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3 S-adenosyl-L-methionine + a [histone H3]-L-lysine36
3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36
overall reaction
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-
?
3 S-adenosyl-L-methionine + [histone H3]-L-lysine36
3 S-adenosyl-L-homocysteine + [histone H3]-N6,N6,N6-trimethyl-L-lysine36
overall reaction
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-
?
S-adenosyl-L-methionine + a [histone H3]-L-lysine36
S-adenosyl-L-homocysteine + a [histone H3]-N6-methyl-L-lysine36
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-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine36
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36
-
-
-
?
S-adenosyl-L-methionine + a [histone H3]-N6-methyl-L-lysine36
S-adenosyl-L-homocysteine + a [histone H3]-N6,N6-dimethyl-L-lysine36
-
-
-
?
S-adenosyl-L-methionine + chicken nucleosome
S-adenosyl-L-homocysteine + chicken nucleosome N6-methyl-L-lysine
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-
?
S-adenosyl-L-methionine + histone H3(K36)
S-adenosyl-L-homocysteine + histone H3(K36) N6-methyl-L-lysine
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-
-
?
S-adenosyl-L-methionine + histone H3(peptide 21-44)
S-adenosyl-L-homocysteine + histone H3(peptide21-44) N6-methyl-L-lysine
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-
-
?
S-adenosyl-L-methionine + recombinant nucleosome
S-adenosyl-L-homocysteine + recombinant nucleosome N6-methyl-L-lysine
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-
?
2 S-adenosyl-L-methionine + [histone H4]-L-lysine44
2 S-adenosyl-L-homocysteine + [histone H4]-N6,N6-dimethyl-L-lysine44
histone H4 lysine-44 is the primary target of NSD2 in the case of octamer substrates, irrespective of the histones being native or recombinant
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?
3 S-adenosyl-L-methionine + a [histone H3]-L-lysine36
3 S-adenosyl-L-homocysteine + a [histone H3]-N6,N6,N6-trimethyl-L-lysine36
overall reaction
-
-
?
S-adenosyl-L-methionine + histone H3(K36)
?
S-adenosyl-L-methionine + [histone H3]-L-lysine36
S-adenosyl-L-homocysteine + [histone H3]-N6-methyl-L-lysine36
-
-
-
?
S-adenosyl-L-methionine + [histone H3]-N6,N6-dimethyl-L-lysine36
S-adenosyl-L-homocysteine + [histone H3]-N6,N6,N6-trimethyl-L-lysine36
highest activity
-
-
?
S-adenosyl-L-methionine + [histone H3]-N6-methyl-L-lysine36
S-adenosyl-L-homocysteine + [histone H3]-N6,N6-dimethyl-L-lysine36
-
-
-
?
additional information
?
-
S-adenosyl-L-methionine + histone H3(K36)
?
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-
?
S-adenosyl-L-methionine + histone H3(K36)
?
NSD2 shows specific targeting of histone H3 lysine-36, DNA acts as an allosteric effector of NSD2 such that H3K36 becomes the preferred target
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-
?
additional information
?
-
enzyme mono- and dimethylates H3K36 and is inactive with H3K4 as substrate. Nucleosome containing histone H3 mutant K36A is not a substrate. Isoform SETD2 is able to trimethylate H3K36 in vitro
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-
?
additional information
?
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-
SETD2 downregulates human ortholog of murine double min 2 protein expression by targeting its P2 promoter and then enhances p53 protein stability, enhances the transcriptional activity of p53, and regulates expression of select p53 target genes
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-
?
additional information
?
-
no activity with unmethylated/methylated [histone H3]-L-lysine27 and [histone H3]-L-lysine20 as well as trimethylated [histone H3]-L-lysine4 and [histone H3]-L-lysine36 peptides
-
-
?
additional information
?
-
the enzyme also efficiently trimethylates [histone H3]-L-lysine4
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?
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Acute Lung Injury
Wolf-Hirschhorn syndrome candidate 1 facilitates alveolar macrophage pyroptosis in sepsis-induced acute lung injury through NEK7-mediated NLRP3 inflammasome activation.
Adenocarcinoma
Loss of Setd2 promotes Kras-induced acinar-to-ductal metaplasia and epithelia-mesenchymal transition during pancreatic carcinogenesis.
Arthritis, Rheumatoid
Altered gene expression profiles of histone lysine methyltransferases and demethylases in rheumatoid arthritis synovial fibroblasts.
