Information on EC 2.1.1.365 - MMP 1-O-methyltransferase

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EC Tree
     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.365 MMP 1-O-methyltransferase
IUBMB Comments
Requires Mg2+. The enzyme, characterized from the bacterium Mycolicibacterium hassiacum, participates in the biosynthesis of 3-O-methylmannose polysaccharides (MMP), which are intracellular polymethylated polysaccharides implicated in the modulation of fatty acid metabolism in nontuberculous mycobacteria. The methylation catalysed by this enzyme was shown to block the reducing end of 3,3'-di-O-methyl-alpha-mannobiose, a probable early precursor of the 3-O-methylmannose polysaccharides.
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The expected taxonomic range for this enzyme is: Mycolicibacterium hassiacum
Reaction Schemes
+
3,3'-di-O-methyl-4alpha-mannobiose
=
+
1,3,3'-tri-O-methyl-4alpha-mannobiose
Synonyms
3-O-methylmannose polysaccharide 1-O-methyltransferase, MET1, S-adenosyl-L-methionine-dependent sugar 1-O-methyltransferase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
S-adenosyl-L-methionine + 3,3'-di-O-methyl-4alpha-mannobiose = S-adenosyl-L-homocysteine + 1,3,3'-tri-O-methyl-4alpha-mannobiose
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