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Disease on EC 2.1.1.361 - [histone H4]-lysine20 N-methyltransferase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
Adenocarcinoma
SETD8 promotes stemness characteristics and is a potential prognostic biomarker of gastric adenocarcinoma.
Anemia
The histone methyltransferase Setd8 alters the chromatin landscape and regulates the expression of key transcription factors during erythroid differentiation.
The Methyltransferase Setd8 Is Essential for Erythroblast Survival and Maturation.
Breast Neoplasms
Genetic Variability in the microRNA Binding Sites of BMPR1B, TGFBR1, IQGAP1, KRAS, SETD8 and RYR3 and Risk of Breast Cancer in Colombian Women.
Loss of DNA Methylation and Histone H4 Lysine 20 Trimethylation in Human Breast Cancer Cells is Associated with Aberrant Expression of DNA Methyltransferase 1, Suv4-20h2 Histone Methyltransferase and Methyl-Binding Proteins.
Monomethyltransferase SETD8 regulates breast cancer metabolism via stabilizing hypoxia-inducible factor 1?.
N-peptide of vMIP-? reverses paclitaxel-resistance by regulating miRNA-335 in breast cancer.
Carcinogenesis
Combined functional genomic and chemical screens identify SETD8 as a therapeutic target in MYC-driven medulloblastoma.
Discovery of a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8.
Downregulation of SETD8 by miR-382 is involved in glioma progression.
Epigenetic Modifier SETD8 as a Therapeutic Target for High-Grade Serous Ovarian Cancer.
Histone H3 lysine 9 and H4 lysine 20 trimethylation and the expression of Suv4-20h2 and Suv-39h1 histone methyltransferases in hepatocarcinogenesis induced by methyl deficiency in rats.
Histone lysine methyltransferase SETD8 promotes carcinogenesis by deregulating PCNA expression.
Histone methyltransferase KMT5A gene modulates oncogenesis and lipid metabolism of papillary thyroid cancer in vitro.
miR-382 inhibits tumor progression by targeting SETD8 in non-small cell lung cancer.
SETD8 is a prognostic biomarker that contributes to stem-like cell properties in non-small cell lung cancer.
SETD8 promotes stemness characteristics and is a potential prognostic biomarker of gastric adenocarcinoma.
The histone lysine methyltransferase SETD8 regulates angiogenesis through HES-1 in human umbilical vein endothelial cells.
[The biological functions of lysine methyltransferase PR-SET7].
Carcinoma
KMT5A promotes metastasis of clear cell renal cell carcinoma through reducing cadherin-1 expression.
Carcinoma, Non-Small-Cell Lung
miR-382 inhibits tumor progression by targeting SETD8 in non-small cell lung cancer.
SETD8 is a prognostic biomarker that contributes to stem-like cell properties in non-small cell lung cancer.
Carcinoma, Renal Cell
KMT5A promotes metastasis of clear cell renal cell carcinoma through reducing cadherin-1 expression.
Chagas Disease
Antiproliferative effects of delta 24(25) sterol methyl transferase inhibitors on Trypanosoma (Schizotrypanum) cruzi: in vitro and in vivo studies.
Colitis
SETD8 involved in the progression of inflammatory bowel disease via epigenetically regulating p62 expression.
COVID-19
Comparative evaluation of 19 reverse transcription loop-mediated isothermal amplification assays for detection of SARS-CoV-2.
Diabetic Nephropathies
ets1 associates with KMT5A to participate in high glucose-mediated EndMT via upregulation of PFN2 expression in diabetic nephropathy.
Friedreich Ataxia
Inhibition of the SUV4-20 H1 histone methyltransferase increases frataxin expression in Friedreich's ataxia patient cells.
Glioma
Downregulation of SETD8 by miR-382 is involved in glioma progression.
Epigenetic therapy with inhibitors of histone methylation suppresses DNA damage signaling and increases glioma cell radiosensitivity.
Infections
Suv4-20h2 protects against influenza virus infection by suppression of chromatin loop formation.