Breast Neoplasms
An epigenomic approach to therapy for tamoxifen-resistant breast cancer.
Breast Neoplasms
An open environment CT-US fusion for tissue segmentation during interventional guidance.
Breast Neoplasms
Caveolin-1 (P132L), a common breast cancer mutation, confers mammary cell invasiveness and defines a novel stem cell/metastasis-associated gene signature.
Breast Neoplasms
DACH1 suppresses breast cancer as a negative regulator of CD44.
Breast Neoplasms
Estrogen inhibits the effects of obesity and alcohol on mammary tumors and fatty liver.
Breast Neoplasms
Genetic alterations of histone lysine methyltransferases and their significance in breast cancer.
Breast Neoplasms
Histone-modifier gene expression profiles are associated with pathological and clinical outcomes in human breast cancer.
Breast Neoplasms
Mammary tumor growth and pulmonary metastasis are enhanced in a hyperlipidemic mouse model.
Breast Neoplasms
MMTV-PyMT and Derived Met-1 Mouse Mammary Tumor Cells as Models for Studying the Role of the Androgen Receptor in Triple-Negative Breast Cancer Progression.
Breast Neoplasms
Paclitaxel (Taxol): an inhibitor of angiogenesis in a highly vascularized transgenic breast cancer.
Breast Neoplasms
Permeability across a novel microfluidic blood-tumor barrier model.
Breast Neoplasms
Reprogramming metabolism by histone methyltransferase NSD2 drives endocrine resistance via coordinated activation of pentose phosphate pathway enzymes.
Breast Neoplasms
Rho-kinase (ROK) promotes CD44v(3,8-10)-ankyrin interaction and tumor cell migration in metastatic breast cancer cells.
Breast Neoplasms
Spatial and temporal-controlled tissue heating on a modified clinical ultrasound scanner for generating mild hyperthermia in tumors.
Breast Neoplasms
The COOH-terminal globular domain of fibrinogen gamma chain suppresses angiogenesis and tumor growth.
Carcinogenesis
Analysis of the role of mutations in the KMT2D histone lysine methyltransferase in bladder cancer.
Carcinogenesis
DACH1 suppresses breast cancer as a negative regulator of CD44.
Carcinogenesis
Euchromatic histone methyltransferase 2 inhibitor, BIX-01294, sensitizes human promyelocytic leukemia HL-60 and NB4 cells to growth inhibition and differentiation.
Carcinogenesis
Histone lysine methyltransferase Wolf-Hirschhorn syndrome candidate 1 is involved in human carcinogenesis through regulation of the Wnt pathway.
Carcinogenesis
Histone lysine-specific methyltransferases and demethylases in carcinogenesis: new targets for cancer therapy and prevention.
Carcinogenesis
Lysine methyltransferase 2D regulates pancreatic carcinogenesis through metabolic reprogramming.
Carcinogenesis
Roles of histone methyl-modifying enzymes in development and progression of cancer.
Carcinogenesis
WHSC1 acts as a prognostic indicator and functions as an oncogene in cervical cancer.
Carcinoma
An antisense oligodeoxynucleotide to p21(Waf1/Cip1) causes apoptosis in human breast cancer cells.
Carcinoma
Genetic alteration of histone lysine methyltransferases and their significance in renal cell carcinoma.
Carcinoma
High-resolution profiling of histone h3 lysine 36 trimethylation in metastatic renal cell carcinoma.
Carcinoma
Loss of SETD2 Induces a Metabolic Switch in Renal Cell Carcinoma Cell Lines toward Enhanced Oxidative Phosphorylation.
Carcinoma
MicroRNA-200c restoration reveals a cytokine profile to enhance M1 macrophage polarization in breast cancer.
Carcinoma
miR-106b-5p targets tumor suppressor gene SETD2 to inactive its function in clear cell renal cell carcinoma.
Carcinoma
MMTV-PyMT and Derived Met-1 Mouse Mammary Tumor Cells as Models for Studying the Role of the Androgen Receptor in Triple-Negative Breast Cancer Progression.
Carcinoma
Physical and functional interaction between polyoma virus middle T antigen and insulin and IGF-I receptors is required for oncogene activation and tumour initiation.
Carcinoma
Rapamycin inhibits growth of premalignant and malignant mammary lesions in a mouse model of ductal carcinoma in situ.
