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DNA-cytosine 5-methylase
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-
-
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DNA-cytosine methyltransferase
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-
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EcoRI methylase
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-
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methylphosphotriester-DNA methyltransferase
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-
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methyltransferase, deoxyribonucleate
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-
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type II DNA methylase
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-
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additional information
cytosine DNA methyltransferase
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-
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DNA methyltransferase
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-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
methyl group transfer
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-
-
-
SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:DNA (cytosine-5-)-methyltransferase
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CAS REGISTRY NUMBER
COMMENTARY
9037-42-7
-
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
-
-
-
?
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
substrate is chloroplast DNA, no activity with mitochondrial DNA. Substrate sources are etiolated leaf-rice DNA, dry embryo-rice DNA, 10-day-old shoot-rice DNA, mature leaf-rice DNA. The purified protein prefers hemi-methylated DNA substrate, substrate specificity, the enzyme is specific for d(C-G) sites, overview
-
-
?
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
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-
-
?
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
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-
-
?
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
substrate is chloroplast DNA, no activity with mitochondrial DNA. Substrate sources are etiolated leaf-rice DNA, dry embryo-rice DNA, 10-day-old shoot-rice DNA, mature leaf-rice DNA. The purified protein prefers hemi-methylated DNA substrate, substrate specificity, the enzyme is specific for d(C-G) sites, overview
-
-
?
S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
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-
-
?
S-adenosyl-L-methionine + DNA
S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
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native plant DNA or hemimethylated poly(dI-MedC)*poly(dI-dC)
-
?
additional information
?
-
MTase performs two basic kinds of methylation activities: maintenance methylation, i.e. addition of methyl groups to cytosines of a hemimethylated DNA after DNA replication, and de novo methylation, i.e. methylation of cytosines in nonmethylated DNA
-
-
?
additional information
?
-
MTase performs two basic kinds of methylation activities: maintenance methylation, i.e. addition of methyl groups to cytosines of a hemimethylated DNA after DNA replication, and de novo methylation, i.e. methylation of cytosines in nonmethylated DNA
-
-
?
additional information
?
-
Q10C15
MTase performs two basic kinds of methylation activities: maintenance methylation, i.e. addition of methyl groups to cytosines of a hemimethylated DNA after DNA replication, and de novo methylation, i.e. methylation of cytosines in nonmethylated DNA
-
-
?
additional information
?
-
MTase performs two basic kinds of methylation activities: maintenance methylation, i.e. addition of methyl groups to cytosines of a hemimethylated DNA after DNA replication, and de novo methylation, i.e. methylation of cytosines in nonmethylated DNA
-
-
?
additional information
?
-
Q8H854
MTase performs two basic kinds of methylation activities: maintenance methylation, i.e. addition of methyl groups to cytosines of a hemimethylated DNA after DNA replication, and de novo methylation, i.e. methylation of cytosines in nonmethylated DNA
-
-
?
additional information
?
-
MTase performs two basic kinds of methylation activities: maintenance methylation, i.e. addition of methyl groups to cytosines of a hemimethylated DNA after DNA replication, and de novo methylation, i.e. methylation of cytosines in nonmethylated DNA
-
-
?
additional information
?
-
-
MTase performs two basic kinds of methylation activities: maintenance methylation, i.e. addition of methyl groups to cytosines of a hemimethylated DNA after DNA replication, and de novo methylation, i.e. methylation of cytosines in nonmethylated DNA
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
-
-
-
?
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
-
-
-
?
DNA + S-adenosyl-L-methionine
DNA containing 5-methylcytosine + S-adenosyl-L-homocysteine
-
-
-
?
additional information
?
-
MTase performs two basic kinds of methylation activities: maintenance methylation, i.e. addition of methyl groups to cytosines of a hemimethylated DNA after DNA replication, and de novo methylation, i.e. methylation of cytosines in nonmethylated DNA
-
-
?
additional information
?