Infertility
PR-Set7 deficiency limits uterine epithelial population growth hampering postnatal gland formation in mice.
Inflammatory Bowel Diseases
SETD8 involved in the progression of inflammatory bowel disease via epigenetically regulating p62 expression.
Influenza, Human
Suv4-20h2 protects against influenza virus infection by suppression of chromatin loop formation.
Leukemia
Identification of PR-SET7 and EZH2 selective inhibitors inducing cell death in human leukemia U937 cells.
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Suv4-20h1 promotes G1 to S phase transition by downregulating p21
Lung Neoplasms
miR-382 inhibits tumor progression by targeting SETD8 in non-small cell lung cancer.
PR-Set7 is Degraded in a Conditional Cul4A Transgenic Mouse Model of Lung Cancer.
SETD8 is a prognostic biomarker that contributes to stem-like cell properties in non-small cell lung cancer.
Lymphatic Metastasis
Histone methyltransferase KMT5A gene modulates oncogenesis and lipid metabolism of papillary thyroid cancer in vitro.
SETD8 is a prognostic biomarker that contributes to stem-like cell properties in non-small cell lung cancer.
SETD8 promotes stemness characteristics and is a potential prognostic biomarker of gastric adenocarcinoma.
Medulloblastoma
Combined functional genomic and chemical screens identify SETD8 as a therapeutic target in MYC-driven medulloblastoma.
Multiple Myeloma
Targeting the methyltransferase SETD8 impairs tumor cell survival and overcomes drug resistance independently of p53 status in multiple myeloma.
Neoplasm Metastasis
Histone methyltransferase KMT5A gene modulates oncogenesis and lipid metabolism of papillary thyroid cancer in vitro.
KMT5A promotes metastasis of clear cell renal cell carcinoma through reducing cadherin-1 expression.
MicroRNA-384 downregulates SETD8 expression to suppress cell growth and metastasis in osteosarcoma cells.
miR-382 inhibits tumor progression by targeting SETD8 in non-small cell lung cancer.
SETD8 is a prognostic biomarker that contributes to stem-like cell properties in non-small cell lung cancer.
SETD8 promotes stemness characteristics and is a potential prognostic biomarker of gastric adenocarcinoma.
[The biological functions of lysine methyltransferase PR-SET7].
Neoplasms
Combined functional genomic and chemical screens identify SETD8 as a therapeutic target in MYC-driven medulloblastoma.
Downregulation of SETD8 by miR-382 is involved in glioma progression.
Functional polymorphism at the miR-502-binding site in the 3' untranslated region of the SETD8 gene increased the risk of prostate cancer in a sample of Iranian population.
Gene Expression Analysis of Two Epithelial-mesenchymal Transition-related Genes: Long Noncoding RNA-ATB and SETD8 in Gastric Cancer Tissues.
Histone H3 lysine 9 and H4 lysine 20 trimethylation and the expression of Suv4-20h2 and Suv-39h1 histone methyltransferases in hepatocarcinogenesis induced by methyl deficiency in rats.
Histone lysine methyltransferase SETD8 promotes carcinogenesis by deregulating PCNA expression.
KMT5A promotes metastasis of clear cell renal cell carcinoma through reducing cadherin-1 expression.
Loss of miR-217 promotes osteosarcoma cell proliferation through targeting SETD8.
Meiotic gatekeeper STRA8 regulates cell cycle by interacting with SETD8 during spermatogenesis.
Methyl deficiency, alterations in global histone modifications, and carcinogenesis.
MicroRNA-384 downregulates SETD8 expression to suppress cell growth and metastasis in osteosarcoma cells.
miR-382 inhibits tumor progression by targeting SETD8 in non-small cell lung cancer.
MiR-502/SET8 regulatory circuit in pathobiology of breast cancer.
Monomethyltransferase SETD8 regulates breast cancer metabolism via stabilizing hypoxia-inducible factor 1?.
mRNA expression profiling of histone modifying enzymes in pediatric acute monoblastic leukemia.