Carcinoma, Ductal
Rapamycin inhibits growth of premalignant and malignant mammary lesions in a mouse model of ductal carcinoma in situ.
Carcinoma, Hepatocellular
Comprehensive Bioinformatics Analysis of Key Methyltransferases and Demethylases for Histone Lysines in Hepatocellular Carcinoma.
Carcinoma, Intraductal, Noninfiltrating
Rapamycin inhibits growth of premalignant and malignant mammary lesions in a mouse model of ductal carcinoma in situ.
Carcinoma, Non-Small-Cell Lung
The molecular landscape of histone lysine methyltransferases and demethylases in non-small cell lung cancer.
Carcinoma, Renal Cell
Genetic alteration of histone lysine methyltransferases and their significance in renal cell carcinoma.
Carcinoma, Renal Cell
High-resolution profiling of histone h3 lysine 36 trimethylation in metastatic renal cell carcinoma.
Carcinoma, Renal Cell
Loss of SETD2 Induces a Metabolic Switch in Renal Cell Carcinoma Cell Lines toward Enhanced Oxidative Phosphorylation.
Carcinoma, Renal Cell
miR-106b-5p targets tumor suppressor gene SETD2 to inactive its function in clear cell renal cell carcinoma.
Chagas Disease
Antiproliferative effects of delta 24(25) sterol methyl transferase inhibitors on Trypanosoma (Schizotrypanum) cruzi: in vitro and in vivo studies.
Cleft Palate
Retinoic acid inhibits histone methyltransferase Whsc1 during palatogenesis.
Colitis
Rebooting the microbiome.
Dwarfism
H3K36 methylation is critical for brassinosteroid-regulated plant growth and development in rice.
Head and Neck Neoplasms
Epigenetic perspective into head and neck cancer through in silico gene expression profiling of histone lysine methyltransferases.
Hepatitis B
An Alternatively Spliced Sirtuin 2 Isoform 5 Inhibits Hepatitis B Virus Replication from cccDNA by Repressing Epigenetic Modifications Made by Histone Lysine Methyltransferases.
Infections
A human gut ecosystem protects against C. difficile disease by targeting TcdA.
Infections
Administration of defined microbiota is protective in a murine Salmonella infection model.
Infections
Molecular analysis of astacin-like metalloproteases of Ostertagia ostertagi.
Leishmaniasis, Visceral
Leishmania donovani Subverts Host Immune Response by Epigenetic Reprogramming of Macrophage M(Lipopolysaccharides + IFN-?)/M(IL-10) Polarization.
Leukemia
Activating Fc receptors are required for antitumor efficacy of the antibodies directed toward CD25 in a murine model of adult t-cell leukemia.
Leukemia
Alternative translation initiation generates the N-terminal truncated form of RUNX1 that retains hematopoietic activity.
Leukemia
Expression of tumor invasion factors determines systemic engraftment and induction of humoral hypercalcemia in a mouse model of adult T cell leukemia.
Leukemia
Global identification of MLL2-targeted loci reveals MLL2's role in diverse signaling pathways.
Leukemia
Identification of Novel Disruptor of Telomeric Silencing 1-like (DOT1L) Inhibitors through Structure-Based Virtual Screening and Biological Assays.
Leukemia
Isolation of MLL1 Inhibitory RNA Aptamers.
Leukemia, T-Cell
Effective treatment of a murine model of adult T-cell leukemia using 211At-7G7/B6 and its combination with unmodified anti-Tac (daclizumab) directed toward CD25.
Leukemia, T-Cell
Expression of tumor invasion factors determines systemic engraftment and induction of humoral hypercalcemia in a mouse model of adult T cell leukemia.
Lung Neoplasms
Lung tumor-associated dendritic cell-derived resistin promoted cancer progression by increasing Wolf-Hirschhorn syndrome candidate 1/Twist pathway.
Lung Neoplasms
The molecular landscape of histone lysine methyltransferases and demethylases in non-small cell lung cancer.
Lymphoma
KRAS and NKX2-1 Mutations in Invasive Mucinous Adenocarcinoma of the Lung.
Measles
Success of measles virotherapy in ATL depends on type I interferon secretion and responsiveness.
Multiple Myeloma
A unique mRNA initiated within a middle intron of WHSC1/MMSET encodes a DNA binding protein that suppresses human IL-5 transcription.
