Reference on EC 2.1.1.366 - [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Hachiya, R.; Shiihashi, T.; Shirakawa, I.; Iwasaki, Y.; Matsumura, Y.; Oishi, Y.; Nakayama, Y.; Miyamoto, Y.; Manabe, I.; Ochi, K.; Tanaka, M.; Goda, N.; Sakai, J.; Suganami, T.; Ogawa, Y.
The H3K9 methyltransferase Setdb1 regulates TLR4-mediated inflammatory responses in macrophages
Sci. Rep.
6
28845
2016
Mus musculus (O88974)
Wang, H.; An, W.; Cao, R.; Xia, L.; Erdjument-Bromage, H.; Chatton, B.; Tempst, P.; Roeder, R.G.; Zhang, L.
mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression
Mol. Cell
12
475-487
2003
Homo sapiens (Q15047)
Yang, L.; Xia, L.; Wu, D.Y.; Wang, H.; Chansky, H.A.; Schubach, W.H.; Hickstein, D.D.; Zhang, Y.
Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor
Oncogene
21
148-152
2002
Mus musculus (O88974)
Price, A.J.; Manjegowda, M.C.; Kain, J.; Anandh, S.; Bochkis, I.M.
Hdac3, Setdb1, and Kap1 mark H3K9me3/H3K14ac bivalent regions in young and aged liver
Aging Cell
19
e13092
2020
Mus musculus (O88974)
Tachibana, K.; Gotoh, E.; Kawamata, N.; Ishimoto, K.; Uchihara, Y.; Iwanari, H.; Sugiyama, A.; Kawamura, T.; Mochizuki, Y.; Tanaka, T.; Sakai, J.; Hamakubo, T.; Kodama, T.; Doi, T.
Analysis of the subcellular localization of the human histone methyltransferase SETDB1
Biochem. Biophys. Res. Commun.
465
725-731
2015
Homo sapiens (Q15047)
Yahiro, K.; Higashihori, N.; Moriyama, K.
Histone methyltransferase Setdb1 is indispensable for Meckels cartilage development
Biochem. Biophys. Res. Commun.
482
883-888
2017
Mus musculus
Basavapathruni, A.; Gureasko, J.; Porter Scott, M.; Hermans, W.; Godbole, A.; Leland, P.A.; Boriack-Sjodin, P.A.; Wigle, T.J.; Copeland, R.A.; Riera, T.V.
Characterization of the enzymatic activity of SETDB1 and its 1 1 complex with ATF7IP
Biochemistry
55
1645-1651
2016
Homo sapiens (Q15047)
Liu, T.; Chen, X.; Li, T.; Li, X.; Lyu, Y.; Fan, X.; Zhang, P.; Zeng, W.
Histone methyltransferase SETDB1 maintains survival of mouse spermatogonial stem/progenitor cells via PTEN/AKT/FOXO1 pathway
Biochim. Biophys. Acta
1860
1094-1102
2017
Mus musculus (O88974)
Cao, N.; Yu, Y.; Zhu, H.; Chen, M.; Chen, P.; Zhuo, M.; Mao, Y.; Li, L.; Zhao, Q.; Wu, M.; Ye, M.
SETDB1 promotes the progression of colorectal cancer via epigenetically silencing p21 expression
Cell Death Dis.
11
351
2020
Homo sapiens (Q15047)
Fatima, A.; Irmak, D.; Noormohammadi, A.; Rinschen, M.M.; Das, A.; Leidecker, O.; Schindler, C.; Sanchez-Gaya, V.; Wagle, P.; Pokrzywa, W.; Hoppe, T.; Rada-Iglesias, A.; Vilchez, D.
The ubiquitin-conjugating enzyme UBE2K determines neurogenic potential through histone H3 in human embryonic stem cells
Commun. Biol.