-
MTase performs two basic kinds of methylation activities: maintenance methylation, i.e. addition of methyl groups to cytosines of a hemimethylated DNA after DNA replication, and de novo methylation, i.e. methylation of cytosines in nonmethylated DNA
-
-
?
additional information
?
-
Q10C15
MTase performs two basic kinds of methylation activities: maintenance methylation, i.e. addition of methyl groups to cytosines of a hemimethylated DNA after DNA replication, and de novo methylation, i.e. methylation of cytosines in nonmethylated DNA
-
-
?
additional information
?
-
MTase performs two basic kinds of methylation activities: maintenance methylation, i.e. addition of methyl groups to cytosines of a hemimethylated DNA after DNA replication, and de novo methylation, i.e. methylation of cytosines in nonmethylated DNA
-
-
?
additional information
?
-
Q8H854
MTase performs two basic kinds of methylation activities: maintenance methylation, i.e. addition of methyl groups to cytosines of a hemimethylated DNA after DNA replication, and de novo methylation, i.e. methylation of cytosines in nonmethylated DNA
-
-
?
additional information
?
-
MTase performs two basic kinds of methylation activities: maintenance methylation, i.e. addition of methyl groups to cytosines of a hemimethylated DNA after DNA replication, and de novo methylation, i.e. methylation of cytosines in nonmethylated DNA
-
-
?
additional information
?
-
-
MTase performs two basic kinds of methylation activities: maintenance methylation, i.e. addition of methyl groups to cytosines of a hemimethylated DNA after DNA replication, and de novo methylation, i.e. methylation of cytosines in nonmethylated DNA
-
-
?
COFACTOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
inhibitory effects by methyl donor analogs, base analogs, cations, and cationic amines on rice DNA MTase
-
additional information
inhibitory effects by methyl donor analogs, base analogs, cations, and cationic amines on rice DNA MTase
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additional information
-
inhibitory effects by methyl donor analogs, base analogs, cations, and cationic amines on rice DNA MTase
-
additional information
inhibitory effects by methyl donor analogs, base analogs, cations, and cationic amines on rice DNA MTase
-
additional information
inhibitory effects by methyl donor analogs, base analogs, cations, and cationic amines on rice DNA MTase
-
additional information
-
inhibitory effects by methyl donor analogs, base analogs, cations, and cationic amines on rice DNA MTase
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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
additional information
additional information
-
Km-value for poly(dI-MedC)*poly(dI-dC): 0.017 mg/ml
-
SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
0.0013
purified enzyme with substrate hemi-methylated DNA substrate poly(dI-mdC)poly(dI-dC)
0.0013
purified enzyme with substrate hemi-methylated DNA substrate poly(dI-mdC)poly(dI-dC)
pH OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
pH RANGE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
TEMPERATURE OPTIMUM
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
only the OsMET1-1 mRNAis slightly accumulated in young leaves, in which virtually no OsMET1-2 transcripts is detectable
DNA MTase activity is remarkably increased during imbibing dry seeds
DNA MTase activity is remarkably increased during imbibing dry seeds
additional information
additional information
microarray-based gene expression profile of all 10 MTases during 22 stages and tissues that include 14 stages of reproductive development and five vegetative tissues together with three stresses, cold, salt and dehydration stress, revealing specific windows of MTase activity during panicle and seed development, overview
additional information
microarray-based gene expression profile of all 10 MTases during 22 stages and tissues that include 14 stages of reproductive development and five vegetative tissues together with three stresses, cold, salt and dehydration stress, revealing specific windows of MTase activity during panicle and seed development, overview
additional information
Q10C15
microarray-based gene expression profile of all 10 MTases during 22 stages and tissues that include 14 stages of reproductive development and five vegetative tissues together with three stresses, cold, salt and dehydration stress, revealing specific windows of MTase activity during panicle and seed development, overview
additional information