Multiple Myeloma
Sabotaging of the oxidative stress response by an oncogenic noncoding RNA.
Multiple Sclerosis
Structural and functional differences between glycosylated and non-glycosylated forms of human interferon-beta (IFN-beta).
Myelodysplastic Syndromes
SET Domain Containing 2 Deficiency in Myelodysplastic Syndrome.
Neoplasm Metastasis
Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion.
Neoplasm Metastasis
Lysines 207 and 325 methylation of WDR5 catalyzed by SETD6 promotes breast cancer cell proliferation and migration.
Neoplasm Metastasis
Metastatic Thymoma Harboring a Deleterious BRCA2 Mutation Derives Durable Clinical Benefit from Olaparib.
Neoplasm Metastasis
MMTV-PyMT and Derived Met-1 Mouse Mammary Tumor Cells as Models for Studying the Role of the Androgen Receptor in Triple-Negative Breast Cancer Progression.
Neoplasm Metastasis
The COOH-terminal globular domain of fibrinogen gamma chain suppresses angiogenesis and tumor growth.
Neoplasm Metastasis
The milk protein ?-casein functions as a tumor suppressor via activation of STAT1 signaling, effectively preventing breast cancer tumor growth and metastasis.
Neoplasm Metastasis
Tumor Microenvironment Regulates Metastasis and Metastasis Genes of Mouse MMTV-PymT Mammary Cancer Cells In Vivo.
Neoplasms
A cytoplasmic COMPASS is necessary for cell survival and triple-negative breast cancer pathogenesis by regulating metabolism.
Neoplasms
An Imaging-Driven Model for Liposomal Stability and Circulation.
Neoplasms
An open environment CT-US fusion for tissue segmentation during interventional guidance.
Neoplasms
An optical and microPET assessment of thermally-sensitive liposome biodistribution in the Met-1 tumor model: Importance of formulation.
Neoplasms
Cancers and the NSD family of histone lysine methyltransferases.
Neoplasms
CD44v(3,8-10) is involved in cytoskeleton-mediated tumor cell migration and matrix metalloproteinase (MMP-9) association in metastatic breast cancer cells.
Neoplasms
CRISPR/Cas9-mediated knockout of NSD1 suppresses the hepatocellular carcinoma development via the NSD1/H3/Wnt10b signaling pathway.
Neoplasms
DACH1 suppresses breast cancer as a negative regulator of CD44.
Neoplasms
Genomic characterization of sarcomatoid transformation in clear cell renal cell carcinoma.
Neoplasms
Histone methyltransferase NSD2 mediates the survival and invasion of triple-negative breast cancer cells via stimulating ADAM9-EGFR-AKT signaling.
Neoplasms
Histone methyltransferase SETD2 modulates alternative splicing to inhibit intestinal tumorigenesis.
Neoplasms
Histone-modifier gene expression profiles are associated with pathological and clinical outcomes in human breast cancer.
Neoplasms
Impact of Epigenetic Regulation on Head and Neck Squamous Cell Carcinoma.
Neoplasms
In vivo validation and 3D visualization of broadband ultrasound molecular imaging.
Neoplasms
Inhibiting PI3K reduces mammary tumor growth and induces hyperglycemia in a mouse model of insulin resistance and hyperinsulinemia.
Neoplasms
Insulin-sensitizing therapy attenuates type 2 diabetes-mediated mammary tumor progression.
Neoplasms
KDM4/JMJD2 histone demethylases: epigenetic regulators in cancer cells.
Neoplasms
KRAS and NKX2-1 Mutations in Invasive Mucinous Adenocarcinoma of the Lung.
Neoplasms
Long non-coding RNAs MACC1-AS1 and FOXD2-AS1 mediate NSD2-induced cisplatin resistance in esophageal squamous cell carcinoma.
Neoplasms
Loss of Setd2 promotes Kras-induced acinar-to-ductal metaplasia and epithelia-mesenchymal transition during pancreatic carcinogenesis.
Neoplasms
Magnetic resonance thermometry at 7T for real-time monitoring and correction of ultrasound induced mild hyperthermia.
Neoplasms
Mammary tumor growth and pulmonary metastasis are enhanced in a hyperlipidemic mouse model.
Neoplasms
Measles Virotherapy in a Mouse Model of Adult T cell Leukemia/Lymphoma.