PR-Set7 is Degraded in a Conditional Cul4A Transgenic Mouse Model of Lung Cancer.
SETD8 is a prognostic biomarker that contributes to stem-like cell properties in non-small cell lung cancer.
SETD8 potentiates constitutive ERK1/2 activation via epigenetically silencing DUSP10 expression in pancreatic cancer.
SETD8 promotes stemness characteristics and is a potential prognostic biomarker of gastric adenocarcinoma.
Structure-activity relationship studies of SETD8 inhibitors.
Structures of Nahuoic Acids B-E Produced in Culture by a Streptomyces sp. Isolated from a Marine Sediment and Evidence for the Inhibition of the Histone Methyl Transferase SETD8 in Human Cancer Cells by Nahuoic Acid A.
Targeting the methyltransferase SETD8 impairs tumor cell survival and overcomes drug resistance independently of p53 status in multiple myeloma.
The histone lysine methyltransferase SETD8 regulates angiogenesis through HES-1 in human umbilical vein endothelial cells.
The PR-Set7 binding domain of Riz1 is required for the H4K20me1-H3K9me1 trans-tail 'histone code' and Riz1 tumor suppressor function.
Turning a Substrate Peptide into a Potent Inhibitor for the Histone Methyltransferase SETD8.
[The biological functions of lysine methyltransferase PR-SET7].
Neuroblastoma
Epigenetic siRNA and Chemical Screens Identify SETD8 Inhibition as a Therapeutic Strategy for p53 Activation in High-Risk Neuroblastoma.
Osteosarcoma
Loss of miR-217 promotes osteosarcoma cell proliferation through targeting SETD8.
MicroRNA-127-3p inhibits proliferation and invasion by targeting SETD8 in human osteosarcoma cells.
MicroRNA-384 downregulates SETD8 expression to suppress cell growth and metastasis in osteosarcoma cells.
Structures of Nahuoic Acids B-E Produced in Culture by a Streptomyces sp. Isolated from a Marine Sediment and Evidence for the Inhibition of the Histone Methyl Transferase SETD8 in Human Cancer Cells by Nahuoic Acid A.
Ovarian Neoplasms
Epigenetic Modifier SETD8 as a Therapeutic Target for High-Grade Serous Ovarian Cancer.
Pancreatic Neoplasms
SETD8 potentiates constitutive ERK1/2 activation via epigenetically silencing DUSP10 expression in pancreatic cancer.
Pituitary Neoplasms
LncRNA LINC00473 is involved in the progression of invasive pituitary adenoma by upregulating KMT5A via ceRNA-mediated miR-502-3p evasion.
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Association of functional polymorphism at the miR-502-binding site in the 3' untranslated region of the SETD8 gene with risk of childhood acute lymphoblastic leukemia, a preliminary report.
Prostatic Neoplasms
Functional polymorphism at the miR-502-binding site in the 3' untranslated region of the SETD8 gene increased the risk of prostate cancer in a sample of Iranian population.
Histone H4 Lys 20 methyltransferase SET8 promotes androgen receptor-mediated transcription activation in prostate cancer.
Retinoblastoma
The SETD8/PR-Set7 Methyltransferase Functions as a Barrier to Prevent Senescence-Associated Metabolic Remodeling.
Stomach Neoplasms
Gene Expression Analysis of Two Epithelial-mesenchymal Transition-related Genes: Long Noncoding RNA-ATB and SETD8 in Gastric Cancer Tissues.
Thyroid Cancer, Papillary
Histone methyltransferase KMT5A gene modulates oncogenesis and lipid metabolism of papillary thyroid cancer in vitro.
Virus Diseases
Suv4-20h2 protects against influenza virus infection by suppression of chromatin loop formation.
[histone h4]-lysine20 n-methyltransferase deficiency
PR-Set7 deficiency limits uterine epithelial population growth hampering postnatal gland formation in mice.