microarray-based gene expression profile of all 10 MTases during 22 stages and tissues that include 14 stages of reproductive development and five vegetative tissues together with three stresses, cold, salt and dehydration stress, revealing specific windows of MTase activity during panicle and seed development, overview
additional information
Q8H854
microarray-based gene expression profile of all 10 MTases during 22 stages and tissues that include 14 stages of reproductive development and five vegetative tissues together with three stresses, cold, salt and dehydration stress, revealing specific windows of MTase activity during panicle and seed development, overview
additional information
microarray-based gene expression profile of all 10 MTases during 22 stages and tissues that include 14 stages of reproductive development and five vegetative tissues together with three stresses, cold, salt and dehydration stress, revealing specific windows of MTase activity during panicle and seed development, overview
additional information
-
microarray-based gene expression profile of all 10 MTases during 22 stages and tissues that include 14 stages of reproductive development and five vegetative tissues together with three stresses, cold, salt and dehydration stress, revealing specific windows of MTase activity during panicle and seed development, overview
additional information
only the OsMET1-1 mRNAis slightly accumulated in young leaves, in which virtually no OsMET1-2 transcripts is detectable
additional information
only the OsMET1-1 mRNAis slightly accumulated in young leaves, in which virtually no OsMET1-2 transcripts is detectable
additional information
-
only the OsMET1-1 mRNAis slightly accumulated in young leaves, in which virtually no OsMET1-2 transcripts is detectable
LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY
GeneOntology No.
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
TEMPERATURE STABILITY
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
STORAGE STABILITY
ORGANISM
UNIPROT
LITERATURE
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
native enzyme from nuclear extracts from shoots of 10-day-old rice seedlings, 800fold by anion exchange and heparin affinity chromatography, and gel filtration
native enzyme from nuclear extracts from shoots of 10-day-old rice seedlings, 800fold by anion exchange and heparin affinity chromatography, and gel filtration
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
gene MET1-1, DNA and amino acid sequence determination and analysis
gene MET1-2, DNA and amino acid sequence determination and analysis
gene MET1B or MET1-2, phylogenetic analysis, microarray-based gene expression profile of all 10 MTases during 22 stages and tissues that include 14 stages of reproductive development and five vegetative tissues together with three stresses, cold, salt and dehydration stress, revealing specific windows of MTase activity during panicle and seed development, overview
gene OsCMT1, phylogenetic analysis, microarray-based gene expression profile of all 10 MTases during 22 stages and tissues that include 14 stages of reproductive development and five vegetative tissues together with three stresses, cold, salt and dehydration stress, revealing specific windows of MTase activity during panicle and seed development, overview
gene Zmt3, phylogenetic analysis, microarray-based gene expression profile of all 10 MTases during 22 stages and tissues that include 14 stages of reproductive development and five vegetative tissues together with three stresses, cold, salt and dehydration stress, revealing specific windows of MTase activity during panicle and seed development, overview
phylogenetic analysis, microarray-based gene expression profile of all 10 MTases during 22 stages and tissues that include 14 stages of reproductive development and five vegetative tissues together with three stresses, cold, salt and dehydration stress, revealing specific windows of MTase activity during panicle and seed development, overview
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Giordano, M.; Mattachini, M.E.; Cella, R.; Pedrali-Noy, G.
Purification and properties of a novel DNA methyltransferase from cultured rice cells
Biochem. Biophys. Res. Commun.
177
711-719
1991
Oryza sativa
Sharma, R.; Mohan Singh, R.; Malik, G.; Deveshwar, P.; Tyagi, A.; Kapoor, S.; Kapoor, M.
Rice cytosine DNA methyltransferases - gene expression profiling during reproductive development and abiotic stress
FEBS J.
276
6301-6311
2009
Oryza sativa (B1Q3J6), Oryza sativa (B9FJ44), Oryza sativa (Q10C15), Oryza sativa (Q10SU5), Oryza sativa (Q8H854), Oryza sativa (Q8SBB4), Oryza sativa
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