Neoplasms
MMTV-PyMT and Derived Met-1 Mouse Mammary Tumor Cells as Models for Studying the Role of the Androgen Receptor in Triple-Negative Breast Cancer Progression.
Neoplasms
Molecular pathways in renal cell carcinoma: recent advances in genetics and molecular biology.
Neoplasms
Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas.
Neoplasms
Physical and functional interaction between polyoma virus middle T antigen and insulin and IGF-I receptors is required for oncogene activation and tumour initiation.
Neoplasms
Rapamycin inhibits growth of premalignant and malignant mammary lesions in a mouse model of ductal carcinoma in situ.
Neoplasms
Reprogramming metabolism by histone methyltransferase NSD2 drives endocrine resistance via coordinated activation of pentose phosphate pathway enzymes.
Neoplasms
Rho-kinase (ROK) promotes CD44v(3,8-10)-ankyrin interaction and tumor cell migration in metastatic breast cancer cells.
Neoplasms
Role of several histone lysine methyltransferases in tumor development.
Neoplasms
Sabotaging of the oxidative stress response by an oncogenic noncoding RNA.
Neoplasms
SETD2: an epigenetic modifier with tumor suppressor functionality.
Neoplasms
SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer.
Neoplasms
Spatial and temporal-controlled tissue heating on a modified clinical ultrasound scanner for generating mild hyperthermia in tumors.
Neoplasms
SPOP-containing complex regulates SETD2 stability and H3K36me3-coupled alternative splicing.
Neoplasms
Success of measles virotherapy in ATL depends on type I interferon secretion and responsiveness.
Neoplasms
Targeting the Nuclear Receptor-Binding SET Domain Family of Histone Lysine Methyltransferases for Cancer Therapy: Recent Progress and Perspectives.
Neoplasms
The COOH-terminal globular domain of fibrinogen gamma chain suppresses angiogenesis and tumor growth.
Neoplasms
The milk protein ?-casein functions as a tumor suppressor via activation of STAT1 signaling, effectively preventing breast cancer tumor growth and metastasis.
Neoplasms
The Role of Nuclear Receptor-Binding SET Domain Family Histone Lysine Methyltransferases in Cancer.
Neoplasms
Trityl-based EPR probe with enhanced sensitivity to oxygen.
Neoplasms
Tumor Microenvironment Regulates Metastasis and Metastasis Genes of Mouse MMTV-PymT Mammary Cancer Cells In Vivo.
Neoplasms
Unsafe SETs: histone lysine methyltransferases and cancer.
Neoplasms
Wolf-Hirschhorn Syndrome Candidate 1 (whsc1) Functions as a Tumor Suppressor by Governing Cell Differentiation.
Neoplasms
Wolf-Hirschhorn syndrome candidate 1 facilitates alveolar macrophage pyroptosis in sepsis-induced acute lung injury through NEK7-mediated NLRP3 inflammasome activation.
Overweight
Estrogen inhibits the effects of obesity and alcohol on mammary tumors and fatty liver.
Prostatic Neoplasms
Integrated Analysis of Genetic Abnormalities of the Histone Lysine Methyltransferases in Prostate Cancer.
Sarcoma
KRAS and NKX2-1 Mutations in Invasive Mucinous Adenocarcinoma of the Lung.
Squamous Cell Carcinoma of Head and Neck
Impact of Epigenetic Regulation on Head and Neck Squamous Cell Carcinoma.
Triple Negative Breast Neoplasms
MMTV-PyMT and Derived Met-1 Mouse Mammary Tumor Cells as Models for Studying the Role of the Androgen Receptor in Triple-Negative Breast Cancer Progression.
Wolf-Hirschhorn Syndrome
A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf-Hirschhorn syndrome.
Wolf-Hirschhorn Syndrome
A microdeletion proximal of the critical deletion region is associated with mild Wolf-Hirschhorn syndrome.
Wolf-Hirschhorn Syndrome
A Scalable Platform for Producing Recombinant Nucleosomes with Codified Histone Methyltransferase Substrate Preferences.
Wolf-Hirschhorn Syndrome
A unique mRNA initiated within a middle intron of WHSC1/MMSET encodes a DNA binding protein that suppresses human IL-5 transcription.
Wolf-Hirschhorn Syndrome
Functional characterization of the zebrafish WHSC1-related gene, a homolog of human NSD2.
