Information on EC 2.1.1.360 - [histone H3]-lysine79 N-trimethyltransferase

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EC Tree
IUBMB Comments
The enzyme successively methylates the L-lysine79 residue of histone H3 (H3K79), ultimately generating a trimethylated form. These modifications influence the binding of chromatin-associated proteins. This is the only known methylation event of a lysine residue within the core region of a histone, as all other such modifications occur at the tail.
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Word Map
  • 2.1.1.360
  • psoriatic
  • arthritis
  • autocalibrating
  • k-space
  • acceleration
  • artifact
  • coil
  • noise
  • phantom
  • signal-to-noise
  • enthesitis
  • undersampled
  • rheumatology
  • aliasing
  • echo
  • dermatologists
  • dactylitis
  • interpolation
  • rheumatologist
  • omeract
  • stockholm
  • g-factors
  • breath-holding
  • self-calibrated
  • tesla
  • cartesian
  • eular
  • trainees
  • in-plane
  • contrast-to-noise
  • echo-planar
  • spirit
  • spondyloarthritis
  • nyquist
  • breakout
  • single-shot
  • free-breathing
  • prologue
  • phase-encoding
  • interleaved
  • plenary
  • precession
  • multi-slice
  • medicine
  • 32-channel
The enzyme appears in viruses and cellular organisms
Synonyms
Dot1, Dot1-like protein, DOT1B, DOT1L, grappa, H3K79 methylase, H3K79 methyltransferase, histone 3 lysine 79 methyltransferase (H3K79me1/me2/me3), histone H3 Lys79 methyltransferase, histone H3 lysine-79 methyltransferase, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine79 = 3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine79
show the reaction diagram
overall reaction
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S-adenosyl-L-methionine + a [histone H3]-L-lysine79 = S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine79
show the reaction diagram
(1a)
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S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine79 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine79
show the reaction diagram
(1c)
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S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine79 = S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine79
show the reaction diagram
(1b)
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PATHWAY SOURCE
PATHWAYS
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