3
262
2020
Homo sapiens (Q15047)
Hirota, T.; Blakeley, P.; Sangrithi, M.N.; Mahadevaiah, S.K.; Encheva, V.; Snijders, A.P.; ElInati, E.; Ojarikre, O.A.; de Rooij, D.G.; Niakan, K.K.; Turner, J.M.A.
SETDB1 links the meiotic DNA damage response to sex chromosome silencing in mice
Dev. Cell
47
645-659.e6
2018
Mus musculus (O88974)
Mochizuki, K.; Tando, Y.; Sekinaka, T.; Otsuka, K.; Hayashi, Y.; Kobayashi, H.; Kamio, A.; Ito-Matsuoka, Y.; Takehara, A.; Kono, T.; Osumi, N.; Matsui, Y.
SETDB1 is essential for mouse primordial germ cell fate determination by ensuring BMP signaling
Development
145
dev164160
2018
Mus musculus (O88974)
Singh, S.K.; Bahal, R.; Rasmussen, T.P.
Evidence that miR-152-3p is a positive regulator of SETDB1-mediated H3K9 histone methylation and serves as a toggle between histone and DNA methylation
Exp. Cell Res.
395
112216
2020
Homo sapiens (Q15047)
Ogawa, S.; Fukuda, A.; Matsumoto, Y.; Hanyu, Y.; Sono, M.; Fukunaga, Y.; Masuda, T.; Araki, O.; Nagao, M.; Yoshikawa, T.; Goto, N.; Hiramatsu, Y.; Tsuda, M.; Maruno, T.; Nakanishi, Y.; Hussein, M.S.; Tsuruyama, T.; Takaori, K.; Uemoto, S.; Seno, H.
SETDB1 inhibits p53-mediated apoptosis and is required for formation of pancreatic ductal adenocarcinomas in mice
Gastroenterology
159
682-696.e13
2020
Homo sapiens (Q15047), Mus musculus (O88974)
Cruz-Tapias, P.; Robin, P.; Pontis, J.; Del Maestro, L.; Ait-Si-Ali, S.
The H3K9 methylation writer SETDB1 and its reader MPP8 cooperate to silence satellite DNA repeats in mouse embryonic stem cells
Genes (Basel)
10
750
2019
Mus musculus
Orouji, E.; Federico, A.; Larribere, L.; Novak, D.; Lipka, D.B.; Assenov, Y.; Sachindra, S.; Hueser, L.; Granados, K.; Gebhardt, C.; Plass, C.; Umansky, V.; Utikal, J.
Histone methyltransferase SETDB1 contributes to melanoma tumorigenesis and serves as a new potential therapeutic target
Int. J. Cancer
145
3462-3477
2019
Homo sapiens (Q15047), Mus musculus (O88974)
Lee, S.; Lee, C.; Hwang, C.Y.; Kim, D.; Han, Y.; Hong, S.N.; Kim, S.H.; Cho, K.H.
Network inference analysis identifies SETDB1 as a key regulator for reverting colorectal cancer cells into differentiated normal-like cells
Mol. Cancer Res.
18
118-129
2020
Homo sapiens (Q15047)
Fritsch, L.; Robin, P.; Mathieu, J.R.; Souidi, M.; Hinaux, H.; Rougeulle, C.; Harel-Bellan, A.; Ameyar-Zazoua, M.; Ait-Si-Ali, S.
A subset of the histone H3 lysine 9 methyltransferases Suv39h1, G9a, GLP, and SETDB1 participate in a multimeric complex
Mol. Cell
37
46-56
2010
Homo sapiens (Q15047)
Kato, M.; Takemoto, K.; Shinkai, Y.
A somatic role for the histone methyltransferase Setdb1 in endogenous retrovirus silencing
Nat. Commun.