Wolf-Hirschhorn Syndrome
Histone lysine methyltransferase Wolf-Hirschhorn syndrome candidate 1 is involved in human carcinogenesis through regulation of the Wnt pathway.
Wolf-Hirschhorn Syndrome
Identification of a novel proliferation-related protein, WHSC1 4a, in human gliomas.
Wolf-Hirschhorn Syndrome
Lung tumor-associated dendritic cell-derived resistin promoted cancer progression by increasing Wolf-Hirschhorn syndrome candidate 1/Twist pathway.
Wolf-Hirschhorn Syndrome
Retinoic acid inhibits histone methyltransferase Whsc1 during palatogenesis.
Wolf-Hirschhorn Syndrome
Sabotaging of the oxidative stress response by an oncogenic noncoding RNA.
Wolf-Hirschhorn Syndrome
WHSC1 acts as a prognostic indicator and functions as an oncogene in cervical cancer.
Wolf-Hirschhorn Syndrome
WHSC1 links transcription elongation to HIRA-mediated histone H3.3 deposition.
Wolf-Hirschhorn Syndrome
WHSC1 promotes oncogenesis through regulation of NIMA-related kinase-7 in squamous cell carcinoma of the head and neck.
Wolf-Hirschhorn Syndrome
WHSC1/NSD2 regulates immune infiltration in prostate cancer.
Wolf-Hirschhorn Syndrome
Wolf-Hirschhorn Syndrome Candidate 1 (whsc1) Functions as a Tumor Suppressor by Governing Cell Differentiation.
Wolf-Hirschhorn Syndrome
Wolf-Hirschhorn syndrome candidate 1 facilitates alveolar macrophage pyroptosis in sepsis-induced acute lung injury through NEK7-mediated NLRP3 inflammasome activation.
Wolf-Hirschhorn Syndrome
Wolf-Hirschhorn syndrome candidate 1 is involved in the cellular response to DNA damage.
Wolf-Hirschhorn Syndrome
Wolf-Hirschhorn Syndrome Candidate 1 Is Necessary for Correct Hematopoietic and B Cell Development.
[histone h3]-lysine36 n-trimethyltransferase deficiency
SET Domain Containing 2 Deficiency in Myelodysplastic Syndrome.
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Xie, P.; Tian, C.; An, L.; Nie, J.; Lu, K.; Xing, G.; Zhang, L.; He, F.
Histone methyltransferase protein SETD2 interacts with p53 and selectively regulates its downstream genes
Cell. Signal.
20
1671-1678
2008
Homo sapiens
brenda
Li, Y.; Trojer, P.; Xu, C.F.; Cheung, P.; Kuo, A.; Drury, W.J.; Qiao, Q.; Neubert, T.A.; Xu, R.M.; Gozani, O.; Reinberg, D.
The target of the NSD family of histone lysine methyltransferases depends on the nature of the substrate
J. Biol. Chem.
284
34283-34295
2009
Homo sapiens (O96028), Homo sapiens (Q9BYW2), Homo sapiens
brenda
Tanaka, Y.; Kawahashi, K.; Katagiri, Z.; Nakayama, Y.; Mahajan, M.; Kioussis, D.
Dual function of histone H3 lysine 36 methyltransferase ASH1 in regulation of Hox gene expression
PLoS ONE
6
e28171
2011
Homo sapiens
brenda
Eram, M.S.; Kuznetsova, E.; Li, F.; Lima-Fernandes, E.; Kennedy, S.; Chau, I.; Arrowsmith, C.H.; Schapira, M.; Vedadi, M.
Kinetic characterization of human histone H3 lysine 36 methyltransferases, ASH1L and SETD2
Biochim. Biophys. Acta
1850
1842-1848
2015
Homo sapiens (Q9BYW2)
brenda
Li, F.; Mao, G.; Tong, D.; Huang, J.; Gu, L.; Yang, W.; Li, G.M.
The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutSalpha
Cell
153
590-600
2013
Homo sapiens (Q9BYW2), Homo sapiens
brenda
Pfister, S.X.; Ahrabi, S.; Zalmas, L.P.; Sarkar, S.; Aymard, F.; Bachrati, C.Z.; Helleday, T.; Legube, G.; La Thangue, N.B.; Porter, A.C.; Humphrey, T.C.
SETD2-dependent histone H3K36 trimethylation is required for homologous recombination repair and genome stability
Cell Rep.
7
2006-2018
2014
Homo sapiens (Q9BYW2)
brenda
Eram, M.S.; Bustos, S.P.; Lima-Fernandes, E.; Siarheyeva, A.; Senisterra, G.; Hajian, T.; Chau, I.; Duan, S.; Wu, H.; Dombrovski, L.; Schapira, M.; Arrowsmith, C.H.; Vedadi, M.
Trimethylation of histone H3 lysine 36 by human methyltransferase PRDM9 protein
J. Biol. Chem.
289
12177-12188
2014
Homo sapiens (Q9NQV7)
brenda
Hacker, K.E.; Fahey, C.C.; Shinsky, S.A.; Chiang, Y.J.; DiFiore, J.V.; Jha, D.K.; Vo, A.H.; Shavit, J.A.; Davis, I.J.; Strahl, B.D.; Rathmell, W.K.
Structure/function analysis of recurrent mutations in SETD2 protein reveals a critical and conserved role for a SET domain residue in maintaining protein stability and histone H3 Lys-36 trimethylation
J. Biol. Chem.
291
21283-21295
2016
Saccharomyces cerevisiae (P46995), Homo sapiens (Q9BYW2)
brenda
Li, L.; Wang, Y.
Cross-talk between the H3K36me3 and H4K16ac histone epigenetic marks in DNA double-strand break repair
J. Biol. Chem.
292
11951-11959
2017
Homo sapiens (Q9BYW2)
brenda
Huang, H.; Weng, H.; Zhou, K.; Wu, T.; Zhao, B.S.; Sun, M.; Chen, Z.; Deng, X.; Xiao, G.; Auer, F.; Klemm, L.; Wu, H.; Zuo, Z.; Qin, X.; Dong, Y.; Zhou, Y.; Qin, H.; Tao, S.; Du, J.; Liu, J.; Lu, Z.; Yin, H.; Mesquita, A.; Yuan, C.L.; Hu, Y.C.; Sun, W.; Su, R.; Dong, L.; Shen, C.; Li, C.; Qing, Y.; Jiang, X.; Wu, X.; Sun, M.
Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally
Nature
567
414-419
2019
Homo sapiens (Q9BYW2)
brenda
Carvalho, S.; Raposo, A.C.; Martins, F.B.; Grosso, A.R.; Sridhara, S.C.; Rino, J.; Carmo-Fonseca, M.; de Almeida, S.F.
Histone methyltransferase SETD2 coordinates FACT recruitment with nucleosome dynamics during transcription
Nucleic Acids Res.
41
2881-2893
2013
Homo sapiens (Q9BYW2)
brenda
Zhu, K.; Lei, P.J.; Ju, L.G.; Wang, X.; Huang, K.; Yang, B.; Shao, C.; Zhu, Y.; Wei, G.; Fu, X.D.; Li, L.; Wu, M.
SPOP-containing complex regulates SETD2 stability and H3K36me3-coupled alternative splicing
Nucleic Acids Res.
45
92-105
2017
Homo sapiens (Q9BYW2)
brenda
Ho, T.H.; Park, I.Y.; Zhao, H.; Tong, P.; Champion, M.D.; Yan, H.; Monzon, F.A.; Hoang, A.; Tamboli, P.; Parker, A.S.; Joseph, R.W.; Qiao, W.; Dykema, K.; Tannir, N.M.; Castle, E.P.; Nunez-Nateras, R.; Teh, B.T.; Wang, J.; Walker, C.L.; Hung, M.C.; Jonasch, E.
High-resolution profiling of histone h3 lysine 36 trimethylation in metastatic renal cell carcinoma
Oncogene
35
1565-1574
2016
Homo sapiens (Q9BYW2)
brenda
Hu, M.; Sun, X.J.; Zhang, Y.L.; Kuang, Y.; Hu, C.Q.; Wu, W.L.; Shen, S.H.; Du, T.T.; Li, H.; He, F.; Xiao, H.S.; Wang, Z.G.; Liu, T.X.; Lu, H.; Huang, Q.H.; Chen, S.J.; Chen, Z.
Histone H3 lysine 36 methyltransferase Hypb/Setd2 is required for embryonic vascular remodeling
Proc. Natl. Acad. Sci. USA
107
2956-2961
2010
Mus musculus (E9Q5F9), Homo sapiens (Q9BYW2)
brenda