9
1683
2018
Mus musculus (O88974)
Jiang, Y.; Loh, Y.E.; Rajarajan, P.; Hirayama, T.; Liao, W.; Kassim, B.S.; Javidfar, B.; Hartley, B.J.; Kleofas, L.; Park, R.B.; Labonte, B.; Ho, S.M.; Chandrasekaran, S.; Do, C.; Ramirez, B.R.; Peter, C.J.; C W, J.T.; Safaie, B.M.; Morishita, H.; Roussos, P.; Nestler, E.J.; Schaefer, A.; Tycko, B.; Brennand, K.
The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain
Nat. Genet.
49
1239-1250
2017
Mus musculus (O88974)
Zeng, T.; Han, L.; Pierce, N.; Pfeifer, G.; Szabo, P.
EHMT2 and SETDB1 protect the maternal pronucleus from 5mC oxidation
Proc. Natl. Acad. Sci. USA
166
10834-10841
2019
Mus musculus (O88974)
Koryakov, D.E.
Diversity and functional specialization of H3K9-specific histone methyltransferases
Bioessays
46
e2300163
2024
Caenorhabditis elegans (G5EEU2)
Li, J.; Zheng, S.; Dong, Y.; Xu, H.; Zhu, Y.; Weng, J.; Sun, D.; Wang, S.; Xiao, L.; Jiang, Y.
Histone methyltransferase SETDB1 regulates the development of cortical Htr3a-positive interneurons and mood behaviors
Biol. Psychiatry
93
279-290
2023
Mus musculus (O88974)
Prashanth, S.; Radha Maniswami, R.; Rajajeyabalachandran, G.; Jegatheesan, S.K.
SETDB1, an H3K9-specific methyltransferase An attractive epigenetic target to combat cancer
Drug Discov. Today
29
103982
2024
Homo sapiens (Q15047)
de Groot, A.P.; Nguyen, H.; Pouw, J.S.; Weersing, E.; Dethmers-Ausema, A.; de Haan, G.
CBX7 inhibitors affect H3K9 methyltransferase-regulated gene repression in leukemic cells
Exp. Hematol.
142
104691
2024
Homo sapiens (Q15047)
Hu, L.; Cheng, Z.; Wu, L.; Luo, L.; Pan, P.; Li, S.; Jia, Q.; Yang, N.; Xu, B.
Histone methyltransferase SETDB1 promotes osteogenic differentiation in osteoporosis by activating OTX2-mediated BMP-Smad and Wnt/beta-catenin pathways
Hum. Cell
36
1373-1388
2023
Mus musculus (O88974)
Rapone, R.; Del Maestro, L.; Bouyioukos, C.; Albini, S.; Cruz-Tapias, P.; Joliot, V.; Cosson, B.; Ait-Si-Ali, S.
The cytoplasmic fraction of the histone lysine methyltransferase Setdb1 is essential for embryonic stem cells
iScience
26
107386
2023
Mus musculus (O88974)
Markouli, M.; Strepkos, D.; Piperi, C.
Structure, activity and function of the SETDB1 protein methyltransferase
Life
11
817
2021
Homo sapiens (Q15047)
Chandrasekaran, T.T.; Choudalakis, M.; Brhm, A.; Weirich, S.; Kouroukli, A.G.; Ammerpohl, O.; Rathert, P.; Bashtrykov, P.; Jeltsch, A.
SETDB1 activity is globally directed by H3K14 acetylation via its triple tudor domain
Nucleic Acids Res.
52
13690-13705
2024
Homo sapiens (Q15047)
Ueshima, S.; Fang, J.
Histone H3K9 methyltransferase SETDB1 augments invadopodia formation to promote tumor metastasis
Oncogene
41
3370-3380
2022
Mus musculus (O88974)
Kazerani, M.; Cernilogar, F.; Pasquarella, A.; Hinterberger, M.; Nuber, A; Klein, L.; Schotta, G.
Histone methyltransferase SETDB1 safeguards mouse fetal hematopoiesis by suppressing activation of cryptic enhancers
Proc. Natl. Acad. Sci. USA
121
e2409656121
2024
Mus musculus (O88974)
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